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Reposted by Grünewald Lab

euroewing.bsky.social @euroewing.bsky.social · Jul 2

At the EEC Network meeting we were privileged to hear of the launch of the Ewing Sarcoma Institute (ESI) from Patrick Grohar & Heinrich Kovar. It is an exciting opportunity for collaboration and to make progress for ES patients and their families. Join the ESI mailing list www.ewingsarcoma.org

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euroewing.bsky.social @euroewing.bsky.social · Jul 2

What a great EEC Network Meeting! Thank you to all the speakers, chairs, patient advocates and @BCRT for funding for help with the organisation. So many highlights but special thanks to Poul Sorensen, Olivier Delattre and Patrick Grohar for sharing their exciting research

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euroewing.bsky.social @euroewing.bsky.social · 20d

A much-needed update on phase I/II trials for recurrent and refractory Ewing sarcoma by Toni Ribelles and a great first activity from the EEC NEWTS group ascopubs.org/doi/10.1200/...

Recurrent and Refractory Ewing Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium | JCO Precision Oncology

PURPOSEUpdated analysis of phase I/II trials in recurrent/refractory (R/R) Ewing sarcoma (EwS) over the past 11 years.METHODSA systematic review was performed to identify phase I/II trials for R/R EwS...

ascopubs.org

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Grünewald Lab @grunewaldlab.bsky.social · 2d

Many thanks!!

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Bone Cancer Research Trust @bcrt-uk.bsky.social · 3d

Lewis was diagnosed with adamantinoma in his shinbone at just 8 years old.

For #BoneCancerAwarenessWeek, he shares his powerful story to raise life-changing awareness of the signs & symptoms 🎗️

Visit: ow.ly/4wEJ50X5J4N

@letsbewheel.bsky.social

#CouldItBeBoneCancer #Awareness #UntilTheresACure

Young man wearing a denim jacket and hoodie using crutches while standing outdoors against a large rock formation.

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Katja Diehl @katjadiehl.bsky.social · 3d

"Wir haben die Geschwindigkeit entwickelt, aber innerlich sind wir stehen geblieben.
Wir lassen Maschinen für uns arbeiten und sie denken auch für uns.
Die Klugheit hat uns hochmütig werden lassen, und unser Wissen kalt und hart.
Wir sprechen zu viel und fühlen zu wenig."

genius.com/The-great-di...

The Great Dictator – Rede an die Menschheit

[Deutscher Text zu „The Great Dictator Speech“] / Es tut mir leid, aber ich möchte nun mal kein Herrscher der Welt sein, denn das liegt mir nicht. / Ich möchte weder herrschen noch

genius.com

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Elena Vasileva @evasileva.bsky.social · 4d

6/9 Single-cell transcriptomic and chromatin profiling of zebrafish tumors revealed that EWSR1::FLI1 expression in neural crest cells drives a mesenchymal/mesodermal shift, with mesodermal genes like #Brachyury (T) strongly upregulated. #NCCs #mesoderm #reprogramming

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Elena Vasileva @evasileva.bsky.social · 4d

1/9 Thrilled to share that our paper, “Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm,” is now published in @cp-cellreports.bsky.social! @amatrudalab.bsky.social @crumplab.bsky.social www.cell.com/cell-reports...

Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm

Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...

www.cell.com

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Kilian Schober @kischober.bsky.social · 7d

German press release: www.uk-erlangen.de/presse/press...

Wie das Immunsystem seine Abwehrtruppen auswählt

Wenn Killerzellen des Immunsystems auf Anzeichen einer Infektion stoßen, teilen sich manche von ihnen danach rasant. Sie wachsen so zu einer großen Abwehrtruppe heran, die dann den Erreger bekämpft. A...

www.uk-erlangen.de

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Kilian Schober @kischober.bsky.social · 10d

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

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Elizabeth McKenna @elizsmckenna.bsky.social · 10d

Now online in Cancer Discovery @aacrjournals.bsky.social: Epigenetic and Transcriptional Programs Define #Osteosarcoma Subtypes and Establish Targetable Vulnerabilities - by Eunice López-Fuentes, Alejandro Sweet-Cordero, and colleagues doi.org/10.1158/2159... @ucsfchildrens.bsky.social

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Grünewald Lab @grunewaldlab.bsky.social · 14d

New review in JCO Precision Oncology by the NEWTS group of the @euroewing.bsky.social consortium:

Recurrent and Refractory Ewing #Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium

ascopubs.org/doi/10.1200/...

International collaboration is KEY for clinical trials!

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Grünewald Lab @grunewaldlab.bsky.social · 15d

www.sciencedirect.com/science/arti...

Refined culture conditions with increased physiological relevance uncover oncogene-dependent metabolic signatures in Ewing sarcoma spheroids

Ewing sarcoma (EwS) cell line culture largely relies on standard techniques, which do not recapitulate physiological conditions. Here, we report on a …

www.sciencedirect.com

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Grünewald Lab @grunewaldlab.bsky.social · 15d

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing #Sarcoma Proliferation and Migration

advanced.onlinelibrary.wiley.com/doi/full/10....

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularizatio...

advanced.onlinelibrary.wiley.com

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Grünewald Lab @grunewaldlab.bsky.social · 17d

New cell lines expanding the diversity of
#Ewing #sarcoma models

onlinelibrary.wiley.com/doi/10.1002/...

New cell lines expanding the diversity of Ewing sarcoma models

A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear...

onlinelibrary.wiley.com

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Grünewald Lab @grunewaldlab.bsky.social · 18d

Very proud on our stellar doctoral student, Maxim Kafka, for being awarded with a Mildred-Scheel doctoral scholarship from the German Cancer Aid.

Maxim is working @dkfz.bsky.social on a follow-up on our recent paper on #SMARCB1-deficient Epitheloid #Sarcoma

onlinelibrary.wiley.com/doi/10.1002/...

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David Meyer @meyerdh.bsky.social · 25d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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Fendt Lab @fendtlab.bsky.social · Sep 5

Big congratulations to @elialab.bsky.social who is an alumni of the lab! So well deserved!

Ilaria Elia @elialab.bsky.social · Sep 5

I am thrilled to share that I have received an ERC Starting Grant for our project SpaceMet!
I am grateful for the ERC’s commitment to ambitious early-stage research and to KU Leuven for their support!
Stay tuned, new postdoc positions coming soon!I @erc.europa.eu @kuleuvenuniversity.bsky.social

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Wolfgang Wick @wickwolfgang.bsky.social · Sep 8

NOA Researchers from 13 German sites led by a team from @uniheidelberg.bsky.social @Universitätsklinikum Heidelberg (UKHD) & @dkfz.bsky.social have successfully completed the multicenter study “NCT Neuro Master Match (N2M2)”.

Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial

Nature Medicine - In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS...

rdcu.be

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Kurianlab @kurianlab.bsky.social · Sep 8

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites

During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

www.biorxiv.org

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Grünewald Lab @grunewaldlab.bsky.social · Sep 8

Great new perperint by Leo Kurian and team!

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Grünewald Lab @grunewaldlab.bsky.social · Sep 4

We are very grateful to our patients, and for generous funding of this project by the German Cancer Aid, the DKTK, and the Boehringer-Ingelheim Foundation!

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Grünewald Lab @grunewaldlab.bsky.social · Sep 4

This project was a true #team effort and great collaboration of @dkfz.bsky.social @uniheidelberg.bsky.social @nct-heidelberg.bsky.social @institutcurie.bsky.social and the Balgrist University Hospital.

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Grünewald Lab @grunewaldlab.bsky.social · Sep 4

These findings reveal a mechanistic link between oncogene fluctuation, amino acid metabolism, and immune evasion, positioning AHR as a central mediator of EwS progression and a tractable therapeutic vulnerability.

7/n

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Grünewald Lab @grunewaldlab.bsky.social · Sep 4

Functionally, AHR silencing restores NK cell-mediated tumor recognition, while also directly suppressing EwS cell proliferation, clonogenicity, and spheroid growth in plasma-like media. Genetic inhibition of AHR reduces tumor burden and metastatic competence in xenograft models.

6/n

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