Pedro Beltrao
@pedrobeltrao.bsky.social
Associate professor at ETH Zurich, studying the cellular consequences of genetic variation. Affiliated with the Swiss Institute of Bioinformatics and a part of the LOOP Zurich.
Pinned
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Reposted by Pedro Beltrao
𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝘀𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝗶𝘀 𝗼𝗽𝗲𝗻 !
The 9th Single Cell Proteomics Conference (#SCP2026) will take place in #Boston, July 2026.
The Single Cell Proteomics Conference focuses on providing opportunities for scientific discussions, interactions and community development.
single-cell.net/proteomics/s...
The 9th Single Cell Proteomics Conference (#SCP2026) will take place in #Boston, July 2026.
The Single Cell Proteomics Conference focuses on providing opportunities for scientific discussions, interactions and community development.
single-cell.net/proteomics/s...
December 1, 2025 at 11:54 AM
𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝘀𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝗶𝘀 𝗼𝗽𝗲𝗻 !
The 9th Single Cell Proteomics Conference (#SCP2026) will take place in #Boston, July 2026.
The Single Cell Proteomics Conference focuses on providing opportunities for scientific discussions, interactions and community development.
single-cell.net/proteomics/s...
The 9th Single Cell Proteomics Conference (#SCP2026) will take place in #Boston, July 2026.
The Single Cell Proteomics Conference focuses on providing opportunities for scientific discussions, interactions and community development.
single-cell.net/proteomics/s...
Reposted by Pedro Beltrao
Been excited about this one for a while! What would you do with a new alphabet and the wealth of protein sequence bioinformatics at your disposal? We're also around at #EMBOComp3D Heidelberg and MLSB Copenhagen this week to discuss
Fresh from bioRxiv our latest work introducing The Embedded Alphabet (TEA), a powerful new representation for protein sequences obtained by discretising ESM2 embeddings into 20 characters.
Pre-print: www.biorxiv.org/content/10.1...
🧵👇(1/n)
Pre-print: www.biorxiv.org/content/10.1...
🧵👇(1/n)
Rewriting protein alphabets with language models
Detecting remote homology with speed and sensitivity is crucial for tasks like function annotation and structure prediction. We introduce a novel approach using contrastive learning to convert protein...
www.biorxiv.org
December 1, 2025 at 10:58 AM
Been excited about this one for a while! What would you do with a new alphabet and the wealth of protein sequence bioinformatics at your disposal? We're also around at #EMBOComp3D Heidelberg and MLSB Copenhagen this week to discuss
Reposted by Pedro Beltrao
Happy to announce VIRE, a planetary-scale database of >1.7M viral genomes reconstructed from 100k+ metagenomes across diverse environments! In collaboration with @fullam.bsky.social, @tsbschm.bsky.social, and @borklab.bsky.social.
academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1225/8356007
academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1225/8356007
VIRE: a metagenome-derived, planetary-scale virome resource with environmental context
Abstract. Viruses are the most abundant biological entities on Earth, yet their global diversity remains largely unexplored. Here, we present VIRE, a compr
academic.oup.com
December 1, 2025 at 4:41 AM
Happy to announce VIRE, a planetary-scale database of >1.7M viral genomes reconstructed from 100k+ metagenomes across diverse environments! In collaboration with @fullam.bsky.social, @tsbschm.bsky.social, and @borklab.bsky.social.
academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1225/8356007
academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1225/8356007
ERC Plus Grants
• No career limit, current ERCs are not eligible
• Major challenge, transformative research
• Up to 7 million euros, up to 7 years
• 30 grants per year, 2 years, only once per lifetime
• Same application format, plus vision statement
• Deadline in September 2026, 2 stage evaluation
• No career limit, current ERCs are not eligible
• Major challenge, transformative research
• Up to 7 million euros, up to 7 years
• 30 grants per year, 2 years, only once per lifetime
• Same application format, plus vision statement
• Deadline in September 2026, 2 stage evaluation
Webinar on the new ERC Plus Grants live starting now www.youtube.com/live/Dzkas7f...
Webinar on the new ERC Plus Grants
YouTube video by European Research Council
www.youtube.com
November 28, 2025 at 2:19 PM
ERC Plus Grants
• No career limit, current ERCs are not eligible
• Major challenge, transformative research
• Up to 7 million euros, up to 7 years
• 30 grants per year, 2 years, only once per lifetime
• Same application format, plus vision statement
• Deadline in September 2026, 2 stage evaluation
• No career limit, current ERCs are not eligible
• Major challenge, transformative research
• Up to 7 million euros, up to 7 years
• 30 grants per year, 2 years, only once per lifetime
• Same application format, plus vision statement
• Deadline in September 2026, 2 stage evaluation
Webinar on the new ERC Plus Grants live starting now www.youtube.com/live/Dzkas7f...
Webinar on the new ERC Plus Grants
YouTube video by European Research Council
www.youtube.com
November 28, 2025 at 1:58 PM
Webinar on the new ERC Plus Grants live starting now www.youtube.com/live/Dzkas7f...
Reposted by Pedro Beltrao
Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 28, 2025 at 8:30 AM
Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pedro Beltrao
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
Instead of simply empowering disadvantaged scientists, advanced AI models are creating an environment of mistrust where we will rely even more on poor proxies of reputation, favoring established scientists, privileged institutions and entrenching us into the system of tiered scientific journals.
November 27, 2025 at 3:50 PM
Instead of simply empowering disadvantaged scientists, advanced AI models are creating an environment of mistrust where we will rely even more on poor proxies of reputation, favoring established scientists, privileged institutions and entrenching us into the system of tiered scientific journals.
Reposted by Pedro Beltrao
There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.
research.pasteur.fr/en/call/mid-...
research.pasteur.fr/en/call/mid-...
Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research
Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...
research.pasteur.fr
November 27, 2025 at 1:38 PM
There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.
research.pasteur.fr/en/call/mid-...
research.pasteur.fr/en/call/mid-...
Reposted by Pedro Beltrao
(1/3) Imagine reconstructing a history over a billion years in the making.
New research from EMBL and @Stanford shows how centromeres retain their function despite their rapid rate of change, and the evolutionary constraints that govern this process.
www.nature.com/articles/s41...
New research from EMBL and @Stanford shows how centromeres retain their function despite their rapid rate of change, and the evolutionary constraints that govern this process.
www.nature.com/articles/s41...
November 26, 2025 at 4:06 PM
(1/3) Imagine reconstructing a history over a billion years in the making.
New research from EMBL and @Stanford shows how centromeres retain their function despite their rapid rate of change, and the evolutionary constraints that govern this process.
www.nature.com/articles/s41...
New research from EMBL and @Stanford shows how centromeres retain their function despite their rapid rate of change, and the evolutionary constraints that govern this process.
www.nature.com/articles/s41...
Reposted by Pedro Beltrao
🧶🧬 We present LMi4Boltz:
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
October 31, 2025 at 8:54 PM
🧶🧬 We present LMi4Boltz:
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
Reposted by Pedro Beltrao
...and if you are interested in doing a PhD with Mafalda and I, we currently have one opening, with deadline this Sunday! www.crg.eu/en/content/t...
www.crg.eu
November 25, 2025 at 11:56 AM
...and if you are interested in doing a PhD with Mafalda and I, we currently have one opening, with deadline this Sunday! www.crg.eu/en/content/t...
Reposted by Pedro Beltrao
i’m not crying you’re crying
xkcd: Fifteen Years
xkcd: Fifteen Years
Fifteen Years
xkcd.com
November 25, 2025 at 1:58 AM
i’m not crying you’re crying
xkcd: Fifteen Years
xkcd: Fifteen Years
Reposted by Pedro Beltrao
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 24, 2025 at 7:23 PM
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
Reposted by Pedro Beltrao
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Proteome-wide model for human disease genetics
Nature Genetics - popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.
rdcu.be
November 24, 2025 at 1:35 PM
popEVE is out in Nature Genetics! 🎉
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders.
rdcu.be/eRu7K
Reposted by Pedro Beltrao
We are recruiting - deadline approaching!!! Postdoc position available in my lab to develop an exciting project with @alexfsantos2401.bsky.social to advance our understanding of food allergy and oral tolerance in early life.
#ILC #organoids #intestine #FoodAllergy
www.kcl.ac.uk/jobs/128585-...
#ILC #organoids #intestine #FoodAllergy
www.kcl.ac.uk/jobs/128585-...
November 24, 2025 at 8:40 AM
We are recruiting - deadline approaching!!! Postdoc position available in my lab to develop an exciting project with @alexfsantos2401.bsky.social to advance our understanding of food allergy and oral tolerance in early life.
#ILC #organoids #intestine #FoodAllergy
www.kcl.ac.uk/jobs/128585-...
#ILC #organoids #intestine #FoodAllergy
www.kcl.ac.uk/jobs/128585-...
Reposted by Pedro Beltrao
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
November 21, 2025 at 5:32 PM
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
Reposted by Pedro Beltrao
💫 Thank you to all participants and speakers who joined us at the 2nd @eurocancerdepmap.bsky.social Symposium!
Together, we’re advancing #cancer functional genomics across Europe.
youtu.be/Qt_ozbzM5js
Together, we’re advancing #cancer functional genomics across Europe.
youtu.be/Qt_ozbzM5js
2nd European Cancer Dependency Map Symposium - 20 Nov 2025
YouTube video by Human Technopole
youtu.be
November 21, 2025 at 2:15 PM
💫 Thank you to all participants and speakers who joined us at the 2nd @eurocancerdepmap.bsky.social Symposium!
Together, we’re advancing #cancer functional genomics across Europe.
youtu.be/Qt_ozbzM5js
Together, we’re advancing #cancer functional genomics across Europe.
youtu.be/Qt_ozbzM5js
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
November 21, 2025 at 1:14 PM
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
Reposted by Pedro Beltrao
The update includes metabolomic, genetic, and imaging data, plus much more, all alongside our existing comprehensive dataset
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Metabolomic, genetic, imaging data and more: new and updated UK Biobank data now available
The latest update to UK Biobank’s comprehensive dataset is available to approved researchers around the world via the Research Analysis Platform (UKB-RAP).
www.ukbiobank.ac.uk
November 20, 2025 at 9:09 AM
The update includes metabolomic, genetic, and imaging data, plus much more, all alongside our existing comprehensive dataset
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Reposted by Pedro Beltrao
The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social
November 20, 2025 at 8:59 AM
The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social
Reposted by Pedro Beltrao
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
www.nature.com
November 19, 2025 at 5:51 PM
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
This looks like a fantastic resource to study human kinase signalling. So much MS instrument time.
Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome https://www.biorxiv.org/content/10.1101/2025.11.18.689017v1
November 19, 2025 at 6:18 AM
This looks like a fantastic resource to study human kinase signalling. So much MS instrument time.
New blog post - AI "peer" review - the impact on scientific publishing. Some thoughts on AI manuscript assessments and potential impacts on scientific publishing www.evocellnet.com/2025/11/ai-p...
AI "peer" review - the impact on scientific publishing
It is the first time, in the second half of this year, that I am not trying to urgently deal with something. So, instead of working on some ...
www.evocellnet.com
November 18, 2025 at 4:02 PM
New blog post - AI "peer" review - the impact on scientific publishing. Some thoughts on AI manuscript assessments and potential impacts on scientific publishing www.evocellnet.com/2025/11/ai-p...