Josh Mattila
@joshmattila.bsky.social
Researching macrophages and neutrophils in TB || Entomology PhD, ticks and tick-borne bacteria || macro photography and reef aquaria enthusiast || opinions my own || Northern Minnnesotan
Reposted by Josh Mattila
Every single congressional Democrat needs to be out there, right now, insisting that Pete Hegseth resign right now and announcing that he will be held accountable for committing war crimes.
If you do not demand accountability here and now, they will only become more emboldened.
If you do not demand accountability here and now, they will only become more emboldened.
Exclusive: Defense Secretary Pete Hegseth gave an order to “kill everybody” in the first strike on suspected drug boats in the Caribbean. After two men survived, the mission commander ordered a second strike to comply with Hegseth’s instructions, according to two sources.
Hegseth order on first Caribbean boat strike, officials say: Kill them all
Defense Secretary Pete Hegseth issued a verbal order to kill all crew members in the Sept. 2 strike on a suspected drug boat. Navy SEALs fired a second missile.
www.washingtonpost.com
November 28, 2025 at 7:19 PM
Every single congressional Democrat needs to be out there, right now, insisting that Pete Hegseth resign right now and announcing that he will be held accountable for committing war crimes.
If you do not demand accountability here and now, they will only become more emboldened.
If you do not demand accountability here and now, they will only become more emboldened.
Reposted by Josh Mattila
Tissue-resident macrophages are doing more than just protecting from infection. In this interesting paper, René Fernando Abarca-Buis et al shows that they can promote reepithelialization and blastema formation and regulate the maturation of chondrocytes. Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
November 28, 2025 at 5:57 PM
Tissue-resident macrophages are doing more than just protecting from infection. In this interesting paper, René Fernando Abarca-Buis et al shows that they can promote reepithelialization and blastema formation and regulate the maturation of chondrocytes. Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Reposted by Josh Mattila
How do cytokines shape immune cells?
We analyzed and visualized Parse Bio's 10M PBMC dataset to give researchers a powerful tool for exploring the dynamics between cytokines & peripheral blood mononuclear cells.
More: https://apps.allenimmunology.org/aifi/resources/parse-10m-cytokines/
#ImmunoSky
We analyzed and visualized Parse Bio's 10M PBMC dataset to give researchers a powerful tool for exploring the dynamics between cytokines & peripheral blood mononuclear cells.
More: https://apps.allenimmunology.org/aifi/resources/parse-10m-cytokines/
#ImmunoSky
November 28, 2025 at 4:10 PM
How do cytokines shape immune cells?
We analyzed and visualized Parse Bio's 10M PBMC dataset to give researchers a powerful tool for exploring the dynamics between cytokines & peripheral blood mononuclear cells.
More: https://apps.allenimmunology.org/aifi/resources/parse-10m-cytokines/
#ImmunoSky
We analyzed and visualized Parse Bio's 10M PBMC dataset to give researchers a powerful tool for exploring the dynamics between cytokines & peripheral blood mononuclear cells.
More: https://apps.allenimmunology.org/aifi/resources/parse-10m-cytokines/
#ImmunoSky
Reposted by Josh Mattila
A golden era of tuberculosis vaccines is coming – but is the world ready? wellcome.org//insights/ar...
A golden era of TB vaccines is coming – but is the world ready? | News | Wellcome
A golden era of TB vaccines is coming. Is the world ready? Alex Pym discusses the urgent need for global preparation to ensure they save lives.
wellcome.org
November 28, 2025 at 12:40 PM
A golden era of tuberculosis vaccines is coming – but is the world ready? wellcome.org//insights/ar...
Reposted by Josh Mattila
Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination
Tattoo ink commonly reaches and persists in this organ in most tattooed subjects, often lifelong.
www.pnas.org/doi/10....
1/5
Tattoo ink commonly reaches and persists in this organ in most tattooed subjects, often lifelong.
www.pnas.org/doi/10....
1/5
Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination | PNAS
Despite safety concerns regarding the toxicity of tattoo ink, no studies have reported
the consequences of tattooing on the immune response. In thi...
www.pnas.org
November 28, 2025 at 12:47 PM
Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination
Tattoo ink commonly reaches and persists in this organ in most tattooed subjects, often lifelong.
www.pnas.org/doi/10....
1/5
Tattoo ink commonly reaches and persists in this organ in most tattooed subjects, often lifelong.
www.pnas.org/doi/10....
1/5
Reposted by Josh Mattila
Rapid and accurate quantification of viable Listeria monocytogenes with clonal specificity using microfluidic droplet digital PCR based technology https://www.biorxiv.org/content/10.1101/2025.11.27.690673v1
November 28, 2025 at 3:16 AM
Rapid and accurate quantification of viable Listeria monocytogenes with clonal specificity using microfluidic droplet digital PCR based technology https://www.biorxiv.org/content/10.1101/2025.11.27.690673v1
Reposted by Josh Mattila
Reuters reached out to everyone that Trump or his subordinates singled out publicly for retribution, and reviewed hundreds of official orders, directives and public records. The result: the most comprehensive accounting yet of his campaign of payback.
www.reuters.com/investigates...
www.reuters.com/investigates...
November 27, 2025 at 1:48 AM
Reuters reached out to everyone that Trump or his subordinates singled out publicly for retribution, and reviewed hundreds of official orders, directives and public records. The result: the most comprehensive accounting yet of his campaign of payback.
www.reuters.com/investigates...
www.reuters.com/investigates...
Reposted by Josh Mattila
Introduce yourself with five concerts you've seen multiple times
Metallica (3x)
Slayer (3x)
Dropkick Murphys (5x)
Neil Young (3x)
Bob Dylan (2x)
Metallica (3x)
Slayer (3x)
Dropkick Murphys (5x)
Neil Young (3x)
Bob Dylan (2x)
Introduce yourself with five concerts you've seen multiple times
Metallica
Anthrax
Suicidal Tendencies
Judas Priest
Aerosmith
Metallica
Anthrax
Suicidal Tendencies
Judas Priest
Aerosmith
Introduce yourself with five concerts you've seen multiple times
R.E.M.
OutKast
Radiohead
Beastie Boys
The Roots
R.E.M.
OutKast
Radiohead
Beastie Boys
The Roots
November 28, 2025 at 12:22 AM
Introduce yourself with five concerts you've seen multiple times
Metallica (3x)
Slayer (3x)
Dropkick Murphys (5x)
Neil Young (3x)
Bob Dylan (2x)
Metallica (3x)
Slayer (3x)
Dropkick Murphys (5x)
Neil Young (3x)
Bob Dylan (2x)
Reposted by Josh Mattila
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
Capsule diversity limits phage host range by affecting RBP interactions in capsulated bacteria. This study shows that generalist phages evolve host range through RBP mutations and recombination, while...
journals.plos.org
November 27, 2025 at 12:28 PM
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
Reposted by Josh Mattila
Are you fascinated by viruses? Would you like to design your own original research project in the UK's largest virology centre? Why not come and do a PhD @cvrinfo.bsky.social - application deadline 6th Jan 2026 (1/1): www.findaphd.com/phds/program...
FindAPhD : The MRC-University of Glasgow Centre for Virus Research (CVR) PhD Funded Programme at University of Glasgow
Apply for a PhD: The MRC-University of Glasgow Centre for Virus Research (CVR) PhD Funded Programme at University of Glasgow
www.findaphd.com
November 27, 2025 at 1:26 PM
Are you fascinated by viruses? Would you like to design your own original research project in the UK's largest virology centre? Why not come and do a PhD @cvrinfo.bsky.social - application deadline 6th Jan 2026 (1/1): www.findaphd.com/phds/program...
Reposted by Josh Mattila
The continuous evolution of HIV shows strong parallels in macaques and humans.
buff.ly/7mX8aWS
buff.ly/7mX8aWS
Viral mutations
The continuous evolution of HIV shows strong parallels in macaques and humans.
buff.ly
November 27, 2025 at 9:01 PM
The continuous evolution of HIV shows strong parallels in macaques and humans.
buff.ly/7mX8aWS
buff.ly/7mX8aWS
Reposted by Josh Mattila
Frikkin amazing stuff.
November 26, 2025 at 8:29 AM
Frikkin amazing stuff.
Reposted by Josh Mattila
New study confirms that short wavelength light (UV & blue) attracts the most nocturnal insects & that intensity increases attraction for all colours. Longer wavelength & lower intensity outdoor lights should reduce biodiversity impacts resjournals.onlinelibrary.wiley.com/doi/10.1111/... #teammoth 🌍
November 26, 2025 at 2:08 PM
New study confirms that short wavelength light (UV & blue) attracts the most nocturnal insects & that intensity increases attraction for all colours. Longer wavelength & lower intensity outdoor lights should reduce biodiversity impacts resjournals.onlinelibrary.wiley.com/doi/10.1111/... #teammoth 🌍
Reposted by Josh Mattila
Virus-specific CD8+ tissue-resident memory T cells trigger epithelial antiviral defenses via IFNγ @cp-immunity.bsky.social @emoryuniversity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
November 26, 2025 at 8:35 PM
Virus-specific CD8+ tissue-resident memory T cells trigger epithelial antiviral defenses via IFNγ @cp-immunity.bsky.social @emoryuniversity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Josh Mattila
Scientists: have you been the target of an online harassment campaign, doxxing, or weaponized FOIA requests? I'd like to talk to you about steps you had to take to protect your digital security for an upcoming Nature story. (You can be anonymous if necessary.)
RTs appreciated.
RTs appreciated.
November 26, 2025 at 12:18 AM
Scientists: have you been the target of an online harassment campaign, doxxing, or weaponized FOIA requests? I'd like to talk to you about steps you had to take to protect your digital security for an upcoming Nature story. (You can be anonymous if necessary.)
RTs appreciated.
RTs appreciated.
Reposted by Josh Mattila
A genome-wide CRISPR knockout in a major malaria vector identifies genes important for fitness & immune-related processes @natcomms.nature.com @perrimonlab.bsky.social @iowastateu.bsky.social @harvardmed.bsky.social @georgesaman.bsky.social @vectorimmunity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 7:41 PM
A genome-wide CRISPR knockout in a major malaria vector identifies genes important for fitness & immune-related processes @natcomms.nature.com @perrimonlab.bsky.social @iowastateu.bsky.social @harvardmed.bsky.social @georgesaman.bsky.social @vectorimmunity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Josh Mattila
NIH extends the Oct-Nov deadlines to Dec 8, 2025 drugmonkey.wordpress.com/2025/11/24/n...
NIH extends the Oct-Nov deadlines to Dec 8, 2025
The NIH has issued a Notice (NOT-OD-26-012) which expands upon the prior warning (NOT-OD-26-005) about extending the current submission deadlines. It seems to be quite comprehensive. All grant appl…
drugmonkey.wordpress.com
November 24, 2025 at 8:19 PM
NIH extends the Oct-Nov deadlines to Dec 8, 2025 drugmonkey.wordpress.com/2025/11/24/n...
Reposted by Josh Mattila
Two new Cochrane reviews show strong and consistent evidence that HPV vaccines are effective in preventing cervical cancer and pre-cancerous changes, especially when given to young people before they are exposed to the virus.
www.cochrane.org/about-us/new...
www.cochrane.org/about-us/new...
November 25, 2025 at 12:40 AM
Two new Cochrane reviews show strong and consistent evidence that HPV vaccines are effective in preventing cervical cancer and pre-cancerous changes, especially when given to young people before they are exposed to the virus.
www.cochrane.org/about-us/new...
www.cochrane.org/about-us/new...
Reposted by Josh Mattila
Got the flu last year on Thanksgiving and it really sucked. Obviously vaccine is no guarantee you won’t get it, but it’s basically free with no downside and is, imho, a no-brainer.
www.scientificamerican.com/article/how-...
www.scientificamerican.com/article/how-...
A New Flu Variant May Make Cold Season Brutal This Year
U.S. flu rates remain low, but experts are keeping an eye on a new strain that’s been linked to unexpectedly early and severe seasons in several other countries
www.scientificamerican.com
November 25, 2025 at 1:09 AM
Got the flu last year on Thanksgiving and it really sucked. Obviously vaccine is no guarantee you won’t get it, but it’s basically free with no downside and is, imho, a no-brainer.
www.scientificamerican.com/article/how-...
www.scientificamerican.com/article/how-...
Reposted by Josh Mattila
Jumping spiders can recognise one another. This ability to learn, remember and represent images is quite surprising for such a tiny-brained animal!
buff.ly/dCkwPr0
buff.ly/dCkwPr0
November 23, 2025 at 11:01 AM
Jumping spiders can recognise one another. This ability to learn, remember and represent images is quite surprising for such a tiny-brained animal!
buff.ly/dCkwPr0
buff.ly/dCkwPr0
Reposted by Josh Mattila
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
www.nature.com
November 19, 2025 at 5:51 PM
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
Reposted by Josh Mattila
I started studying phages just over 4 years ago. The project that started it all is finally published. We isolated 6 closely related anti-Acinetobacter phages and showed that they are not capsule-specific and can reduce bacterial load in a rat model. More work still to come on this! #phagesky #IDsky
A bacteriophage genus infects carbapenem resistant Acinetobacter baumannii via a non-capsular receptor and provides protection in vivo
Microbiology; Virology
www.cell.com
November 22, 2025 at 1:11 PM
I started studying phages just over 4 years ago. The project that started it all is finally published. We isolated 6 closely related anti-Acinetobacter phages and showed that they are not capsule-specific and can reduce bacterial load in a rat model. More work still to come on this! #phagesky #IDsky
Reposted by Josh Mattila
OspA Antibodies Inhibit the In vitro Transmigration of Borreliellia burgdorferi https://www.biorxiv.org/content/10.1101/2025.11.20.689610v1
November 22, 2025 at 12:16 AM
OspA Antibodies Inhibit the In vitro Transmigration of Borreliellia burgdorferi https://www.biorxiv.org/content/10.1101/2025.11.20.689610v1
Reposted by Josh Mattila
Ok, I've learned something new - acid fast stains bind nucleic acids and not mycolic acid on mycobacterial cell wall. The lipid-rich cell wall simply prevents acid-alcohol decolourisation, hence acid -fast.
#TBSky #IDSky @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
#TBSky #IDSky @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Fluorescent acid-fast stains for diagnosing mycobacteria and beyond: back to the future?
Acid-fast stains (AFS) remain indispensable in modern diagnostic microbiology; they
are used for detecting mycobacteria (including Mycobacterium tuberculosis and Mycobacterium
leprae), acid-fast paras...
www.thelancet.com
October 25, 2025 at 6:40 PM
Ok, I've learned something new - acid fast stains bind nucleic acids and not mycolic acid on mycobacterial cell wall. The lipid-rich cell wall simply prevents acid-alcohol decolourisation, hence acid -fast.
#TBSky #IDSky @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
#TBSky #IDSky @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...