Lightnews — Scholar-powered news

Reposted by Maria Barna

Liam Faller @liamfaller.bsky.social · 2d

First ad for a position in my new lab at the University of Bristol! If you are looking for a fully funded PhD in cutting edge science that will be based in a supportive environment, and in a great city, check out the link below!

www.findaphd.com/phds/project...

Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol on FindAPhD.com

PhD Project - Funded PhD: Understanding the role of the ribosomal P-stalk in immune responses at University of Bristol, listed on FindAPhD.com

www.findaphd.com

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Reposted by Maria Barna

Iain Cheeseman @iaincheeseman.bsky.social · 4d

An epic story and a must read. This is really beautiful work to understand the most amazing monthly regeneration event - menstruation. The authors reconstitute this process in mice (which don’t normally menstruate) allowing important new insights. Will also be a powerful model for future work.

Kara McKinley @karalmckinley.bsky.social · 5d

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Çağrı Çevrim @cagricevrim.bsky.social · 5d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

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Reposted by Maria Barna

DevBioStanford @devbiostanford.bsky.social · 7d

Congratulations to Dan Jarosz on being named the first associate dean for basic science in the Stanford School of Medicine!

news.stanford.edu/stories/2025...

Dan Jarosz becomes first senior associate dean for basic science

Jarosz is the inaugural appointment to the newly created position, which will support basic science faculty throughout the Stanford School of Medicine.

news.stanford.edu

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Reposted by Maria Barna

Ryan Flynn @raflynn5.bsky.social · 15d

Reminder to register for “Cracking the Code: Nucleic Acid Medicines Coming of Age” a Nature Conferences here in Boston, December 8th - 10th! natureconferences.streamgo.live/cracking-the...

Great line of up RNA speakers covering basic and translational nucleic acid biology+recent clinical successes

Cracking the Code: Nucleic Acid Medicines Coming of Age

The 2025 conference brings together leading academics and industry professionals to explore developments and challenges in the rapidly evolving field of nucleic acid medicines. By uniting researchers ...

natureconferences.streamgo.live

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Reposted by Maria Barna

Waggoner Lab @labwaggoner.bsky.social · 20d

Mouse studies show that depriving neuroblastoma of polyamine causes a switch in protein synthesis to suppress tumor growth and promote cell differentiation @nature.com @childrensphila.bsky.social @princetonupress.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...

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Maria Barna @mbarnalab.bsky.social · 20d

Kathrin is definitely larger than life! Best recruit ever!!

Kathrin Leppek @katleppek.bsky.social · 21d

This massive poster of the ad campaign for the new recruits at the @unibonn.bsky.social is the nerdiest version and the closest I’ll ever get to a superhero movie poster. #Bauzaun

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Reposted by Maria Barna

Kurianlab @kurianlab.bsky.social · Sep 6

www.sciencedirect.com/science/arti...

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

RNA-binding proteins (RBPs) are best known as effectors along the entire gene expression pathway and as constituents of RNA-protein machines such as t…

www.sciencedirect.com

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Reposted by Maria Barna

Itai Yanai @itaiyanai.bsky.social · May 31

90% of doing science is being open to new ideas.

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Reposted by Maria Barna

Yanjie Chao @yjchao.bsky.social · May 8

Quality over quantity: Small RNA pauses translation elongation to lift protein activity: Molecular Cell www.cell.com/molecular-ce...

Quality over quantity: Small RNA pauses translation elongation to lift protein activity

Small noncoding RNAs typically regulate the translation initiation of target mRNAs and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered a novel regulatory mechan...

www.cell.com

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Reposted by Maria Barna

UCSF Department of Urology @ucsfurology.bsky.social · Apr 24

Dr. Davide Ruggero of UCSF has received a rare renewal of his prestigious ACS Professorship, recognizing his groundbreaking cancer research on protein synthesis. ✨
@ruggerolab.bsky.social @ucsfcancer.bsky.social

urology.ucsf.edu/news/all/202...

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Reposted by Maria Barna

Anders H. Lund @andershlund.bsky.social · Apr 16

I am happy to share the latest paper from the lab. We detail a tripartite cell-free translation system based on the separation of mRNAs, ribosomes and ribosome-depleted cytoplasmic lysate from human cells, allowing for flexible reconstitution of translation reaction.
#RNA #Ribosome

Nature Protocols @natprot.nature.com · Apr 16

New Article! A tripartite cell-free translation system to study mammalian translation

A tripartite cell-free translation system to study mammalian translation

Nature Protocols, Published online: 16 April 2025; doi:10.1038/s41596-025-01155-7This protocol presents a tripartite mammalian cell-free translation system, comprising cytoplasmic and ribosome fractions combined with endogenous or synthetic mRNAs, permitting flexible reconstitution and careful dissection of the mechanisms of translation.

bit.ly

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Reposted by Maria Barna

Shady Saad @shadys11.bsky.social · Apr 21

I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social

www.cell.com/cell/fulltex...

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubility-p...

www.cell.com

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Reposted by Maria Barna

Kurianlab @kurianlab.bsky.social · Apr 16

www.cell.com/cancer-cell/...

Small-molecule RNA therapeutics to target prostate cancer

Kuzuoglu-Ozturk et al. showcase a therapeutic approach, “translatome therapy,” to combat lethal prostate cancer. Zotatifin, a clinical molecule, targets the RNA-helicase eIF4A. Zotatifin decreases the...

www.cell.com

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Reposted by Maria Barna

adelexu.bsky.social @adelexu.bsky.social · Mar 31

This started out as two separate projects, actually! 🤝 @mbarnalab.bsky.social has long been interested in comparing the composition of ribosomes in different parts of a cell, since localized mRNA translation is such an important aspect of gene regulation and protein homeostasis. (2/18)

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Reposted by Maria Barna

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Mar 8

Exciting new work from Barna Lab @stanfordmedicine.bsky.social

www.science.org/doi/10.1126/...

A subcellular map of translational machinery composition and regulation at the single-molecule level

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

www.science.org

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Reposted by Maria Barna

The EMBO Journal @embojournal.org · Mar 13

The crux of rigorously characterizing #IRES:
Kathrin Leppek @katleppek.bsky.social, Maria Barna and colleagues compile a toolbox of approaches to study internal #ribosome entry sites in mammalian cells and embryonic tissues
www.embopress.org/doi/full/10....

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Maria Barna @mbarnalab.bsky.social · Mar 22

Thanks so much Liam! I’m just setting up my BlueSky account right now.

Maria Barna @mbarnalab.bsky.social · Mar 22

Thanks so much Carolyn! I’m just setting up my BlueSky account right now.

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