Andrew Plested
@andrewplested.bsky.social
Glutamate
ORCID: 0000-0001-6062-0832
ORCID: 0000-0001-6062-0832
Pinned
Andrew Plested
@andrewplested.bsky.social
· Oct 12
iGlu3Fast and iGlu3Slow, improved fluorescent reporters for detection of spontaneous glutamate activity in the brain
The genetically-encoded fluorescent glutamate sensor, iGluSnFR3, characterised by a high dynamic range and rapid on-kinetics, is an attractive sensor for glutamate imaging in the central nervous syste...
www.biorxiv.org
The latest version of our collaboration with Katalin Torok and her lab is up. We report some new glutamate sensors. Great work from Sara Bertelli in Berlin and the whole team in London (Holly & Oanh particularly).
www.biorxiv.org/content/10.1...
1/6
1/6
Simply a super paper! Beautiful and profound.
Yu Zhou, @chris-lingle.bsky.social et al. ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent with a trinomial model of random mixing of β subunits. rupress.org/jgp/article/...
November 25, 2025 at 7:43 PM
Simply a super paper! Beautiful and profound.
Reposted by Andrew Plested
Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...
International Day for the Elimination of Violence against Women | United Nations
The International Day for the Elimination of Violence against Women aims to create awareness of the fact that violence against women is a human rights violation that impedes progress in many areas, in...
www.un.org
November 25, 2025 at 4:28 PM
Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...
This morning, I found I could no longer disable AI on Google with the -ai tag.
I switched to DuckDuckGo. The results are better and it´s easy to disable the AI summaries.
I switched to DuckDuckGo. The results are better and it´s easy to disable the AI summaries.
Google at its peak was basically the best information retrieval system in human history and they and every competitor decided going from there to “you didn’t want answers you wanted half-assed auto-complete 80%-wrong hallucinations” in a few years was the right idea
November 25, 2025 at 7:03 AM
This morning, I found I could no longer disable AI on Google with the -ai tag.
I switched to DuckDuckGo. The results are better and it´s easy to disable the AI summaries.
I switched to DuckDuckGo. The results are better and it´s easy to disable the AI summaries.
Nice article about the leading computational model of water. The 8th most cited paper ever, with 45000 citations!
#biophysics #chemistry
news.yale.edu/2025/11/18/d...
#biophysics #chemistry
news.yale.edu/2025/11/18/d...
Decades later, a Yale chemist’s water simulations continue to make waves
A look back at one of the most cited science studies of all time — Sterling Professor of Chemistry William Jorgensen’s landmark 1983 simulations of water.
news.yale.edu
November 25, 2025 at 7:00 AM
Nice article about the leading computational model of water. The 8th most cited paper ever, with 45000 citations!
#biophysics #chemistry
news.yale.edu/2025/11/18/d...
#biophysics #chemistry
news.yale.edu/2025/11/18/d...
Elsevier & Ugc care group-2 journal
We will publish backdated papers also.
Best Regards,
Editor JETM
#AcademicSpam
#TheMindBoggles
We will publish backdated papers also.
Best Regards,
Editor JETM
#AcademicSpam
#TheMindBoggles
November 25, 2025 at 5:31 AM
Elsevier & Ugc care group-2 journal
We will publish backdated papers also.
Best Regards,
Editor JETM
#AcademicSpam
#TheMindBoggles
We will publish backdated papers also.
Best Regards,
Editor JETM
#AcademicSpam
#TheMindBoggles
Reposted by Andrew Plested
i’m not crying you’re crying
xkcd: Fifteen Years
xkcd: Fifteen Years
Fifteen Years
xkcd.com
November 25, 2025 at 1:58 AM
i’m not crying you’re crying
xkcd: Fifteen Years
xkcd: Fifteen Years
Reposted by Andrew Plested
reminder if you're german/germany-based, please consider signing!
Offener Brief gegen die zunehmende unkritische Nutzung von KI an deutschen Hochschulen und Forschungseinrichtungen - bitte teilen! openletter.earth/gegen-die-un...
Gegen die unkritische Anwendung und Implementierung sog. Künstlicher Intelligenz (KI) in der deutschen Wissenschaft und im Hochschulalltag
openletter.earth
November 24, 2025 at 8:15 AM
reminder if you're german/germany-based, please consider signing!
I signed this open letter against the blind adoption of "AI" in our science and in our universities, and I urge other scientists and university staff in Germany to do the same.
Otherwise it's a #RaceToTheBottom
Otherwise it's a #RaceToTheBottom
Offener Brief gegen die zunehmende unkritische Nutzung von KI an deutschen Hochschulen und Forschungseinrichtungen - bitte teilen! openletter.earth/gegen-die-un...
Gegen die unkritische Anwendung und Implementierung sog. Künstlicher Intelligenz (KI) in der deutschen Wissenschaft und im Hochschulalltag
openletter.earth
November 24, 2025 at 8:58 AM
I signed this open letter against the blind adoption of "AI" in our science and in our universities, and I urge other scientists and university staff in Germany to do the same.
Otherwise it's a #RaceToTheBottom
Otherwise it's a #RaceToTheBottom
I always liked physics and didn’t know you could do a degree in engineering. Maureen overslept and by the afternoon we could no longer sign up for the MSc projects we wanted. So, on a whim, with zero biology between us, we chose “Genetic Engineering of a neurotransmitter receptor”.
November 23, 2025 at 12:13 PM
I always liked physics and didn’t know you could do a degree in engineering. Maureen overslept and by the afternoon we could no longer sign up for the MSc projects we wanted. So, on a whim, with zero biology between us, we chose “Genetic Engineering of a neurotransmitter receptor”.
Reposted by Andrew Plested
Why do people think England flags have been raised on lampposts?
White adults
National pride: 26%
Anti-migrant/minority sentiment: 49%
Both: 19%
Ethnic minority adults
National pride: 15%
Anti-migrant/minority sentiment: 55%
Both: 20%
yougov.co.uk/society/arti...
White adults
National pride: 26%
Anti-migrant/minority sentiment: 49%
Both: 19%
Ethnic minority adults
National pride: 15%
Anti-migrant/minority sentiment: 55%
Both: 20%
yougov.co.uk/society/arti...
November 21, 2025 at 10:17 AM
Why do people think England flags have been raised on lampposts?
White adults
National pride: 26%
Anti-migrant/minority sentiment: 49%
Both: 19%
Ethnic minority adults
National pride: 15%
Anti-migrant/minority sentiment: 55%
Both: 20%
yougov.co.uk/society/arti...
White adults
National pride: 26%
Anti-migrant/minority sentiment: 49%
Both: 19%
Ethnic minority adults
National pride: 15%
Anti-migrant/minority sentiment: 55%
Both: 20%
yougov.co.uk/society/arti...
Reposted by Andrew Plested
I do not like your AI slop
I do not want this worthless glop
I do not read its overviews
I don't care what Grok says is true
I do not like it here nor there
I'm tired of it everywhere
I do not want this worthless glop
I do not read its overviews
I don't care what Grok says is true
I do not like it here nor there
I'm tired of it everywhere
November 22, 2025 at 1:15 AM
I do not like your AI slop
I do not want this worthless glop
I do not read its overviews
I don't care what Grok says is true
I do not like it here nor there
I'm tired of it everywhere
I do not want this worthless glop
I do not read its overviews
I don't care what Grok says is true
I do not like it here nor there
I'm tired of it everywhere
Amazing public service from Ed Zitron. Amid all the claims of exponential improvements in AI, there is one thing growing exponentially- the hidden rate at which billions of dollars in costs are outstripping income. @edzitron.com www.wheresyoured.at/oai_docs/
Exclusive: Here's How Much OpenAI Spends On Inference and Its Revenue Share With Microsoft
As with my Anthropic exclusive from a few weeks ago, though this feels like a natural premium piece, I decided it was better to publish on my free one so that you could all enjoy it. If you liked or f...
www.wheresyoured.at
November 22, 2025 at 5:05 PM
Amazing public service from Ed Zitron. Amid all the claims of exponential improvements in AI, there is one thing growing exponentially- the hidden rate at which billions of dollars in costs are outstripping income. @edzitron.com www.wheresyoured.at/oai_docs/
Reposted by Andrew Plested
"If the data is accurate...it would call into question the business model of OpenAI and nearly every other general-purpose LLM vendor" www.ft.com/content/fce7...
How high are OpenAI’s compute costs? Possibly a lot higher than we thought
Inference inferred, revenue reconstructed, cash burn quantified
www.ft.com
November 22, 2025 at 2:13 PM
"If the data is accurate...it would call into question the business model of OpenAI and nearly every other general-purpose LLM vendor" www.ft.com/content/fce7...
Reposted by Andrew Plested
Another AI cover art. Sigh
The second November issue is online.
-> www.embopress.org/toc/14693178...
The cover features work by Tina Mukherjee and co-workers showing that #macrophage metabolic #reprogramming during dietary stress influences adult body size in #Drosophila.
www.embopress.org/doi/full/10....
-> www.embopress.org/toc/14693178...
The cover features work by Tina Mukherjee and co-workers showing that #macrophage metabolic #reprogramming during dietary stress influences adult body size in #Drosophila.
www.embopress.org/doi/full/10....
November 22, 2025 at 9:40 AM
Another AI cover art. Sigh
Reposted by Andrew Plested
75 years young 😍
Happy Birthday Tina Weymouth, born on this day in 1950, Coronado, California
One of the greatest bass line ever:
Talking Heads - Psycho Killer - Old Grey Whistle Test
#punk #punkrock #postpunk #newwave #tinaweymouth #talkingheads #punkrockhistory #otd
Happy Birthday Tina Weymouth, born on this day in 1950, Coronado, California
One of the greatest bass line ever:
Talking Heads - Psycho Killer - Old Grey Whistle Test
#punk #punkrock #postpunk #newwave #tinaweymouth #talkingheads #punkrockhistory #otd
November 22, 2025 at 7:47 AM
75 years young 😍
Happy Birthday Tina Weymouth, born on this day in 1950, Coronado, California
One of the greatest bass line ever:
Talking Heads - Psycho Killer - Old Grey Whistle Test
#punk #punkrock #postpunk #newwave #tinaweymouth #talkingheads #punkrockhistory #otd
Happy Birthday Tina Weymouth, born on this day in 1950, Coronado, California
One of the greatest bass line ever:
Talking Heads - Psycho Killer - Old Grey Whistle Test
#punk #punkrock #postpunk #newwave #tinaweymouth #talkingheads #punkrockhistory #otd
Reposted by Andrew Plested
THIS MADE MY DAY!
November 21, 2025 at 3:14 PM
THIS MADE MY DAY!
Reposted by Andrew Plested
"We’ve arranged a society on science and technology in which nobody understands anything about science and technology, and this combustible mixture of ignorance and power sooner or later is going to blow up in our faces."
- Carl Sagan.
- Carl Sagan.
November 21, 2025 at 3:04 PM
"We’ve arranged a society on science and technology in which nobody understands anything about science and technology, and this combustible mixture of ignorance and power sooner or later is going to blow up in our faces."
- Carl Sagan.
- Carl Sagan.
This breathtaking article underscores the pivotal significance of..... EXCUSE ME did you swallow a dictionary, as we used to say.
But it's important to note that a vibrant tapestry showcasing our..... THAT'S ENOUGH!
en.wikipedia.org/wiki/Wikiped...
But it's important to note that a vibrant tapestry showcasing our..... THAT'S ENOUGH!
en.wikipedia.org/wiki/Wikiped...
Wikipedia:Signs of AI writing - Wikipedia
en.wikipedia.org
November 21, 2025 at 2:31 PM
This breathtaking article underscores the pivotal significance of..... EXCUSE ME did you swallow a dictionary, as we used to say.
But it's important to note that a vibrant tapestry showcasing our..... THAT'S ENOUGH!
en.wikipedia.org/wiki/Wikiped...
But it's important to note that a vibrant tapestry showcasing our..... THAT'S ENOUGH!
en.wikipedia.org/wiki/Wikiped...
Reposted by Andrew Plested
Ive seen this work from Prof Liqun Luo’s presented a few times now and its stunning and heroic.
Nature research paper: Rewiring an olfactory circuit by altering cell-surface combinatorial code
go.nature.com/3MbCoZT
go.nature.com/3MbCoZT
Rewiring an olfactory circuit by altering cell-surface combinatorial code - Nature
In Drosophila, changing the expression of a small set of cell-surface proteins in just one type of olfactory neuron rewires its connections almost entirely to a new postsynaptic partner neuron type, altering the fly’s odour response and courtship behaviour.
go.nature.com
November 21, 2025 at 11:20 AM
Ive seen this work from Prof Liqun Luo’s presented a few times now and its stunning and heroic.
Reposted by Andrew Plested
**NEW CHINA SOLAR EXPANSION STORY**
China has doubled the export of solar cells+wafers to assemble abroad in the last several months.
It still exports about the same amount of solar panels.
In October - for the first time - it exported more cell+wafers than panels 🧵
China has doubled the export of solar cells+wafers to assemble abroad in the last several months.
It still exports about the same amount of solar panels.
In October - for the first time - it exported more cell+wafers than panels 🧵
November 20, 2025 at 4:50 PM
**NEW CHINA SOLAR EXPANSION STORY**
China has doubled the export of solar cells+wafers to assemble abroad in the last several months.
It still exports about the same amount of solar panels.
In October - for the first time - it exported more cell+wafers than panels 🧵
China has doubled the export of solar cells+wafers to assemble abroad in the last several months.
It still exports about the same amount of solar panels.
In October - for the first time - it exported more cell+wafers than panels 🧵
Reposted by Andrew Plested
😵💫 soon the journals will require physical proof of the blot/gel/etc. Thinking about it, we might as well go back to mailing a physical copy of the typed manuscript and photos/negatives.
Finally the scary example. The image of a western blot with a time course experiment, staining a protein of interest, showing the increase of protein over time and a second staining with a control antibody that does not change over time
November 21, 2025 at 1:42 PM
😵💫 soon the journals will require physical proof of the blot/gel/etc. Thinking about it, we might as well go back to mailing a physical copy of the typed manuscript and photos/negatives.
Wow. The feeling, reading a letter of motivation from an applicant and finding a simple grammar mistake in the first paragraph!
Immense relief and even respect that this letter was human-generated!!!
How the world has changed. Spelling mistakes are now valuable!
#enshittification
Immense relief and even respect that this letter was human-generated!!!
How the world has changed. Spelling mistakes are now valuable!
#enshittification
November 21, 2025 at 8:35 AM
Wow. The feeling, reading a letter of motivation from an applicant and finding a simple grammar mistake in the first paragraph!
Immense relief and even respect that this letter was human-generated!!!
How the world has changed. Spelling mistakes are now valuable!
#enshittification
Immense relief and even respect that this letter was human-generated!!!
How the world has changed. Spelling mistakes are now valuable!
#enshittification
Reposted by Andrew Plested
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Postdoctoral Positions in Protein Engineering
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
November 21, 2025 at 7:08 AM
We got a large Helmholtz Bioengineering grant with Oliver Daumke, Artur Yakimovich, Alina Bazarova, and Dietrich Ruess to use protein design to target cancer.
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Five open postdoctoral positions in Generative AI & Protein Engineering. Share & apply!
jobrxiv.org/job/max-delb...
Wonderful paper. Magnetic sense looks a bit like balance.
Time to CRISPR those CaV and BK channels out of the pigeon's semicircular canals to prove it!
#biophysics #ionchannels #magnetoception #birds
Time to CRISPR those CaV and BK channels out of the pigeon's semicircular canals to prove it!
#biophysics #ionchannels #magnetoception #birds
Scientists around former IMP group leader David Keays (@lmumuenchen.bsky.social show that #pigeons detect magnetic fields through their inner ear. Their discovery was now published in the journal @science.org: www.science.org/doi/10.1126/...
More: www.imp.ac.at/news/article...
More: www.imp.ac.at/news/article...
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
www.science.org
November 20, 2025 at 8:31 PM
Wonderful paper. Magnetic sense looks a bit like balance.
Time to CRISPR those CaV and BK channels out of the pigeon's semicircular canals to prove it!
#biophysics #ionchannels #magnetoception #birds
Time to CRISPR those CaV and BK channels out of the pigeon's semicircular canals to prove it!
#biophysics #ionchannels #magnetoception #birds