Rahul K
@theresearch.bsky.social
I run, ski, and engineer cells and materials; asking how nutrient sensing & signaling work: bit.ly/RK-GoogleScholar
🇪🇪: TalTech| Ex: Tartu Ülikool; 🇸🇪: Karolinska Institutet, Chalmers; 🇯🇵: Kyutech; 🇮🇳: IITD
🇪🇪: TalTech| Ex: Tartu Ülikool; 🇸🇪: Karolinska Institutet, Chalmers; 🇯🇵: Kyutech; 🇮🇳: IITD
Pinned
Rahul K
@theresearch.bsky.social
· Nov 11
I’d like to invite everyone working on engineering living materials to share this starter pack. Please drop me a message or leave a comment if you like to join the #ELMs community. go.bsky.app/RinsDZh
Reposted by Rahul K
Print version of @thelancet.com's review of #ScienceUnderSiege
November 28, 2025 at 4:00 PM
Print version of @thelancet.com's review of #ScienceUnderSiege
Reposted by Rahul K
#NoTimeToDie! Welcome mitoxyperiosis! Kanneganti, Wang &co show @cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by
the synergy of innate immune activation and metabolic stress. This process is regulated
by mTORC2 and involves persis...
www.cell.com
November 28, 2025 at 4:56 PM
#NoTimeToDie! Welcome mitoxyperiosis! Kanneganti, Wang &co show @cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!
Reposted by Rahul K
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
Heterochromatin boundaries maintain centromere position, size and number - Nature Structural & Molecular Biology
Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.
www.nature.com
November 27, 2025 at 9:58 PM
Very proud to have our latest work now online in
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
@natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4
www.nature.com/articles/s41...
Reposted by Rahul K
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 28, 2025 at 5:22 PM
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Reposted by Rahul K
Some of the ✨beautiful✨ covers for the November 2025 Issue of ACS Applied Engineering Materials!
pubs.acs.org/toc/aaemdr/c...
Thankful to all of our authors, readers, & reviewers!
pubs.acs.org/toc/aaemdr/c...
Thankful to all of our authors, readers, & reviewers!
November 28, 2025 at 1:05 PM
Some of the ✨beautiful✨ covers for the November 2025 Issue of ACS Applied Engineering Materials!
pubs.acs.org/toc/aaemdr/c...
Thankful to all of our authors, readers, & reviewers!
pubs.acs.org/toc/aaemdr/c...
Thankful to all of our authors, readers, & reviewers!
Reposted by Rahul K
Opticial Control of Cholesterol, attempting to stay as close to the original as possible. Congratulations to Michael Zott, who defined and spearheaded this study, and to our wonderful collaborator Luca Laraia!
Delighted to have collaborated with the @dirktrauner.bsky.social lab on the development and characterisation of #photoswitchable #cholesterol derivatives, now out in @jacs.acspublications.org! (1/3) pubs.acs.org/doi/full/10....
Development of Photoswitchable Cholesterol Derivatives through Side Chain Replacement
Cholesterol is ubiquitous in biology, shaping membrane properties and serving as a biosynthetic precursor for essential signaling molecules and hormones─and, in some contexts, acting as a signaling mo...
pubs.acs.org
November 28, 2025 at 11:40 AM
Opticial Control of Cholesterol, attempting to stay as close to the original as possible. Congratulations to Michael Zott, who defined and spearheaded this study, and to our wonderful collaborator Luca Laraia!
Reposted by Rahul K
Artificial intelligence peer reviewers recommend the acceptance of unsound papers created entirely by AI more than 80% of the time, a new study has found. cen.acs.org/research-int... #chemsky 🧪
AI peer reviewers are fine with AI-fabricated papers
Study finds artificial intelligence reviewers accept AI-generated scientific studies 4 out of 5 times
cen.acs.org
November 28, 2025 at 11:26 AM
Artificial intelligence peer reviewers recommend the acceptance of unsound papers created entirely by AI more than 80% of the time, a new study has found. cen.acs.org/research-int... #chemsky 🧪
Reposted by Rahul K
Fun! Tldr
AI researchers are pissed bc some AI research papers submitted to an AI conference by AI researcher colleagues is AI-written & many are AI-reviewed as found by an AI company's AI model, described in a paper for said AI conference. Said paper was also AI-reviewed (but deffo not AI-written)
AI researchers are pissed bc some AI research papers submitted to an AI conference by AI researcher colleagues is AI-written & many are AI-reviewed as found by an AI company's AI model, described in a paper for said AI conference. Said paper was also AI-reviewed (but deffo not AI-written)
What can researchers do if they suspect that their manuscripts have been peer reviewed using AI?
go.nature.com/4pxUNyD
go.nature.com/4pxUNyD
Major AI conference flooded with peer-reviews written fully by AI
Controversy has erupted after 21% of manuscript reviews for an international AI conference were found to be generated by artificial intelligence.
go.nature.com
November 28, 2025 at 6:51 AM
Fun! Tldr
AI researchers are pissed bc some AI research papers submitted to an AI conference by AI researcher colleagues is AI-written & many are AI-reviewed as found by an AI company's AI model, described in a paper for said AI conference. Said paper was also AI-reviewed (but deffo not AI-written)
AI researchers are pissed bc some AI research papers submitted to an AI conference by AI researcher colleagues is AI-written & many are AI-reviewed as found by an AI company's AI model, described in a paper for said AI conference. Said paper was also AI-reviewed (but deffo not AI-written)
Reposted by Rahul K
Studies in mice reveal that during fasting and refeeding, glucagon regulates renal glucose reabsorption by utilizing the local cellular circadian machinery. #kidney www.nature.com/articles/s41... 🧪
Fasting hijacks proximal tubule circadian control mechanisms to regulate glucose reabsorption via the Nrf1/Sglt2 pathway in mice - Nature Communications
SGLT2 inhibitors lower blood glucose in patients with diabetes. Here, the authors report that fasting reduces renal expression of Sglt2 and glucose reabsorption by modulating circadian clock genes.
www.nature.com
November 28, 2025 at 11:02 AM
Studies in mice reveal that during fasting and refeeding, glucagon regulates renal glucose reabsorption by utilizing the local cellular circadian machinery. #kidney www.nature.com/articles/s41... 🧪
Reposted by Rahul K
Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...
Inhibitors supercharge kinase turnover through native proteolytic circuits - Nature
Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.
doi.org
November 27, 2025 at 6:13 AM
Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...
Reposted by Rahul K
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity www.science.org/doi/10.1126/... @levine-lab.bsky.social very cool work
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 27, 2025 at 8:43 PM
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity www.science.org/doi/10.1126/... @levine-lab.bsky.social very cool work
Reposted by Rahul K
"… in the final stretch of the year, let’s recognize everyone who continues to do the important work of great teaching, despite the discouraging climate." writes H. Holden Thorp in a new #ScienceEditorial. https://scim.ag/3XeEqei
November 27, 2025 at 8:10 PM
"… in the final stretch of the year, let’s recognize everyone who continues to do the important work of great teaching, despite the discouraging climate." writes H. Holden Thorp in a new #ScienceEditorial. https://scim.ag/3XeEqei
Reposted by Rahul K
The currently circulating seasonal #influenza H3N2 subclade K increases unusually early this season. #Vaccination highly recommended especially for individuals >65 years and individuals with #chronic diseases or #immunocompromised. See also the @ecdc.europa.eu assessment: tinyurl.com/7rrsj86h
November 27, 2025 at 7:55 PM
The currently circulating seasonal #influenza H3N2 subclade K increases unusually early this season. #Vaccination highly recommended especially for individuals >65 years and individuals with #chronic diseases or #immunocompromised. See also the @ecdc.europa.eu assessment: tinyurl.com/7rrsj86h
Reposted by Rahul K
(𝘌. 𝘤𝘰𝘭𝘪) chromosome replicationists take note 👇 (paper edited by mike o'donnell, so you know where you are)
#MicroSky
#MicroSky
Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!
Genome integrity relies on rapid recycling of DNA Pol III in bacteria | PNAS
DNA replication requires precise coordination between DNA unwinding and DNA synthesis.
In all domains of life, protein–protein interactions at the ...
www.pnas.org
November 27, 2025 at 7:13 PM
(𝘌. 𝘤𝘰𝘭𝘪) chromosome replicationists take note 👇 (paper edited by mike o'donnell, so you know where you are)
#MicroSky
#MicroSky
Reposted by Rahul K
Reposted by Rahul K
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
November 27, 2025 at 2:18 PM
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
Reposted by Rahul K
Hard choices for preprint servers.
bioRxiv has always declined reviews/hypotheses b/c of concern about signal:noise and a wish to avoid subjective judgments. AI slop makes screening certain content similarly challenging so other servers are adopting new restrictions. Two thoughts... 1/3
bioRxiv has always declined reviews/hypotheses b/c of concern about signal:noise and a wish to avoid subjective judgments. AI slop makes screening certain content similarly challenging so other servers are adopting new restrictions. Two thoughts... 1/3
In light of record submission rates and a large volume of AI-generated slop, SocArXiv recently implemented a policy requiring ORCIDs linked in the OSF profile of submitting authors, and narrowing our focus to social science subjects. Today we are taking two more steps:
/1
/1
November 27, 2025 at 5:46 PM
Hard choices for preprint servers.
bioRxiv has always declined reviews/hypotheses b/c of concern about signal:noise and a wish to avoid subjective judgments. AI slop makes screening certain content similarly challenging so other servers are adopting new restrictions. Two thoughts... 1/3
bioRxiv has always declined reviews/hypotheses b/c of concern about signal:noise and a wish to avoid subjective judgments. AI slop makes screening certain content similarly challenging so other servers are adopting new restrictions. Two thoughts... 1/3
Reposted by Rahul K
🎉 Exciting news! PoL PIs are involved in a new Research Training Group: “The Biological Making of Materials”.
With interdisciplinary research at the forefront, this new wave of PhD students will decipher the mechanisms by which organisms produce functional materials and regulate their properties 🔬
With interdisciplinary research at the forefront, this new wave of PhD students will decipher the mechanisms by which organisms produce functional materials and regulate their properties 🔬
Die @dfg.de richtet an der #TUDresden das Graduiertenkolleg „The Biological Making of Materials” ein. Über einen Zeitraum von fünf Jahren werden damit mehrere Millionen Euro für Forschung zu nachhaltigen Materialien zur Verfügung gestellt.
ℹ️ tu-dresden.de/tu-dresden/n...
ℹ️ tu-dresden.de/tu-dresden/n...
November 27, 2025 at 5:19 PM
🎉 Exciting news! PoL PIs are involved in a new Research Training Group: “The Biological Making of Materials”.
With interdisciplinary research at the forefront, this new wave of PhD students will decipher the mechanisms by which organisms produce functional materials and regulate their properties 🔬
With interdisciplinary research at the forefront, this new wave of PhD students will decipher the mechanisms by which organisms produce functional materials and regulate their properties 🔬
Reposted by Rahul K
📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
November 27, 2025 at 1:17 PM
📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
Reposted by Rahul K
I am very excited to announce that a fully funded PhD position is available in my group.
Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia
Please RT or forward this information to interested candidates.
Deadline: 11.01.26
More info:
shorturl.at/f1TuF
Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia
Please RT or forward this information to interested candidates.
Deadline: 11.01.26
More info:
shorturl.at/f1TuF
November 27, 2025 at 2:24 PM
I am very excited to announce that a fully funded PhD position is available in my group.
Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia
Please RT or forward this information to interested candidates.
Deadline: 11.01.26
More info:
shorturl.at/f1TuF
Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia
Please RT or forward this information to interested candidates.
Deadline: 11.01.26
More info:
shorturl.at/f1TuF
Reposted by Rahul K
Instead of simply empowering disadvantaged scientists, advanced AI models are creating an environment of mistrust where we will rely even more on poor proxies of reputation, favoring established scientists, privileged institutions and entrenching us into the system of tiered scientific journals.
November 27, 2025 at 3:50 PM
Instead of simply empowering disadvantaged scientists, advanced AI models are creating an environment of mistrust where we will rely even more on poor proxies of reputation, favoring established scientists, privileged institutions and entrenching us into the system of tiered scientific journals.
Reposted by Rahul K
#ER_literature Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control www.sciencedirect.com/science/arti...
Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control
N-glycosylation is essential for protein folding in the endoplasmic reticulum (ER). Glycan attachment facilitates the binding of newly synthesized pol…
www.sciencedirect.com
November 27, 2025 at 2:56 PM
#ER_literature Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control www.sciencedirect.com/science/arti...
Reposted by Rahul K
There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.
research.pasteur.fr/en/call/mid-...
research.pasteur.fr/en/call/mid-...
Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research
Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...
research.pasteur.fr
November 27, 2025 at 1:38 PM
There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.
research.pasteur.fr/en/call/mid-...
research.pasteur.fr/en/call/mid-...
Reposted by Rahul K
Happy Thanksgiving to all who celebrate!
November 27, 2025 at 2:49 PM
Happy Thanksgiving to all who celebrate!
Reposted by Rahul K
Transcribing Pol2
With elongation factors
Kinetic control
#ChromatinHaiku #SingleMolecule
www.nature.com/articles/s41...
With elongation factors
Kinetic control
#ChromatinHaiku #SingleMolecule
www.nature.com/articles/s41...
November 27, 2025 at 12:57 PM
Transcribing Pol2
With elongation factors
Kinetic control
#ChromatinHaiku #SingleMolecule
www.nature.com/articles/s41...
With elongation factors
Kinetic control
#ChromatinHaiku #SingleMolecule
www.nature.com/articles/s41...