Waggoner Lab
@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
@biorxivpreprint.bsky.social Antibody feedback establishes an affinity brake in the germinal center
www.biorxiv.org/content/10.1... @ragoninstitute.bsky.social
www.biorxiv.org/content/10.1... @ragoninstitute.bsky.social
November 15, 2025 at 3:29 AM
@biorxivpreprint.bsky.social Antibody feedback establishes an affinity brake in the germinal center
www.biorxiv.org/content/10.1... @ragoninstitute.bsky.social
www.biorxiv.org/content/10.1... @ragoninstitute.bsky.social
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @inserm.fr
www.science.org/doi/10.1126/... @inserm.fr
November 15, 2025 at 3:26 AM
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @inserm.fr
www.science.org/doi/10.1126/... @inserm.fr
CD21 initiates extrafollicular differentiation of autoantibody-secreting cells in an SLE model driven by TLR7 signaling @sciimmunology.bsky.social @bostonchildrens.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 15, 2025 at 3:24 AM
CD21 initiates extrafollicular differentiation of autoantibody-secreting cells in an SLE model driven by TLR7 signaling @sciimmunology.bsky.social @bostonchildrens.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
α2-Adrenergic modulation of neuroimmune interactions differs between the spleen and mesenteric lymph nodes
@rosslabuc.bsky.social @uofcincy.bsky.social @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
@rosslabuc.bsky.social @uofcincy.bsky.social @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
November 15, 2025 at 3:22 AM
α2-Adrenergic modulation of neuroimmune interactions differs between the spleen and mesenteric lymph nodes
@rosslabuc.bsky.social @uofcincy.bsky.social @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
@rosslabuc.bsky.social @uofcincy.bsky.social @jimmunol.bsky.social academic.oup.com/jimmunol/adv...
November 15, 2025 at 3:08 AM
@biorxivpreprint.bsky.social TRAIL-R1 or TRAIL-R2 as biomarkers of sensitivity to Therapeutic Inducers of NK cell Killing (ThINKK) immunotherapy
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 14, 2025 at 7:46 PM
@biorxivpreprint.bsky.social TRAIL-R1 or TRAIL-R2 as biomarkers of sensitivity to Therapeutic Inducers of NK cell Killing (ThINKK) immunotherapy
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
@natimmunol.nature.com News & Views
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
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www.nature.com/articles/s41...
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 14, 2025 at 7:44 PM
@natimmunol.nature.com News & Views
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Quiet custodians of CD8+ T cell fate
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microbial signals in primary and metastatic brain tumors
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@naturemedicine.bsky.social @mdanderson.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@naturemedicine.bsky.social @mdanderson.bsky.social
November 14, 2025 at 7:41 PM
Microbial signals in primary and metastatic brain tumors
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@naturemedicine.bsky.social @mdanderson.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@naturemedicine.bsky.social @mdanderson.bsky.social
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
November 14, 2025 at 3:39 AM
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
A gene-editing approach enables modification of bacteria within the mouse gut @science.org @harriswang.bsky.social @columbiauniversity.bsky.social @shsternberg.bsky.social
www.science.org/doi/10.1126/...
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November 14, 2025 at 3:36 AM
A gene-editing approach enables modification of bacteria within the mouse gut @science.org @harriswang.bsky.social @columbiauniversity.bsky.social @shsternberg.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
November 14, 2025 at 3:29 AM
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
Epithelial-immune cell crosstalk involving IL-17-producing T lymphocytes and neutrophils as essential for the dysplasia-carcinoma progression @cp-cellreports.bsky.social
www.cell.com/cell-reports... @inserm.fr
www.cell.com/cell-reports... @inserm.fr
November 14, 2025 at 3:13 AM
Epithelial-immune cell crosstalk involving IL-17-producing T lymphocytes and neutrophils as essential for the dysplasia-carcinoma progression @cp-cellreports.bsky.social
www.cell.com/cell-reports... @inserm.fr
www.cell.com/cell-reports... @inserm.fr
Perspective @cp-cellmetabolism.bsky.social
From microbiome to metabolism: Bridging a two-decade translational gap
www.cell.com/cell-metabol...
From microbiome to metabolism: Bridging a two-decade translational gap
www.cell.com/cell-metabol...
November 14, 2025 at 3:11 AM
Perspective @cp-cellmetabolism.bsky.social
From microbiome to metabolism: Bridging a two-decade translational gap
www.cell.com/cell-metabol...
From microbiome to metabolism: Bridging a two-decade translational gap
www.cell.com/cell-metabol...
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
November 14, 2025 at 3:06 AM
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
Review @moltherapy.bsky.social
Recent advances of engineered bacteria for therapeutic applications
www.cell.com/molecular-th...
Recent advances of engineered bacteria for therapeutic applications
www.cell.com/molecular-th...
November 14, 2025 at 3:01 AM
Review @moltherapy.bsky.social
Recent advances of engineered bacteria for therapeutic applications
www.cell.com/molecular-th...
Recent advances of engineered bacteria for therapeutic applications
www.cell.com/molecular-th...
Engineered suppressor T cells overexpressing IFN-α and PD-L1 inhibit GVHD but retain GVL effects in mice @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
November 14, 2025 at 3:00 AM
Engineered suppressor T cells overexpressing IFN-α and PD-L1 inhibit GVHD but retain GVL effects in mice @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
An exosome-based delivery system (EMT-Cas12a) enables targeted CRISPR-Cas12a and multiplex crRNA delivery to CD4+ T cells, achieving efficient HIV-1 proviral DNA editing across subtypes @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
November 14, 2025 at 2:58 AM
An exosome-based delivery system (EMT-Cas12a) enables targeted CRISPR-Cas12a and multiplex crRNA delivery to CD4+ T cells, achieving efficient HIV-1 proviral DNA editing across subtypes @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection @natcomms.nature.com @stefaniembader.bsky.social
@wehi-research.bsky.social
www.nature.com/articles/s41...
@wehi-research.bsky.social
www.nature.com/articles/s41...
November 14, 2025 at 2:54 AM
Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection @natcomms.nature.com @stefaniembader.bsky.social
@wehi-research.bsky.social
www.nature.com/articles/s41...
@wehi-research.bsky.social
www.nature.com/articles/s41...
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessment @sigtrans-sttt.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 14, 2025 at 2:52 AM
Immune imprinting toward SARS-CoV-2 XBB: implications for vaccine strategy and variant risk assessment @sigtrans-sttt.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multi-omics, physiology and immunology of pig-to-human decedent kidney xenotransplant @nature.com @columbiauniversity.bsky.social @nyulangone.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 14, 2025 at 2:51 AM
Multi-omics, physiology and immunology of pig-to-human decedent kidney xenotransplant @nature.com @columbiauniversity.bsky.social @nyulangone.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Tiny robots swim through blood, deliver drugs — and then dissolve @nature.com @lizziegibney.bsky.social
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
@science.org
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
@science.org
November 14, 2025 at 1:39 AM
Tiny robots swim through blood, deliver drugs — and then dissolve @nature.com @lizziegibney.bsky.social
www.nature.com/articles/d41...
www.science.org/doi/10.1126/...
@science.org
www.nature.com/articles/d41...
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@science.org
CRISPR vs cholesterol: can gene editing prevent heart disease? @nature.com @heidiledford.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/d41...
CRISPR vs cholesterol: can gene editing prevent heart disease?
Promising results from a small clinical trial highlight a growing interest in designing gene-editing treatments for common illnesses.
www.nature.com
November 14, 2025 at 1:34 AM
CRISPR vs cholesterol: can gene editing prevent heart disease? @nature.com @heidiledford.bsky.social
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Preprint: Engagement of the T cell receptor against an oncolytic virus generates a population of hypereffector CAR T cells with potent antitumor activity
www.researchsquare.com/article/rs-7... @mayocliniccancer.bsky.social
www.researchsquare.com/article/rs-7... @mayocliniccancer.bsky.social
November 14, 2025 at 1:33 AM
Preprint: Engagement of the T cell receptor against an oncolytic virus generates a population of hypereffector CAR T cells with potent antitumor activity
www.researchsquare.com/article/rs-7... @mayocliniccancer.bsky.social
www.researchsquare.com/article/rs-7... @mayocliniccancer.bsky.social
Preprint: HTLV-1 oncoprotein HBZ activates IRF7 but interferes with IRF7-IRF3 interaction to stymie IFN response, but IRF7 transcription of STAT5b promotes proliferation contributing to adult T-cell leukemia/lymphoma
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
November 14, 2025 at 1:31 AM
Preprint: HTLV-1 oncoprotein HBZ activates IRF7 but interferes with IRF7-IRF3 interaction to stymie IFN response, but IRF7 transcription of STAT5b promotes proliferation contributing to adult T-cell leukemia/lymphoma
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
Preprint @cellpress.bsky.social pUS22 is a novel cytomegalovirus necroptosis inhibitor that represses transcription of RIPK3 via inhibition of Sp1 and Sp3
papers.ssrn.com/sol3/papers....
@thecimr.bsky.social
papers.ssrn.com/sol3/papers....
@thecimr.bsky.social
November 14, 2025 at 1:27 AM
Preprint @cellpress.bsky.social pUS22 is a novel cytomegalovirus necroptosis inhibitor that represses transcription of RIPK3 via inhibition of Sp1 and Sp3
papers.ssrn.com/sol3/papers....
@thecimr.bsky.social
papers.ssrn.com/sol3/papers....
@thecimr.bsky.social