eLife
LightNews LightNews
banner
elife.bsky.social
eLife
@elife.bsky.social
17K followers 53 following 1.8K posts
The funder-researcher collaboration and open-access publisher for research in the life and biomedical sciences.

Follow @eLifeCommunity.bsky.social
Posts Replies Media Videos
Pinned
elife.bsky.social
eLife @elife.bsky.social · 27d
We’re pleased to announce our Trained Immunity Focus Issue 🎉

With original research and reviews spanning history, current state and future directions of trained immunity, explore today:
buff.ly/OoqVRjM
Trained Immunity. a new focus issue. explore the collection
Reposted by eLife
hansonmark.bsky.social
Now published as version of record at @elife.bsky.social !

Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️)

elifesciences.org/articles/107...
shop.vbc.ac.at/vdrc_store/d...

#Drosophila #IDsky #SymbioSky #Infection #Immunology
eLife Assessment This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are compelling and the tools provided can be used as they are, or built upon, in various contexts. https://doi.org/10.7554/eLife.107030.3.sa0 Figure 1 validating the mutations used Figure 3 summarising the survival results from a 14-genotype 25-pathogen panel. Tracking of mortality and pathogen growth over time, complemented by Figure 5 (not shown) looking at pathogen load upon death.
November 28, 2025 at 9:34 PM
Reposted by eLife
aidybarnett.bsky.social
Are peer reviewers influenced by their work being cited? Version of record at
@elife.bsky.social. Thorough and useful peer review - who needs and impact factor?!

Links to paper and code/data ⬇️

📄https://elifesciences.org/reviewed-preprints/108748
💻https://github.com/agbarnett/cited_reviewers
elifesciences.org
November 29, 2025 at 2:24 AM
elife.bsky.social
eLife is an independent nonprofit committed to improving the way research is communicated.

We do this through our innovative publishing model, developing open source technologies and community initiatives to improve research culture.

Be a part of it: buff.ly/TDDXVhZ
December 2, 2025 at 4:11 PM
elife.bsky.social
We recognise that there are many reasons authors might not be able to cover a publication fee. To ensure that it isn't a barrier to publication, we offer a simple way for authors to apply for a fee waiver.

Find out more in our author guide: buff.ly/PAVE39b.
November 30, 2025 at 11:01 AM
elife.bsky.social
Brown algae are incredibly useful, in part for their potential to feed us, but also because they are one of a few lineages that evolved multicellularity. Research into the genes behind their lifecycles could hold secrets to evolution.
The double life of brown algae
Brown algae show life-cycle-related patterns of gene expression, which may be – at least partially – conserved between different species.
buff.ly
November 30, 2025 at 9:21 AM
elife.bsky.social
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.

🔗
Transgenerational Epigenetic Inheritance
Please enable JavaScript to proceed.
buff.ly
November 29, 2025 at 11:44 PM
elife.bsky.social
The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
buff.ly/KbO9jwD
When cancer adapts to new organs
The three-dimensional arrangement of DNA within a cell might influence the ability of a tumor to metastasize to specific locations.
buff.ly
November 29, 2025 at 2:59 PM
elife.bsky.social
Jumping spiders can recognise one another. This ability to learn, remember and represent images is quite surprising for such a tiny-brained animal!
buff.ly/dCkwPr0
November 29, 2025 at 11:01 AM
elife.bsky.social
New work reveals Gyc76C as the receptor for the anti-diuretic hormone ITPa in flies, uncovering how it helps control hydration and metabolic balance.
buff.ly/iTlvevz
November 28, 2025 at 9:02 PM
elife.bsky.social
eLife assessments are a new evaluation tool for research. They are designed to provide readers with richer and more nuanced assessments of articles than binary publishing decisions.

Learn how we write them: buff.ly/10CDKWp
November 28, 2025 at 2:59 PM
elife.bsky.social
This study presents new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment.
buff.ly/5dt10lY
November 28, 2025 at 9:21 AM
elife.bsky.social
Two rainforest butterflies have evolved to look more alike, likely to confuse shared predators. But why don’t they get confused themselves?

To avoid mating with the wrong species, they’ve cleverly evolved distinct scents.
buff.ly/fxVrlCI
November 27, 2025 at 11:28 PM
elife.bsky.social
The continuous evolution of HIV shows strong parallels in macaques and humans.
buff.ly/7mX8aWS
Viral mutations
The continuous evolution of HIV shows strong parallels in macaques and humans.
buff.ly
November 27, 2025 at 9:01 PM
elife.bsky.social
Peer review is often criticised for being slow, biased and quashing revolutionary ideas.

With our consultative review process, reviewers discuss their reviews with each other before reaching a decision and limit suggestions for extra work. buff.ly/AnqASqz
November 27, 2025 at 2:44 PM
elife.bsky.social
Did you know you can read the peer reviews for all papers published in eLife?

We're on a mission to make publishing more transparent. Take a look at the #PeerReview tabs of our latest articles or learn about what we're doing for research communication:
About eLife · eLife
eLife is a non-profit organization committed to making peer review and publishing better for science. In particular, using the publish-review-curate (PRC) approach, we are working to reform the way…
buff.ly
November 26, 2025 at 11:28 PM
elife.bsky.social
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins.
buff.ly/hFHjKy9
November 26, 2025 at 4:15 PM
elife.bsky.social
Using an elegant single-cell RNA-seq analysis approach, researchers show that the gene Eed is essential for guiding facial bone formation and early tissue growth.
buff.ly/g4JqhjJ
November 26, 2025 at 11:01 AM
Reposted by eLife
animal-prattle.bsky.social
Congrats to @robertslab.bsky.social, the version of record of this paper is now published in @elife.bsky.social

Nice use of optimal transport methods to measure acoustic distance, if you're into that sort of thing 😉

elifesciences.org/articles/101...

#prattle 💬
#bioacoustics
A deep learning approach for the analysis of birdsong
An open-source deep learning toolkit performs accurate annotation and similarity scoring of zebra finch song, along with comprehensive feature extraction, enabling consistent, interpretable comparison...
elifesciences.org
November 24, 2025 at 6:23 PM
elife.bsky.social
1/ This Review Article from our new Focus Issue outlines how #epigenetic and metabolic rewiring enables innate immune cells to ‘remember’ past challenges, shaping protection, pathology, and new therapeutic strategies.
buff.ly/NHdWyKS
Triggers of trained immunity across all tissues.
November 25, 2025 at 9:01 PM
elife.bsky.social
Catch up with the Community Voices podcast.

Our interviews with inspiring academics cover topics spanning citizenship as a privilege, how postdoc training needs to change, the intersection of queerness, religion, and science, and plenty more.
Community | eLife Community Voices · eLife
Hear from researchers across the globe about what matters to them in relation to research culture.
buff.ly
November 25, 2025 at 4:11 PM
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
November 25, 2025 at 11:02 AM
elife.bsky.social
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.

buff.ly/gMbJWcX
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
buff.ly
November 24, 2025 at 11:28 PM
elife.bsky.social
We have an amazing opportunity for Early-Career Researchers to join our Board of Directors!

We're looking for someone with experience in leading #OpenScience projects to support and lead eLife in our mission to change research communication.

🔗 buff.ly/SZgtgVv
November 24, 2025 at 9:02 PM
elife.bsky.social
Looking for a home for your structural biology paper?

We welcome studies that advance our understanding of molecular mechanisms in biology, using experimental and computational approaches to provide quantitative insights.

See what we publish ⬇️
Client Challenge
Please enable JavaScript to proceed.
buff.ly
November 24, 2025 at 11:44 AM
Reposted by eLife
renslolab.bsky.social
The version of record is now out in eLife! For the next chapter in this story check out www.biorxiv.org/content/10.1...

In @elife.bsky.social: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 doi.org/10.7554/eLif...
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2
The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in ...
doi.org
November 20, 2025 at 9:02 PM