In this Review, Weingarth and colleagues discuss both recently discovered compounds and established envelope-targeting antibiotics, including compounds that target Gram-positive bacteria, more complex Gram-negative bacteria and mycobacterial pathogens, with a particular focus on their drug–target interactions.

The primary input to deciding on the merit of proposals submitted to the NIH for potential funding, as most of my remaining blog audience well knows, is the outcome of the initial peer-review proce…

Protein kinases are key regulators of intracellular signaling, showing activities in specific subcellular compartments and in micro- or nano-domains. Genetically encoded biosensors based on Förster′s ...

Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...

Jailed for three days without an explanation or ability to notify anyone, George Retes argues the only path to healing starts with the government taking accountability for its actions.

Under Trump, the Department of Education has been bringing in activists hostile to public schools. It could mean a new era of private and religious schools boosted by tax dollars — and the end of publ...

A special fundraising initiative recently launched at Bemidji State University is aimed at replanting trees on campus. That's after a destructive storm in June destroyed an estimated 9 million trees t...

Key cellular processes for the rickettsial obligate intracellular lifestyle, including internalization by phagocytosis, regulation of intracellular trafficking, and evasion of lysosomal destruction to...

The administration is culling the best and brightest from the federal workforce for a rounding error’s worth in savings.

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

Image Analysis Specialist/Engineer/Coordinator, Helsinki Bioimaging

Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the tra...

The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.