Journal of Cell Biology
@jcb.org
Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org
🌐 https://rupress.org/jcb
🌐 https://rupress.org/jcb
Pinned
Journal of Cell Biology
@jcb.org
· Sep 3
Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...
#Reproducibility
#Reproducibility
Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
December 2, 2025 at 6:30 PM
Lerche, Mathieu, @johannaivaska.bsky.social @ivaskalab.bsky.social et al. reveal that newly synthesized #integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and #adhesion. rupress.org/jcb/article/...
Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience
December 2, 2025 at 5:01 PM
Yamasaki, Konno, Tomita @yaleschoolofmed.bsky.social et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. rupress.org/jcb/article/...
#Adhesion #Neuroscience
#Adhesion #Neuroscience
Homocysteine disrupts lysosomal function by V-ATPase inhibition, say Yang Yang, Qianjin Kong, Chaolian Liu, Mei Yang, Chonglin Yang and colleagues (Yunnan University): rupress.org/jcb/article/...
#Organelles #Metabolism #Lysosomes
#Organelles #Metabolism #Lysosomes
December 2, 2025 at 3:30 PM
Homocysteine disrupts lysosomal function by V-ATPase inhibition, say Yang Yang, Qianjin Kong, Chaolian Liu, Mei Yang, Chonglin Yang and colleagues (Yunnan University): rupress.org/jcb/article/...
#Organelles #Metabolism #Lysosomes
#Organelles #Metabolism #Lysosomes
JCB’s December issue is here! rupress.org/jcb/issue/22...
The cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
The cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
December 1, 2025 at 3:04 PM
JCB’s December issue is here! rupress.org/jcb/issue/22...
The cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
The cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained w/ Wheat Germ Agglutinin (cyan) to visualize the plasma membrane, retraction fibers, & migrasomes. (Fan et al. doi.org/10.1083/jcb....)
Reposted by Journal of Cell Biology
Enzyme Mos–MAPK acts as a switch between mitotic & meiotic cell division
📷 Ivan Avilov et al @plenart.bsky.social lab Max Planck Institute for Dynamics and Self-Organization, Göttingen in
@jcb.org
➡️ bpod.org.uk/archive/2025... with
@DrJohnAnkers
📷 Ivan Avilov et al @plenart.bsky.social lab Max Planck Institute for Dynamics and Self-Organization, Göttingen in
@jcb.org
➡️ bpod.org.uk/archive/2025... with
@DrJohnAnkers
November 30, 2025 at 9:22 AM
Enzyme Mos–MAPK acts as a switch between mitotic & meiotic cell division
📷 Ivan Avilov et al @plenart.bsky.social lab Max Planck Institute for Dynamics and Self-Organization, Göttingen in
@jcb.org
➡️ bpod.org.uk/archive/2025... with
@DrJohnAnkers
📷 Ivan Avilov et al @plenart.bsky.social lab Max Planck Institute for Dynamics and Self-Organization, Göttingen in
@jcb.org
➡️ bpod.org.uk/archive/2025... with
@DrJohnAnkers
Bacterial CipB is an exogenous receptor to drive the #mitophagy-TFEB axis and promote pathogenesis, say Shuai Liu, Shan Li and colleagues (Huazhong Agricultural University): rupress.org/jcb/article/...
#Microbiology #autophagy #Inflammation
#Microbiology #autophagy #Inflammation
November 28, 2025 at 8:15 PM
Bacterial CipB is an exogenous receptor to drive the #mitophagy-TFEB axis and promote pathogenesis, say Shuai Liu, Shan Li and colleagues (Huazhong Agricultural University): rupress.org/jcb/article/...
#Microbiology #autophagy #Inflammation
#Microbiology #autophagy #Inflammation
Talin-tensin3 interactions regulate fibrillar #adhesion formation and tensin3 phase separation, say Xingchen Li, Igor Barsukov, Thomas Zacharchenko, Christoph Ballestrem, @mcrcellmatrix.bsky.social and colleagues: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #StructuralBiology
#Cytoskeleton #Biochemistry #StructuralBiology
November 28, 2025 at 2:15 PM
Talin-tensin3 interactions regulate fibrillar #adhesion formation and tensin3 phase separation, say Xingchen Li, Igor Barsukov, Thomas Zacharchenko, Christoph Ballestrem, @mcrcellmatrix.bsky.social and colleagues: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #StructuralBiology
#Cytoskeleton #Biochemistry #StructuralBiology
Inwardly rectifying potassium channels promote directional sensing during #neutrophil chemotaxis, say Tianqi Wang, Daniel Kim, Chang Ding, GuangJun Zhang, Qing Deng, and colleagues (Purdue University) rupress.org/jcb/article/...
#Migration #motility #Immunology
#Migration #motility #Immunology
November 26, 2025 at 7:30 PM
Inwardly rectifying potassium channels promote directional sensing during #neutrophil chemotaxis, say Tianqi Wang, Daniel Kim, Chang Ding, GuangJun Zhang, Qing Deng, and colleagues (Purdue University) rupress.org/jcb/article/...
#Migration #motility #Immunology
#Migration #motility #Immunology
Spotlight: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
November 26, 2025 at 6:02 PM
Spotlight: Freeman and Grinstein discuss a study from Riederer et al. (rupress.org/jcb/article/...) questioning whether TMEM175 contributes to #Parkinsons disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. rupress.org/jcb/article/...
Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis, say Nicolas Joly and Lionel Pintard @ccdlab.bsky.social @ijmonod.bsky.social: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry
#Cytoskeleton #Biochemistry
November 26, 2025 at 2:45 PM
Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis, say Nicolas Joly and Lionel Pintard @ccdlab.bsky.social @ijmonod.bsky.social: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry
#Cytoskeleton #Biochemistry
Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine #metabolism and the cause of the life-threatening disease #homocystinuria, disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. rupress.org/jcb/article/...
#lysosomes
#lysosomes
November 25, 2025 at 7:00 PM
Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine #metabolism and the cause of the life-threatening disease #homocystinuria, disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. rupress.org/jcb/article/...
#lysosomes
#lysosomes
Reposted by Journal of Cell Biology
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @jcb.org
📃 Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
🔗 rupress.org/jcb/article-...
📖 @jcb.org
📃 Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
🔗 rupress.org/jcb/article-...
November 25, 2025 at 4:07 PM
✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article
📖 @jcb.org
📃 Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
🔗 rupress.org/jcb/article-...
📖 @jcb.org
📃 Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis
🔗 rupress.org/jcb/article-...
Reposted by Journal of Cell Biology
Congratulations to @justusfrancis.bsky.social for receiving the Alan Hall Travel Award from @jcb.org. This is a great support for him to present at the @ascbiology.bsky.social #CellBio2025 meeting. #CSIR India #CSIR-CCMB
November 22, 2025 at 11:40 AM
Congratulations to @justusfrancis.bsky.social for receiving the Alan Hall Travel Award from @jcb.org. This is a great support for him to present at the @ascbiology.bsky.social #CellBio2025 meeting. #CSIR India #CSIR-CCMB
🎉 Congratulations to Yu Deng, winner of the 2025 Norton B. Gilula Travel Award! Yu is a PhD student from Dr. Peter Devreotes’ lab at @jhu.edu. Be sure to catch Yu’s talk during #CellBio2025!
Read about this year's winners 👉 rupress.org/jcb/pages/al...
Read about this year's winners 👉 rupress.org/jcb/pages/al...
November 24, 2025 at 3:30 PM
🎉 Congratulations to Yu Deng, winner of the 2025 Norton B. Gilula Travel Award! Yu is a PhD student from Dr. Peter Devreotes’ lab at @jhu.edu. Be sure to catch Yu’s talk during #CellBio2025!
Read about this year's winners 👉 rupress.org/jcb/pages/al...
Read about this year's winners 👉 rupress.org/jcb/pages/al...
🎉 Congratulations to Justus Francis (@justusfrancis.bsky.social), winner of the 2025 Alan Hall Travel Award! Justus is a graduate student in @sc-lab.bsky.social. Be sure to catch Justus’s talk during #CellBio2025!
Read about this year's winners 👉 rupress.org/jcb/pages/al...
Read about this year's winners 👉 rupress.org/jcb/pages/al...
November 24, 2025 at 3:15 PM
🎉 Congratulations to Justus Francis (@justusfrancis.bsky.social), winner of the 2025 Alan Hall Travel Award! Justus is a graduate student in @sc-lab.bsky.social. Be sure to catch Justus’s talk during #CellBio2025!
Read about this year's winners 👉 rupress.org/jcb/pages/al...
Read about this year's winners 👉 rupress.org/jcb/pages/al...
A new probe illuminates endo-lysosomal Ca²⁺ measurements: a role for vesicular IP3 receptors? Anthony Morgan @ox.ac.uk highlights a new reporter for endo-lysosomal Ca²⁺ developed by Calvo et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors
Calvo et al. describe a new bioluminescent sensor for measuring luminal Ca2+ in a mildly acidic subcompartment of the endo-lysosomal system. This Ca2+ stor
rupress.org
November 24, 2025 at 3:02 PM
A new probe illuminates endo-lysosomal Ca²⁺ measurements: a role for vesicular IP3 receptors? Anthony Morgan @ox.ac.uk highlights a new reporter for endo-lysosomal Ca²⁺ developed by Calvo et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
#CellSignaling
#CellSignaling
Xun Cao, Yiming Peng, Mengyuan Yang, Daisuke Takao and colleagues (Huazhong Agricultural University) present a high-content image-based phenotyping pipeline for quantitative analysis of organelle morphology. rupress.org/jcb/article/...
November 21, 2025 at 8:15 PM
Xun Cao, Yiming Peng, Mengyuan Yang, Daisuke Takao and colleagues (Huazhong Agricultural University) present a high-content image-based phenotyping pipeline for quantitative analysis of organelle morphology. rupress.org/jcb/article/...
Liu et al. discover that pathogenic bacteria use a shared strategy to exploit the host’s cellular recycling process, #mitophagy. Through an effector protein that acts as an external receptor, bacteria suppress inflammatory responses to promote #infection rupress.org/jcb/article/...
#Autophagy
#Autophagy
November 21, 2025 at 5:45 PM
Liu et al. discover that pathogenic bacteria use a shared strategy to exploit the host’s cellular recycling process, #mitophagy. Through an effector protein that acts as an external receptor, bacteria suppress inflammatory responses to promote #infection rupress.org/jcb/article/...
#Autophagy
#Autophagy
Xingchen Li, Christoph Ballestrem, et al. @mcrcellmatrix.bsky.social show that multidomain interactions between talin and tensin3 regulate #integrin activity, fibrillar #adhesion formation, #fibronectin assembly, and mechanosensitive tensin3 phase separation. rupress.org/jcb/article/...
November 21, 2025 at 5:00 PM
Xingchen Li, Christoph Ballestrem, et al. @mcrcellmatrix.bsky.social show that multidomain interactions between talin and tensin3 regulate #integrin activity, fibrillar #adhesion formation, #fibronectin assembly, and mechanosensitive tensin3 phase separation. rupress.org/jcb/article/...
Explore new insights into the biology of axon-carrying–dendrite neurons, the role of mitochondrial fission in astrocyte morphogenesis, and the regulation of membrane contact sites in photoreceptors, as well as a new framework for synaptic vesicle segmentation 👉 rupress.org/jcb/collecti...
November 21, 2025 at 3:30 PM
Explore new insights into the biology of axon-carrying–dendrite neurons, the role of mitochondrial fission in astrocyte morphogenesis, and the regulation of membrane contact sites in photoreceptors, as well as a new framework for synaptic vesicle segmentation 👉 rupress.org/jcb/collecti...
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation, say Clyde Savio Pinto, Saskia E. Bakker, Andrejus Suchenko, Masanori Mishima, Mohan Balasubramanian @sporemohan.bsky.social and colleagues: rupress.org/jcb/article/...
November 21, 2025 at 2:45 PM
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation, say Clyde Savio Pinto, Saskia E. Bakker, Andrejus Suchenko, Masanori Mishima, Mohan Balasubramanian @sporemohan.bsky.social and colleagues: rupress.org/jcb/article/...
👏 Here's link to the paper by @impeiyee.bsky.social et al.: rupress.org/jcb/article/...
November 21, 2025 at 2:17 PM
👏 Here's link to the paper by @impeiyee.bsky.social et al.: rupress.org/jcb/article/...
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion, say Camilla Teng @xsciteng.bsky.social, Jeffrey Bush @jeffbush.bsky.social and colleagues @ctbatucsf.bsky.social: rupress.org/jcb/article/...
#Development #Adhesion
#Development #Adhesion
November 20, 2025 at 7:45 PM
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion, say Camilla Teng @xsciteng.bsky.social, Jeffrey Bush @jeffbush.bsky.social and colleagues @ctbatucsf.bsky.social: rupress.org/jcb/article/...
#Development #Adhesion
#Development #Adhesion
📢 Attention #EESNucleus attendees! TODAY (Nov. 20) at 12:10 - 1:40 pm (CET): Join @jcb.org Scientific Editor Gabriele Stephan at the Meet the Editor session during lunchtime! www.embl.org/about/info/c...
#EESNucleus @events.embl.org
#EESNucleus @events.embl.org
November 20, 2025 at 9:01 AM
📢 Attention #EESNucleus attendees! TODAY (Nov. 20) at 12:10 - 1:40 pm (CET): Join @jcb.org Scientific Editor Gabriele Stephan at the Meet the Editor session during lunchtime! www.embl.org/about/info/c...
#EESNucleus @events.embl.org
#EESNucleus @events.embl.org
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...
November 19, 2025 at 6:15 PM
Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...