Jennifer Bussell PhD
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jenbussell.bsky.social
Jennifer Bussell PhD
@jenbussell.bsky.social

Neuroscientist studying information seeking and curiosity via mouse models at Columbia University. Previously at Vosshall Lab at Rockefeller University. Mom in Brooklyn, former S Carolinian www.jenniferbussell.org

Political science 68%
Sociology 15%
Pinned
Absolutely thrilled to share my postdoc work in the Axel lab. We found odor-evoked representations of the intrinsic value of information in mouse orbitofrontal cortex and showed that mice desire knowledge as its own reward. Now on bioRxiv! www.biorxiv.org/content/10.1...
Representations of information value in mouse orbitofrontal cortex during information seeking
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org

Reposted by Jennifer Bussell

This is a powerful message from Freeman Hrabowski.

🧵

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Reposted by Jennifer Bussell

Can you easily distinguish between value, valence, and salience?

Probably not, but the prefrontal cortex of mice seems to achieve this by creating a sort of multidimensional orthogonal neural space, where each dimension corresponds to one of these subjective elements

www.nature.com/articles/s41...
Prefrontal neural geometry of learned cues guides motivated behaviours - Nature
The dorsomedial prefrontal cortex encodes the value, salience and valence of learned stimuli along distinct neural dimensions, and the geometry of these representations shapes motivated behaviours in ...
www.nature.com
Just because good news is worth celebrating:

There is now a Prep medication that is an *every six month* injection.

HIV has, effectively, a vaccination.
Imagination in bonobos!

I am thrilled to share a new paper w/ Amalia Bastos, out now in @science.org

We provide the first experimental evidence that a nonhuman animal can follow along a pretend scenario & track imaginary objects. Work w/ Kanzi, the bonobo, at Ape Initiative

youtu.be/NUSHcQQz2Ko
Apes Share Human Ability to Imagine
YouTube video by Johns Hopkins University
youtu.be

Reposted by Jennifer Bussell

And the amazing resource that is the Atlas of Inspiring LatinX/Hispanic Scientists, which you can learn more about and access here:

www.fredhutch.org/en/about/abo...
Inspiring Hispanic/Latinx Scientists
The Atlas of Inspiring Hispanic/Latinx Scientists is a grassroots effort developed to showcase the expertise, talents, and diversity of Hispanic and Latinx scientific faculty.
www.fredhutch.org

Reposted by Jennifer Bussell

I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond!

www.wiley.com/en-us/resear...

Reposted by Jennifer Bussell

Final paper of my PhD 🤗

www.nature.com/articles/s44...

There is growing interest in how cognitive control may improve value-based decision making.

However, we find that a recent paper overestimated the role of control in their task, leading to erroneous interpretations of dACC recordings.
Misspecified models create the appearance of adaptive control during value-based choice - Communications Psychology
In a new computational analysis of previous work, this study shows that a control-free mechanism better accounts for value-based decisions than an account that assumes top-down control invigorating th...
www.nature.com
Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign.

(1) $48.7 billion for NIH
(2) Full IDC recovery
(3) No more multi-year funding
(4) No NIH reorganization, maintaining the current IC structure.

Reposted by Jennifer Bussell

first empirical paper from the Aulet lab! What does learning to count do to a brain? We trained neural networks on different tasks and only counting (i.e., predicting the number of dots in a dot array) reorganized representations around number. New preprint:
"...women receive substantially lower potential ratings despite receiving higher performance ratings... lower potential ratings do not reflect accurate forecasts of future performance: Women subsequently outperform male colleagues..."
pubs.aeaweb.org/doi/pdfplus/...

Reposted by Jennifer Bussell

Sesame Street has uploaded a bunch of classic episodes to YouTube that are free to watch, including the very first episode from 1969, the one where Mister Rogers visits, and the episode where Mr. Snuffulupagus is finally revealed. [kottke.org]
Watch Classic Episodes of Sesame Street for Free on YouTube
Sesame Street has uploaded a bunch of classic episodes to YouTube that are free to watch, including the very first episode from 1969, the one where Mister Rogers visits, and the episode where Mr. Snuffulupagus is fin
kottke.org
New at Can We Still Govern: NIH scientist @markhisted.org reviews the damage done to American biomedical science in the last year and looks ahead:
"Scientists should not be political partisans, but they should be partisans for liberal democratic principles."🧵
donmoynihan.substack.com/p/american-b...
American biomedical science in 2026
Where we are, how we got here, and what to do next
donmoynihan.substack.com
This must be weird news to see if you’re one of the literally hundreds or even thousands of university administrators who preemptively censored faculty, scrubbed websites, changed the names of centers, etc.

Reposted by Jennifer Bussell

If you / your lab / your institution rely on NIH funding, you need to read this and understand how this is one of many changes affecting you. www.nature.com/articles/d41...
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
www.nature.com
RFK Jr. appointee Kirk Milhoan has just clearly stated, out loud, that he wants to experiment on the people of the United States by seeing what happens as vaccination coverage plummets and infectious diseases spread.
🚨 New from me: Grant review at more than half of NIH's institutes could be frozen by the end of the year.

That's because crucial NIH grant-review panels are slated to be empty at those institutes by Jan 2027.

A wonky bureaucratic problem with big implications.

A short 🧵
Exclusive: key NIH review panels due to lose all members by the end of 2026
Thirteen of the agency’s advisory councils, which must review grant applications before funding is awarded, are on track to have no voting members.
www.nature.com
As #NYC is potentially facing historic levels of snow this weekend, now is the time to star preparing to help our neighbors.

dora.nyc is ready - but we need your help.

Upload resources, donate, volunteer.

Reposted by Jennifer Bussell

Hey ventral pallidum fans, see our new paper showing that #VP GABA neurons, known for reward, also regulate aversive motivation! Inhibiting these cells with #DREADDs potentiates active or passive defenses to threats, likely via LHb.
Congrats to Erica Ramirez & Marty Martinez!
doi.org/10.1016/j.yn...
Redirecting
doi.org
This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again.

www.nature.com/immersive/d4...

Reposted by Jennifer Bussell

Just spoke to The Hill about how the dismantling of the NIH is impacting science in America. We still face a cliff of unfathomable heights, w easily 1000+ labs poised to close in the next year due to funding ending. A generation of young scientists lost because there is nowhere for them to train.
The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning.

www.appropriations.senate.gov/news/majorit...

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Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Related Agencies, and Transportation, Housing and Urban Development, and Related Agencies Bi...
United States Senate Committee on Appropriations
www.appropriations.senate.gov

Reposted by Jennifer Bussell

New in Nature Neuroscience: We developed a flexible model that reveals how animals learn tasks—uncovering stages, sudden insights, and gradual improvements unique to each animal.
Learning isn't monotonic, and our model captures that complexity 🐭📊
www.nature.com/articles/s41...
Infinite hidden Markov models can dissect the complexities of learning - Nature Neuroscience
Bruijns et al. present a modeling tool that enables the tracking of learning dynamics across subjects to reveal how behaviors emerge and adapt. Applying the tool to a decision-making task in mice unco...
www.nature.com
This is so grim. Science isn’t just something nerds do, but the foundation of the modern world. What the Trump regime has done to US science will harm Americans for generations.
‘Shattered’: US scientists speak out about how Trump policies disrupted their careers
Researchers lay bare the human toll of lay-offs, funding cuts and attacks on science one year after the president’s return to the White House.
www.nature.com

Reposted by Jennifer Bussell

Teach neuroscience to undergraduates? Learn how to incorporate our connectomics data into your courses!

🧠 "Incorporating open connectomics data into teaching neuroscience"
🗓️ July 23-24
🛫 Travel funds available
⏳ Apply by Feb. 2: https://bit.ly/3LAfOdy

#neuroskyence
Incorporating open connectomics data into teaching neuroscience
Learn to analyze open neuroscience data and introduce dry lab modules into your existing classes at the Incorporating Open Connectomics data into...
alleninstitute.org

Reposted by Jennifer Bussell

I’m very happy to share the latest from my lab published in @Nature

Hippocampal neurons that initially encode reward shift their tuning over the course of days to precede or predict reward.

Full text here:
rdcu.be/eY5nh

Reposted by Jennifer Bussell

Dopamine Accumulation Dynamics Control Time Perception https://www.biorxiv.org/content/10.64898/2026.01.13.699158v1

Reposted by Jennifer Bussell

Exciting new preprint on oxytocin neural circuits for massage led by Manon Bohic in Vicky Abraira’s lab. Sasha and I were glad to contribute imaging experiments to this collaborative effort, spanning mice to humans. Vicky is a master at bringing people together.

www.biorxiv.org/content/10.6...
Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of Massage
Across social species, social touch enhances well-being and reduces pain - two seemingly distinct benefits that enhance survival. Yet where and how the nervous system integrates these functions, and w...
www.biorxiv.org

Reposted by Jennifer Bussell

What a breakthrough! Such a puzzle for 30 years, this is real progress!

I wonder how general this mechanism of repression is for other systems where highly-selective expression is needed.

www.biorxiv.org/content/10.6...
The transcription of a single olfactory receptor per neuron is enforced by epigenetic silencing of their enhancers
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
www.biorxiv.org

Reposted by Jennifer Bussell

Universities should build accessory lab units (ALUs) that let elders still do some of their own science but also be nearby to watch over their grand-trainees.
👀

“If you are a 75-year-old professor reading this, now would be a good time to take emeritus status. It’s something that a lot of people could do that would contribute enormously. The job market for young people would be in much better shape if most people over 75 retired.”

Reposted by Jennifer Bussell

Folks interested in science philanthropy should read this interview w/Simons Foundation President David Spergel on the role of philanthropy, support of early career scientists (from incentives to a call for more retirements), and the pivot point between future scenarios.

issues.org/american-sci...
“There Are Two Possible Futures for American Science.”
The Simons Foundation president talks about science philanthropy, the future of the research enterprise, and remaining hopeful.
issues.org