Josh Currie
@joshcurrie.bsky.social
Studying principles of tissue regeneration in the axolotl and looking toward regenerative therapies. Asst. Professor at Wake Forest University. Views my own. He/him.
https://www.currie-regenerationlab.com/
https://www.currie-regenerationlab.com/
Pinned
Josh Currie
@joshcurrie.bsky.social
· Nov 11
As a re-introduction to new followers, my lab at Wake Forest University studies mechanisms of regeneration in the phenomenal #axolotl with an emphasis on imaging. We think that visualizing cells and molecules in 3D/4D is vital to understanding how regeneration works!
currie-regenerationlab.com
currie-regenerationlab.com
Reposted by Josh Currie
Very excited to share the latest work from our lab in @insight.jci.org, highlighting a role for the #septin #cytoskeleton in protecting against "leaky gut", by recruiting non-muscle myosin II and stabilizing the tight junction.
Credit to @dominikrobak.bsky.social for the stunning cover image!
Credit to @dominikrobak.bsky.social for the stunning cover image!
This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social& team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...
November 24, 2025 at 6:01 PM
Very excited to share the latest work from our lab in @insight.jci.org, highlighting a role for the #septin #cytoskeleton in protecting against "leaky gut", by recruiting non-muscle myosin II and stabilizing the tight junction.
Credit to @dominikrobak.bsky.social for the stunning cover image!
Credit to @dominikrobak.bsky.social for the stunning cover image!
Reposted by Josh Currie
Meet the Alpine Salamander.
It may look like just another amphibian, but did you know they have one of the longest gestation periods in the animal kingdom?
Their babies take 2-4 YEARS to be born.
Yes, you read that right, up to 4 years of pregnancy.
#nature #amphibian #salamander #animals #wild
It may look like just another amphibian, but did you know they have one of the longest gestation periods in the animal kingdom?
Their babies take 2-4 YEARS to be born.
Yes, you read that right, up to 4 years of pregnancy.
#nature #amphibian #salamander #animals #wild
November 24, 2025 at 12:11 AM
Meet the Alpine Salamander.
It may look like just another amphibian, but did you know they have one of the longest gestation periods in the animal kingdom?
Their babies take 2-4 YEARS to be born.
Yes, you read that right, up to 4 years of pregnancy.
#nature #amphibian #salamander #animals #wild
It may look like just another amphibian, but did you know they have one of the longest gestation periods in the animal kingdom?
Their babies take 2-4 YEARS to be born.
Yes, you read that right, up to 4 years of pregnancy.
#nature #amphibian #salamander #animals #wild
Reposted by Josh Currie
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
November 24, 2025 at 6:57 PM
Confirmation of the new triage line at 65-70% of proposals. Introduction of a new “competitive but ND” class to permit exception pay pickups.
I have at least one undergraduate in class that I can tell uses a LLM to read and summarize papers for discussions. They have very little insight into any detail of the paper. Knowledge that's a mile wide but an inch deep, as they say...
Relying on ChatGPT to teach you about a topic leaves you with shallower knowledge than Googling and reading about it, according to new research that compared what more than 10,000 people knew after using one method or the other.
Shared by @gizmodo.com: buff.ly/yAAHtHq
Shared by @gizmodo.com: buff.ly/yAAHtHq
November 24, 2025 at 3:07 PM
I have at least one undergraduate in class that I can tell uses a LLM to read and summarize papers for discussions. They have very little insight into any detail of the paper. Knowledge that's a mile wide but an inch deep, as they say...
Reposted by Josh Currie
New release of the TrackMate single particle tracking plugin for ImageJ by @jytinevez.bsky.social looks amazing! forum.image.sc/t/trackmate-...
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
TrackMate v8 - segmentation editor and Python CLI integration
TrackMate v8: 2D Segmentation Editor & Python CLI Integration Hi everyone, I am excited to announce TrackMate v8, a major update introducing key improvements for both end-users and developers. Mai...
forum.image.sc
November 24, 2025 at 2:14 PM
New release of the TrackMate single particle tracking plugin for ImageJ by @jytinevez.bsky.social looks amazing! forum.image.sc/t/trackmate-...
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
Reposted by Josh Currie
Shocker... 🙃 www.embopress.org/doi/full/10....
Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro | EMBO reports
imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific
manner, both in cells and in vitro, highlighting the need for careful validation in
condensate studi...
www.embopress.org
November 22, 2025 at 3:55 PM
Shocker... 🙃 www.embopress.org/doi/full/10....
Reposted by Josh Currie
In the spirit of togetherness, international followers, please share your country's most dangerous cooking method.
November 17, 2025 at 7:39 PM
In the spirit of togetherness, international followers, please share your country's most dangerous cooking method.
Reposted by Josh Currie
Don't do any of this.
November 17, 2025 at 6:54 PM
Don't do any of this.
Reposted by Josh Currie
🚨New paper! 🚨
@jasminealqassar.bsky.social led this work on the silk glands of the pantry moth.
These two long tubes inside the caterpillar continuously make a ton of silk
How does this special organ work?
www.cell.com/iscience/ful...
@cp-iscience.bsky.social
🧵THREAD🧵
@jasminealqassar.bsky.social led this work on the silk glands of the pantry moth.
These two long tubes inside the caterpillar continuously make a ton of silk
How does this special organ work?
www.cell.com/iscience/ful...
@cp-iscience.bsky.social
🧵THREAD🧵
November 16, 2025 at 2:06 AM
🚨New paper! 🚨
@jasminealqassar.bsky.social led this work on the silk glands of the pantry moth.
These two long tubes inside the caterpillar continuously make a ton of silk
How does this special organ work?
www.cell.com/iscience/ful...
@cp-iscience.bsky.social
🧵THREAD🧵
@jasminealqassar.bsky.social led this work on the silk glands of the pantry moth.
These two long tubes inside the caterpillar continuously make a ton of silk
How does this special organ work?
www.cell.com/iscience/ful...
@cp-iscience.bsky.social
🧵THREAD🧵
Reposted by Josh Currie
Exciting News! 😎 syGlass is proud to announce our new collaboration with Sony, featuring their revolutionary glasses-free 3D Spatial Reality Display. Experience the future of visualization at the 2025 Society for Neuroscience conference. Stop by our booth #813 to see it in action!
#sfn25 #sfn2025
#sfn25 #sfn2025
November 14, 2025 at 5:21 PM
Reposted by Josh Currie
Happy to see our paper “Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue” in @natbiotech.nature.com – with Tobias Moser’s lab from @unimedizin-goe.bsky.social and @janwenzel.bsky.social
www.nature.com/articles/s41...
#microscopy #lightsheet
www.nature.com/articles/s41...
#microscopy #lightsheet
November 14, 2025 at 4:41 PM
Happy to see our paper “Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue” in @natbiotech.nature.com – with Tobias Moser’s lab from @unimedizin-goe.bsky.social and @janwenzel.bsky.social
www.nature.com/articles/s41...
#microscopy #lightsheet
www.nature.com/articles/s41...
#microscopy #lightsheet
Reposted by Josh Currie
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
MultiSite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox for use in vertebrate model systems
Summary: A comprehensive suite of Gateway-compatible plasmids for in vitro and in vivo transgenesis in vertebrate model systems has been developed, together with a relational, modifiable, open-source ...
journals.biologists.com
November 14, 2025 at 5:33 PM
New paper from the lab on a new Gateway compatible toolkit for transgenesis in eukaryotes, led by former technician Will Gillespie.
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Open access @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Reposted by Josh Currie
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
November 14, 2025 at 5:45 PM
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
It's wild thinking about my cursed NIH R35 app
Submitted in Jan 2025
Pulled by NIH in May for a foreign letter 🙄 and resubmitted 2 days later for May deadline
Study section scheduled for Oct
Likely not reviewed until Jan 2026
Waiting a year for REVIEWS seems pretty unsustainable pre-tenure 🫠
Submitted in Jan 2025
Pulled by NIH in May for a foreign letter 🙄 and resubmitted 2 days later for May deadline
Study section scheduled for Oct
Likely not reviewed until Jan 2026
Waiting a year for REVIEWS seems pretty unsustainable pre-tenure 🫠
November 14, 2025 at 3:49 PM
It's wild thinking about my cursed NIH R35 app
Submitted in Jan 2025
Pulled by NIH in May for a foreign letter 🙄 and resubmitted 2 days later for May deadline
Study section scheduled for Oct
Likely not reviewed until Jan 2026
Waiting a year for REVIEWS seems pretty unsustainable pre-tenure 🫠
Submitted in Jan 2025
Pulled by NIH in May for a foreign letter 🙄 and resubmitted 2 days later for May deadline
Study section scheduled for Oct
Likely not reviewed until Jan 2026
Waiting a year for REVIEWS seems pretty unsustainable pre-tenure 🫠
Reposted by Josh Currie
This is utterly insane
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 2:47 AM
This is utterly insane
Reposted by Josh Currie
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
buff.ly/UEtcRd4
November 12, 2025 at 4:15 PM
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
buff.ly/UEtcRd4
Reposted by Josh Currie
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
November 12, 2025 at 10:31 AM
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
Reposted by Josh Currie
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 10, 2025 at 5:47 PM
Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Josh Currie
Hydra (Hydra vulgaris) ✨Small but mighty! Hydra can regenerate its entire body, even its head 🧠 A classic model for regeneration, stem cell dynamics, and body axis patterning 📸 Image by Daniel Bressan de Andrade #ModelMonday #DevBio #Regeneration
November 11, 2025 at 2:28 AM
Hydra (Hydra vulgaris) ✨Small but mighty! Hydra can regenerate its entire body, even its head 🧠 A classic model for regeneration, stem cell dynamics, and body axis patterning 📸 Image by Daniel Bressan de Andrade #ModelMonday #DevBio #Regeneration
Reposted by Josh Currie
Raptor recovery… Marsh Harrier, Goshawk, White-tailed Eagle and Osprey have all increased substantially over recent decades. Ospreys have colonised new counties at the rate of one a year, including Co. Fermanagh in 2023, the first breeding on the island of Ireland in 200 yrs #ukbirding #ornithology
November 9, 2025 at 8:45 AM
Raptor recovery… Marsh Harrier, Goshawk, White-tailed Eagle and Osprey have all increased substantially over recent decades. Ospreys have colonised new counties at the rate of one a year, including Co. Fermanagh in 2023, the first breeding on the island of Ireland in 200 yrs #ukbirding #ornithology
🤣
November 8, 2025 at 6:52 AM
🤣
Reposted by Josh Currie
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
Reposted by Josh Currie
For fellow professors that require “interview a professor“ assignments, just know I will find you and I will have my revenge.
November 4, 2025 at 9:44 PM
For fellow professors that require “interview a professor“ assignments, just know I will find you and I will have my revenge.
My only regret is that this testimony came after Halloween. I need some "exploding sandwich on snowflake gestapo" costumes in my feed
The officer Sandwich Guy is charged with assaulting testifies that he could feel the impact of the sandwich through his ballistic vest, and it “exploded all over my uniform.” He says he could “smell the onions and the mustard.”
November 5, 2025 at 2:22 AM
My only regret is that this testimony came after Halloween. I need some "exploding sandwich on snowflake gestapo" costumes in my feed
Yep, the kid is having a totally normal childhood, definitely not being exploited for cheap weekend lab labor. Nothing to see here....
November 3, 2025 at 8:29 PM
Yep, the kid is having a totally normal childhood, definitely not being exploited for cheap weekend lab labor. Nothing to see here....