The EMBO Journal
@embojournal.org
Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
Fast-fair-transparent / Open Access / Open Science
Fast-fair-transparent / Open Access / Open Science
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
December 1, 2025 at 3:21 PM
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
@andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social
www.embopress.org/doi/full/10....
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
December 1, 2025 at 3:20 PM
Mono-ADP-ribosylation as a degradation mark?
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
@andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch
www.embopress.org/doi/full/10....
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 28, 2025 at 4:10 PM
Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
November 28, 2025 at 11:42 AM
MCM loading onto replication origins: when does it need ORC6 and when not?
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa
www.embopress.org/doi/full/10....
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
November 28, 2025 at 11:40 AM
Weekend reading:
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness
www.embopress.org/doi/full/10....
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
November 28, 2025 at 7:28 AM
New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development:
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation
www.embopress.org/doi/full/10....
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
November 27, 2025 at 10:56 AM
Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus!
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Xue-Xin Chen and coworkers
www.embopress.org/doi/full/10....
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
November 27, 2025 at 9:12 AM
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses
www.embopress.org/doi/full/10....
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
November 21, 2025 at 12:59 PM
The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Petr Broz @brozlab.bsky.social and colleagues
www.embopress.org/doi/full/10....
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
November 21, 2025 at 7:32 AM
Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex
Dan Shen et al
www.embopress.org/doi/full/10....
Dan Shen et al
www.embopress.org/doi/full/10....
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
November 20, 2025 at 7:01 PM
Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy?
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP)
www.embopress.org/doi/full/10....
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
November 20, 2025 at 6:57 PM
Now published in peer-reviewed version:
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap
www.embopress.org/doi/full/10....
Christoph Ringli and collaborators identify a new regulator of the Arabidopsis extensin-mediated cell wall integrity sensing: phosphatase PP2C12 inhibiting receptor kinase FERONIA
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 20, 2025 at 1:57 PM
Christoph Ringli and collaborators identify a new regulator of the Arabidopsis extensin-mediated cell wall integrity sensing: phosphatase PP2C12 inhibiting receptor kinase FERONIA
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cytosolic receptors and signaling in antifungal immunity
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
November 20, 2025 at 1:56 PM
Cytosolic receptors and signaling in antifungal immunity
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity
www.embopress.org/doi/full/10....
Chromatin recruitment and cohesion establishment of human Sororin requires not just SMC3 acetylation, but also S-phase PARylation of the Sororin-binding microprotein RSMC
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
November 20, 2025 at 7:41 AM
Chromatin recruitment and cohesion establishment of human Sororin requires not just SMC3 acetylation, but also S-phase PARylation of the Sororin-binding microprotein RSMC
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Wenya Hou, Huiqiang Lou and collaborators
www.embopress.org/doi/full/10....
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
November 19, 2025 at 3:20 PM
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 18, 2025 at 11:22 AM
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
November 17, 2025 at 2:28 PM
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
How can gut microbes modulate host lifespan?
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
November 17, 2025 at 1:22 PM
How can gut microbes modulate host lifespan?
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
@jogender-singh.bsky.social & coworkers show that in C. elegans, lifespan extension arises from microbial perturbation of iron homeostasis and oxidative stress response activation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
Issue 22:
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
November 17, 2025 at 9:48 AM
Issue 22:
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Maternal antibody interference with rotavirus vaccination
Conserved complex controls developmental & circadian timing
Review: Type IV secretion systems
Method: T-cell smFISH images transcription, RNA localization & fate
Cover: @jomaalab.bsky.social et al
www.embopress.org/toc/14602075...
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:02 AM
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
November 13, 2025 at 11:54 AM
piRNA-directed DNA methylation may not be a mammalian invention, but can already be found in the germline of axolotl salamanders
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
Donal O’Carroll and coworkers
www.embopress.org/doi/full/10....
C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
November 10, 2025 at 12:28 PM
C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
Chen et al show that CRP binds to a wide variety of bacterial capsule types to facilitate bacterial capture by liver-resident macrophages
www.embopress.org/doi/full/10....
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
November 7, 2025 at 12:53 PM
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
Jungsan Sohn and colleagues
www.embopress.org/doi/full/10....
What signaling dependencies underlie cancer transmissability in Tasmanian devils?
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....
November 7, 2025 at 11:11 AM
What signaling dependencies underlie cancer transmissability in Tasmanian devils?
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....
Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies
www.embopress.org/doi/full/10....