Cells & Development
@cellsdev.bsky.social
'Cells & Development' journal (formerly 'Mechanisms of Development'). Official journal of the International Society of Developmental Biology isdb.bsky.social
"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
November 7, 2025 at 9:12 PM
"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes".
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read.
doi.org/10.1016/j.cd...
From the lab of Chinmoy Patra discussing the importance of ECM in heart morphogenesis and the roles of secreted molecules in mediating fibrosis or regeneration after myocardial injury.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of Chinmoy Patra discussing the importance of ECM in heart morphogenesis and the roles of secreted molecules in mediating fibrosis or regeneration after myocardial injury.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
From the lab of Maxwell Heiman discussing the interesting topic of apical ECM and the function of sensing organs and how these ECM proteins can both mechanically and biochemically modulate the organ's functions.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of Maxwell Heiman discussing the interesting topic of apical ECM and the function of sensing organs and how these ECM proteins can both mechanically and biochemically modulate the organ's functions.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
From the lab of Jean Schwarzbauer identified IGFBP3 as the most up-regulated gene in fibrotic human lung fibroblasts and can be used as a potential biomarker for idiopathic pulmonary fibrosis.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of Jean Schwarzbauer identified IGFBP3 as the most up-regulated gene in fibrotic human lung fibroblasts and can be used as a potential biomarker for idiopathic pulmonary fibrosis.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
From the lab of Eva Matalova exploring the role of TGF-B in gld osteoblastic cells.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of Eva Matalova exploring the role of TGF-B in gld osteoblastic cells.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
From the lab of @rachellennon.bsky.social showing how fluid flow can alter Collagen IV network architecture using a very neat kidney co-culture system.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of @rachellennon.bsky.social showing how fluid flow can alter Collagen IV network architecture using a very neat kidney co-culture system.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
From the lab of Scott Holley showing the distinct functions that fibronectin 1a and 1b have during zebrafish development using live imaging.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of Scott Holley showing the distinct functions that fibronectin 1a and 1b have during zebrafish development using live imaging.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
From the lab of Brian Stramer discussing how the ECM actively involved in shaping embryo morphogenesis.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of Brian Stramer discussing how the ECM actively involved in shaping embryo morphogenesis.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
From the lab of Kenneth Yamada showing how mRNAs coding for basement membrane proteins are polarised apically in mouse embryonic salivary gland outer epithelial cells and are trafficked by microtubules.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 30, 2025 at 5:48 PM
From the lab of Kenneth Yamada showing how mRNAs coding for basement membrane proteins are polarised apically in mouse embryonic salivary gland outer epithelial cells and are trafficked by microtubules.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...
October 24, 2025 at 11:32 PM
Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...
How do endodermal cells behave during gastrulation? In this paper, the authors found that a gradient of BMP regulates mesoderm and endoderm convergent extension. Endoderm cells also use the mesoderm and Cxcr4a signalling to guide their movement. The imaging is beautiful!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
October 17, 2025 at 6:27 PM
How do endodermal cells behave during gastrulation? In this paper, the authors found that a gradient of BMP regulates mesoderm and endoderm convergent extension. Endoderm cells also use the mesoderm and Cxcr4a signalling to guide their movement. The imaging is beautiful!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
In honor of the passing of Sir John Gurdon, we will revisit the concept of chimerism across scales in this review from the lab of @drmichaellevin.bsky.social. Grafting and nucleus transplanting have been the cornerstone of modern #devbio. We have come so far!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
October 11, 2025 at 12:14 PM
In honor of the passing of Sir John Gurdon, we will revisit the concept of chimerism across scales in this review from the lab of @drmichaellevin.bsky.social. Grafting and nucleus transplanting have been the cornerstone of modern #devbio. We have come so far!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
We often talk about what signals does the organiser release. But have you ever stopped and asked what does it mean to be the organiser? What cells make up the organiser? Where do they go? What do they do?
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...
October 3, 2025 at 4:36 PM
We often talk about what signals does the organiser release. But have you ever stopped and asked what does it mean to be the organiser? What cells make up the organiser? Where do they go? What do they do?
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...
In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
September 26, 2025 at 5:17 PM
In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
September 12, 2025 at 4:15 PM
Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Our September issue cover is now online.
You can check out the issue here:
www.sciencedirect.com/journal/cell...
You can check out the issue here:
www.sciencedirect.com/journal/cell...
September 12, 2025 at 4:04 PM
Our September issue cover is now online.
You can check out the issue here:
www.sciencedirect.com/journal/cell...
You can check out the issue here:
www.sciencedirect.com/journal/cell...
For decades, living embryos were the favourite tool to study development. However, their complexity hindered precise dissection of many processes. This comprehensive review provides a comparison between embryos and the power of gastruloids, opening up a new wave of dev bio.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
September 5, 2025 at 5:30 PM
For decades, living embryos were the favourite tool to study development. However, their complexity hindered precise dissection of many processes. This comprehensive review provides a comparison between embryos and the power of gastruloids, opening up a new wave of dev bio.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Many phenotypes from cells on plastic dishes just don't seem to translate to cells in vivo, particularly isolated primary cells. @raimonsunyer.bsky.social et al discussed how cells mechanically adapt, and the different ways we can mitigate this in this very helpful review:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
August 29, 2025 at 4:31 PM
Many phenotypes from cells on plastic dishes just don't seem to translate to cells in vivo, particularly isolated primary cells. @raimonsunyer.bsky.social et al discussed how cells mechanically adapt, and the different ways we can mitigate this in this very helpful review:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
What are the physics behind lumen formation? In this interesting and interdisciplinary review, Guillaume Salbreux et al described the physical laws from osmotic pressure to electrical potential that govern this biological process. Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
August 22, 2025 at 3:17 PM
What are the physics behind lumen formation? In this interesting and interdisciplinary review, Guillaume Salbreux et al described the physical laws from osmotic pressure to electrical potential that govern this biological process. Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
For something as classic as the Spemann-Mangold organizer first discovered in amphibians, the existence of such an organiser in mammals remains elusive. In this thought provoking review by Kate Mcdole et al, they discuss the evidence for and against such organiser in mouse.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
August 15, 2025 at 4:15 PM
For something as classic as the Spemann-Mangold organizer first discovered in amphibians, the existence of such an organiser in mammals remains elusive. In this thought provoking review by Kate Mcdole et al, they discuss the evidence for and against such organiser in mouse.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
August 8, 2025 at 3:06 PM
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and @stramerlab.bsky.social discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
AKAP14 is of those genes that is highly expressed, yet when knocked down by 60% even in a mouse model shows no apparent effects on the organism, no effects on meiotic progression, sperm count, motility and morphology. How weird?Check out this intriguing paper here: doi.org/10.1016/j.cd...
August 1, 2025 at 1:22 PM
AKAP14 is of those genes that is highly expressed, yet when knocked down by 60% even in a mouse model shows no apparent effects on the organism, no effects on meiotic progression, sperm count, motility and morphology. How weird?Check out this intriguing paper here: doi.org/10.1016/j.cd...
Continuing with the theme of organiser biology, Alexandra Neaverson and Benjamin Steventon discussed in this beautifully illustrated review the idea that "neural specification and patterning occur before organiser formation" in Xenopus, zebrafish, chick, and mouse.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
July 25, 2025 at 12:36 PM
Continuing with the theme of organiser biology, Alexandra Neaverson and Benjamin Steventon discussed in this beautifully illustrated review the idea that "neural specification and patterning occur before organiser formation" in Xenopus, zebrafish, chick, and mouse.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Check out this insightful review by Alfonso Martinez Arias et al where they show how studying the organiser in amphibian embryos helps us understand the development of the body axis in mammalians, and the use of gastruloids to study the Primitive Streak.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
July 18, 2025 at 9:08 PM
Check out this insightful review by Alfonso Martinez Arias et al where they show how studying the organiser in amphibian embryos helps us understand the development of the body axis in mammalians, and the use of gastruloids to study the Primitive Streak.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
This comprehensive review by Manuel Zúniga-García and Juan Rafael Riesgo-Escovar focuses on the evolutionarily conserved fos gene family in different species of invertebrates (🪰,🪱). The authors argued that fos genes were coopted from stress responses to development. doi.org/10.1016/j.cd...
July 11, 2025 at 4:03 PM
This comprehensive review by Manuel Zúniga-García and Juan Rafael Riesgo-Escovar focuses on the evolutionarily conserved fos gene family in different species of invertebrates (🪰,🪱). The authors argued that fos genes were coopted from stress responses to development. doi.org/10.1016/j.cd...