The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
Fast-fair-transparent / Open Access / Open Science
Fast-fair-transparent / Open Access / Open Science
Pinned
EJ Issue 2 for 2026:
Review:
Golgi adaptations in neurons
Highlight:
T-cell decoding strategies
Method:
In vivo proximity labeling with endogenous TurboID & mass spec
Cover:
Notch in glandular stem cells by @davidecinat.bsky.social and colleagues
link.springer.com/journal/4431...
Review:
Golgi adaptations in neurons
Highlight:
T-cell decoding strategies
Method:
In vivo proximity labeling with endogenous TurboID & mass spec
Cover:
Notch in glandular stem cells by @davidecinat.bsky.social and colleagues
link.springer.com/journal/4431...
Reposted by The EMBO Journal
1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging'
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵
link.springer.com/article/10.1...
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵
link.springer.com/article/10.1...
January 20, 2026 at 12:16 PM
1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging'
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵
link.springer.com/article/10.1...
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵
link.springer.com/article/10.1...
What underlies the impact of sperm aging on fertility and offspring health?
small ncRNA profiling by Kenneth Aston, Tong Zhou, @qichen-lab.bsky.social and colleagues reveals a drastic shift in RNA complements able to affect recipient cell metabolism
link.springer.com/article/10.1...
small ncRNA profiling by Kenneth Aston, Tong Zhou, @qichen-lab.bsky.social and colleagues reveals a drastic shift in RNA complements able to affect recipient cell metabolism
link.springer.com/article/10.1...
Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging - The EMBO Journal
Sperm aging impacts male fertility and offspring health, highlighting the need for reliable aging biomarkers to guide reproductive decisions. However, the molecular determinants of sperm fitness durin...
link.springer.com
January 20, 2026 at 3:19 PM
What underlies the impact of sperm aging on fertility and offspring health?
small ncRNA profiling by Kenneth Aston, Tong Zhou, @qichen-lab.bsky.social and colleagues reveals a drastic shift in RNA complements able to affect recipient cell metabolism
link.springer.com/article/10.1...
small ncRNA profiling by Kenneth Aston, Tong Zhou, @qichen-lab.bsky.social and colleagues reveals a drastic shift in RNA complements able to affect recipient cell metabolism
link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 20, 2026 at 3:18 PM
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
by @fischmidtlab.bsky.social
link.springer.com/article/10.1...
The splice of life:
Carissa Emerson Hunter & Yi Xing review how alternative splicing shapes regulatory and phenotypic evolution
link.springer.com/article/10.1...
Carissa Emerson Hunter & Yi Xing review how alternative splicing shapes regulatory and phenotypic evolution
link.springer.com/article/10.1...
January 19, 2026 at 1:49 PM
The splice of life:
Carissa Emerson Hunter & Yi Xing review how alternative splicing shapes regulatory and phenotypic evolution
link.springer.com/article/10.1...
Carissa Emerson Hunter & Yi Xing review how alternative splicing shapes regulatory and phenotypic evolution
link.springer.com/article/10.1...
EJ Issue 2 for 2026:
Review:
Golgi adaptations in neurons
Highlight:
T-cell decoding strategies
Method:
In vivo proximity labeling with endogenous TurboID & mass spec
Cover:
Notch in glandular stem cells by @davidecinat.bsky.social and colleagues
link.springer.com/journal/4431...
Review:
Golgi adaptations in neurons
Highlight:
T-cell decoding strategies
Method:
In vivo proximity labeling with endogenous TurboID & mass spec
Cover:
Notch in glandular stem cells by @davidecinat.bsky.social and colleagues
link.springer.com/journal/4431...
January 19, 2026 at 8:34 AM
EJ Issue 2 for 2026:
Review:
Golgi adaptations in neurons
Highlight:
T-cell decoding strategies
Method:
In vivo proximity labeling with endogenous TurboID & mass spec
Cover:
Notch in glandular stem cells by @davidecinat.bsky.social and colleagues
link.springer.com/journal/4431...
Review:
Golgi adaptations in neurons
Highlight:
T-cell decoding strategies
Method:
In vivo proximity labeling with endogenous TurboID & mass spec
Cover:
Notch in glandular stem cells by @davidecinat.bsky.social and colleagues
link.springer.com/journal/4431...
Reposted by The EMBO Journal
Congratulations to EMBO Members Yasmine Belkaid and Fiona Doetsch, who were awarded the Collen-Jeantet Prize for Translational Medicine and the Louis-Jeantet Prize for Medicine, respectively.
https://www.jeantet.ch/en/
#LifeSciences #research #award 🧪
https://www.jeantet.ch/en/
#LifeSciences #research #award 🧪
January 16, 2026 at 5:37 AM
Congratulations to EMBO Members Yasmine Belkaid and Fiona Doetsch, who were awarded the Collen-Jeantet Prize for Translational Medicine and the Louis-Jeantet Prize for Medicine, respectively.
https://www.jeantet.ch/en/
#LifeSciences #research #award 🧪
https://www.jeantet.ch/en/
#LifeSciences #research #award 🧪
Reposted by The EMBO Journal
The EMBO Workshop "#Centrosomes: From fundamentals to diseases" in #Lausanne, Switzerland, 1–4 September 2026 will highlight the advances in the field of centrosome #research. Register now!
Deadline: 1 June
https://meetings.embo.org/event/26-centrosomes
#EMBOCentrosomes #EMBOevents #conference 🧪
Deadline: 1 June
https://meetings.embo.org/event/26-centrosomes
#EMBOCentrosomes #EMBOevents #conference 🧪
January 16, 2026 at 12:10 PM
The EMBO Workshop "#Centrosomes: From fundamentals to diseases" in #Lausanne, Switzerland, 1–4 September 2026 will highlight the advances in the field of centrosome #research. Register now!
Deadline: 1 June
https://meetings.embo.org/event/26-centrosomes
#EMBOCentrosomes #EMBOevents #conference 🧪
Deadline: 1 June
https://meetings.embo.org/event/26-centrosomes
#EMBOCentrosomes #EMBOevents #conference 🧪
MYO5A-mediated stabilization promotes the acquisition of fusion competence in sealed autophagosomes
Ravi Manjithaya and coworkers
link.springer.com/article/10.1...
Ravi Manjithaya and coworkers
link.springer.com/article/10.1...
MYO5A-mediated stabilization promotes the acquisition of fusion competence in sealed autophagosomes - The EMBO Journal
Autophagy requires precise regulation of autophagosome-lysosome fusion, yet the molecular details of this process remain incompletely understood. Here, we identify the class V myosin MYO5A as a critic...
link.springer.com
January 16, 2026 at 10:33 AM
MYO5A-mediated stabilization promotes the acquisition of fusion competence in sealed autophagosomes
Ravi Manjithaya and coworkers
link.springer.com/article/10.1...
Ravi Manjithaya and coworkers
link.springer.com/article/10.1...
Epimutations: raw material for evolution?
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
link.springer.com
January 16, 2026 at 10:33 AM
Epimutations: raw material for evolution?
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Nabeel Ganem & @psarkies.bsky.social explore how epimutations mediating transgenerational epigenetic inheritance compare to DNA sequence mutations w.r.t. influence on drift and natural selection
link.springer.com/article/10.1...
Cancer in disguise: a parasite within
Perspective by Marek Wagner & Shigeo Koyasu explores mechanistic parallels between cancer and helminth infection, and how they might be leveraged for therapy
link.springer.com/article/10.1...
Perspective by Marek Wagner & Shigeo Koyasu explores mechanistic parallels between cancer and helminth infection, and how they might be leveraged for therapy
link.springer.com/article/10.1...
January 16, 2026 at 10:32 AM
Cancer in disguise: a parasite within
Perspective by Marek Wagner & Shigeo Koyasu explores mechanistic parallels between cancer and helminth infection, and how they might be leveraged for therapy
link.springer.com/article/10.1...
Perspective by Marek Wagner & Shigeo Koyasu explores mechanistic parallels between cancer and helminth infection, and how they might be leveraged for therapy
link.springer.com/article/10.1...
Interesting read at our friends from @emboreports.org:
An evaluation system for scientific journals
link.springer.com/article/10.1...
see also their related editorial by @berndpulverer.bsky.social on Equitable Open Access:
link.springer.com/article/10.1...
An evaluation system for scientific journals
link.springer.com/article/10.1...
see also their related editorial by @berndpulverer.bsky.social on Equitable Open Access:
link.springer.com/article/10.1...
An evaluation system for scientific journals - EMBO Reports
EMBO Reports - Scientific journals disseminate research findings and serve as a currency for measuring the reputation of scientists. Given their importance for science and for scientists’...
link.springer.com
January 15, 2026 at 11:44 AM
Interesting read at our friends from @emboreports.org:
An evaluation system for scientific journals
link.springer.com/article/10.1...
see also their related editorial by @berndpulverer.bsky.social on Equitable Open Access:
link.springer.com/article/10.1...
An evaluation system for scientific journals
link.springer.com/article/10.1...
see also their related editorial by @berndpulverer.bsky.social on Equitable Open Access:
link.springer.com/article/10.1...
Reposted by The EMBO Journal
📱Is the origin of animals comparable to the origin of the smartphones? Yes! See our new review in @embojournal.org where we show how important it was the new "Operating System" (animalOS)for animals to evolve! with @ricardsole.bsky.social, Nick and Elena @ibe-barcelona.bsky.social @csic.es @prbb.org
January 15, 2026 at 11:00 AM
📱Is the origin of animals comparable to the origin of the smartphones? Yes! See our new review in @embojournal.org where we show how important it was the new "Operating System" (animalOS)for animals to evolve! with @ricardsole.bsky.social, Nick and Elena @ibe-barcelona.bsky.social @csic.es @prbb.org
Reposted by The EMBO Journal
What if animals emerged by installing a new biological operating system that repurposed what already existed, much like the rise of the smartphone? Here's our new paper in @embojournal.org @ibe-barcelona.bsky.social @melisupf.bsky.social @sfiscience.bsky.social link.springer.com/article/10.1...
January 15, 2026 at 11:00 AM
What if animals emerged by installing a new biological operating system that repurposed what already existed, much like the rise of the smartphone? Here's our new paper in @embojournal.org @ibe-barcelona.bsky.social @melisupf.bsky.social @sfiscience.bsky.social link.springer.com/article/10.1...
Reposted by The EMBO Journal
I am thrilled to share with you the outcome of the first collaboration with Albesa-Jove's lab (albesalab.org), in which we characterised the molecular mechanisms underlying the binding of a T6SS adaptor-effector pair in P. putida, Tap3–Tke5. (🧵1/9). Read the full paper here: doi.org/10.1038/s443...
January 14, 2026 at 11:38 AM
I am thrilled to share with you the outcome of the first collaboration with Albesa-Jove's lab (albesalab.org), in which we characterised the molecular mechanisms underlying the binding of a T6SS adaptor-effector pair in P. putida, Tap3–Tke5. (🧵1/9). Read the full paper here: doi.org/10.1038/s443...
Structural insights into the antibacterial function of the Pseudomonas putida effector Tke5
@pbernalt6ss.bsky.social, David Albesa-Jové and coworkers
link.springer.com/article/10.1...
@pbernalt6ss.bsky.social, David Albesa-Jové and coworkers
link.springer.com/article/10.1...
January 13, 2026 at 11:39 AM
Structural insights into the antibacterial function of the Pseudomonas putida effector Tke5
@pbernalt6ss.bsky.social, David Albesa-Jové and coworkers
link.springer.com/article/10.1...
@pbernalt6ss.bsky.social, David Albesa-Jové and coworkers
link.springer.com/article/10.1...
ROS generated in Arabidopsis roots recruit the beneficial rhizobacterium Pseudomonas anguilliseptica to promote plant growth and enhance pathogen resistance
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
January 13, 2026 at 7:55 AM
ROS generated in Arabidopsis roots recruit the beneficial rhizobacterium Pseudomonas anguilliseptica to promote plant growth and enhance pathogen resistance
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
Yan Liang, Bin Ma and coworkers
link.springer.com/article/10.1...
Ordering of cell cycle events by regulated proteolysis is not just for eukaryotes:
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
January 12, 2026 at 2:19 PM
Ordering of cell cycle events by regulated proteolysis is not just for eukaryotes:
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
@buzzbaum.bsky.social et al define mechanisms underlying switch-like degradation of archaeal ESCRT-III CvdB in Sulfolobus
Thanks to @reviewcommons.org for another #RefereedPreprint
link.springer.com/article/10.1...
Wenli Jiang et al show that turnover of the neuronal scaffold protein ARMS is regulated by autophagy, via a non-canonical ARMS interaction specifically with the Atg8-family GABARAP
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 12, 2026 at 10:38 AM
Wenli Jiang et al show that turnover of the neuronal scaffold protein ARMS is regulated by autophagy, via a non-canonical ARMS interaction specifically with the Atg8-family GABARAP
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Diversity in mechanisms for epigenetic specification of vertebrate centromeres:
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
January 12, 2026 at 8:21 AM
Diversity in mechanisms for epigenetic specification of vertebrate centromeres:
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
Tetsuya Hori, @tatsuofukagawa.bsky.social et al show that HJURP-dependent CENP-A deposition in chicken DT40 cells requires both Mis18 complex and CENP-C
link.springer.com/article/10.1...
Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Client Challenge
link.springer.com
January 9, 2026 at 1:06 PM
Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
January 9, 2026 at 9:06 AM
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
Reposted by The EMBO Journal
Check out our latest story on AHR and PARP7 (TIPARP) degradation by the ADP-ribose-targeting E3 ligase DTX2 in the first issue of 2026 @embojournal.org!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation - The EMBO Journal
ADP-ribosylation is an important protein post-translational modification catalysed by a family of PARP enzymes in humans and is involved in DNA damage and immunity among other processes. While poly-AD...
link.springer.com
January 8, 2026 at 2:20 PM
Check out our latest story on AHR and PARP7 (TIPARP) degradation by the ADP-ribose-targeting E3 ligase DTX2 in the first issue of 2026 @embojournal.org!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Revisiting giant virus-host dynamics in brown algae: Susana Coelho and colleagues @mpi-bio-fml.bsky.social review old stories and new perspectives
link.springer.com/article/10.1...
link.springer.com/article/10.1...
January 8, 2026 at 2:17 PM
Revisiting giant virus-host dynamics in brown algae: Susana Coelho and colleagues @mpi-bio-fml.bsky.social review old stories and new perspectives
link.springer.com/article/10.1...
link.springer.com/article/10.1...
FlowVision:
@guijacquemet.bsky.social @johannaivaska.bsky.social et al describe a fast label-free live imaging approach revealing key principles of cancer cell arrest on endothelial monolayers–such as flow dynamics & CD44 interaction with matrix hyaluronic acid
link.springer.com/article/10.1...
@guijacquemet.bsky.social @johannaivaska.bsky.social et al describe a fast label-free live imaging approach revealing key principles of cancer cell arrest on endothelial monolayers–such as flow dynamics & CD44 interaction with matrix hyaluronic acid
link.springer.com/article/10.1...
Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal
The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...
link.springer.com
January 8, 2026 at 2:16 PM
FlowVision:
@guijacquemet.bsky.social @johannaivaska.bsky.social et al describe a fast label-free live imaging approach revealing key principles of cancer cell arrest on endothelial monolayers–such as flow dynamics & CD44 interaction with matrix hyaluronic acid
link.springer.com/article/10.1...
@guijacquemet.bsky.social @johannaivaska.bsky.social et al describe a fast label-free live imaging approach revealing key principles of cancer cell arrest on endothelial monolayers–such as flow dynamics & CD44 interaction with matrix hyaluronic acid
link.springer.com/article/10.1...
Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis
Celia Baroux and collaborators
link.springer.com/article/10.1...
Celia Baroux and collaborators
link.springer.com/article/10.1...
January 8, 2026 at 9:05 AM
Pre-meiotic H1.1 degradation is essential for Arabidopsis gametogenesis
Celia Baroux and collaborators
link.springer.com/article/10.1...
Celia Baroux and collaborators
link.springer.com/article/10.1...