Journal of General Physiology
@jgp.org
Journal of General Physiology publishes research in physiological problems at cellular and molecular level - Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jgp
🌐 rupress.org/jgp
Sharma, Goldfarb et al. @huntercollege.bsky.social show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
December 2, 2025 at 5:00 PM
Sharma, Goldfarb et al. @huntercollege.bsky.social show the differential effects of CTD missense mutations on cardiac sodium channel activation, inactivation, persistent current, & accessory protein modulation and suggest the structural bases for these mutational effects. rupress.org/jgp/article/...
β2 and β3a regulatory subunits can coassemble in the same BK channels, say Yu Zhou, Christopher Lingle (@chris-lingle.bsky.social) and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/...
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
December 2, 2025 at 3:30 PM
β2 and β3a regulatory subunits can coassemble in the same BK channels, say Yu Zhou, Christopher Lingle (@chris-lingle.bsky.social) and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/...
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
#CellularPhysiology #IntercellularSignaling #Biochemistry #Biophysics #IonChannels
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility, say Alejandro Alvarez-Arce, David Barefield @barefieldlab.bsky.social and colleagues @loyolachicago.bsky.social: rupress.org/jgp/article/...
#Myofilaments #CardiacMuscle
#Myofilaments #CardiacMuscle
November 26, 2025 at 3:45 PM
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility, say Alejandro Alvarez-Arce, David Barefield @barefieldlab.bsky.social and colleagues @loyolachicago.bsky.social: rupress.org/jgp/article/...
#Myofilaments #CardiacMuscle
#Myofilaments #CardiacMuscle
Yu Zhou, @chris-lingle.bsky.social et al. ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent with a trinomial model of random mixing of β subunits. rupress.org/jgp/article/...
November 25, 2025 at 7:00 PM
Yu Zhou, @chris-lingle.bsky.social et al. ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. They show that ternary β2:β3:α complexes form, consistent with a trinomial model of random mixing of β subunits. rupress.org/jgp/article/...
Optical control of PI(4,5)P₂ sensitivity of ion channels by manipulation of single lysine residue. New study from Junxian Zhou, Yasushi Okamura, and colleagues (University of Osaka): rupress.org/jgp/article/...
#MolecularPhysiology #Biophysics #MembraneTransport #CellBiology #IonChannels
#MolecularPhysiology #Biophysics #MembraneTransport #CellBiology #IonChannels
November 25, 2025 at 2:30 PM
Optical control of PI(4,5)P₂ sensitivity of ion channels by manipulation of single lysine residue. New study from Junxian Zhou, Yasushi Okamura, and colleagues (University of Osaka): rupress.org/jgp/article/...
#MolecularPhysiology #Biophysics #MembraneTransport #CellBiology #IonChannels
#MolecularPhysiology #Biophysics #MembraneTransport #CellBiology #IonChannels
Explore new #Neuroscience research published in JGP, featuring articles on the role of voltage-gated sodium channels in pain sensation and their potential as therapeutic targets, as well as studies investigating the regulation of NMDA receptor activation, and more 👉 rupress.org/jgp/collecti...
November 21, 2025 at 4:15 PM
Explore new #Neuroscience research published in JGP, featuring articles on the role of voltage-gated sodium channels in pain sensation and their potential as therapeutic targets, as well as studies investigating the regulation of NMDA receptor activation, and more 👉 rupress.org/jgp/collecti...
New study from Alvarez-Arce et al. @barefieldlab.bsky.social shows that premature stop variants in myosin-binding protein H-like prevent sarcomere incorporation of the translated protein regardless of the location of the premature stop along the protein. rupress.org/jgp/article/...
#Myofilaments
#Myofilaments
November 19, 2025 at 5:00 PM
New study from Alvarez-Arce et al. @barefieldlab.bsky.social shows that premature stop variants in myosin-binding protein H-like prevent sarcomere incorporation of the translated protein regardless of the location of the premature stop along the protein. rupress.org/jgp/article/...
#Myofilaments
#Myofilaments
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 19, 2025 at 4:15 PM
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
Zhou, Okamura et al. introduce a novel optogenetic approach to control ion channel activity using a photocaged lysine. Combined with VSP, the method provides new insights into PI(4,5)P₂-dependent ion channels. rupress.org/jgp/article/...
#MolecularPhysiology #Biophysics #IonChannels
#MolecularPhysiology #Biophysics #IonChannels
November 18, 2025 at 5:01 PM
Zhou, Okamura et al. introduce a novel optogenetic approach to control ion channel activity using a photocaged lysine. Combined with VSP, the method provides new insights into PI(4,5)P₂-dependent ion channels. rupress.org/jgp/article/...
#MolecularPhysiology #Biophysics #IonChannels
#MolecularPhysiology #Biophysics #IonChannels
Vasylyev, Waxman et al. show that the Na⁺ channel Naᵥ1.8 amplifies DRG neuron excitability close to the activation potential threshold, while Naᵥ1.7 acts closer to resting potential. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 18, 2025 at 4:15 PM
Vasylyev, Waxman et al. show that the Na⁺ channel Naᵥ1.8 amplifies DRG neuron excitability close to the activation potential threshold, while Naᵥ1.7 acts closer to resting potential. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 18, 2025 at 3:45 PM
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
Mn quenching in activated #zebrafish muscle fibers does not result from store‐operated Ca entry, say Francisco Jaque-Fernandez, Bruno Allard and colleagues (Université Claude Bernard, @cnrs.fr): rupress.org/jgp/article/...
#CellularPhysiology #SkeletalMuscle
#CellularPhysiology #SkeletalMuscle
November 18, 2025 at 2:15 PM
Mn quenching in activated #zebrafish muscle fibers does not result from store‐operated Ca entry, say Francisco Jaque-Fernandez, Bruno Allard and colleagues (Université Claude Bernard, @cnrs.fr): rupress.org/jgp/article/...
#CellularPhysiology #SkeletalMuscle
#CellularPhysiology #SkeletalMuscle
Chernyshkova, Firsov et al. show that light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 17, 2025 at 6:15 PM
Chernyshkova, Firsov et al. show that light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
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Miaomiao He and @lwollmuth.bsky.social show that activation efficiency in NMDARs can be regulated by environmental surroundings and varies across different subunits. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 17, 2025 at 4:15 PM
Miaomiao He and @lwollmuth.bsky.social show that activation efficiency in NMDARs can be regulated by environmental surroundings and varies across different subunits. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
Attending #SfN25 in San Diego? Visit @rupress.org booth #3719 to chat about the journal and pick up our #Neuroscience Collection magazine 📚 as well as an exclusive pouch! 🎁 We look forward to meeting you! 💬 💡
November 17, 2025 at 3:00 PM
Attending #SfN25 in San Diego? Visit @rupress.org booth #3719 to chat about the journal and pick up our #Neuroscience Collection magazine 📚 as well as an exclusive pouch! 🎁 We look forward to meeting you! 💬 💡
McIlvried, @johndr01.bsky.social, @robgereau.bsky.social et al. show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sustained depolarization. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 16, 2025 at 6:15 PM
McIlvried, @johndr01.bsky.social, @robgereau.bsky.social et al. show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sustained depolarization. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
Köster, @lampertlab.bsky.social et al. characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 16, 2025 at 4:15 PM
Köster, @lampertlab.bsky.social et al. characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
@eveaviles.bsky.social et al. report that ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 15, 2025 at 6:15 PM
@eveaviles.bsky.social et al. report that ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
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Thoreson et al. find that the architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 15, 2025 at 4:15 PM
Thoreson et al. find that the architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
Medrihan, Milosevic and colleagues show that projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in depression rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
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November 14, 2025 at 6:15 PM
Medrihan, Milosevic and colleagues show that projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in depression rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
The Bean Lab uses the Nav1.8 inhibitors suzetrigine, A-887826, & LTGO-33 to show differences in the kinetics with which the compounds unbind from depolarized channels and rebind to resting state channels. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 14, 2025 at 4:15 PM
The Bean Lab uses the Nav1.8 inhibitors suzetrigine, A-887826, & LTGO-33 to show differences in the kinetics with which the compounds unbind from depolarized channels and rebind to resting state channels. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
Wood et al. review the development of analgesic drugs targeting sodium channels Naᵥ1.7 and Naᵥ1.8. FDA approval of the Naᵥ1.8 antagonist suzetrigine presages an exciting new era in analgesic treatment. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
November 13, 2025 at 4:15 PM
Wood et al. review the development of analgesic drugs targeting sodium channels Naᵥ1.7 and Naᵥ1.8. FDA approval of the Naᵥ1.8 antagonist suzetrigine presages an exciting new era in analgesic treatment. rupress.org/jgp/article/...
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
📙 In #Neuroscience collection 👉 rupress.org/jgp/collecti...
#SfN25
From the adaptive plasticity of sensory neurons to the influence of synaptic architecture on glutamate dynamics within rod photoreceptor synapses, explore new #Neuroscience research in JGP to accompany #SfN25 @sfn.org! 👉 rupress.org/jgp/collecti...
November 13, 2025 at 3:15 PM
From the adaptive plasticity of sensory neurons to the influence of synaptic architecture on glutamate dynamics within rod photoreceptor synapses, explore new #Neuroscience research in JGP to accompany #SfN25 @sfn.org! 👉 rupress.org/jgp/collecti...
Regulation of voltage-sensing structures of Caᵥ1.2 calcium channel by the auxiliary β3-subunit. New study from Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, and Alan Neely (Universidad de Valparaíso): rupress.org/jgp/article/...
#Biophysics #CardiacMuscle #MembraneTransport #IonChannels
#Biophysics #CardiacMuscle #MembraneTransport #IonChannels
November 12, 2025 at 7:15 PM
Regulation of voltage-sensing structures of Caᵥ1.2 calcium channel by the auxiliary β3-subunit. New study from Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, and Alan Neely (Universidad de Valparaíso): rupress.org/jgp/article/...
#Biophysics #CardiacMuscle #MembraneTransport #IonChannels
#Biophysics #CardiacMuscle #MembraneTransport #IonChannels
Jaque-Fernandez, Allard et al. @cnrs.fr show that depolarization of #zebrafish #SkeletalMuscle fibers evokes a Mn²⁺ quenching signal that does not result from store-operated Ca²⁺ entry but from a displacement of Mn²⁺ accumulated on intracellular Ca²⁺ buffers rupress.org/jgp/article/...
November 11, 2025 at 5:02 PM
Jaque-Fernandez, Allard et al. @cnrs.fr show that depolarization of #zebrafish #SkeletalMuscle fibers evokes a Mn²⁺ quenching signal that does not result from store-operated Ca²⁺ entry but from a displacement of Mn²⁺ accumulated on intracellular Ca²⁺ buffers rupress.org/jgp/article/...