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marcveld.bsky.social
Marc Veldhoen
@marcveld.bsky.social
11K followers 1.3K following 17K posts
Professor of Immunology 🇳🇱 🇬🇧 Lisbon, 🇵🇹 #Immunology Time for Science, not silence https://scholar.google.co.uk/citations?user=7vG1jLIAAAAJ&hl=en https://orcid.org/0000-0002-1478-9562 threads.net/@marc_veld mastodon.online/@marc_veld
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · Dec 23
Service post:
This account is on anti-science, COVID-19 denial, Long COVID denial, etc., blocklists. All fine, but I'm also running an automated block program. Some unblock me only to find they’re already blocked.

A reminder: be cautious with blocklists.

Unlike X, once blocked = blocked.
Postbox filled with mail, and the forbidden sign behind it.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 16m
With 200 cherry-picked, mostly low-impact papers, general webpages, press releases, and predatory journals, among others, it is a significant task to review all references and demonstrate that they are flawed or misinterpreted.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 18m
Yes and no. The issue is that you build up immunity to these infections from early life. This protects you fine until old age, when your immune system is getting weaker. If you do not build up immunity, or insufficiently, you can get very ill when you inevitably encounter the pathogen
Reposted by Marc Veldhoen
marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
Truly bizarre how a bunch of non-specialists club together under the cosplay banner of the WHN, and push out anti-science pulp.

@ajpmonline.bsky.social
@ajpmfocus.bsky.social

Comparing SARS-CoV-2 with HIV and COVID-19 with AIDS is bizarre, false and harmful.

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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
Also not. Symptoms are caused by the inflammatory response. For some this is heavier, some respond differently.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
Why does @ajpmonline.bsky.social, @ajpmfocus.bsky.social, publush anti-scientific papers? This one is trully shameful, scientifically incorrect, not substantiated by primary data, written by a bunch of conspiracy activists.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
Secondary effects have reduced in the years after the pandemic, and are now at background levels.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3d
Enduring Outcomes of COVID-19 Work Absences on the US Labor Market

Much is made of this, the "COVID kills us all" crowd is up in arms agatin. What does the paper actually show?

jamanetwork.com/jour...
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
Health and lifespan are now higher than before the pandemic.
bsky.app/profile/mar...

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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1d
Health progress in a post-COVID-19 world

This will be difficult reading for some....
The good news is that populations are healthier overall.

www.thelancet.com/jo...
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Health progress in a post-COVID-19 world
The COVID-19 pandemic upended global mortality and morbidity. COVID-19 was ranked as the number one age-standardised cause of death globally in 2021 but by 2023 had dropped to the 20th cause of death among all leading global causes, replaced by ischaemic heart disease and stroke as the two leading causes of death. During the COVID-19 pandemic, disability-adjusted life-years (DALYs) due to infectious, maternal, neonatal, and nutritional diseases all increased, but have since returned to pre-pandemic levels.
www.thelancet.com
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
These science-undermining papers do everyone a disservice. The content is clearly incorrect, the message is false, but it can cause panic and a high level of concern; those who do suffer from the consequences of SC2 will be taken less and less seriously due to this nonsense.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
it is your immune system responding to an invasion with a virus, bacteria, fungus or parasite.

This "narrative review" does not examine anything; it cherry picks, twists and overinterprets things the authors clearly are ill equiped for to understand.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
There is no "Tissue reservoir persistence drives long-term damage" after SARS-CoV-2 infection, etc.

The absence of any knowledge by the authors starts with the statement that both SC2 and HIV infections start with cold-like symptoms. Indeed, so do nearly all infections:
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
The arguments do not hold. SARS-CoV-2 is not a cronic infection, coronaviruses are not retro-, papiloma- or herpes-viruses. SARS-CoV-2 does not result in dysfunction, exhaustion, depletion or damage of "the immune system", this means you do not understand how it works.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1h
Truly bizarre how a bunch of non-specialists club together under the cosplay banner of the WHN, and push out anti-science pulp.

@ajpmonline.bsky.social
@ajpmfocus.bsky.social

Comparing SARS-CoV-2 with HIV and COVID-19 with AIDS is bizarre, false and harmful.

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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
Part of the earlier outbreak may be mass tourism such as from Australia and New Zealand, which saw a peak of H3N2 Influenza A at the end of their winter. Changes in climate and reduced exposure to this circulating variant are other explanations.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
Outbreaks are classified as epidemics when the number of infections is higher than expected in a given area over a particular period of time. This happens frequently with Influenza, mainly during winter in temperate climates. The young and the elderly are the risk groups.

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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
"As of 10 October, 6,013 cases of influenza virus have been reported in Japan. More than 100 schools have closed, and nearly half of the 287 people who were hospitalized for flu in September were children aged 14 or younger."
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
Japan declares a flu epidemic — what this means for other nations

Researchers say that the number of infections for this time of year is unusual (November is usual), it is unlikely to become a global pandemic.

www.nature.com/artic...
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Japan declares a flu epidemic — what this means for other nations
Nature - Researchers say that the number of infections for this time of year is unusual.
www.nature.com
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
This is particularly required after T cell receptor activation, required to dampen proximal signalling events. If this does not happen, Th17 cells show enhance cytokine production. High levels of IL-22 result in itestinal lipid malabsorption.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
The reason is an increase in Th17 cells, the CD4 T cells known for fighting extracellular pathogens, but also for maintaining the epithelial barier via their production of IL-22. Aster-A is required to maintain plasma membrane cholesterol homeostasis in TH17 cells.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
In mice in which T cells are lacking Aster (CD4-Cre), which moves cholesterol from the plasma membrabne to the ER, dietary fatty acid absorption is decreased. Mice with Aster-deficiency in only T cells were resistant to obesity due to a high fat diet.
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marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 3h
T cell cholesterol transport links intestinal immune responses to dietary lipid absorption

T cells can influence many things, inlcuding the absorption of fat in the intestine.

www.science.org/doi/...
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T cell cholesterol transport links intestinal immune responses to dietary lipid absorption
The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A linked plasma membrane (PM) cholesterol availability in ...
www.science.org
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Reposted by Marc Veldhoen
marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1d
A rediculously huge overinterpretation of biology, looking at a very small sample, high heterogeneity, and some transcriptional noise or tail of physiological epithelial repair processes..... Really, really terrible these accounts.

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Reposted by Marc Veldhoen
marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 2d
Antivaxxers are faced with an overwhelming amount of data, evidence, that shows their claims are very wrong. So they have to claim conspiracy and government involvement.

Covid19 doomers are similar. They use the same arguments, can't read papers, cherry-pick, twist data, and
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Reposted by Marc Veldhoen
marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1d
Health progress in a post-COVID-19 world

This will be difficult reading for some....
The good news is that populations are healthier overall.

www.thelancet.com/jo...
1/4
Health progress in a post-COVID-19 world
The COVID-19 pandemic upended global mortality and morbidity. COVID-19 was ranked as the number one age-standardised cause of death globally in 2021 but by 2023 had dropped to the 20th cause of death among all leading global causes, replaced by ischaemic heart disease and stroke as the two leading causes of death. During the COVID-19 pandemic, disability-adjusted life-years (DALYs) due to infectious, maternal, neonatal, and nutritional diseases all increased, but have since returned to pre-pandemic levels.
www.thelancet.com
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Reposted by Marc Veldhoen
marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1d
There is no evidence; all the data show it isn´t true. Paracetamol or vaccines do not cause or contribute to autism..... but since it is an ideology to think this, they will "make up" their "evidence", and fool many, yet again.
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Reposted by Marc Veldhoen
marcveld.bsky.social
Marc Veldhoen @marcveld.bsky.social · 1d
COVID-19 has been fashionable in research, which happens with many subjects draing attention. Every (sub)field wants to tie its findings to SARS-CoV-2 and its favourate system or cell type. Some of it is interesting and important to know/understand. But much of it… isn’t.
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