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Reposted by Wallace Marshall

Marie Zelená @mariezelena.bsky.social · 2d

Our collaboration with @mbonhivers.bsky.social is now out in @plosbiology.org! 🎉Using U-ExM, we mapped the formation of the flagellar pocket collar in T. brucei. Huge thanks to everyone involved — one step closer to #PhDone!

#ExM #oneringtorulethemall #Bilbo1 #trypanosoma #protistsonsky

PLOS Biology @plosbiology.org · 2d

The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6

A Trypanosoma brucei cell visualized by confocal microscopy after ultrastructure expansion. The cell was immunolabelled for the BILBO1 protein (yellow) and stained with fluorescent NHS-ester (grey). The flagellar pocket is highlighted in pink. Credit: Marie Zelená

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Wallace Marshall @wallaceucsf.bsky.social · 4d

shit man, when I first saw the video and started watching it, I thought maybe you had been the guy who got stabbed!! I am very relieved that you are ok!!!!

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Wallace Marshall @wallaceucsf.bsky.social · 5d

Are you in/near the SF Bay Area? Do you like Science? What about Festivals? Then you might want to check out the Bay Area Science Festival Oct 25. I’ll be there showing how single cells can learn!

www.bayareasciencefestival.org

Home - Bay Area Science Festival

Bring the whole family to experience 100+ jaw-dropping demonstrations, hands-on experiments, astounding games, behind the scenes lab tours, film screenings

www.bayareasciencefestival.org

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Wallace Marshall @wallaceucsf.bsky.social · 12d

at least they make it easy to decide how to respond

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Wallace Marshall @wallaceucsf.bsky.social · 19d

had a fun joint opening lecture for #UCSFTetrad Cellbio course with @nachury - but a question arose about eukaryotic evolution: if asgards used symbiotic bacteria for respiration, is there similarity with how RBCs use the liver for respiration? is the alanine cycle a vestige of eukaryogenesis?

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Reposted by Wallace Marshall

Ben Engel @cellarchlab.com · 22d

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

eLife @elife.bsky.social · 22d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

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Reposted by Wallace Marshall

Wenying Shou @shougroup.bsky.social · 22d

Again I am years behind: I have only recently noticed that critical information such as equal-contribution authorship is lost in important platforms such as PubMed, Google Scholar, ORCID...

Fairness is critical to every one. Why nothing has been done to correct this?

Something needs to be done!

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Wallace Marshall @wallaceucsf.bsky.social · 25d

Proud (and surprised) to be awarded a UCSF Medical School Excellence in Teaching Award! Celebrating here with my REGN module colleagues Igor Mitrovic and Kathy Hyland

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Wallace Marshall @wallaceucsf.bsky.social · Sep 12

Thanks for letting me know!! They musta changed it. New link

www.ascb.org/society-news...

ASCB and MBoC Announce 2025 Paper of the Year Award Winners - ASCB

ASCB and its research journal, Molecular Biology of the Cell (MBoC), are proud to recognize the outstanding scientific achievements of early career researchers through the 2025 Paper of the Year Award...

www.ascb.org

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Wallace Marshall @wallaceucsf.bsky.social · Sep 12

The link seems to have changed please check it out here.

www.ascb.org/society-news...

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Reposted by Wallace Marshall

Yuping Chen @yuping.bsky.social · Sep 11

Next week, we have Ulises Diaz from UCSF giving us a talk in the Physical Properties of the Cytoplasm online seminar series. For more info, visit cytophys.org. Join us.

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Wallace Marshall @wallaceucsf.bsky.social · Sep 10

congratulations to vincentv boudreau and @aralbright.bsky.social for winning the MBoC Paper of the Year award from @ASCBiology for their work on the cell biology and genome of Stentor pyriformis www.ascb.org/society-news...

www.ascb.org

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Wallace Marshall @wallaceucsf.bsky.social · Sep 5

great seeing you today!!!!

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Reposted by Wallace Marshall

Xavier Trepat @xaviertrepat.bsky.social · Sep 1

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

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Reposted by Wallace Marshall

Vesna Grujcic @vesnagrujcic.bsky.social · Aug 30

How do microbes become permanent partners? 🌊🔬🦠 Check out our new study published in Current Biology showing how cyanobacterial genomes evolve step-by-step into endosymbionts of diatoms. www.sciencedirect.com/science/arti...
@currentbiology.bsky.social @mehrshmali.bsky.social

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Wallace Marshall @wallaceucsf.bsky.social · Aug 23

The Ulva-covered sea steps of Venice. Hard to believe each green sheet is only two cell layers thick!

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Wallace Marshall @wallaceucsf.bsky.social · Aug 20

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Wallace Marshall @wallaceucsf.bsky.social · Aug 20

Hard to say - to a first approximation the total intensity doesn’t vary much on the AP axis. In our proteomic dissection different centrin family members did show differential enrichment. The monoclonal we use is thought recognize many different centrin family members.

Wallace Marshall @wallaceucsf.bsky.social · Aug 19

From here, you will witness the final destruction of the Alliance and the end of your insignificant rebellion

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Wallace Marshall @wallaceucsf.bsky.social · Aug 19

Niklas Steube and Gautam Dey contributed an analysis of centrin and SFI1 phylogeny in Stentor. We also thank Rajorshi Paul and Ambika Nadkarni in @TangSindy lab as well as Joe Lannan for help with contraction assays.

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Wallace Marshall @wallaceucsf.bsky.social · Aug 19

Length of the lateral SFI1 filaments correlates with stripe width. Since widest stripes are the oldest, we hypothesize that filaments grow at a constant rate, and that filament length may encode circumferential positional information. Right now this is just an hypothesis…

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Wallace Marshall @wallaceucsf.bsky.social · Aug 19

this result from Tartar suggested that the cell surface has positional information that reflects circumferential position, and mismatches in this positional information could trigger formation of a new primordium. But how does a cell encode circumferential position?

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Wallace Marshall @wallaceucsf.bsky.social · Aug 19

amazingly, you can create a new primordium site by grafting pieces of the Stentor cortex in such as a way as to juxtapose wider and narrower stripes, even if grafted pieces do not contain the original contrast zone.

onlinelibrary.wiley.com/doi/10.1002/...

Grafting experiments concerning primordium formation in Stentor coeruleus

Click on the article title to read more.

onlinelibrary.wiley.com

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Wallace Marshall @wallaceucsf.bsky.social · Aug 19

the point at which the narrowest stripes meet the widest stripes is known as the contrast zone or locus of stripe contrast. This region is where an oral primordium forms during membranellar band regeneration.

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Wallace Marshall @wallaceucsf.bsky.social · Aug 19

but what about those lateral filaments? The surface of Stentor is covered with blue stripes which represent the gaps between the KM fibers. These stripes are non-uniform in width, gradually becoming more narrow as one goes around the cell counter-clockwise.

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