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International Society of Developmental Biology @isdb.bsky.social · 1d

A new review from the @mayorlab.bsky.social on the chemical and physical cues regulating neural crest cells migration is out. Check it out!
www.annualreviews.org/content/jour...

Neural Crest Migration Orchestrated by Molecular and Mechanical Signals

The neural crest is a highly migratory multipotent cell population traveling large distances in the vertebrate embryo. Neural crest cells migrate collectively in subpopulations, ranging in size from s...

www.annualreviews.org

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Cells & Development @cellsdev.bsky.social · 3d

In honor of the passing of Sir John Gurdon, we will revisit the concept of chimerism across scales in this review from the lab of @drmichaellevin.bsky.social. Grafting and nucleus transplanting have been the cornerstone of modern #devbio. We have come so far!
www.sciencedirect.com/science/arti...

Schematic of the study of multiscale chimerism.

Chimeras at different scales: subcellular, molecular, cellular, tissue, organ, and population.

What determines the anatomical setpoint of regenerative homeostasis?

Planarian flatworms regenerate after amputation using a resident population of stem cells. This process reliably stops when the correct species-specific head shape is restored. The following thought experiment illustrates the profound knowledge gap in our understanding of the rules of morphogenesis despite ample information about genes required for neoblast differentiation.

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Cells & Development @cellsdev.bsky.social · 3d

In honor of the passing of Sir John Gurdon, we will revisit the concept of chimerism across scales in this review from the lab of @drmichaellevin.bsky.social. Grafting and nucleus transplanting have been the cornerstone of modern #devbio. We have come so far!
www.sciencedirect.com/science/arti...

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Cells & Development @cellsdev.bsky.social · 10d

We need to be better! 😤

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Cells & Development @cellsdev.bsky.social · 11d

We often talk about what signals does the organiser release. But have you ever stopped and asked what does it mean to be the organiser? What cells make up the organiser? Where do they go? What do they do?
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...

Cell movements around the organizer/node after stage HH4.

Fate maps of the ectodermal (dorsal) layer of the organizer/node, based on Selleck and Stern (1991) (Selleck and Stern, 1991).

Cell movements of populations contributing to the organizer.

Stages of early chick development referred to in the text. The diagrams show some of the features used to classify the stages in relation to primitive streak formation.

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Cells & Development @cellsdev.bsky.social · 11d

We often talk about what signals does the organiser release. But have you ever stopped and asked what does it mean to be the organiser? What cells make up the organiser? Where do they go? What do they do?
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...

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Cells & Development @cellsdev.bsky.social · 18d

In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...

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Lori O'Brien @llobrienlab.bsky.social · 18d

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

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Cells & Development @cellsdev.bsky.social · 18d

In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...

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Cells & Development @cellsdev.bsky.social · Sep 12

Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms.
doi.org/10.1016/j.cd...

Fig. 1. EMT dynamics in developmental models.

Fig. 2. A hypothetical model of EMT dynamics.

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Cells & Development @cellsdev.bsky.social · Sep 12

Our September issue cover is now online.
You can check out the issue here:
www.sciencedirect.com/journal/cell...

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Journal of Cell Biology @jcb.org · Sep 11

In 2019, Anna Jost & @jencwaters.bsky.social reviewed best practices for validating quantitative #microscopy methods & discuss strategies to avoid unconscious bias in imaging experiments rupress.org/jcb/article/...

📕 In #Reproducibility & Best Practices in Cell Biology: rupress.org/jcb/collecti...

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Jonas Wietek @jwietek.bsky.social · Sep 12

Led by the awesome @dzelmanoff.bsky.social

Jonas Wietek @jwietek.bsky.social · Sep 11

www.science.org/doi/10.1126/...

From the one and only @oyiz.bsky.social lab

Oxytocin signaling regulates maternally directed behavior during early life

Oxytocin is essential in shaping social behavior across the lifespan. Although the role of oxytocin signaling in parental care has been widely investigated, little is known about its function in socia...

www.science.org

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V4SDB @v4sdb.bsky.social · Sep 10

We are grateful to all our sponsors who made the V4SDB Meeting 2025 in 🇸🇰 possible and accessible, specifically
Visegrád Fund, @biologists.bsky.social, @isdb.bsky.social, @cellsdev.bsky.social, @devdynamics.bsky.social, MUNI SCI, Allgene, BRIX, LABO-SK, and Merck Life Science.
Thank you!

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Roberto Mayor Lab @mayorlab.bsky.social · Sep 10

Early Career Opportunity
Mentorship & career development, access to world-class facilities, and a collaborative, supportive environment. We are particularly interested in researchers in Synthetic Dev. Biol. Mechanobiology and AI . #AcademicJobs #EarlyCareerResearcher #UCL #DevelopmentalBiology

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Cells & Development @cellsdev.bsky.social · Sep 5

For decades, living embryos were the favourite tool to study development. However, their complexity hindered precise dissection of many processes. This comprehensive review provides a comparison between embryos and the power of gastruloids, opening up a new wave of dev bio.
doi.org/10.1016/j.cd...

Fig. 1. Schematic overview of mouse gastrulation

Fig. 4. Different aspects of computational modelling of gastrulation.

Fig. 3. Protein localisation, cell sorting behaviours and signalling pathway activation in gastruloids. Depicted are schematic representations based on integration of existing, fragmented data. Note that there is considerable variation in gastruloid development and existing data quality and resolution, and these cartoons represent our interpretation of average domains of immunofluorescence staining.

Fig. 2. Schematic overview of signalling induced GRNs during gastrulation.

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International Society of Developmental Biology @isdb.bsky.social · Aug 29

A cryosection from an embryo stained for the neural crest (🟠) using HCR, and DAPI (⚪).
Can you guess what embryo this is?
#FluorescenceFriday
Image credit: Ines Fernandez Mosquera, PhD student at @ucl.ac.uk

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Cells & Development @cellsdev.bsky.social · Aug 29

Many phenotypes from cells on plastic dishes just don't seem to translate to cells in vivo, particularly isolated primary cells. @raimonsunyer.bsky.social et al discussed how cells mechanically adapt, and the different ways we can mitigate this in this very helpful review:
doi.org/10.1016/j.cd...

The molecular clutch model offers insights into how cells adapt to rigid substrates such as tissue culture polystyrene (TCPS).

Culturing cells on stiff substrates alters their mechanical phenotype. Stiff substrates, such as tissue culture polystyrene (TCPS), trigger adhesion reinforcement.

Cell selection and mechanoadaptation when isolating primary cells. This figure illustrates how primary cells isolated from a tissue explant are affected by the stiffness of the culture surface.

Strategies to mitigate stiff mechanoadaptation in cell culture.

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Cells & Development @cellsdev.bsky.social · Aug 22

What are the physics behind lumen formation? In this interesting and interdisciplinary review, Guillaume Salbreux et al described the physical laws from osmotic pressure to electrical potential that govern this biological process. Check it out here:
doi.org/10.1016/j.cd...

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James Briscoe @jamesbriscoe.bsky.social · Aug 4

A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning

Everything from bistable switches & oscillators to phase portraits & more with Python code to explore

journals.biologists.com/dev/article/...

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms

Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

journals.biologists.com

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Max Farnworth @maxfarnworth.bsky.social · Aug 22

If you happen (…!) to be interested in what fascinates me about science and brain evolution and what I am up to, click here:
doi.org/10.1242/dev....

Thanks to @dev-journal.bsky.social and @biologists.bsky.social for the interview 🙏

Pathway to Independence – an interview with Max Farnworth

Max Farnworth completed his PhD in Gregor Bucher's lab at the University of Göttingen, Germany, where he explored how heterochrony shapes the evolution and development of insect brains. He then joined...

doi.org

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Cells & Development @cellsdev.bsky.social · Aug 22

What are the physics behind lumen formation? In this interesting and interdisciplinary review, Guillaume Salbreux et al described the physical laws from osmotic pressure to electrical potential that govern this biological process. Check it out here:
doi.org/10.1016/j.cd...

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Reposted by Cells & Development

Cells & Development @cellsdev.bsky.social · Aug 15

For something as classic as the Spemann-Mangold organizer first discovered in amphibians, the existence of such an organiser in mammals remains elusive. In this thought provoking review by Kate Mcdole et al, they discuss the evidence for and against such organiser in mouse.
doi.org/10.1016/j.cd...

Cell migration and morphogenesis in the organizer.

The AVE and PrCP in the formation of the head in mouse.

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Cells & Development @cellsdev.bsky.social · Aug 15

For something as classic as the Spemann-Mangold organizer first discovered in amphibians, the existence of such an organiser in mammals remains elusive. In this thought provoking review by Kate Mcdole et al, they discuss the evidence for and against such organiser in mouse.
doi.org/10.1016/j.cd...

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Reposted by Cells & Development

International Society of Developmental Biology @isdb.bsky.social · Aug 15

A classical neural crest migration. Even if the movie is a little bit shaky, their migration is still somehow mesmerising. It must be the stripes! 🤔 #fluorescencefriday

Movie by Kai Weissenbruch

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