Ardem Patapoutian
@ardemp.bskyverified.social
Scripps Research Professor. HHMI Investigator. Nobel Prize Physiology or Medicine 2021. Opinions are my own and do not reflect those of my employer.
Pinned
Hey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.
At the Nobel Prize Museum you can find the phone Thomas Perlmann uses to call medicine laureates, including the call I assume that reached my 94 year old dad when I had do not disturb on. You can see the confidentiality steps taken by literature committee members. Even find PIEZO paraphernalia.
December 7, 2025 at 6:10 PM
At the Nobel Prize Museum you can find the phone Thomas Perlmann uses to call medicine laureates, including the call I assume that reached my 94 year old dad when I had do not disturb on. You can see the confidentiality steps taken by literature committee members. Even find PIEZO paraphernalia.
Mary Brunkow was generous in thanking her mentors during her The Nobel Prize lecture! Always good to look back and remember those who have made an impact in your career. She is among a long line of pre-med students who worked in a lab and fell in love with research and changed plans!
December 7, 2025 at 5:35 PM
Mary Brunkow was generous in thanking her mentors during her The Nobel Prize lecture! Always good to look back and remember those who have made an impact in your career. She is among a long line of pre-med students who worked in a lab and fell in love with research and changed plans!
Fred Ramsdell showed a photo of himself standing by a trailer labeled “Nobel Museum” and joked, “this is as close as I will get to a Nobel Prize.” Turns out he was wrong, and he is a recipient this year. He even thanked the mouse for the research. Love it!
December 7, 2025 at 5:29 PM
Fred Ramsdell showed a photo of himself standing by a trailer labeled “Nobel Museum” and joked, “this is as close as I will get to a Nobel Prize.” Turns out he was wrong, and he is a recipient this year. He even thanked the mouse for the research. Love it!
The Nobel Prize Physiology lecture about to start!
www.nobelprize.org
www.nobelprize.org
December 7, 2025 at 12:44 PM
The Nobel Prize Physiology lecture about to start!
www.nobelprize.org
www.nobelprize.org
Sophisticated Stockholm!
December 7, 2025 at 11:30 AM
Sophisticated Stockholm!
Have we lost some of the academic magic in the US? A true privilege to give the Sherrington Prize Lecture at Oxford. A wonderful audience, a fantastic dinner at Merton College, and even the Merton Choir. Special for me since Sherrington coined proprioception and interoception.
December 4, 2025 at 11:48 PM
Have we lost some of the academic magic in the US? A true privilege to give the Sherrington Prize Lecture at Oxford. A wonderful audience, a fantastic dinner at Merton College, and even the Merton Choir. Special for me since Sherrington coined proprioception and interoception.
Reposted by Ardem Patapoutian
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...
www.sciencedirect.com
December 4, 2025 at 4:42 PM
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...
A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...
Renal PIEZO2 is an essential regulator of renin
The force-sensing ion channel PIEZO2 is an essential regulator of the renin-angiotensin-aldosterone
system (RAAS), a pathway that controls blood volume. Loss of PIEZO2 in the kidney
cells that produce...
www.cell.com
December 4, 2025 at 11:27 PM
A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...
Reposted by Ardem Patapoutian
Finally getting some theological clarity on the ethics of reclining in one’s plane seat
November 29, 2025 at 12:13 PM
Finally getting some theological clarity on the ethics of reclining in one’s plane seat
Reposted by Ardem Patapoutian
This is great to hear, and I hope encouraging to other institutions
Harvard gets its research funding back through defiance and lawsuits.
Majority of Harvard’s Research Funding Has Been Restored
As of Tuesday, Harvard University had recouped most of the federal research funding it lost when the Trump administration froze its access to grants earlier this year, multiple local news organization...
www.insidehighered.com
November 29, 2025 at 1:10 PM
This is great to hear, and I hope encouraging to other institutions
I was one of those immigrants, and we commit fewer crimes than people born here.
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
Trump says he wants to 'permanently pause' migration to the US from poorer countries
President Donald Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the United States by revoking their legal status...
apnews.com
November 28, 2025 at 3:19 PM
I was one of those immigrants, and we commit fewer crimes than people born here.
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
“Trump says he wants to “permanently pause migration” from poorer nations and is promising to seek to expel millions of immigrants from the US by revoking their legal status.”
apnews.com/article/trum...
#PIEZO hat trick. OG grey, the 2021 one with the dynamite sign, and the new 25th anniversary edition. Given mostly to lab members, alumni, and a few colleagues.
November 27, 2025 at 6:36 PM
#PIEZO hat trick. OG grey, the 2021 one with the dynamite sign, and the new 25th anniversary edition. Given mostly to lab members, alumni, and a few colleagues.
Shakespeare: “love is blind, and lovers cannot see…”
This hairdo doesn't just help male pheasants woo females--it also obscures their vision, making them more vulnerable to predators. Fun story at @science.org
Love practically makes these birds go blind
Unusually obstructive plumage compromises the vision of two types of pheasants—a first in birds
www.science.org
November 26, 2025 at 2:57 PM
Shakespeare: “love is blind, and lovers cannot see…”
Great story by @carlzimmer.com in @nytimes.com that nicely conveys the excitement for the emerging field of interoception. @dulaclab.bsky.social and others are featured, including my tattoo 😳!
Gift article link: www.nytimes.com/2025/11/25/s...
Gift article link: www.nytimes.com/2025/11/25/s...
November 25, 2025 at 1:42 PM
Great story by @carlzimmer.com in @nytimes.com that nicely conveys the excitement for the emerging field of interoception. @dulaclab.bsky.social and others are featured, including my tattoo 😳!
Gift article link: www.nytimes.com/2025/11/25/s...
Gift article link: www.nytimes.com/2025/11/25/s...
Reposted by Ardem Patapoutian
After immigrating to the U.S. from Lebanon, neuroscientist @ardemp.bskyverified.social found belonging in science—and did Nobel-winning work on the sense of touch: buff.ly/boCE6ZY
November 24, 2025 at 1:07 PM
After immigrating to the U.S. from Lebanon, neuroscientist @ardemp.bskyverified.social found belonging in science—and did Nobel-winning work on the sense of touch: buff.ly/boCE6ZY
🌶️🌶️🌶️
A gel-based artificial tongue can determine the spiciness of a wide range of foods
go.nature.com/4oafMqh
go.nature.com/4oafMqh
Synthetic tongue rates chillies’ heat — and spares human tasters
Gel-based device inspired by the cooling powers of milk assesses peppers whose burn ranges from mild to dangerous.
go.nature.com
November 24, 2025 at 12:41 PM
🌶️🌶️🌶️
Worked in a Drosophila genetics lab for the sole purpose of getting a letter of recommendation from the lab head for medical school. I loved being in the lab so much that I gave up on medical school and went to graduate school instead.
November 23, 2025 at 2:28 PM
Worked in a Drosophila genetics lab for the sole purpose of getting a letter of recommendation from the lab head for medical school. I loved being in the lab so much that I gave up on medical school and went to graduate school instead.
Reposted by Ardem Patapoutian
Rising junior and senior undergrads: this is a terrific opportunity for a 9 weeks summer internship as a Cech Fellow in an HHMI lab: deadline for applications is December 22!
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
bit.ly
November 21, 2025 at 7:18 PM
Rising junior and senior undergrads: this is a terrific opportunity for a 9 weeks summer internship as a Cech Fellow in an HHMI lab: deadline for applications is December 22!
We had the most amazing 25 year lab anniversary today. Blown away by the science from my alumni and very proud of the current members. The community they have built is remarkable and it felt like a family reunion. The tacos, drinks, cake, and jazz were pretty great too.
November 21, 2025 at 6:19 AM
We had the most amazing 25 year lab anniversary today. Blown away by the science from my alumni and very proud of the current members. The community they have built is remarkable and it felt like a family reunion. The tacos, drinks, cake, and jazz were pretty great too.
Reposted by Ardem Patapoutian
A beautiful paper on the role of Piezos in uterine biology. I have known first author Yunxiao Zhang since 2012. Yunxiao is rare talent (and a wonderfully kind human being) now on the job market!
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
November 20, 2025 at 2:35 PM
A beautiful paper on the role of Piezos in uterine biology. I have known first author Yunxiao Zhang since 2012. Yunxiao is rare talent (and a wonderfully kind human being) now on the job market!
So looking forward to our 25 year lab anniversary celebrations tomorrow. I love seeing alumni and current lab members mix and exchange ideas and stories. It will be an awesome day.
November 19, 2025 at 4:55 PM
So looking forward to our 25 year lab anniversary celebrations tomorrow. I love seeing alumni and current lab members mix and exchange ideas and stories. It will be an awesome day.
Love this quote from Mauricio Pochettino, USA National Team coach: “Let’s be realistic, and do the impossible.”
November 19, 2025 at 1:53 PM
Love this quote from Mauricio Pochettino, USA National Team coach: “Let’s be realistic, and do the impossible.”
Reposted by Ardem Patapoutian
New @science.org study from @ardemp.bskyverified.social’s lab, co-authored by @yunxiao-dr.bsky.social, shows how PIEZO proteins sense stretch and pressure in the uterus to help coordinate labor, while connexin 43 synchronizes muscle activity across cells.
Scripps Research study reveals how uterine contractions are regulated by stretch and pressure during childbirth
www.scripps.edu
November 17, 2025 at 6:43 PM
New @science.org study from @ardemp.bskyverified.social’s lab, co-authored by @yunxiao-dr.bsky.social, shows how PIEZO proteins sense stretch and pressure in the uterus to help coordinate labor, while connexin 43 synchronizes muscle activity across cells.
Personal apologies to everyone who came to “sunny” San Diego for #SfN2025.🌧️😱
November 15, 2025 at 5:05 PM
Personal apologies to everyone who came to “sunny” San Diego for #SfN2025.🌧️😱
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
November 13, 2025 at 10:05 PM
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...