Kurianlab
@kurianlab.bsky.social
RNA biology of embryonic development and disease #heart #ribosome #translational_control #RBP #splicing @UK_Frankfurt Alum:@salkinstitute @UcSandiego
https://kurianlab.com/
https://kurianlab.com/
Pinned
Kurianlab
@kurianlab.bsky.social
· Sep 8
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kurianlab
🚀 Postdoc opportunity!
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
Postdoctoral Researcher positions-Kapahi lab - Buck Institute - Career Page
The Kapahi lab seeks postdocs to lead innovative projects exploring how circadian clocks & nutrient-responsive pathways influence eye & neuronal degeneration.
buckinstitute.applytojob.com
November 30, 2025 at 2:09 AM
🚀 Postdoc opportunity!
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
Reposted by Kurianlab
Who’s keeping track of where all this ‘protection money’ Universities are paying is going? Who’s keeping track of where the money from the tariffs is going? Because services are gutted, Universities are squeezed like scrawny kids on the school yard, yet the deficit keeps growing. Who’s getting rich?
November 29, 2025 at 5:56 AM
Who’s keeping track of where all this ‘protection money’ Universities are paying is going? Who’s keeping track of where the money from the tariffs is going? Because services are gutted, Universities are squeezed like scrawny kids on the school yard, yet the deficit keeps growing. Who’s getting rich?
Reposted by Kurianlab
GUARDIAN: “Per head, 🇺🇸 output is six times China’s, and yet, inexplicably, there seem to be more abjectly poor Americans than Chinese. 🇺🇸 inequality is breathtaking… keeps getting worse…”
Wanting to address this isn’t radical.
NOT wanting to is.
www.theguardian.com/us-news/2025...
Wanting to address this isn’t radical.
NOT wanting to is.
www.theguardian.com/us-news/2025...
November 28, 2025 at 3:15 PM
GUARDIAN: “Per head, 🇺🇸 output is six times China’s, and yet, inexplicably, there seem to be more abjectly poor Americans than Chinese. 🇺🇸 inequality is breathtaking… keeps getting worse…”
Wanting to address this isn’t radical.
NOT wanting to is.
www.theguardian.com/us-news/2025...
Wanting to address this isn’t radical.
NOT wanting to is.
www.theguardian.com/us-news/2025...
Reposted by Kurianlab
this is very interesting!
@astridhaase.bsky.social
are these pseudogenes sitting in the previously annotated major pachytene clusters?
And do you see phased piRNA production from the targeted genes (like Spin1) due to slicing?
lovely work.
www.biorxiv.org/content/10.1...
@astridhaase.bsky.social
are these pseudogenes sitting in the previously annotated major pachytene clusters?
And do you see phased piRNA production from the targeted genes (like Spin1) due to slicing?
lovely work.
www.biorxiv.org/content/10.1...
Pachytene piRNAs define a conserved program of meiotic gene regulation
PIWI-interacting RNAs (piRNAs) safeguard genome integrity and fertility across animals and in humans[1][1]-[3][2]. In mammals, pre-pachytene piRNAs execute the ancestral program of transposon silencin...
www.biorxiv.org
November 28, 2025 at 11:12 AM
this is very interesting!
@astridhaase.bsky.social
are these pseudogenes sitting in the previously annotated major pachytene clusters?
And do you see phased piRNA production from the targeted genes (like Spin1) due to slicing?
lovely work.
www.biorxiv.org/content/10.1...
@astridhaase.bsky.social
are these pseudogenes sitting in the previously annotated major pachytene clusters?
And do you see phased piRNA production from the targeted genes (like Spin1) due to slicing?
lovely work.
www.biorxiv.org/content/10.1...
Reposted by Kurianlab
· #AcademicSky ·
The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
ERC’s new €7m Plus Grants open to researchers at any career stage - Research Professional News
European Research Council president describes scheme as part attempt to lure US talent
www.researchprofessionalnews.com
November 28, 2025 at 8:27 PM
· #AcademicSky ·
The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
I cannot stress this enough.
Germany is becoming a phd factory while there is limited future, especially for foreigners after.
Germany is becoming a phd factory while there is limited future, especially for foreigners after.
German academia: great place to work? You should think twice before giving it a try: Permanent positions are very rare, most scholars have to drop out after some precarious years. @dianakwon.bsky.social has written a great piece about this for @nature.com and also talked to yours truly. #IchBinHanna
How to stop the revolving door of German academia
Germany is one of the most popular destinations for students and scholars worldwide, but those pursuing academic careers face significant hurdles to success.
www.nature.com
November 28, 2025 at 4:38 PM
I cannot stress this enough.
Germany is becoming a phd factory while there is limited future, especially for foreigners after.
Germany is becoming a phd factory while there is limited future, especially for foreigners after.
Reposted by Kurianlab
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
November 28, 2025 at 3:12 PM
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
RBP2GO - Version 2.0
rbp2gov2.dkfz.de
November 27, 2025 at 4:49 AM
Reposted by Kurianlab
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
November 26, 2025 at 4:00 PM
Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson
Current Protocols 2025, 5:e70264
doi: 10.1002/cpz1.70264
#MicroSky
Reposted by Kurianlab
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Postdoc (m/f/d) in Endosymbiosis Research
karriere.hhu.de
November 25, 2025 at 11:21 AM
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
MERFISH+ by Quan Zhu and colleagues
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
MERFISH+, a large-scale, multi-omics spatial technology resolves the molecular holograms of the 3D human developing heart
Hybridization-based spatial transcriptomics technologies have advanced our ability to map cellular and subcellular organization in complex tissues. However, existing methods remain constrained in gene...
www.biorxiv.org
November 25, 2025 at 5:47 PM
MERFISH+ by Quan Zhu and colleagues
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
- new chemistry that allows better signal retention, which increases multiplexability to 1800 RNAs
- combined RNA-DNA MERFISH
-3D spatially-resolved multi-omic atlas
- 13sq cm imaging area
*Quan is in the job market*
www.biorxiv.org/content/10.1...
Reposted by Kurianlab
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
November 24, 2025 at 1:15 PM
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
GENOMIC IMPRINTING | Edge.org
www.edge.org
November 25, 2025 at 5:37 AM
www.biorxiv.org/content/10.1...
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
www.biorxiv.org
November 24, 2025 at 7:55 AM
www.biorxiv.org/content/10.1...
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
Check this new method from the brilliant Jovanoviclab:
jovanoviclab.com
Reposted by Kurianlab
Nice piece highlighting the innovative science at Firefly Bio, making ADCs with PROTAC-like drugs: degrader-antibody conjugates, or “DACs”, with better precision and tolerability
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Editor’s pick: Firefly Bio - Nature Biotechnology
Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Firefly Bio seeks to improve on antibody–drug conjugates and proteolysis-targeting...
www.nature.com
November 21, 2025 at 4:52 PM
Nice piece highlighting the innovative science at Firefly Bio, making ADCs with PROTAC-like drugs: degrader-antibody conjugates, or “DACs”, with better precision and tolerability
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kurianlab
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
November 21, 2025 at 8:20 AM
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
Reposted by Kurianlab
Dear reviewer its not really helpful if you list all the good things about us but you still reject the grant because you don't like the workplan
November 20, 2025 at 11:43 AM
Dear reviewer its not really helpful if you list all the good things about us but you still reject the grant because you don't like the workplan
Reposted by Kurianlab
Wild to think that just a few months ago this administration was cracking down on universities for not doing enough to root out antisemitism www.washingtonpost.com/national-sec...
U.S. Coast Guard will no longer classify swastikas, nooses as hate symbols
The military service, which falls under the Department of Homeland Security, has drafted a new policy that classifies such items “potentially divisive.”
www.washingtonpost.com
November 20, 2025 at 7:41 PM
Wild to think that just a few months ago this administration was cracking down on universities for not doing enough to root out antisemitism www.washingtonpost.com/national-sec...
Reposted by Kurianlab
VACCINES DO NOT CAUSE AUTISM, YOU FLAMING SHITBIRDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
November 20, 2025 at 3:08 AM
VACCINES DO NOT CAUSE AUTISM, YOU FLAMING SHITBIRDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
WE HAVE, IN FACT, NOT IGNORED YOUR NOW-DEFUNCT HYPOTHESIS. WE INVESTIGATED IT TO THE TUNE OF STUDIES WITH DATA FROM MILLIONS OF KIDS.
Reposted by Kurianlab
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/