Journal of General Physiology
@jgp.org
Journal of General Physiology publishes research in physiological problems at cellular and molecular level - Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jgp
🌐 rupress.org/jgp
Pinned
📣#CallForPapers on the topic of SGP's (@sgpweb.bsky.social) 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Learn more and submit your research 👉 rupress.org/JGP/pages/ca...
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic #bradycardia. New study from Luca M.G. Palloni, Dario DiFrancesco and colleagues (University of Milano): rupress.org/jgp/article/...
#MolecularPhysiology #CellularPhysiology #CardiacMuscle #SignalTransduction
#MolecularPhysiology #CellularPhysiology #CardiacMuscle #SignalTransduction
February 13, 2026 at 2:45 PM
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic #bradycardia. New study from Luca M.G. Palloni, Dario DiFrancesco and colleagues (University of Milano): rupress.org/jgp/article/...
#MolecularPhysiology #CellularPhysiology #CardiacMuscle #SignalTransduction
#MolecularPhysiology #CellularPhysiology #CardiacMuscle #SignalTransduction
McGuinness, Shen, Khalili-Araghi, Weber et al. reveal the role of #claudin-15 D55 residue in ion size & charge selectivity. A reduced model of claudin-15 offers novel insights into ion conductance, providing a valuable tool for therapeutic modulation of #TightJunctions rupress.org/jgp/article/...
February 12, 2026 at 5:01 PM
McGuinness, Shen, Khalili-Araghi, Weber et al. reveal the role of #claudin-15 D55 residue in ion size & charge selectivity. A reduced model of claudin-15 offers novel insights into ion conductance, providing a valuable tool for therapeutic modulation of #TightJunctions rupress.org/jgp/article/...
Latest in Research News: a recent JGP study from Antonella Dapino and Sebastián Curti (rupress.org/jgp/article/...) reveals that the D-type K⁺ current regulates coincidence detection by shaping electrical transmission between pairs of MesV neurons. rupress.org/jgp/article/...
February 11, 2026 at 5:00 PM
Latest in Research News: a recent JGP study from Antonella Dapino and Sebastián Curti (rupress.org/jgp/article/...) reveals that the D-type K⁺ current regulates coincidence detection by shaping electrical transmission between pairs of MesV neurons. rupress.org/jgp/article/...
📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
February 11, 2026 at 3:25 PM
📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
Using a prepulse protocol on insect Caᵥ4 calcium channel, Cens, Charnet et al. @ibmm-balard.bsky.social report a current facilitation restricted to the descending branch of the I–V curve. Facilitation was less pronounced when a loop III-IV inactivation motif was mutated rupress.org/jgp/article/...
February 10, 2026 at 5:04 PM
Using a prepulse protocol on insect Caᵥ4 calcium channel, Cens, Charnet et al. @ibmm-balard.bsky.social report a current facilitation restricted to the descending branch of the I–V curve. Facilitation was less pronounced when a loop III-IV inactivation motif was mutated rupress.org/jgp/article/...
New work from Palloni, DiFrancesco et al. shows that AMPK inhibits HCN4 membrane expression by direct channel phosphorylation, and shows that this process contributes to age-dependent intrinsic cardiac rate slowing. rupress.org/jgp/article/...
February 6, 2026 at 5:00 PM
New work from Palloni, DiFrancesco et al. shows that AMPK inhibits HCN4 membrane expression by direct channel phosphorylation, and shows that this process contributes to age-dependent intrinsic cardiac rate slowing. rupress.org/jgp/article/...
Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current. New study from Antonella Dapino and Sebastián Curti (Universidad de la República, Uruguay) rupress.org/jgp/article/...
#CellularPhysiology #IonChannels #GapJunctions
#CellularPhysiology #IonChannels #GapJunctions
February 6, 2026 at 2:45 PM
Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current. New study from Antonella Dapino and Sebastián Curti (Universidad de la República, Uruguay) rupress.org/jgp/article/...
#CellularPhysiology #IonChannels #GapJunctions
#CellularPhysiology #IonChannels #GapJunctions
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
February 4, 2026 at 3:45 PM
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations. New review from Anthony Hessel @hesselanthony.bsky.social, Christopher Rand @crand22.bsky.social, Khoi Nguyen and colleagues: rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
The relationship between apparent potentiation and the magnitude of the control response. New tutorial from Joe Henry Steinbach and Gustav Akk @washumedicine.bsky.social: rupress.org/jgp/article/...
#Biophysics #MolecularPhysiology #MembraneTransport
#Biophysics #MolecularPhysiology #MembraneTransport
February 3, 2026 at 3:45 PM
The relationship between apparent potentiation and the magnitude of the control response. New tutorial from Joe Henry Steinbach and Gustav Akk @washumedicine.bsky.social: rupress.org/jgp/article/...
#Biophysics #MolecularPhysiology #MembraneTransport
#Biophysics #MolecularPhysiology #MembraneTransport
Reposted by Journal of General Physiology
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
February 2, 2026 at 4:36 PM
📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
#IonChannels #CallForPapers
February 2, 2026 at 4:30 PM
📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
#IonChannels #CallForPapers
📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, @osamaharraz.bsky.social, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
February 2, 2026 at 2:15 PM
📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, @osamaharraz.bsky.social, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...
Electrical synapses enable neural circuits to perform as coincidence detectors. Dapino and Curti show that the temporal precision of this operation is critically determined by voltage-dependent conductances of the soma and proximal axon. rupress.org/jgp/article/...
#CellularPhysiology #IonChannels
#CellularPhysiology #IonChannels
January 30, 2026 at 5:00 PM
Electrical synapses enable neural circuits to perform as coincidence detectors. Dapino and Curti show that the temporal precision of this operation is critically determined by voltage-dependent conductances of the soma and proximal axon. rupress.org/jgp/article/...
#CellularPhysiology #IonChannels
#CellularPhysiology #IonChannels
Reposted by Journal of General Physiology
Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"!
Review: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
January 28, 2026 at 7:43 PM
Really happy about this paper getting published, where we muse on some of the finer aspects of the permeablized fiber mechanics technique. Have things you wished were covered? Go write one of these up to! Science is better when we all share our "institutional knowledge"!
Review: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
January 28, 2026 at 5:03 PM
Review: @hesselanthony.bsky.social @crand22.bsky.social, Nguyen et al. provide useful tips and tricks for all those beginning their journey into permeabilized muscle fiber mechanics. rupress.org/jgp/article/...
#Myofilaments #SkeletalMuscle #CardiacMuscle
#Myofilaments #SkeletalMuscle #CardiacMuscle
New tutorial: Electrophysiological potentiation is calculated from the ratio of amplitudes of responses to agonist in the presence and absence of a modulator. Steinbach and Akk show that potentiation depends on the relative magnitude of the control response. rupress.org/jgp/article/...
January 27, 2026 at 5:00 PM
New tutorial: Electrophysiological potentiation is calculated from the ratio of amplitudes of responses to agonist in the presence and absence of a modulator. Steinbach and Akk show that potentiation depends on the relative magnitude of the control response. rupress.org/jgp/article/...
📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
January 26, 2026 at 4:15 PM
📣 #CallForPapers 📣 Emerging Research on Ion Channels in Health and Disease. Submit your research on topics including #IonChannel structure and biophysical properties, regulatory mechanisms, pharmacology, physiological functions, disease relevance, and drug discovery. 👉 rupress.org/JGP/pages/ca...
Inhibition of Caᵥ1.4 channels by Caᵥ3 channel antagonists ML218 and Z944. New study from Jinglang Sun, Amy Lee @utaustin.bsky.social and colleagues: rupress.org/jgp/article/...
@vyy-sf.bsky.social
#MolecularPharmacology #IonChannels
@vyy-sf.bsky.social
#MolecularPharmacology #IonChannels
January 14, 2026 at 8:30 PM
Inhibition of Caᵥ1.4 channels by Caᵥ3 channel antagonists ML218 and Z944. New study from Jinglang Sun, Amy Lee @utaustin.bsky.social and colleagues: rupress.org/jgp/article/...
@vyy-sf.bsky.social
#MolecularPharmacology #IonChannels
@vyy-sf.bsky.social
#MolecularPharmacology #IonChannels
Manganese and intracellular calcium handling. Godfrey Smith @glasgow.ac.uk and David Eisner @manchester.ac.uk provide a commentary on recent work by the Bruno Allard group (rupress.org/jgp/article/...): rupress.org/jgp/article/...
January 13, 2026 at 6:15 PM
Manganese and intracellular calcium handling. Godfrey Smith @glasgow.ac.uk and David Eisner @manchester.ac.uk provide a commentary on recent work by the Bruno Allard group (rupress.org/jgp/article/...): rupress.org/jgp/article/...
Jinglang Sun, Amy Lee et al. @utaustin.bsky.social show that the commonly used Caᵥ3 T-type channel-selective antagonists, ML218 & Z944, modulate the activity of Caᵥ1.4 L-type channels through a mechanism involving the dihydropyridine-binding site. rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
January 7, 2026 at 2:30 PM
Jinglang Sun, Amy Lee et al. @utaustin.bsky.social show that the commonly used Caᵥ3 T-type channel-selective antagonists, ML218 & Z944, modulate the activity of Caᵥ1.4 L-type channels through a mechanism involving the dihydropyridine-binding site. rupress.org/jgp/article/...
#MolecularPharmacology
#MolecularPharmacology
Commentary on work (rupress.org/jgp/article/...) that featured manganese quench measurements in skeletal muscle, in particular a transient quench signal that was thought to represent Ca²⁺ transiently displacing Mn²⁺ bound to endogenous Ca²⁺ buffers inside muscle cells. rupress.org/jgp/article/...
January 6, 2026 at 2:15 PM
Commentary on work (rupress.org/jgp/article/...) that featured manganese quench measurements in skeletal muscle, in particular a transient quench signal that was thought to represent Ca²⁺ transiently displacing Mn²⁺ bound to endogenous Ca²⁺ buffers inside muscle cells. rupress.org/jgp/article/...
🔔 #CallForPapers on Chloride Channels and Transporters: ⏰ DEADLINE EXTENDED to January 30, 2026! We welcome papers on diverse membrane protein families involved in transporting anions 👉 rupress.org/JGP/pages/ca...
@sgpweb.bsky.social
@sgpweb.bsky.social
January 5, 2026 at 8:15 PM
🔔 #CallForPapers on Chloride Channels and Transporters: ⏰ DEADLINE EXTENDED to January 30, 2026! We welcome papers on diverse membrane protein families involved in transporting anions 👉 rupress.org/JGP/pages/ca...
@sgpweb.bsky.social
@sgpweb.bsky.social
JGP’s January issue is here! rupress.org/jgp/issue/15...
Sharma et al. surveyed structures of voltage-gated sodium channels to identify Nav1.5 carboxyl-terminal residues that independently regulate channel activation, inactivation, and modulation in presence of FHF2. doi.org/10.1085/jgp....
Sharma et al. surveyed structures of voltage-gated sodium channels to identify Nav1.5 carboxyl-terminal residues that independently regulate channel activation, inactivation, and modulation in presence of FHF2. doi.org/10.1085/jgp....
January 5, 2026 at 4:30 PM
JGP’s January issue is here! rupress.org/jgp/issue/15...
Sharma et al. surveyed structures of voltage-gated sodium channels to identify Nav1.5 carboxyl-terminal residues that independently regulate channel activation, inactivation, and modulation in presence of FHF2. doi.org/10.1085/jgp....
Sharma et al. surveyed structures of voltage-gated sodium channels to identify Nav1.5 carboxyl-terminal residues that independently regulate channel activation, inactivation, and modulation in presence of FHF2. doi.org/10.1085/jgp....
📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers #WSCC26
#IonChannels #CallForPapers #WSCC26
January 5, 2026 at 4:03 PM
📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers #WSCC26
#IonChannels #CallForPapers #WSCC26
A critical residue mediates proper assembly and gating of GIRK2 channels. New study from Ha Nguyen, Paul A. Slesinger and colleagues @sinaibrain.bsky.social: rupress.org/jgp/article/...
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
December 26, 2025 at 3:15 PM
A critical residue mediates proper assembly and gating of GIRK2 channels. New study from Ha Nguyen, Paul A. Slesinger and colleagues @sinaibrain.bsky.social: rupress.org/jgp/article/...
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels