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Çağrı Çevrim @cagricevrim.bsky.social · 8h

Thank you Smita!

Çağrı Çevrim @cagricevrim.bsky.social · 8h

Thank you!

Çağrı Çevrim @cagricevrim.bsky.social · 1d

Thanks Aida ❤️

Reposted by Çağrı Çevrim

Shefali @iamshef.bsky.social · 1d

Amazing work - and this will open so many doors for women health care. It's insane how little we know about female physiology. Congratulations @cagricevrim.bsky.social and the team on this incredible endeavor! 👏🏽🎉
#womenhealth 💪🏽

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 2

Reposted by Çağrı Çevrim

Dafni Hadjieconomou @drosostalis.bsky.social · 1d

Wowed!

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 1 3

Reposted by Çağrı Çevrim

Neha Ghosh @nehaghosh.bsky.social · 1d

Menstruation- a natural regenerative process in women, yet understudied and under discussed. But, this phenomenal work is a start for making all the difference 🎉

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

2 3

Reposted by Çağrı Çevrim

Navin Pokala 🇺🇸🇺🇦🇨🇦🇬🇱 @navinpokala.bsky.social · 1d

This is a really interesting study with an incredibly creative approach, applying chemical-genetic tools usually used for neuroscience research towards understanding the molecular and cellular mechanisms underlying menstruation.

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

2 4

Reposted by Çağrı Çevrim

Iain Cheeseman @iaincheeseman.bsky.social · 1d

An epic story and a must read. This is really beautiful work to understand the most amazing monthly regeneration event - menstruation. The authors reconstitute this process in mice (which don’t normally menstruate) allowing important new insights. Will also be a powerful model for future work.

Kara McKinley @karalmckinley.bsky.social · 2d

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

3 17

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I know, right??

1

Reposted by Çağrı Çevrim

Hannah Haberkern @hannah-haberkern.bsky.social · 2d

Amazing! Hard to believe this didn't exist until now.

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 2 4

Reposted by Çağrı Çevrim

@NicoliLab @nicolilab.bsky.social · 2d

OMG 😱 a true game changer for biology! Menstruation is a natural miracle of tissue regeneration. Amazing biology to come!

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 6 15

Reposted by Çağrı Çevrim

Adam Gracz @graczlab.bsky.social · 2d

This is probably one of the coolest and most creative mouse models I’ve ever seen!

Kara McKinley @karalmckinley.bsky.social · 2d

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Çağrı Çevrim @cagricevrim.bsky.social · 2d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

1 3 6

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Thank you for your kind words ❤️ Coming from someone who works with Hofstenia, that means a lot!

1

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Thank you!
It’s nice to see other people sharing our excitement!

1

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Thanks Anna! ❤️

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Thank you!

1

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Last but not least, a huge thanks to all co-authors and collaborators.
This was truly a team effort that brought together many people with different expertise.

1 3

Çağrı Çevrim @cagricevrim.bsky.social · 2d

In short, we developed the first transgenic menstruating mouse and discovered a new principle of endometrial layering and regeneration.
X-Mens opens the door to studying menstrual biology and pathologies with precision and help closing the longstanding gap in women’s health research.

1 2 6

Çağrı Çevrim @cagricevrim.bsky.social · 2d

So the entire endometrium is organized radially, from undifferentiated fibroblasts to the most mature decidual cells.

1 3

Çağrı Çevrim @cagricevrim.bsky.social · 2d

These rings form a gradient. Young decidual cells sit at the edge, mature ones at the center. As the gradient expands, it pushes undifferentiated fibroblasts to the periphery, creating the basalis, and defining the plane of shedding.

1 2

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Next, we built a fine time-series of X-Mens cycles to see how these layers form.
To our surprise, the functionalis is not a single layer.
It has three concentric rings of decidual cells, each at a different stage of differentiation.

1 4

Çağrı Çevrim @cagricevrim.bsky.social · 2d

And our comparative analysis showed that the functionalis and basalis layers in X-Mens mice and humans are highly similar.

1 4

Çağrı Çevrim @cagricevrim.bsky.social · 2d

We used Slide-tags, a spatial single-cell RNA sequencing method, to map this layering in detail using both human and X-Mens uterine samples.

1 6

Çağrı Çevrim @cagricevrim.bsky.social · 2d

We next took a century old challenge.
The human endometrium has been known to have two layers:
the functionalis, which decidualizes and sheds, and the basalis, which stays intact and regenerates the tissue.
The amazing part?
X-Mens mice show the same architecture.

1 5

Çağrı Çevrim @cagricevrim.bsky.social · 2d

X-Mens menstruation recapitulates key aspects of human menstruation.
Single-cell analyses showed shared genetic programs between the two species.

1 5