Kurianlab
@kurianlab.bsky.social
RNA biology of embryonic development and disease #heart #ribosome #translational_control #RBP #splicing @UK_Frankfurt Alum:@salkinstitute @UcSandiego
https://kurianlab.com/
https://kurianlab.com/
Pinned
Kurianlab
@kurianlab.bsky.social
· Sep 8
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kurianlab
@psomagen, not here, on Ultima Genomics pricing for Short Read NGS sequencing on the UG100 instrument. Specs at bit.ly/ngsspecs
November 18, 2025 at 6:34 AM
@psomagen, not here, on Ultima Genomics pricing for Short Read NGS sequencing on the UG100 instrument. Specs at bit.ly/ngsspecs
Reposted by Kurianlab
Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
November 17, 2025 at 11:28 AM
Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
Reposted by Kurianlab
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted by Kurianlab
☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp
bit.ly/4oHxUZp
A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation - Nature Cell Biology
The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...
bit.ly
November 15, 2025 at 8:17 PM
☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp
bit.ly/4oHxUZp
Reposted by Kurianlab
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 5, 2025 at 2:45 PM
Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Wei Wang, @lionlchristiaen.bsky.social and colleagues
www.embopress.org/doi/full/10....
Reposted by Kurianlab
We are delighted to announce our #HighlyCited2025 researchers: Ronny Thomale, @angelifriedmann.bsky.social , Georg Gasteiger, @dominicgrun.bsky.social, and Christoph Wanner. Congratulations!
➡️ www.uni-wuerzburg.de/en/news-and-...
➡️ www.uni-wuerzburg.de/en/news-and-...
November 12, 2025 at 9:19 AM
We are delighted to announce our #HighlyCited2025 researchers: Ronny Thomale, @angelifriedmann.bsky.social , Georg Gasteiger, @dominicgrun.bsky.social, and Christoph Wanner. Congratulations!
➡️ www.uni-wuerzburg.de/en/news-and-...
➡️ www.uni-wuerzburg.de/en/news-and-...
Reposted by Kurianlab
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
November 12, 2025 at 5:42 PM
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
Reposted by Kurianlab
The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.
November 11, 2025 at 2:15 PM
The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.
Reposted by Kurianlab
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
buff.ly/UEtcRd4
November 12, 2025 at 4:15 PM
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
buff.ly/UEtcRd4
Reposted by Kurianlab
Lab is thrilled to leave frigid NY to go to sunny San Diego for #SfN2025 😂
Mon AM posters:
LBP182 - Psilocybin and layer 1 interneurons
LBP183 - Psilocybin in chronic stress model
LBP184 - Drugs + snRNAseq
Tue PM posters:
LL18 - Psilocybin and pyramidal cell types
MM3 - Drugs + rabies tracing
Mon AM posters:
LBP182 - Psilocybin and layer 1 interneurons
LBP183 - Psilocybin in chronic stress model
LBP184 - Drugs + snRNAseq
Tue PM posters:
LL18 - Psilocybin and pyramidal cell types
MM3 - Drugs + rabies tracing
November 13, 2025 at 9:33 PM
Lab is thrilled to leave frigid NY to go to sunny San Diego for #SfN2025 😂
Mon AM posters:
LBP182 - Psilocybin and layer 1 interneurons
LBP183 - Psilocybin in chronic stress model
LBP184 - Drugs + snRNAseq
Tue PM posters:
LL18 - Psilocybin and pyramidal cell types
MM3 - Drugs + rabies tracing
Mon AM posters:
LBP182 - Psilocybin and layer 1 interneurons
LBP183 - Psilocybin in chronic stress model
LBP184 - Drugs + snRNAseq
Tue PM posters:
LL18 - Psilocybin and pyramidal cell types
MM3 - Drugs + rabies tracing
Reposted by Kurianlab
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
www.science.org
November 13, 2025 at 7:05 PM
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Reposted by Kurianlab
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
November 13, 2025 at 10:05 PM
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
That is collective punishment dressed up as security policy. It is about racialised suspicion: defining Chinese and Chinese-heritage scientists as a threat instead of as colleagues. History has seen this before. It was racist then, and it is racist now; it is disgusting.
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 6:40 AM
That is collective punishment dressed up as security policy. It is about racialised suspicion: defining Chinese and Chinese-heritage scientists as a threat instead of as colleagues. History has seen this before. It was racist then, and it is racist now; it is disgusting.
Reposted by Kurianlab
Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let.
www.tiktok.com/t/ZP8Dteoop/
www.tiktok.com/t/ZP8Dteoop/
I guess I am hitting a nerve, because they just put me on admin leave.
TikTok video by Jenna
www.tiktok.com
November 13, 2025 at 11:18 PM
Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let.
www.tiktok.com/t/ZP8Dteoop/
www.tiktok.com/t/ZP8Dteoop/
Reposted by Kurianlab
Thank you for your bravery as an advocate for honest and accurate science, for your passion to pursue the mission of human health, for your service to the nation, and for being a role model to us all. May HHS and NIH leadership see the light and course correct for the benefit of all Americans 🙏
Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let.
www.tiktok.com/t/ZP8Dteoop/
www.tiktok.com/t/ZP8Dteoop/
I guess I am hitting a nerve, because they just put me on admin leave.
TikTok video by Jenna
www.tiktok.com
November 14, 2025 at 3:36 AM
Thank you for your bravery as an advocate for honest and accurate science, for your passion to pursue the mission of human health, for your service to the nation, and for being a role model to us all. May HHS and NIH leadership see the light and course correct for the benefit of all Americans 🙏
Reposted by Kurianlab
Every single time I apply with a colleague to a bilateral grant that involves the #CNPq 🇧🇷is a chance for one its reviewers to tell me how I have a mediocre scientific carreer - not sure why the personal swings but this is anything but professional 🧐
November 14, 2025 at 5:27 AM
Every single time I apply with a colleague to a bilateral grant that involves the #CNPq 🇧🇷is a chance for one its reviewers to tell me how I have a mediocre scientific carreer - not sure why the personal swings but this is anything but professional 🧐
Reposted by Kurianlab
Removing a monument honoring Black US soldiers has nothing to do with DEI. It’s erasure of history and it’s straight-up racism.
November 13, 2025 at 11:39 AM
Removing a monument honoring Black US soldiers has nothing to do with DEI. It’s erasure of history and it’s straight-up racism.
Reposted by Kurianlab
www.cell.com/cell/fulltex...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Grammars inferred using NARDINI+ (GIN) is a resource that uncovers molecular grammars
of intrinsically disordered regions (IDRs) across the human proteome, revealing how
distinct grammars underlie pro...
www.cell.com
November 13, 2025 at 1:38 AM
www.cell.com/cell/fulltex...
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Molecular grammars of predicted intrinsically disordered regions that span the human proteome
Reposted by Kurianlab
International scientists constitute the engine of much of the most exciting US science. My friend Sonali Majumdar has written precisely the kind of guide that international scientists crave in order succeed as resilient and brilliant scientists. Check it out! @sonali-m-19.bsky.social
November 13, 2025 at 2:18 AM
International scientists constitute the engine of much of the most exciting US science. My friend Sonali Majumdar has written precisely the kind of guide that international scientists crave in order succeed as resilient and brilliant scientists. Check it out! @sonali-m-19.bsky.social
Reposted by Kurianlab
Are there also folks looking for unmotivated, unenthusiastic postdocs or graduate students? Judging from how often I see these words in ads or postings, there must be some ads I am missing...
:)
:)
November 13, 2025 at 4:31 AM
Are there also folks looking for unmotivated, unenthusiastic postdocs or graduate students? Judging from how often I see these words in ads or postings, there must be some ads I am missing...
:)
:)
Reposted by Kurianlab
We are delighted to announce our next RNA Society Member Spotlight!
www.rnasociety.org/dr--bel-n-moro
Dr. Belén Moro holds the position of Pre-Award Grant Manager at the Vall d’Hebron Research Institute (VHIR) in Barcelona, Spain.
www.rnasociety.org/dr--bel-n-moro
Dr. Belén Moro holds the position of Pre-Award Grant Manager at the Vall d’Hebron Research Institute (VHIR) in Barcelona, Spain.
November 13, 2025 at 5:00 AM
We are delighted to announce our next RNA Society Member Spotlight!
www.rnasociety.org/dr--bel-n-moro
Dr. Belén Moro holds the position of Pre-Award Grant Manager at the Vall d’Hebron Research Institute (VHIR) in Barcelona, Spain.
www.rnasociety.org/dr--bel-n-moro
Dr. Belén Moro holds the position of Pre-Award Grant Manager at the Vall d’Hebron Research Institute (VHIR) in Barcelona, Spain.
Reposted by Kurianlab
"Even Nobel Prize Winners Deal With Imposter Syndrome": Check this out @scifri.bsky.social: www.sciencefriday.com/segments/ard...
Even Nobel Prize Winners Deal With Imposter Syndrome
Neuroscientist Ardem Patapoutian immigrated to the US, found belonging in science, and did groundbreaking work on sense of touch.
www.sciencefriday.com
November 11, 2025 at 6:07 PM
"Even Nobel Prize Winners Deal With Imposter Syndrome": Check this out @scifri.bsky.social: www.sciencefriday.com/segments/ard...