Maria Barna
@mbarnalab.bsky.social
So happy to be with amazing former postdocs at the RNA Canada 2024 meeting!! I’m so happy that @OZhulyn is dressed in pink!!
March 24, 2025 at 1:19 AM
So happy to be with amazing former postdocs at the RNA Canada 2024 meeting!! I’m so happy that @OZhulyn is dressed in pink!!
8/9
Cancer-specific rRNA variant expression is found in the TCGA dataset. By comparing cancer and control biopsies, we find cancer-specific rRNA variant expression in different cancer types, including an increase in lowly abundant rRNA variants.
Cancer-specific rRNA variant expression is found in the TCGA dataset. By comparing cancer and control biopsies, we find cancer-specific rRNA variant expression in different cancer types, including an increase in lowly abundant rRNA variants.
March 24, 2025 at 1:19 AM
8/9
Cancer-specific rRNA variant expression is found in the TCGA dataset. By comparing cancer and control biopsies, we find cancer-specific rRNA variant expression in different cancer types, including an increase in lowly abundant rRNA variants.
Cancer-specific rRNA variant expression is found in the TCGA dataset. By comparing cancer and control biopsies, we find cancer-specific rRNA variant expression in different cancer types, including an increase in lowly abundant rRNA variants.
7/9
We discover in the GTEx dataset tissue specific rRNA variant expression levels, including rRNA variant expression level differences between brain tissues (derived from the ectoderm lineage) and digestive system tissues (derived from the endoderm lineage).
We discover in the GTEx dataset tissue specific rRNA variant expression levels, including rRNA variant expression level differences between brain tissues (derived from the ectoderm lineage) and digestive system tissues (derived from the endoderm lineage).
March 24, 2025 at 1:19 AM
7/9
We discover in the GTEx dataset tissue specific rRNA variant expression levels, including rRNA variant expression level differences between brain tissues (derived from the ectoderm lineage) and digestive system tissues (derived from the endoderm lineage).
We discover in the GTEx dataset tissue specific rRNA variant expression levels, including rRNA variant expression level differences between brain tissues (derived from the ectoderm lineage) and digestive system tissues (derived from the endoderm lineage).
6/9
By structure probing full-length 28S (DMS + RIBO-RT), we find that 28S subtypes have different structures. This includes a major change in structure at the expansion segment es27l near a GGC indel variant.
By structure probing full-length 28S (DMS + RIBO-RT), we find that 28S subtypes have different structures. This includes a major change in structure at the expansion segment es27l near a GGC indel variant.
March 24, 2025 at 1:19 AM
6/9
By structure probing full-length 28S (DMS + RIBO-RT), we find that 28S subtypes have different structures. This includes a major change in structure at the expansion segment es27l near a GGC indel variant.
By structure probing full-length 28S (DMS + RIBO-RT), we find that 28S subtypes have different structures. This includes a major change in structure at the expansion segment es27l near a GGC indel variant.
4/9
We in-situ sequence ribosomes with variations by developing a new technology, SWITCH-seq, and find that variants are co-expressed in individual cells in single-cell resolution.
We in-situ sequence ribosomes with variations by developing a new technology, SWITCH-seq, and find that variants are co-expressed in individual cells in single-cell resolution.
March 24, 2025 at 1:19 AM
4/9
We in-situ sequence ribosomes with variations by developing a new technology, SWITCH-seq, and find that variants are co-expressed in individual cells in single-cell resolution.
We in-situ sequence ribosomes with variations by developing a new technology, SWITCH-seq, and find that variants are co-expressed in individual cells in single-cell resolution.
3/9
By full-length rRNA sequencing, RIBO-RT, we discovered ~1500 variants and tens of high-abundant variants in translating ribosomes that we curate into an atlas of human rRNA variations. Highly expressed variants are localized in eukaryotic solvent-exposed expansion segments.
By full-length rRNA sequencing, RIBO-RT, we discovered ~1500 variants and tens of high-abundant variants in translating ribosomes that we curate into an atlas of human rRNA variations. Highly expressed variants are localized in eukaryotic solvent-exposed expansion segments.
March 24, 2025 at 1:18 AM
3/9
By full-length rRNA sequencing, RIBO-RT, we discovered ~1500 variants and tens of high-abundant variants in translating ribosomes that we curate into an atlas of human rRNA variations. Highly expressed variants are localized in eukaryotic solvent-exposed expansion segments.
By full-length rRNA sequencing, RIBO-RT, we discovered ~1500 variants and tens of high-abundant variants in translating ribosomes that we curate into an atlas of human rRNA variations. Highly expressed variants are localized in eukaryotic solvent-exposed expansion segments.
1/9
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
March 24, 2025 at 1:18 AM
1/9
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer.
doi.org/10.1016/j.xgen…
So proud of my graduate student Sonia Bustos for doing an amazing job and passing her quals!
March 24, 2025 at 1:18 AM
So proud of my graduate student Sonia Bustos for doing an amazing job and passing her quals!
Specialized ribosome cake pops that come in all different colors. We made these for happy hour with 18 different kinds of sprinkles!
March 24, 2025 at 1:16 AM
Specialized ribosome cake pops that come in all different colors. We made these for happy hour with 18 different kinds of sprinkles!
Just got back from an amazing camping trip with the lab. I'm so grateful for having such brilliant and also fun lab members! It was really a big adventure but we made it.
March 24, 2025 at 1:16 AM
Just got back from an amazing camping trip with the lab. I'm so grateful for having such brilliant and also fun lab members! It was really a big adventure but we made it.
Fun hiking trip with the lab! Enjoying the beautiful Californian weather.
March 24, 2025 at 1:16 AM
Fun hiking trip with the lab! Enjoying the beautiful Californian weather.
Happy Holidays!! The latest picture of our lab celebrating with a white elephant party. Also a farewell to @KatLeppek, an amazing postdoc, who is moving on to start her own lab. We will miss her tremendously. I’m feeling grateful for having such a wonderful lab.
March 24, 2025 at 1:16 AM
Happy Holidays!! The latest picture of our lab celebrating with a white elephant party. Also a farewell to @KatLeppek, an amazing postdoc, who is moving on to start her own lab. We will miss her tremendously. I’m feeling grateful for having such a wonderful lab.
Maria at home base (Stanford Genetics department retreat).
March 24, 2025 at 1:15 AM
Maria at home base (Stanford Genetics department retreat).
A cool cover that captures the great work identifying hundreds of genetic interactions with eIF4E--unveiling new RNA biology and cancer vulnerabilities.Congrats @RuggeroDavide @DuyguKuzuoglu @LukeGilbertSF @genophoria!
cell.com/cell-reports/f…
cell.com/cell-reports/f…
March 24, 2025 at 1:15 AM
A cool cover that captures the great work identifying hundreds of genetic interactions with eIF4E--unveiling new RNA biology and cancer vulnerabilities.Congrats @RuggeroDavide @DuyguKuzuoglu @LukeGilbertSF @genophoria!
cell.com/cell-reports/f…
cell.com/cell-reports/f…
Today was the last day of a brilliant graduate student-Gun Woo Byeon! He is graduating with three first author papers and I couldn’t be more proud of his amazing accomplishments! We will miss him tremendously but wish him all the best in his new postdoc in the @seeliglab!
March 24, 2025 at 1:15 AM
Today was the last day of a brilliant graduate student-Gun Woo Byeon! He is graduating with three first author papers and I couldn’t be more proud of his amazing accomplishments! We will miss him tremendously but wish him all the best in his new postdoc in the @seeliglab!
We might have found the official lab snack. Can we get a sponsor for lab meeting food (once we are back)?
March 24, 2025 at 1:15 AM
We might have found the official lab snack. Can we get a sponsor for lab meeting food (once we are back)?
Thanks so much for the excellent and very thoughtful News & Views by Burcu Erdogan and @JessLaMae! -MB
nature.com/articles/s4155…
nature.com/articles/s4155…
March 24, 2025 at 1:15 AM
Thanks so much for the excellent and very thoughtful News & Views by Burcu Erdogan and @JessLaMae! -MB
nature.com/articles/s4155…
nature.com/articles/s4155…
Happy to share our latest paper on filopodia! The lab's second passion outside of ribosomes. Remote control to move cargo along filopodial networks with light.
nature.com/articles/s4155…
nature.com/articles/s4155…
March 24, 2025 at 1:15 AM
Happy to share our latest paper on filopodia! The lab's second passion outside of ribosomes. Remote control to move cargo along filopodial networks with light.
nature.com/articles/s4155…
nature.com/articles/s4155…
Last day of an incredible postdoc @KotaroFujii1 who is going to be opening up his new lab soon at. I’m so proud of him! We will miss him terribly. Looking forward to his next exciting discovery! Maria
neurogenetics.med.ufl.edu/faculty/kotaro…
neurogenetics.med.ufl.edu/faculty/kotaro…
March 24, 2025 at 1:15 AM
Last day of an incredible postdoc @KotaroFujii1 who is going to be opening up his new lab soon at. I’m so proud of him! We will miss him terribly. Looking forward to his next exciting discovery! Maria
neurogenetics.med.ufl.edu/faculty/kotaro…
neurogenetics.med.ufl.edu/faculty/kotaro…
I’m at a symposium and thinking about giving a talk on the expansion segments of the ribosome when I found this tile in my restroom. I think it is a sign...M.B.
March 24, 2025 at 1:14 AM
I’m at a symposium and thinking about giving a talk on the expansion segments of the ribosome when I found this tile in my restroom. I think it is a sign...M.B.
And the lab is going to new heights literally...
March 24, 2025 at 1:14 AM
And the lab is going to new heights literally...
1. Not many people know that my mom was an immigrant who came to the US to give me a better life. As a first-generation college student, I would have never imagined becoming a tenured professor at Stanford. I’m extremely grateful to the scientific community for their support!!
March 24, 2025 at 1:14 AM
1. Not many people know that my mom was an immigrant who came to the US to give me a better life. As a first-generation college student, I would have never imagined becoming a tenured professor at Stanford. I’m extremely grateful to the scientific community for their support!!
Checking out the lab’s new home across the street today.
March 24, 2025 at 1:14 AM
Checking out the lab’s new home across the street today.
Amazing Mechanical Pipe Organ original from 1900! It is said to be the equivalent of an orchestra of 100 musicians. It was restored by Paul Bocuse, giving everyone “the fleeting impression that we are still in the good old days”. Loving my trip to Lyon.
March 24, 2025 at 1:14 AM
Amazing Mechanical Pipe Organ original from 1900! It is said to be the equivalent of an orchestra of 100 musicians. It was restored by Paul Bocuse, giving everyone “the fleeting impression that we are still in the good old days”. Loving my trip to Lyon.
Davide celebrating the ACS professorship in style with a private violinist at Abbaye Pual Bocuse in Lyon! Amazing cancer center @crcl symposium on ribosomes in health and disease. I’m feeling spoiled with 3 star Michael food and music.
March 24, 2025 at 1:14 AM
Davide celebrating the ACS professorship in style with a private violinist at Abbaye Pual Bocuse in Lyon! Amazing cancer center @crcl symposium on ribosomes in health and disease. I’m feeling spoiled with 3 star Michael food and music.