The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
Fast-fair-transparent / Open Access / Open Science
Fast-fair-transparent / Open Access / Open Science
Pinned
Issue 22:
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
December 1, 2025 at 3:21 PM
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
December 1, 2025 at 3:20 PM
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 28, 2025 at 4:10 PM
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
November 28, 2025 at 11:42 AM
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
November 28, 2025 at 11:40 AM
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
November 28, 2025 at 7:28 AM
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
November 27, 2025 at 10:56 AM
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
November 27, 2025 at 9:12 AM
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Our paper on dynein-2's track recognition mechanism is now published in The EMBO Journal @embojournal.org!!
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal
imageimageDynein-2 is a motor protein essential for retrograde intraflagellar transport (IFT)
on the A-tubule of ciliary doublet microtubules. Here, biochemical and cryo-ET analyses
demonstrate that d...
www.embopress.org
November 26, 2025 at 4:57 PM
Our paper on dynein-2's track recognition mechanism is now published in The EMBO Journal @embojournal.org!!
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
✨ Happy to share that our work is now published in @embojournal.org ! ✨
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of maternal-to-zygotic transition in teleosts | The EMBO Journal
imageimagePost-translational regulation during the maternal-to-zygotic transition (MZT) remains
largely unexplored. Using an optimized CRISPR-RfxCas13d screening strategy, this study
identifies Bckdk ...
www.embopress.org
November 20, 2025 at 3:14 PM
✨ Happy to share that our work is now published in @embojournal.org ! ✨
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Our fantastic collaboration between @crisprscan.bsky.social
@bazzinilab.bsky.social
Here is the updated thread (1/13):
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal
The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...
link.springer.com
November 20, 2025 at 3:17 PM
Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
@alexandraboegli.bsky.social @embojournal.org
link.springer.com/article/10.1...
Reposted by The EMBO Journal
Early registration and abstract deadlines are 15 December for @fusionconf.bsky.social "Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference". @embojournal.org Senior Editor Daniel Klimmeck is looking forward to this meeting in Malta!
For info & registration: bit.ly/43AaInH
For info & registration: bit.ly/43AaInH
Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference | Fusion Conferences
Biennial international 2026 Mitochondria and Cell Fate Transitions Conference in Malta. Register now to apply for short talk and poster opportunities.
bit.ly
November 21, 2025 at 11:35 AM
Early registration and abstract deadlines are 15 December for @fusionconf.bsky.social "Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference". @embojournal.org Senior Editor Daniel Klimmeck is looking forward to this meeting in Malta!
For info & registration: bit.ly/43AaInH
For info & registration: bit.ly/43AaInH
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 21, 2025 at 12:59 PM
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
November 21, 2025 at 7:32 AM
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
November 20, 2025 at 7:01 PM
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
November 20, 2025 at 6:57 PM
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Christoph Ringli and collaborators identify a new regulator of the Arabidopsis extensin-mediated cell wall integrity sensing: phosphatase PP2C12 inhibiting receptor kinase FERONIA
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 20, 2025 at 1:57 PM
Christoph Ringli and collaborators identify a new regulator of the Arabidopsis extensin-mediated cell wall integrity sensing: phosphatase PP2C12 inhibiting receptor kinase FERONIA
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cytosolic receptors and signaling in antifungal immunity
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
November 20, 2025 at 1:56 PM
Cytosolic receptors and signaling in antifungal immunity
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Chromatin recruitment and cohesion establishment of human Sororin requires not just SMC3 acetylation, but also S-phase PARylation of the Sororin-binding microprotein RSMC
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
November 20, 2025 at 7:41 AM
Chromatin recruitment and cohesion establishment of human Sororin requires not just SMC3 acetylation, but also S-phase PARylation of the Sororin-binding microprotein RSMC
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
November 19, 2025 at 3:20 PM
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
Reposted by The EMBO Journal
We are pleased to once again partner with @fusionconf.bsky.social for the 2026 conference season! Looking forward to "Fibroblast Growth Factor Signalling in Development, Health & Disease Conference" in March when @embomolmed.org editor Lise Roth will attend.
Registration until 5 Feb: bit.ly/49nSmKj
Registration until 5 Feb: bit.ly/49nSmKj
Fibroblast Growth Factor Signalling in Development, Health & Disease Conference | Fusion Conferences
Receptor Tyrosine Kinases (RTKs) are cell-surface receptors that, upon ligand binding, regulate cell-to-cell communication during embryonic development and in adult life. Among RTKs, the twenty-two Fi...
bit.ly
November 19, 2025 at 10:43 AM
We are pleased to once again partner with @fusionconf.bsky.social for the 2026 conference season! Looking forward to "Fibroblast Growth Factor Signalling in Development, Health & Disease Conference" in March when @embomolmed.org editor Lise Roth will attend.
Registration until 5 Feb: bit.ly/49nSmKj
Registration until 5 Feb: bit.ly/49nSmKj
Reposted by The EMBO Journal
Our new paper is officially published today in
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of maternal-to-zygotic transition in teleosts | The EMBO Journal
imageimagePost-translational regulation during the maternal-to-zygotic transition (MZT) remains
largely unexplored. Using an optimized CRISPR-RfxCas13d screening strategy, this study
identifies Bckdk ...
www.embopress.org
November 18, 2025 at 3:10 PM
Our new paper is officially published today in
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
@embojournal.org !
We show that protein phosphorylation plays a key regulatory role during early embryogenesis.
An amazing collaboration with
@crisprscan.bsky.social
🔗 www.embopress.org/doi/full/10....
.
Reposted by The EMBO Journal
NEW #research: A new @embojournal.org paper from
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
Decoding early development
Stowers Associate Investigator Ariel Bazzini, Ph.D., discusses a collaboration that uncovered a new mechanism guiding the earliest steps of life.
bit.ly
November 18, 2025 at 6:45 PM
NEW #research: A new @embojournal.org paper from
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
@bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky
🔗 Read more: bit.ly/4i6Hdjl
Starting today: @events.embl.org #EESNucleus
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
As my conference year draws to a close: still one last highlight coming up #EESNucleus on home turf @events.embl.org!
November 18, 2025 at 11:41 AM
Starting today: @events.embl.org #EESNucleus
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 18, 2025 at 11:22 AM
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....