Daniel Drucker
@danieljdrucker.bsky.social
A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
Pinned
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor
Glucagon-like peptide 1 receptor (GLP-1R) agonists exhibit anti-inflammatory actions,
yet the importance of direct immune cell GLP-1R signaling remains uncertain. Although
T cells respond to GLP-1, lo...
www.cell.com
Our latest assessment of 3 widely used GLP-1R antisera independently with @daveyboyhod Some are useful, others not fit for purpose. Use of non-validated antisera sows confusion in the field and creates problems that are difficult to later rectify www.cell.com/cell-metabol...
The Evoke trials have (once again) humbled many of us, reminding the field that "paving the way for incretin-based therapies as a future cornerstone in the management of neurodegenerative disorders" is a far more challenging task then originally envisioned #Alzheimers disease
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
bit.ly
November 29, 2025 at 10:14 PM
The Evoke trials have (once again) humbled many of us, reminding the field that "paving the way for incretin-based therapies as a future cornerstone in the management of neurodegenerative disorders" is a far more challenging task then originally envisioned #Alzheimers disease
Important reminder 🐭🧍The transcription factor CUX1 regulates adipocyte differentiation in opposite directions in humans and mice, emphasizing the need for species-specific models in metabolic disease research 🧪 www.sciencedirect.com/science/arti...
November 28, 2025 at 10:34 PM
Important reminder 🐭🧍The transcription factor CUX1 regulates adipocyte differentiation in opposite directions in humans and mice, emphasizing the need for species-specific models in metabolic disease research 🧪 www.sciencedirect.com/science/arti...
Some new preclinical and clinical data for CT-388, a once weekly cAMP signal-biased dual GLP-1R/GIPR agonist with minimal GLP-1R/GIPR internalization #obesity #weightloss www.sciencedirect.com/science/arti... 🧪
Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity
Biased agonism of the glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptors (GLP-1R/GIPR) yields greater weight loss and bett…
www.sciencedirect.com
November 28, 2025 at 10:26 PM
Some new preclinical and clinical data for CT-388, a once weekly cAMP signal-biased dual GLP-1R/GIPR agonist with minimal GLP-1R/GIPR internalization #obesity #weightloss www.sciencedirect.com/science/arti... 🧪
A clinical study (1 yr) in PPL with #obesity raises the possibility that #exercise might preserve LEAP2 levels after #weightloss in females, supporting weight loss maintenance. www.cell.com/iscience/ful... 🧪
Exercise Maintains LEAP2 Levels after Weight Loss in Females with Obesity
LEAP2 is an anorexigenic hormone, but its long-term decrease after diet-induced weight
loss may promote weight regain. This study examined whether exercise, GLP-1RA (liraglutide),
or their combination...
www.cell.com
November 28, 2025 at 10:13 PM
A clinical study (1 yr) in PPL with #obesity raises the possibility that #exercise might preserve LEAP2 levels after #weightloss in females, supporting weight loss maintenance. www.cell.com/iscience/ful... 🧪
Targeting FFAR4 for metabolic disorders. Still promising? www.cell.com/cell-reports... 🧪
Two decades of FFAR4 biology: From nutrient sensing to therapeutic targeting
FFAR4 is a lipid-sensing GPCR with pivotal roles in metabolic regulation and inflammation
resolution. This review by Kong et al. integrates recent structural insights into
FFAR4 activation, its expand...
www.cell.com
November 28, 2025 at 10:00 PM
Targeting FFAR4 for metabolic disorders. Still promising? www.cell.com/cell-reports... 🧪
Studies in mice reveal that during fasting and refeeding, glucagon regulates renal glucose reabsorption by utilizing the local cellular circadian machinery. #kidney www.nature.com/articles/s41... 🧪
Fasting hijacks proximal tubule circadian control mechanisms to regulate glucose reabsorption via the Nrf1/Sglt2 pathway in mice - Nature Communications
SGLT2 inhibitors lower blood glucose in patients with diabetes. Here, the authors report that fasting reduces renal expression of Sglt2 and glucose reabsorption by modulating circadian clock genes.
www.nature.com
November 28, 2025 at 11:02 AM
Studies in mice reveal that during fasting and refeeding, glucagon regulates renal glucose reabsorption by utilizing the local cellular circadian machinery. #kidney www.nature.com/articles/s41... 🧪
A valuable repository to the research community for a clearer understanding of circulating EV biology. www.nature.com/articles/s41... 🧪
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma - Nature Cell Biology
The composition of extracellular vesicles (EVs) is central to their function, yet the field lacks systematic characterization. Here Rai et al. perform proteomic and lipidomic analyses of circulating h...
www.nature.com
November 28, 2025 at 10:45 AM
A valuable repository to the research community for a clearer understanding of circulating EV biology. www.nature.com/articles/s41... 🧪
A significantly higher risk of second-generation DES stent failure in individuals with #T1D followed by those with type 2 diabetes, compared with individuals without diabetes. This elevated risk was attributed to both in-stent restenosis and stent thrombosis🧪. diabetesjournals.org/care/article...
Coronary Stent Failure in Patients With Diabetes: A Nationwide Observational Study From SWEDEHEART
OBJECTIVE. The association between diabetes and coronary stent failure is poorly established with second-generation drug-eluting stents (DES). We aimed to
diabetesjournals.org
November 27, 2025 at 11:45 PM
A significantly higher risk of second-generation DES stent failure in individuals with #T1D followed by those with type 2 diabetes, compared with individuals without diabetes. This elevated risk was attributed to both in-stent restenosis and stent thrombosis🧪. diabetesjournals.org/care/article...
The daily torrent of real world data continues. Here (lower) rates of suicidal ideation, depression and anxiety in children treated with GLP-1 medicines in Florida 🧪https://www.medrxiv.org/content/10.1101/2025.11.11.25339931v1
November 27, 2025 at 11:20 AM
The daily torrent of real world data continues. Here (lower) rates of suicidal ideation, depression and anxiety in children treated with GLP-1 medicines in Florida 🧪https://www.medrxiv.org/content/10.1101/2025.11.11.25339931v1
Rare but real. Hypophysitis www.nature.com/articles/s41... 🧪
An update on hypophysitis - Nature Reviews Endocrinology
Hypophysitis is a rare disease characterized by inflammation of the pituitary gland that can cause hypopituitarism-related symptoms, headaches and visual disturbances. This Review discusses the curren...
www.nature.com
November 27, 2025 at 11:07 AM
Rare but real. Hypophysitis www.nature.com/articles/s41... 🧪
Here the authors highlight the therapeutic potential of targeting adipocyte TGR5 for MASLD intervention 🧪https://diabetesjournals.org/diabetes/article/doi/10.2337/db25-0344/163910/Adipose-TGR5-Deletion-Promotes-Hepatic-Steatosis ada.silverchair-cdn.com/ada/content_...
November 27, 2025 at 3:11 AM
Here the authors highlight the therapeutic potential of targeting adipocyte TGR5 for MASLD intervention 🧪https://diabetesjournals.org/diabetes/article/doi/10.2337/db25-0344/163910/Adipose-TGR5-Deletion-Promotes-Hepatic-Steatosis ada.silverchair-cdn.com/ada/content_...
Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications
Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...
www.nature.com
November 26, 2025 at 6:37 PM
Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications
Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...
www.nature.com
November 26, 2025 at 6:36 PM
Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Towards a better understanding of GLP-1 medicine efficacy beyond PK-incorporation of receptor occupancy and residency time assessed in vivo www.thelancet.com/journals/ebi...
Positron emission tomography to assess drug occupancy at peripheral and central incretin receptors
PET imaging in pigs demonstrated in vivo GLP-1R engagement by SAR441255 and tirzepatide,
and GIPR engagement by SAR441255 in the pancreas. SAR441255 exhibited dose-dependent
GLP-1R occupancy in the pa...
www.thelancet.com
November 26, 2025 at 11:38 AM
Towards a better understanding of GLP-1 medicine efficacy beyond PK-incorporation of receptor occupancy and residency time assessed in vivo www.thelancet.com/journals/ebi...
More detailed functional interrogation of enteric neuron subpopulations www.cell.com/cell/abstrac...
Properties and functions of transcriptionally distinct enteric neurons
Developing genetic access to transcriptionally distinct enteric neurons in vivo enables
the examination of morphological heterogeneity across cell types as well as cell-type-specific
influences on GI ...
www.cell.com
November 26, 2025 at 11:15 AM
More detailed functional interrogation of enteric neuron subpopulations www.cell.com/cell/abstrac...
Multiomic characterization of the aging mouse reveals fundamental insights into the aging process and identifies new therapeutic targets to maintain organ health www.cell.com/cell-metabol...
A metabolic atlas of mouse aging
Pilley et al. describe how metabolite levels change in 12 organs from male and female
mice across five ages, spanning adolescence to old age. They reveal that organs show
distinct age- and sex-specifi...
www.cell.com
November 26, 2025 at 1:39 AM
Multiomic characterization of the aging mouse reveals fundamental insights into the aging process and identifies new therapeutic targets to maintain organ health www.cell.com/cell-metabol...
A reminder that MODY (and type 1 diabetes) can present in older individuals and must remain in the differential diagnosis for new onset #diabetes across the lifespan diabetesjournals.org/diabetes/art...
MODY Is Prevalent in Later-Onset Diabetes and Has Potential for Targeted Therapy but Is Challenging to Identify
Maturity onset diabetes of the young (MODY) can present after the age of 40 years, but its prevalence and clinical characteristics, and the utility of simp
diabetesjournals.org
November 25, 2025 at 9:52 PM
A reminder that MODY (and type 1 diabetes) can present in older individuals and must remain in the differential diagnosis for new onset #diabetes across the lifespan diabetesjournals.org/diabetes/art...
New top line P2 data for Amycretin, a unimolecular agonist of the glucagon-like peptide 1 (GLP-1) and amylin receptors, intended for once-weekly subcutaneous administration and once-daily oral administration, in PPL with #T2D #weightloss
www.novonordisk.com/content/nnco...
www.novonordisk.com/content/nnco...
November 25, 2025 at 11:40 AM
New top line P2 data for Amycretin, a unimolecular agonist of the glucagon-like peptide 1 (GLP-1) and amylin receptors, intended for once-weekly subcutaneous administration and once-daily oral administration, in PPL with #T2D #weightloss
www.novonordisk.com/content/nnco...
www.novonordisk.com/content/nnco...
Beyond the bacterial #microbiome a new focus on harnessing the gut non-bacterial microbial entities in the therapeutics and prevention of metabolic diseases www.sciencedirect.com/science/arti...
November 25, 2025 at 11:29 AM
Beyond the bacterial #microbiome a new focus on harnessing the gut non-bacterial microbial entities in the therapeutics and prevention of metabolic diseases www.sciencedirect.com/science/arti...
New from Lihi Eder and colleagues-The #obesity inflammation immune axis with a focus on #psoriasis related disorders www.nature.com/articles/s41...
The obesity–inflammation axis in psoriatic disease: mechanisms and therapeutic strategies - Nature Reviews Rheumatology
This Review explores the complex relationship between obesity and psoriatic disease. The authors highlight the underlying mechanisms that drive this association and propose a comprehensive approach to...
www.nature.com
November 24, 2025 at 5:33 PM
New from Lihi Eder and colleagues-The #obesity inflammation immune axis with a focus on #psoriasis related disorders www.nature.com/articles/s41...
Oral semaglutide disappoints in the two evoke trials, failing to reduce the rate of cognitive decline #Alzheimers disease #Dementia www.novonordisk.com/content/nnco...
November 24, 2025 at 11:31 AM
Oral semaglutide disappoints in the two evoke trials, failing to reduce the rate of cognitive decline #Alzheimers disease #Dementia www.novonordisk.com/content/nnco...
On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Bridging the variant-to-function gap in type 2 diabetes: advances and challenges - Diabetologia
Type 2 diabetes is a polygenic, heterogeneous disease affecting over 530 million individuals worldwide, a number projected to rise to 1.3 billion by 2050. Genome-wide association studies have identifi...
link.springer.com
November 22, 2025 at 8:54 PM
On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...
P3 data for Efsubaglutide the once weekly immunoglobulin-based GLP-1 medicine approved in China for #T2D @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial - Diabetologia
Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become an important option in clinical use for type 2 diabetes due to their dual benefits of glycaemic management and metaboli...
link.springer.com
November 22, 2025 at 8:15 PM
P3 data for Efsubaglutide the once weekly immunoglobulin-based GLP-1 medicine approved in China for #T2D @diabetologiajnl.bsky.social link.springer.com/article/10.1...
As disclosure of evoke and evoke+ trial results for oral semaglutide in people with imaging or biomarker+ #Alzheimers disease approaches, a reminder of the primary and secondary endpoints alzres.biomedcentral.com/articles/10....
November 22, 2025 at 11:46 AM
As disclosure of evoke and evoke+ trial results for oral semaglutide in people with imaging or biomarker+ #Alzheimers disease approaches, a reminder of the primary and secondary endpoints alzres.biomedcentral.com/articles/10....
Human #genetic evidence in humans is consistent with direct TAS2R38 actions in postprandial glycemia, supporting TAS2R38 as a novel therapeutic target for glucose regulation.
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
November 21, 2025 at 11:27 AM
Human #genetic evidence in humans is consistent with direct TAS2R38 actions in postprandial glycemia, supporting TAS2R38 as a novel therapeutic target for glucose regulation.
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...