Ivan Zanoni
@lozanzi.bsky.social
Associate Professor at Harvard Medical School, in love with a red-haired beautiful woman, his kids... and immunology. He/him/his. 🇮🇹 🇺🇸 Views my own.
Reposted by Ivan Zanoni
#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia.
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS
1. Sera from individuals acutely ill with lobar pneumonia possess the capacity to precipitate in high titre a non-protein somatic fraction derived from pne
rupress.org
December 21, 2025 at 5:40 PM
#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia.
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
@RockUPress @RockefellerUniv
rupress.org/jem/article/...
#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...
HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion
Melanoma cells escape immune surveillance by releasing MHC-antigen-loaded large EVs,
known as melanosomes, that directly engage and impair CD8+ T cell receptors.
www.cell.com
December 20, 2025 at 3:50 PM
#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...
Reposted by Ivan Zanoni
9/ Read the paper here 👉 onlinelibrary.wiley.com/doi/10.1002/...
And stay tuned — exciting new discoveries on liver Tregs are coming soon 👀🧬
And stay tuned — exciting new discoveries on liver Tregs are coming soon 👀🧬
Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade
This is an update to the Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition), Chapter 3: 12C, by Cossarizza et al. Administration of anti-ARTC2 nanobody...
onlinelibrary.wiley.com
December 20, 2025 at 7:52 AM
9/ Read the paper here 👉 onlinelibrary.wiley.com/doi/10.1002/...
And stay tuned — exciting new discoveries on liver Tregs are coming soon 👀🧬
And stay tuned — exciting new discoveries on liver Tregs are coming soon 👀🧬
Highly recommended 👇👇👇
Two pieces of fun news:
1. We've launched a new website for our lab: www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
1. We've launched a new website for our lab: www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
The Bryson Lab | Vaccine Development & Research at MIT
Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.
www.brysonlab.org
December 18, 2025 at 8:24 PM
Highly recommended 👇👇👇
#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Human gut M cells resemble dendritic cells and present gluten antigen - Nature
An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...
doi.org
December 13, 2025 at 3:57 PM
#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Ivan Zanoni
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
December 12, 2025 at 4:40 PM
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
Always fun to spend time outside the lab with such an amazing & passionate group of scientists. #LabHolydaysParty #SecretSanta🎅🏼 #LoveMyLab #LoveScience #LoveImmunology
December 11, 2025 at 10:31 PM
Always fun to spend time outside the lab with such an amazing & passionate group of scientists. #LabHolydaysParty #SecretSanta🎅🏼 #LoveMyLab #LoveScience #LoveImmunology
#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!
Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses - Nature Metabolism
Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.
www.nature.com
December 10, 2025 at 8:31 PM
#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!
#SharingIsCaring, not always! Lou &co show @cp-cellmetabolism.bsky.social that lactate driven by excessive exercise leads to release of muscle mitochondria-derived vesicles that impair cognitive functions by disrupting hippocampal neuron bioenergy via cGAS/STING activation & via PAF!
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender
Excessive exercise impairs cognitive function, but the underlying mechanism remains unclear. Here, we show that excessive vigorous exercise-induced la…
www.sciencedirect.com
December 10, 2025 at 3:57 PM
#SharingIsCaring, not always! Lou &co show @cp-cellmetabolism.bsky.social that lactate driven by excessive exercise leads to release of muscle mitochondria-derived vesicles that impair cognitive functions by disrupting hippocampal neuron bioenergy via cGAS/STING activation & via PAF!
#WeekendRead! #FriendOrFoe? Yu, Lozinski, Dong, &co show @natneuro.nature.com that host-derived oxidized lipid deposition in the brain supports multiple sclerosis development via microglia dysfunction/replacement by monocyte-derived macrophages & interleukin-1 #IL1 signaling! doi.org/10.1038/s415...
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling - Nature Neuroscience
In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...
doi.org
December 6, 2025 at 4:21 PM
#WeekendRead! #FriendOrFoe? Yu, Lozinski, Dong, &co show @natneuro.nature.com that host-derived oxidized lipid deposition in the brain supports multiple sclerosis development via microglia dysfunction/replacement by monocyte-derived macrophages & interleukin-1 #IL1 signaling! doi.org/10.1038/s415...
#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...
Architecture of the neutrophil compartment - Nature
Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and ...
doi.org
December 4, 2025 at 12:44 AM
#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...
#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!
Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis
Benamar et al. demonstrate that Notch3+ Treg cells are increased in multiple sclerosis
and in EAE. They are induced in the gut by microbiota and translocate to the CNS to
degenerate into pathogenic Th...
www.cell.com
November 29, 2025 at 5:31 PM
#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!
#NoTimeToDie! Welcome mitoxyperiosis! Kanneganti, Wang &co show @cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by
the synergy of innate immune activation and metabolic stress. This process is regulated
by mTORC2 and involves persis...
www.cell.com
November 28, 2025 at 4:56 PM
#NoTimeToDie! Welcome mitoxyperiosis! Kanneganti, Wang &co show @cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!
Reposted by Ivan Zanoni
Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former).
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
November 26, 2025 at 1:53 PM
Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former).
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
Reposted by Ivan Zanoni
We're hiring for tenure-track faculty! Please apply if you have interests in immune responses to microbes and/or cancer, immune regulation, microbial infections (bacteria, viruses, parasites, fungi), the microbiota, and/or interests that span these disciplines.
arizona.csod.com/ux/ats/caree...
arizona.csod.com/ux/ats/caree...
Assistant/Associate/Full Professor (T/TE)
Establish or continue a successful, extramurally funded research program that will advance knowledge in the broad areas of immunobiology, as defined a...
arizona.csod.com
November 24, 2025 at 8:02 PM
We're hiring for tenure-track faculty! Please apply if you have interests in immune responses to microbes and/or cancer, immune regulation, microbial infections (bacteria, viruses, parasites, fungi), the microbiota, and/or interests that span these disciplines.
arizona.csod.com/ux/ats/caree...
arizona.csod.com/ux/ats/caree...
#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche - Nature Immunology
Turley and colleagues find that Gremlin1-expressing lymph node fibroblastic reticular cells support dendritic cell homeostasis via provision of FLT3L.
www.nature.com
November 22, 2025 at 3:58 PM
#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!
Reposted by Ivan Zanoni
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 4:09 PM
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Reposted by Ivan Zanoni
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
www.embopress.org
November 20, 2025 at 3:15 PM
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal
The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...
link.springer.com
November 20, 2025 at 5:41 PM
#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
Reposted by Ivan Zanoni
New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...
Reframing IL-27: a central regulator of CD8+ T cell immunity
Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies re…
www.sciencedirect.com
November 20, 2025 at 6:24 AM
New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...
#WeekendRead! #FriendOrFoes?! Zhang &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 exploits changes in membrane integrity to activate a GPI-anchored hydrolase which degrades cGAMP preventing #cGAS/#STING activation & favoring virus infection
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
Wang et al. find that cell membrane stress upon viral infection induces expression
and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B),
which, in turn, degrades cGAMP to s...
www.cell.com
November 16, 2025 at 4:37 PM
#WeekendRead! #FriendOrFoes?! Zhang &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 exploits changes in membrane integrity to activate a GPI-anchored hydrolase which degrades cGAMP preventing #cGAS/#STING activation & favoring virus infection
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
#WeekendRead! #EveryCellIsAnImmuneCell! Riedel, Mattavelli, Helal &co show @cp-immunity.bsky.social that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis!
dlvr.it/TPCYjz
dlvr.it/TPCYjz
A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is characterized by high risks of relapse or
metastatic disease. Mattavelli et al. identify a chemokine axis that recruits immunosuppressive
monocytes to tumor-dra...
dlvr.it
November 15, 2025 at 3:54 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Riedel, Mattavelli, Helal &co show @cp-immunity.bsky.social that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis!
dlvr.it/TPCYjz
dlvr.it/TPCYjz
Reposted by Ivan Zanoni
Thank you for your contribution, Ivan. It was great working with you!✨
November 13, 2025 at 2:54 PM
Thank you for your contribution, Ivan. It was great working with you!✨
Fantastic @ Nature Biotechnology by @bocklab.bsky.social &co, link to go and whisper to your cells 👉 doi.org/10.1038/s415...
November 12, 2025 at 12:03 PM
Fantastic @ Nature Biotechnology by @bocklab.bsky.social &co, link to go and whisper to your cells 👉 doi.org/10.1038/s415...
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 10, 2025 at 5:26 PM
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇