Waggoner Lab
@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
Preprint: Autoantibody Origins in Lupus and in Relapse Post CAR-T Therapy @vinuesalab.bsky.social
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
December 4, 2025 at 3:57 AM
Preprint: Autoantibody Origins in Lupus and in Relapse Post CAR-T Therapy @vinuesalab.bsky.social
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
Preprint: Time-of-day modulates the abundance, spatial organization, and cytokine–chemokine production of tumor-infiltrating immune cells via circadian DC Cx3cl1 mediated recruitment of CX3CR1+CD8+ T cells
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
Timing of Immune Checkpoint Blockade Shapes Anti-Tumor Immunity via a Clock-Dependent Chemokine Axis
Circadian clocks regulate immunity, yet how they shape the tumor immune microenvironment and influence cancer immunotherapy remains unclear. Here, we show that
papers.ssrn.com
December 4, 2025 at 3:55 AM
Preprint: Time-of-day modulates the abundance, spatial organization, and cytokine–chemokine production of tumor-infiltrating immune cells via circadian DC Cx3cl1 mediated recruitment of CX3CR1+CD8+ T cells
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
One dose of either a bivalent or nonavalent HPV vaccine provided protection against HPV16 or HPV18 infection and was not inferior to two doses @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
December 4, 2025 at 3:52 AM
One dose of either a bivalent or nonavalent HPV vaccine provided protection against HPV16 or HPV18 infection and was not inferior to two doses @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
December 4, 2025 at 3:50 AM
A Threat to Evidence-Based Vaccine Policy and Public Health Security at the FDA @nejm.org
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Review @cp-molcell.bsky.social @drewoberst.bsky.social @whateveroptosis.bsky.social
The landscape of regulated cell death: It’s all downhill from here
www.cell.com/molecular-ce...
The landscape of regulated cell death: It’s all downhill from here
www.cell.com/molecular-ce...
December 4, 2025 at 3:45 AM
Review @cp-molcell.bsky.social @drewoberst.bsky.social @whateveroptosis.bsky.social
The landscape of regulated cell death: It’s all downhill from here
www.cell.com/molecular-ce...
The landscape of regulated cell death: It’s all downhill from here
www.cell.com/molecular-ce...
Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV @cp-cellreports.bsky.social @utaustin.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
December 4, 2025 at 3:41 AM
Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV @cp-cellreports.bsky.social @utaustin.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Order in which cancer-driving mutations occur affects the chance of tumor development @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
December 4, 2025 at 3:37 AM
Order in which cancer-driving mutations occur affects the chance of tumor development @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Augmentation of DNA exonuclease TREX1 in macrophages as a therapy for cardiac ischemic injury
Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction.
www.science.org
December 4, 2025 at 3:35 AM
Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages and driving lung fibrosis
www.science.org/doi/10.1126/... @yalepress.bsky.social
www.science.org/doi/10.1126/... @yalepress.bsky.social
December 4, 2025 at 3:35 AM
Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages and driving lung fibrosis
www.science.org/doi/10.1126/... @yalepress.bsky.social
www.science.org/doi/10.1126/... @yalepress.bsky.social
Vitamin E–functionalized LNP delivering TCPTP mRNA remodels the hepatic metabolic and immune microenvironment to alleviate the progression of MAFLD
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 4, 2025 at 3:32 AM
Vitamin E–functionalized LNP delivering TCPTP mRNA remodels the hepatic metabolic and immune microenvironment to alleviate the progression of MAFLD
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and metabolism in microglia
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 4, 2025 at 3:31 AM
PILRA is a therapeutic target for Alzheimer’s disease that regulates neuroinflammation and metabolism in microglia
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
IL-1 receptor antagonism alleviates immunological dysregulation that drives influenza-associated pulmonary aspergillosis in mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 4, 2025 at 3:27 AM
IL-1 receptor antagonism alleviates immunological dysregulation that drives influenza-associated pulmonary aspergillosis in mice
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice
www.science.org/doi/10.1126/... @evaconde.bsky.social @inserm.fr
Commentaries:
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @evaconde.bsky.social @inserm.fr
Commentaries:
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
December 4, 2025 at 3:23 AM
Vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice
www.science.org/doi/10.1126/... @evaconde.bsky.social @inserm.fr
Commentaries:
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @evaconde.bsky.social @inserm.fr
Commentaries:
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
VAPB is a critical regulating factor in cGAS-STING–mediated innate immune responses
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 4, 2025 at 3:17 AM
VAPB is a critical regulating factor in cGAS-STING–mediated innate immune responses
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Rapid companion test distinguishes HIV-1 infection from vaccine-related false positives, improving diagnosis and trials
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 4, 2025 at 3:16 AM
Rapid companion test distinguishes HIV-1 infection from vaccine-related false positives, improving diagnosis and trials
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Artificial intelligence may help design neoantigen cancer vaccines that work better by engaging B cells
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 4, 2025 at 3:13 AM
Artificial intelligence may help design neoantigen cancer vaccines that work better by engaging B cells
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
December 4, 2025 at 3:09 AM
XPR1 regulates fetal liver macrophage development, identity, and pyrenocyte clearance @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases @jem.org rupress.org/jem/article/...
December 4, 2025 at 3:07 AM
SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases @jem.org rupress.org/jem/article/...
The ‘silent’ brain cells that shape our behavior, memory and health @nature.com www.nature.com/articles/d41...
The ‘silent’ brain cells that shape our behaviour, memory and health
Astrocytes make up one-quarter of the brain, but researchers are only now realizing their true value.
www.nature.com
December 4, 2025 at 2:58 AM
The ‘silent’ brain cells that shape our behavior, memory and health @nature.com www.nature.com/articles/d41...
Discovery of a small molecule TLR3 agonist adjuvant @natcomms.nature.com @bostonchildrens.bsky.social @daviddowling.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 4, 2025 at 2:58 AM
Discovery of a small molecule TLR3 agonist adjuvant @natcomms.nature.com @bostonchildrens.bsky.social @daviddowling.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas @natmicrobiol.nature.com @rockefeller.edu
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas - Nature Microbiology
Targeting two distinct steps of the transcription process yields synergistic antibiotics that kill non-replicating Mycobacterium tuberculosis and reduce drug resistance.
www.nature.com
December 4, 2025 at 2:53 AM
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas @natmicrobiol.nature.com @rockefeller.edu
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gut microbiome-mediated transformation of dietary phytonutrients is associated with health outcomes @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gut microbiome-mediated transformation of dietary phytonutrients is associated with health outcomes - Nature Microbiology
Systematic analysis and machine learning coupled with in vitro and in vivo validation link gut microbiome-mediated transformation of dietary phytonutrients to health outcomes.
www.nature.com
December 4, 2025 at 2:44 AM
Gut microbiome-mediated transformation of dietary phytonutrients is associated with health outcomes @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Critical role of chaperone-mediated autophagy in maintaining homeostasis and promoting regeneration of skeletal muscle @natcellbio.nature.com @einsteinmededu.bsky.social @upf.edu
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
December 4, 2025 at 2:41 AM
Critical role of chaperone-mediated autophagy in maintaining homeostasis and promoting regeneration of skeletal muscle @natcellbio.nature.com @einsteinmededu.bsky.social @upf.edu
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Fat-related sensory cues during development act as signals that can prime central responses to food cues and whole-body metabolism regulation @natmetabolism.nature.com @sophiesteculorum.bsky.social @mpi-metabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Fat sensory cues in early life program central response to food and obesity - Nature Metabolism
Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.
www.nature.com
December 4, 2025 at 2:37 AM
Fat-related sensory cues during development act as signals that can prime central responses to food cues and whole-body metabolism regulation @natmetabolism.nature.com @sophiesteculorum.bsky.social @mpi-metabolism.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Lineage-determining transcription factors (EBF1 TCF1) radially position enhancers within gene loci to enable multi-enhancer regulation of key oncogenes @ single-allele level @natcellbio.nature.com @pennmedicine.bsky.social @atishayjay.bsky.social @vahedilab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 4, 2025 at 2:34 AM
Lineage-determining transcription factors (EBF1 TCF1) radially position enhancers within gene loci to enable multi-enhancer regulation of key oncogenes @ single-allele level @natcellbio.nature.com @pennmedicine.bsky.social @atishayjay.bsky.social @vahedilab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...