Michael Hoffman
@michaelhoffman.bsky.social
Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network.
Associate Professor, Medical Biophysics, University of Toronto.
Disclosures: https://github.com/michaelmhoffman/disclosure/
Associate Professor, Medical Biophysics, University of Toronto.
Disclosures: https://github.com/michaelmhoffman/disclosure/
Pinned
Reposted by Michael Hoffman
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Faculty Position in Computational Biology
Applications are invited for an Assistant/ Associate Professorship in Computational Biology to commence on 1 April 2026 or shortly thereafter. This is a joint post between the Department of Applied
www.cam.ac.uk
November 11, 2025 at 9:05 PM
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Bluesky seems a bit glitchy at the mo
November 11, 2025 at 8:49 PM
Bluesky seems a bit glitchy at the mo
Reposted by Michael Hoffman
US senators will say anything. "Standing up to donald trump gave him more power." No it didn't. That isn't true.
This is what bullies want you to think, and it's why they get stronger
November 11, 2025 at 8:09 PM
US senators will say anything. "Standing up to donald trump gave him more power." No it didn't. That isn't true.
Reposted by Michael Hoffman
Joyce Carol Oates sitting across a desk from Kendrick Lamar:
"So I'm putting a team together..."
Isaac Chotiner knocks on the open door.
"So I'm putting a team together..."
Isaac Chotiner knocks on the open door.
Personally, I will be trying to avoid the notice of Joyce Carol Oates and Kendrick Lamar for the rest of my natural life
I need Joyce Carol Oates to be mean to me online so I can get my life together
November 11, 2025 at 7:24 PM
Joyce Carol Oates sitting across a desk from Kendrick Lamar:
"So I'm putting a team together..."
Isaac Chotiner knocks on the open door.
"So I'm putting a team together..."
Isaac Chotiner knocks on the open door.
Reposted by Michael Hoffman
No one will ever sum up Bari Weiss's career more succinctly than "what's the point of standards"
“Standards will be eliminated or severely cut back. Bari has told people that she wants to get rid of standards and is shocked that they have so much power. She asks ‘What’s the point of standards?’
November 11, 2025 at 3:46 PM
No one will ever sum up Bari Weiss's career more succinctly than "what's the point of standards"
Reposted by Michael Hoffman
What’s the difference between compromise and capitulation? Compromise trades concessions. Capitulation pays ransom to stop deliberate suffering, and teaches your opponent that coercion works. There are effective responses to coercive bargaining. What we saw was not one of them.
The Compassion Trap: How the Shutdown Weaponized Democratic Values Against Democracy Itself
When Opposition Parties Stop Fighting Because the Cruelty Becomes Unbearable. And Why They Shouldn't.
open.substack.com
November 11, 2025 at 6:26 PM
What’s the difference between compromise and capitulation? Compromise trades concessions. Capitulation pays ransom to stop deliberate suffering, and teaches your opponent that coercion works. There are effective responses to coercive bargaining. What we saw was not one of them.
Reposted by Michael Hoffman
As of this morning, it is imperative that the Democratic caucus in the senate remove Schumer as Minority Leader, Durbin as minority whip and Cortez Masto as Vice Chair of Outreach.
Replace them today with Van Hollen, Murphy and Merkley. Or anyone else who actually knows how to lead and discipline.
Replace them today with Van Hollen, Murphy and Merkley. Or anyone else who actually knows how to lead and discipline.
November 10, 2025 at 2:58 PM
As of this morning, it is imperative that the Democratic caucus in the senate remove Schumer as Minority Leader, Durbin as minority whip and Cortez Masto as Vice Chair of Outreach.
Replace them today with Van Hollen, Murphy and Merkley. Or anyone else who actually knows how to lead and discipline.
Replace them today with Van Hollen, Murphy and Merkley. Or anyone else who actually knows how to lead and discipline.
Reposted by Michael Hoffman
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Michael Hoffman
After yesterday’s surrender, we’re launching the largest Democratic primary program that we’ve ever run.
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
Democratic leaders have failed us again. It's time to get new leaders.
After yet another capitulation by Chuck Schumer and Senate Democrats, it's clear we need new leadership capable of mounting a serious opposition to Trump's authoritarian regime. We're launching our la...
www.indivisible2026.org
November 11, 2025 at 12:00 AM
After yesterday’s surrender, we’re launching the largest Democratic primary program that we’ve ever run.
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
We will not back any Senate primary candidate unless they call for Schumer to step down as Minority Leader.
If you’re as pissed as we are, join this campaign to rebuild the Democratic Party. 👇
Reposted by Michael Hoffman
same. I also thanked them for voting no on the CR
I called both my senators and told staff that as a constituent I wanted to express the need for new Democratic caucus leadership in the Senate. Took two minutes.
November 11, 2025 at 12:01 AM
same. I also thanked them for voting no on the CR
I called both my senators and told staff that as a constituent I wanted to express the need for new Democratic caucus leadership in the Senate. Took two minutes.
November 10, 2025 at 11:51 PM
I called both my senators and told staff that as a constituent I wanted to express the need for new Democratic caucus leadership in the Senate. Took two minutes.
Reposted by Michael Hoffman
Dealer: alright everyone ante up
Chuck Schumer: I fold
Dealer: … we haven’t even dealt the hand yet
Chuck Schumer: I 👏 fold 👏
Chuck Schumer: I fold
Dealer: … we haven’t even dealt the hand yet
Chuck Schumer: I 👏 fold 👏
November 9, 2025 at 11:50 PM
Dealer: alright everyone ante up
Chuck Schumer: I fold
Dealer: … we haven’t even dealt the hand yet
Chuck Schumer: I 👏 fold 👏
Chuck Schumer: I fold
Dealer: … we haven’t even dealt the hand yet
Chuck Schumer: I 👏 fold 👏
The definitive obituary of James Watson, written by the late, great Sharon Begley @statnews.com www.statnews.com/2025/11/07/j...
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 10, 2025 at 5:51 PM
The definitive obituary of James Watson, written by the late, great Sharon Begley @statnews.com www.statnews.com/2025/11/07/j...
Reposted by Michael Hoffman
Concepts of a plan of a promise of a vote
November 10, 2025 at 12:37 AM
Concepts of a plan of a promise of a vote
Reposted by Michael Hoffman
Reposted by Michael Hoffman
"When I picked up my granddaughter from the federal agents, she had a dirty diaper, a bruise on her face, and was developing a rash. She was exhausted and cried… My heart aches knowing this could happen to others, to my kids, or even me, despite being U.S. citizens.”
November 8, 2025 at 3:26 PM
"When I picked up my granddaughter from the federal agents, she had a dirty diaper, a bruise on her face, and was developing a rash. She was exhausted and cried… My heart aches knowing this could happen to others, to my kids, or even me, despite being U.S. citizens.”
Reposted by Michael Hoffman
In the name of protecting Jews, Jews have their funding cancelled, get kicked out of seminars, and are removed from leadership positions in Jewish Studies to be replaced by non-Jews.
Latest write-up about outrageous administrative over reach at IU. www.jta.org/2025/11/07/u...
In Indiana, a vaunted Jewish studies program is upended by red-state politics over Israel and speech - Jewish Telegraphic Agency
A leadership shakeup, a defunded graduate student and political pressure from above have turned a storied program into a flashpoint for Trump-era campus politics.
www.jta.org
November 8, 2025 at 3:58 AM
In the name of protecting Jews, Jews have their funding cancelled, get kicked out of seminars, and are removed from leadership positions in Jewish Studies to be replaced by non-Jews.
Reposted by Michael Hoffman
No cap, imma use this just to swap yeet() for filter()
Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp....
genzplyr is dplyr, but bussin fr fr no cap.
genzplyr is dplyr, but bussin fr fr no cap.
GitHub - hadley/genzplyr: dplyr but make it bussin fr fr no cap
dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.
github.com
November 8, 2025 at 3:52 AM
No cap, imma use this just to swap yeet() for filter()
Reposted by Michael Hoffman
There are many reasons I love Los Angeles (and will visit again once the current cr*p down south fades) - this story adds to that.
www.thestar.com/sports/blue-...
www.thestar.com/sports/blue-...
‘I hope this becomes a lasting tradition.’ Dodgers fans ease Blue Jays’ World Series loss with $30,000 in donations to SickKids
Many fans donated $51 as a tribute to the Blue Jays relievers who put the number 51 on their caps to pay respects to L.A. pitcher Alex Vesia.
www.thestar.com
November 7, 2025 at 4:23 PM
There are many reasons I love Los Angeles (and will visit again once the current cr*p down south fades) - this story adds to that.
www.thestar.com/sports/blue-...
www.thestar.com/sports/blue-...
Reposted by Michael Hoffman
Me waiting for the bus omw to kick your ass
May 13, 2025 at 8:57 PM
Me waiting for the bus omw to kick your ass
Em dashes aren't the smoking gun some make them out to be, but do real humans ever use as many emoji in the middle of long text as I have been seeing in recent months?
November 7, 2025 at 1:24 AM
Em dashes aren't the smoking gun some make them out to be, but do real humans ever use as many emoji in the middle of long text as I have been seeing in recent months?
Reposted by Michael Hoffman
Ah ha ha ha ha ha ha ha ha ha ha lulz
Meanwhile in Canada: Tory MP crosses the floor to the Liberals on budget week, citing poor Tory leadership; in response, Polievre talks too much in the House and somehow gets usurped by the Bloc in opposition:
November 6, 2025 at 8:18 PM
Ah ha ha ha ha ha ha ha ha ha ha lulz
Prosecutors used to be able to get a grand jury to indict a ham sandwich.
After the damage Republicans have done to Justice's reputation, they can't even get a petit jury to convict on throwing one.
After the damage Republicans have done to Justice's reputation, they can't even get a petit jury to convict on throwing one.
Jeanine Pirro tried to make an example of Sean Dunn.
She ended up delivering a hero to Washington, D.C.
www.huffpost.com/entry/dc-san...
She ended up delivering a hero to Washington, D.C.
www.huffpost.com/entry/dc-san...
DC ‘Sandwich Guy’ Found Not Guilty After Defense Successfully Highlights Absurdity Of It All
Jeanine Pirro tried to make an example of Sean Dunn. She ended up delivering a hero to Washington, D.C.
www.huffpost.com
November 6, 2025 at 8:21 PM
Prosecutors used to be able to get a grand jury to indict a ham sandwich.
After the damage Republicans have done to Justice's reputation, they can't even get a petit jury to convict on throwing one.
After the damage Republicans have done to Justice's reputation, they can't even get a petit jury to convict on throwing one.
Reposted by Michael Hoffman
holy shit -- one of Trump's toadies just passed out and the White House event is brought to an abrupt end
November 6, 2025 at 5:38 PM
holy shit -- one of Trump's toadies just passed out and the White House event is brought to an abrupt end