Journal of Experimental Medicine
@jem.org
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jem
🌐 rupress.org/jem
Monogenic disorders of the IRF transcription factors. New review from Mattison Stojcic, Pariya Yousefi, Catherine Biggs, and Stuart Turvey @turveylab.bsky.social: rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity #InbornErrorsOfImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity #InbornErrorsOfImmunity
November 28, 2025 at 8:45 PM
Monogenic disorders of the IRF transcription factors. New review from Mattison Stojcic, Pariya Yousefi, Catherine Biggs, and Stuart Turvey @turveylab.bsky.social: rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity #InbornErrorsOfImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity #InbornErrorsOfImmunity
SLC7A8 is essential for metabolic fitness and function of Th2 cells, say Santosh Panda, Marco Colonna and colleagues @washumedicine.bsky.social: rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
November 28, 2025 at 3:30 PM
SLC7A8 is essential for metabolic fitness and function of Th2 cells, say Santosh Panda, Marco Colonna and colleagues @washumedicine.bsky.social: rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
New study by Tam et al. (rupress.org/jem/article/...) reveals that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells (cDC1s). Insights from Bosteels, Stainier, and @reisesousalab.bsky.social: rupress.org/jem/article/...
November 27, 2025 at 8:30 PM
New study by Tam et al. (rupress.org/jem/article/...) reveals that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells (cDC1s). Insights from Bosteels, Stainier, and @reisesousalab.bsky.social: rupress.org/jem/article/...
Abdelaal, Gherardin, Rossjohn, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
November 26, 2025 at 6:45 PM
Abdelaal, Gherardin, Rossjohn, @waelawad.bsky.social et al show that host-generated riboflavin breakdown products can bind to the immune protein MR1. Unlike microbial vitamin B precursors, these compounds reduce MR1 surface levels & may dampen #MAIT cell immune activation rupress.org/jem/article/...
Kurz, Lütge, Ludewig et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
November 26, 2025 at 6:02 PM
Kurz, Lütge, Ludewig et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
Reposted by Journal of Experimental Medicine
Excited to share our new paper in
@jem.org! 🎉
We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno
🧵👇1/6
@jem.org! 🎉
We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno
🧵👇1/6
Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
November 25, 2025 at 10:03 PM
New report from Zhou et al. (rupress.org/jem/article/...) provides important new insights into the genotype–phenotype correlation and the molecular pathogenesis of essential #thrombocythemia. Insights by Skoda and Silvennoinen: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
November 25, 2025 at 8:15 PM
New report from Zhou et al. (rupress.org/jem/article/...) provides important new insights into the genotype–phenotype correlation and the molecular pathogenesis of essential #thrombocythemia. Insights by Skoda and Silvennoinen: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
November 25, 2025 at 7:00 PM
Hernández-García, Iborra and colleagues show that #plasmacytoid dendritic cells amplify the response of tissue-resident memory CD8⁺ T cells (#Trm) during viral reinfection, enhancing local #antiviral protection. rupress.org/jem/article/...
#MucosalImmunology
#MucosalImmunology
Hanson Tam, Jason Cyster et al. identify GPR34 as a receptor required for cDC1 efferocytosis and cross-presentation and suggest a model where PLA1A catabolizes phosphatidylserine on apoptotic cells to generate GPR34 ligands. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
November 24, 2025 at 7:45 PM
Hanson Tam, Jason Cyster et al. identify GPR34 as a receptor required for cDC1 efferocytosis and cross-presentation and suggest a model where PLA1A catabolizes phosphatidylserine on apoptotic cells to generate GPR34 ligands. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
#InnateImmunity #inflammation
@hhmi.org
✍️ 💻 JEM's latest #CME activity @mskcme.bsky.social is now available! New content 📄: “Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis (Zhou et al. doi.org/10.1084/jem....
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
November 24, 2025 at 3:15 PM
✍️ 💻 JEM's latest #CME activity @mskcme.bsky.social is now available! New content 📄: “Heterozygous human JAK2V617F activates AhR to drive essential thrombocythemia and promote thrombosis (Zhou et al. doi.org/10.1084/jem....
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
Begin the CME here 👉 mskcc.cloud-cme.com/course/cours...
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
November 21, 2025 at 8:15 PM
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
Reposted by Journal of Experimental Medicine
📢📢NEW PAPER📢📢
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
November 21, 2025 at 5:51 PM
📢📢NEW PAPER📢📢
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Sequencing has greatly accelerated the number of known human genetic immune disorders--we immunologists call them 'inborn errors of immunity'.
This review in @jem.org is our attempt to summarize all the described single gene defects affecting the IRF family of transcription factors.
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
November 21, 2025 at 5:45 PM
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
Panda et al. of the Colonna lab identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
November 21, 2025 at 5:01 PM
Panda et al. of the Colonna lab identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
#SfN25
#SfN25
November 21, 2025 at 3:30 PM
ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
#SfN25
#SfN25
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
November 20, 2025 at 7:45 PM
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
AC/DC: Highway to Cell. Victor Bosteels (@victor-bosteels.bsky.social), William Stainier, and Caetano Reis e Sousa (@reisesousalab.bsky.social) @crick.ac.uk discuss work by Tam et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#InnateImmunity #DendriticCells
#InnateImmunity #DendriticCells
November 20, 2025 at 3:30 PM
AC/DC: Highway to Cell. Victor Bosteels (@victor-bosteels.bsky.social), William Stainier, and Caetano Reis e Sousa (@reisesousalab.bsky.social) @crick.ac.uk discuss work by Tam et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#InnateImmunity #DendriticCells
#InnateImmunity #DendriticCells
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS), investigating how normal hematopoietic #StemCells develop into cancerous cells, as well as developing targeted therapies for MDS patients. We spoke to Esther for our latest #PeopleAndIdeas: rupress.org/jem/article/...
November 19, 2025 at 8:15 PM
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS), investigating how normal hematopoietic #StemCells develop into cancerous cells, as well as developing targeted therapies for MDS patients. We spoke to Esther for our latest #PeopleAndIdeas: rupress.org/jem/article/...
@vinitiwari1.bsky.social & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 19, 2025 at 4:15 PM
@vinitiwari1.bsky.social & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 19, 2025 at 4:15 PM
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
New findings from Bauer, Halin et al. @ethz.ch reveal key differences between human and murine dermal afferent #lymphatics and provide a deeper understanding of human lymphatic-related (patho)physiological processes: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation
#CardiovascularBiology #InnateImmunity #inflammation
November 18, 2025 at 7:45 PM
New findings from Bauer, Halin et al. @ethz.ch reveal key differences between human and murine dermal afferent #lymphatics and provide a deeper understanding of human lymphatic-related (patho)physiological processes: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation
#CardiovascularBiology #InnateImmunity #inflammation
In this review, Lennol, @maudgratuze.bsky.social et al. assess all the available evidence regarding how two crucial elements are intertwined in #Alzheimers disease pathophysiology: tau and apoE. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 18, 2025 at 4:15 PM
In this review, Lennol, @maudgratuze.bsky.social et al. assess all the available evidence regarding how two crucial elements are intertwined in #Alzheimers disease pathophysiology: tau and apoE. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 18, 2025 at 3:45 PM
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote #thrombocytosis. Radek Skoda and Olli Silvennoinen (@bcmhouston.bsky.social) highlight new work from the Bo Huang group (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
November 18, 2025 at 3:45 PM
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote #thrombocytosis. Radek Skoda and Olli Silvennoinen (@bcmhouston.bsky.social) highlight new work from the Bo Huang group (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Papadopoulos, Kipnis et al. present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 17, 2025 at 4:15 PM
Papadopoulos, Kipnis et al. present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25