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International Society of Developmental Biology

@isdb.bsky.social

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ISDB is a non-profit scientific association that promotes the study of developmental biology

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International Society of Developmental Biology @isdb.bsky.social · Nov 15

Hello my lovely developmental biologists, The International Society for Developmental Biology is here with y'all in this #BlueSky. If you follow us on Twitter (we refuse to call it X), please drop us a follow here! Let's connect! #DevelopmentalBiology #cellbiology

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International Society of Developmental Biology @isdb.bsky.social · 1d

A new review from the @mayorlab.bsky.social on the chemical and physical cues regulating neural crest cells migration is out. Check it out!
www.annualreviews.org/content/jour...

Neural Crest Migration Orchestrated by Molecular and Mechanical Signals

The neural crest is a highly migratory multipotent cell population traveling large distances in the vertebrate embryo. Neural crest cells migrate collectively in subpopulations, ranging in size from s...

www.annualreviews.org

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Development @dev-journal.bsky.social · 4d

Coupling and decoupling of the cell cycle from cell differentiation in development

In this Spotlight, @kkukreja.bsky.social & Allon Klein discuss the dependence of animal cell differentiation on cell cycle, and how their decoupling facilitates development

journals.biologists.com/dev/article-...

Figure 1 - Common chemical and genetic methods for arresting the cell cycle in developmental studies. Function of the mentioned genes/proteins: CDK4/6, cyclin-dependent kinases that phosphorylate Rb, releasing E2F transcription factors to activate S-phase genes and promote the G1→S transition; CDKN1C (p57Kip2), Cyclin-dependent kinase inhibitor; E2f, transcription factor family activating S-phase genes; Rbf, retinoblastoma-family protein that represses E2F activity; Myc, transcription factor promoting cell growth and G1→S progression; APC/C, E3 ubiquitin ligase targeting mitotic regulators for degradation; emi1 (fbxo5), APC/C inhibitor that prevents premature degradation of mitotic regulators; Cdc25, phosphatase that activates Cdk1; Cdk1 (encoded by Cdc2 in Drosophila and Schizosaccharomyces pombe), master cell-cycle kinase driving G2→M transition by phosphorylating substrates for mitotic entry, including condensins, spindle assembly factors and nuclear envelope breakdown proteins.

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Cells & Development @cellsdev.bsky.social · 3d

In honor of the passing of Sir John Gurdon, we will revisit the concept of chimerism across scales in this review from the lab of @drmichaellevin.bsky.social. Grafting and nucleus transplanting have been the cornerstone of modern #devbio. We have come so far!
www.sciencedirect.com/science/arti...

Schematic of the study of multiscale chimerism.

Chimeras at different scales: subcellular, molecular, cellular, tissue, organ, and population.

What determines the anatomical setpoint of regenerative homeostasis?

Planarian flatworms regenerate after amputation using a resident population of stem cells. This process reliably stops when the correct species-specific head shape is restored. The following thought experiment illustrates the profound knowledge gap in our understanding of the rules of morphogenesis despite ample information about genes required for neoblast differentiation.

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The Company of Biologists @biologists.bsky.social · 5d

Registration is now open to attend Journal of Cell Science's meeting on Imaging Cell Dynamics, organised by Francesca Bottanelli, Guillaume Jacquemet, Michael Way and Giulia Zanetti.

Find out more: biologists.com/meetings/jcs...

#JCSimaging #Microscopy #Microscope #Imaging #Cells #CellScience

Imaging Cell Dynamics
11-14 May 2026
Montanyà Hotel, Catalonia, Spain
Register now - early-bird deadline: 16 January 2026
Journal of Cell Science Meeting

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Journal of Cell Science @jcellsci.bsky.social · 5d

Edward Jenkins, Clare Latta and Hoang Anh Le @anhhle2702.bsky.social reflect on the major themes and discussion points from The Company of Biologists @biologists.bsky.social Workshop on ‘Immune Cell Interactions in Development, Homeostasis and Immunity’.
journals.biologists.com/jcs/article/...

Screenshot of pdf on 'Immune cell interactions in development and homeostasis and immunity' by Edward Jenkins, Clare Latta and Hoang Anh Le.

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Journal of Cell Science @jcellsci.bsky.social · 14d

We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...

#cellbiology #nucleus #notforprofit #freetopublish

Promotional graphic for a special issue of Journal of Cell Science titled 'Cell Biology of the Nucleus.' Guest Editor: Abby Buchwalter. Submission deadline: 3 November 2025. The image features a stylized cell with a bright pink, heart-shaped nucleus on a black background. Text includes a call for papers.

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Ozren Bogdanovic @obog.bsky.social · 8d

We’re looking for a Research Assistant / Lab Manager to join the 🧬 Developmental Epigenomics lab at the Andalusian Centre for Developmental Biology (CABD, Seville 🇪🇸)!
🐟 Work with zebrafish, CRISPR–Cas9, and genomics technologies
💫 3-year fully funded position
Details 👉 www.bogdanoviclab.org

Bogdanovic Lab

www.bogdanoviclab.org

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Journal of Cell Science @jcellsci.bsky.social · 11d

Mario Ledesma-Terrón, Diego Pérez-Dones, David Míguez and colleagues @cbm-csic-uam.bsky.social @ifimacuam.bsky.social present OSCAR, a framework to quantify 3D stacks with high cellular density.
journals.biologists.com/jcs/article-...

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Eric Peterman @errricpeterman.bsky.social · 11d

cover image yeeeeeeeeehawwwww #flourescentfriday
check out our work in the most recent issue of @jcellsci.bsky.social !

Cover: Skin-resident macrophages (white) migrate towards a scratch wound (centre) in a zebrafish skin explant. To reach the wound margin, migrating macrophages must navigate through a dense network of epithelial cells, which are visualised using a reporter for epithelial junctions (α-catenin-Citrine, magenta). Live-cell imaging and chemical perturbations demonstrate that skin macrophages require microtubules to efficiently respond to tissue damage and navigate epithelial obstacles. See article by E. Peterman et al. (jcs264101).

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Alfonso Martinez Arias @amartinezarias.bsky.social · 11d

Organizing time past, remembered this summary of many thoughts that I continue to pursue
And nowhere rings more true that ‘the detail of pattern is the movement’ than in the actions of cells as they build #embryos
www.youtube.com/watch?v=bbQV...
#CellsRUs #MasterBuilder

Landscapes and embryos : A film from A. Martinez Arias

YouTube video by Cambridge University

www.youtube.com

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Rachael Ott @rachaelott.bsky.social · 11d

For #FluorescenceFriday, RhoA (blue) and the actin cytoskeleton (magenta) are shown in a set of primary microglia 🔬 #Neuroscience #Microscopy

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Marco A. Maximo Prado @maximoprado.bsky.social · 11d

Great collaborative effort to get this done

The MIND Platform @ Western @mind-western.bsky.social · 11d

#fluorescencefriday special. Half marmoset 🧠 cleared and stained using SHIELD and imaged by lightsheet microscopy. Courtesy of Jesleen Saini @shahrzadbahrampour.bsky.social and @stefan-everling.bsky.social

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Maik Bischoff @maikbischoff.bsky.social · 11d

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls

Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨

🔗 www.nikonsmallworld.com/galleries/20...

#NikonSmallWorld #Microscopy #ScienceArt

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Michalis Averof @michalis-averof.bsky.social · 11d

Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale

apply here: www.averof-lab.org/pages/tracman

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Michalis Averof @michalis-averof.bsky.social · Jul 13

We've just been awarded a grant to study the cellular basis of regeneration – to track the progenitors of sensory organs in the context of leg regeneration, in our favourite crustacean tinyurl.com/parhyale, based on live imaging and cell tracking. The project involves some cool collaborations... 1/3

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Cells & Development @cellsdev.bsky.social · 11d

We often talk about what signals does the organiser release. But have you ever stopped and asked what does it mean to be the organiser? What cells make up the organiser? Where do they go? What do they do?
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...

Cell movements around the organizer/node after stage HH4.

Fate maps of the ectodermal (dorsal) layer of the organizer/node, based on Selleck and Stern (1991) (Selleck and Stern, 1991).

Cell movements of populations contributing to the organizer.

Stages of early chick development referred to in the text. The diagrams show some of the features used to classify the stages in relation to primitive streak formation.

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International Society of Developmental Biology @isdb.bsky.social · 11d

This looks like a fantastic workshop!

Centro Andaluz de Biología del Desarrollo @cabd-upo-csic.bsky.social · 13d

Amazing @embo.org workshop coming up!!! Are you interested in #MZT? Get to know the program and the deadlines!

🗣️ outstanding group of speakers
📍 amazing city of #Sevilla
🗓️ May 4-7th, 2026

Organized by Miguel A. Moreno-Mateos from #CABD
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Moreno-Mateos Lab @crisprscan.bsky.social · 14d

Glad to share that the website for the MZT EMBO workshop that I organize together with Ana Boskovic (EMBL, Rome), Antonio Giraldez (Yale U) and Melissa Harrison (U Wisconsin) is out: meetings.embo.org/event/26-awa...
Please spread the word and join us in beautiful Seville next 4-7 May!

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Lori O'Brien @llobrienlab.bsky.social · 18d

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

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Dan Jagger @auditorynerves.bsky.social · 19d

‘Shake it off’: Taylor Swift’s changing voice shows how our accents evolve.

Researchers have confirmed what Taylor Swift fans have long suspected: the music megastar’s dialect & pitch have shifted throughout her career.

🧪👄📣
www.nature.com/articles/d41...

‘Shake it off’: Taylor Swift’s changing voice shows how our accents evolve

An analysis of Swift’s interviews suggests her speech pattern has changed over her career.

www.nature.com

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Development @dev-journal.bsky.social · 18d

Transitions in development – an interview with Mijo Šimunović
We caught up with Mijo Šimunović from @columbiauniversity.bsky.social to learn more about Mijo's transition to becoming a group leader and Mijo's insights on the growing need for cross-disciplinary research: doi.org/10.1242/dev....

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Edouard Hannezo @ehannezo.bsky.social · 18d

Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...

Edouard Hannezo @ehannezo.bsky.social · Dec 17

Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk

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Cells & Development @cellsdev.bsky.social · 18d

In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...

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Cells & Development @cellsdev.bsky.social · Sep 12

Our September issue cover is now online.
You can check out the issue here:
www.sciencedirect.com/journal/cell...

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Ryan Savill @cryaaa.bsky.social · Sep 12

(1/14) I’m happy and proud to introduce: SpinePy – a framework to detect the "spine" of gastruloids and measure biological and physical signals in a local dynamic 3D coordinate system. www.biorxiv.org/content/10.1...

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Cells & Development @cellsdev.bsky.social · Sep 12

Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms.
doi.org/10.1016/j.cd...

Fig. 1. EMT dynamics in developmental models.

Fig. 2. A hypothetical model of EMT dynamics.

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International Society of Developmental Biology @isdb.bsky.social · Sep 12

This is the cutest thing I've seen all day or year!!!

Chise @sailorrooscout.bsky.social · Sep 12

Oh to be a little Tardigrade scratching its back on a bubble. 🫧🐻🧪