Science Magazine
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Cutting-edge research, news, commentary, and visuals from the Science family of journals. https://www.science.org
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As the Moon eclipsed the Sun on 8 April 2024, birds took note.

Leveraging nature’s own experiment, scientists and the public joined forces to show how different species responded to sudden midafternoon darkness followed by a new “dawn.” Learn more this week in Science: https://scim.ag/48WbhLL
As the Moon eclipsed the Sun on 8 April 2024, birds like these rock pigeons (Columba livia) took note.
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This week’s new issue of #ScienceSignaling has arrived!

CRISPR experiments uncover a factor that facilitates immune receptor diversity, scientists identify a self-limiting mechanism that keeps the important Wnt signaling pathway in check, and more. https://scim.ag/4h9Pm5X
The image is a color-enhanced transmission electron micrograph of a human lymphocyte during metaphase.
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"I have decided to reject feelings of humiliation and instead embrace humility; to accept my vulnerabilities and my limitations and welcome the new perspectives they provide." #ScienceWorkingLife https://scim.ag/4mX4GUJ
An illustration of a man speaking into a microphone in front of an audience, with text: How my stutter is teaching me humility—in science and beyond.
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In humans, #SARSCoV2 booster vaccines recall memory B cells to germinal centers, where they undergo additional selection to recognize both ancestral and evolving Omicron variants of the virus.

Learn more in #ScienceImmunology: https://scim.ag/3J9cQvk
Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.
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Mushrooms from the genus Psilocybe can provoke psychedelic experiences thanks to compounds including psilocybin.

A new study finds that within another genus of “magic” mushrooms, psilocybin is synthesized using a completely different chemical pathway. https://scim.ag/47hEBv1
In mind-bending twist, ‘magic’ mushrooms evolved twice independently
Study identifies entirely new suite of enzymes that can make psilocybin
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The October issue of #ScienceImmunology is out!

This month's cover highlights a Review that delves into brain tumor development and examines factors contributing to the immunosuppressive brain tumor microenvironment. Learn about this and more: https://scim.ag/46HgHcl
This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) tumor microenvironments as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain.
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Replicating RNA vaccines based on older #H5N1 antigens can shield macaques from lethal infections with contemporary H5N1 strains, according to new work that hints current vaccine stockpiles can still offer cross-protection. #ScienceTranslationalMedicine https://scim.ag/3W1QdMn
A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge
LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.
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In Science, researchers report the observation of dendritic nanotubes in brain tissue from mice and humans. The discovery suggests that the current understanding of the brain’s organization may be incomplete, overlooking a hidden layer of connectivity. #SciencePerspective https://scim.ag/470Cdr4
Hidden networks in the brain
Dendritic nanotubes extend brain connectivity beyond synapses
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Reposted by Science Magazine
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@science.org ATP-dependent remodeling of #chromatin #condensates reveals distinct #mesoscale outcomes | Science www.science.org/doi/10.1126/...
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Last week @science.org mRNA initiation and termination are spatially coordinated | Science www.science.org/doi/10.1126/... from @anafiszbein.bsky.social @athmapai.bsky.social et al.
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Male mice that exercise can pass their newly gained fitness on to male offspring.

If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm
Well-exercised male mice appear to pass fitness to their male offspring
Surprising epigenetic effect relies on snippets of RNA packaged within sperm
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By studying a species of tardigrade identified last year, researchers in Science have gleaned valuable insights into the animal’s ability to withstand radiation. https://scim.ag/4nKCMwD #ScienceMagArchives
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“We can continue accelerating toward an AI-powered future that amplifies existing inequities, or we can deliberately steer toward one that increases prospects for shared global prosperity,” writes Chinasa T. Okolo in a new #ScienceExpertVoices article. https://scim.ag/46JkNka
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Researchers show that innate immune signaling forms a protective response to equip β cells with the means to compensate for metabolic stress in type 2 diabetes.

Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4q2qDEO
In this image, the color changes show accruing mitochondrial damage, marking the importance of quality control and removing damaged mitochondria in maintaining the optimal pool for β cell insulin secretion.
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I can’t think of a better reason to finally join Bluesky - my first first-authored paper is out! It being published in @science.org is surreal. This was a community effort in every sense, led by an incredible team with @rosvall-lab.bsky.social @mathcancer.bsky.social @juncowren.bsky.social
science.org
As the Moon eclipsed the Sun on 8 April 2024, birds took note.

Leveraging nature’s own experiment, scientists and the public joined forces to show how different species responded to sudden midafternoon darkness followed by a new “dawn.” Learn more this week in Science: https://scim.ag/48WbhLL
As the Moon eclipsed the Sun on 8 April 2024, birds like these rock pigeons (Columba livia) took note.
science.org
Federal researchers are confronting growing uncertainty about their future, as the 10-day-old shutdown of the U.S. government is now poised to extend into at least next week. https://scim.ag/4n1uy22
As U.S. shutdown drags on, ‘it’s just one blow after another’
Federal researchers confront growing uncertainty about future
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science.org
As the Moon eclipsed the Sun on 8 April 2024, birds took note.

Merging community science, #MachineLearning, and a continent-wide natural experiment, researchers in Science reveal the immediate effects of light disruption on bird behavior. https://scim.ag/48oTmNO