Journal of Experimental Medicine
@jem.org
Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, and neurobiology research. Published by Rockefeller University Press @rupress.org
🌐 rupress.org/jem
🌐 rupress.org/jem
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
November 21, 2025 at 8:15 PM
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
November 21, 2025 at 5:45 PM
Stojcic et al. @turveylab.bsky.social review the biology and clinical features of inborn errors of IRFs, a group of monogenic disorders affecting the IRF family of transcription factors. rupress.org/jem/article/...
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
#Immunodeficiency #HumanDiseaseGenetics #GenesAndImmunity
Panda et al. of the Colonna lab identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
November 21, 2025 at 5:01 PM
Panda et al. of the Colonna lab identify SLC7A8 as a Th2-specific amino acid transporter essential for Th2 proliferation, cytokine production, and type 2 immunity. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies
ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
#SfN25
#SfN25
November 21, 2025 at 3:30 PM
ICYMI: Read the latest #neuroscience research in JEM! The collection highlights the latest discoveries in meningeal #lymphatics, #pain, #neurodegeneration, #tauopathy, and #MultipleSclerosis. 👉 rupress.org/jem/collecti...
#SfN25
#SfN25
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
November 20, 2025 at 7:45 PM
Chen, Weichselbaum et al. @ludwigcancer.bsky.social discover that YTHDF2 in #DendriticCells negatively regulates antitumor immunity of #radiotherapy (RT), providing a clinically actionable strategy to overcome RT resistance and #metastasis. rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
AC/DC: Highway to Cell. Victor Bosteels (@victor-bosteels.bsky.social), William Stainier, and Caetano Reis e Sousa (@reisesousalab.bsky.social) @crick.ac.uk discuss work by Tam et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#InnateImmunity #DendriticCells
#InnateImmunity #DendriticCells
November 20, 2025 at 3:30 PM
AC/DC: Highway to Cell. Victor Bosteels (@victor-bosteels.bsky.social), William Stainier, and Caetano Reis e Sousa (@reisesousalab.bsky.social) @crick.ac.uk discuss work by Tam et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#InnateImmunity #DendriticCells
#InnateImmunity #DendriticCells
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS), investigating how normal hematopoietic #StemCells develop into cancerous cells, as well as developing targeted therapies for MDS patients. We spoke to Esther for our latest #PeopleAndIdeas: rupress.org/jem/article/...
November 19, 2025 at 8:15 PM
Esther Obeng leads a research group focused on myelodysplastic syndromes (MDS), investigating how normal hematopoietic #StemCells develop into cancerous cells, as well as developing targeted therapies for MDS patients. We spoke to Esther for our latest #PeopleAndIdeas: rupress.org/jem/article/...
@vinitiwari1.bsky.social & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 19, 2025 at 4:15 PM
@vinitiwari1.bsky.social & Mikael Simons review the relationship between lipid #metabolism & CNS #inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 19, 2025 at 4:15 PM
Final day at #SfN25! If you're in San Diego, stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
New findings from Bauer, Halin et al. @ethz.ch reveal key differences between human and murine dermal afferent #lymphatics and provide a deeper understanding of human lymphatic-related (patho)physiological processes: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation
#CardiovascularBiology #InnateImmunity #inflammation
November 18, 2025 at 7:45 PM
New findings from Bauer, Halin et al. @ethz.ch reveal key differences between human and murine dermal afferent #lymphatics and provide a deeper understanding of human lymphatic-related (patho)physiological processes: rupress.org/jem/article/...
#CardiovascularBiology #InnateImmunity #inflammation
#CardiovascularBiology #InnateImmunity #inflammation
In this review, Lennol, @maudgratuze.bsky.social et al. assess all the available evidence regarding how two crucial elements are intertwined in #Alzheimers disease pathophysiology: tau and apoE. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 18, 2025 at 4:15 PM
In this review, Lennol, @maudgratuze.bsky.social et al. assess all the available evidence regarding how two crucial elements are intertwined in #Alzheimers disease pathophysiology: tau and apoE. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
November 18, 2025 at 3:45 PM
Attending #SfN25 in San Diego? Stop by @rupress.org booth #3719 to discuss your research and our journal! Don't forget to pick up our #Neuroscience Collection magazine 📚 We look forward to meeting you! 💬 💡
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote #thrombocytosis. Radek Skoda and Olli Silvennoinen (@bcmhouston.bsky.social) highlight new work from the Bo Huang group (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
November 18, 2025 at 3:45 PM
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote #thrombocytosis. Radek Skoda and Olli Silvennoinen (@bcmhouston.bsky.social) highlight new work from the Bo Huang group (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...
#Hematopoiesis
#Hematopoiesis
Papadopoulos, Kipnis et al. present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 17, 2025 at 4:15 PM
Papadopoulos, Kipnis et al. present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Attending #SfN25 in San Diego? Visit @rupress.org booth #3719 to chat about the journal and pick up our #Neuroscience Collection magazine 📚 as well as an exclusive pouch! 🎁 We look forward to meeting you! 💬 💡
November 17, 2025 at 3:00 PM
Attending #SfN25 in San Diego? Visit @rupress.org booth #3719 to chat about the journal and pick up our #Neuroscience Collection magazine 📚 as well as an exclusive pouch! 🎁 We look forward to meeting you! 💬 💡
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells is promoted by GPR34 and lysophosphatidylserine, say Hanson Tam, Jason Cyster and colleagues: rupress.org/jem/article/...
#InnateImmunity #inflammation
@HHMI.org
#InnateImmunity #inflammation
@HHMI.org
November 17, 2025 at 2:30 PM
Splenic cDC1 efferocytosis and cross-presentation to CD8 T cells is promoted by GPR34 and lysophosphatidylserine, say Hanson Tam, Jason Cyster and colleagues: rupress.org/jem/article/...
#InnateImmunity #inflammation
@HHMI.org
#InnateImmunity #inflammation
@HHMI.org
@jengommerman.bsky.social lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/...
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
November 16, 2025 at 4:15 PM
@jengommerman.bsky.social lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/...
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
Antunes, Zamponi et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 15, 2025 at 4:15 PM
Antunes, Zamponi et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
✍️ 💻 What’s a Journal-Based #CME activity? A full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME activity in collaboration with @mskcme.bsky.social is NOW available 👉 mskcc.cloud-cme.com/course/cours...
November 14, 2025 at 8:15 PM
✍️ 💻 What’s a Journal-Based #CME activity? A full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our latest CME activity in collaboration with @mskcme.bsky.social is NOW available 👉 mskcc.cloud-cme.com/course/cours...
#Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. From Frolov, @haohuang0086.bsky.social, Stumm, @masslab.bsky.social, Beyer et al.: rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 14, 2025 at 4:15 PM
#Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. From Frolov, @haohuang0086.bsky.social, Stumm, @masslab.bsky.social, Beyer et al.: rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
New findings from Bissett, Lambe et al. @ovg.ox.ac.uk support further testing of mucosal booster vaccines against respiratory viruses, particularly as a means of simultaneously overcoming deleterious immunological imprinting and enhancing mucosal responses. rupress.org/jem/article/...
#SARSCoV2
#SARSCoV2
November 13, 2025 at 7:45 PM
New findings from Bissett, Lambe et al. @ovg.ox.ac.uk support further testing of mucosal booster vaccines against respiratory viruses, particularly as a means of simultaneously overcoming deleterious immunological imprinting and enhancing mucosal responses. rupress.org/jem/article/...
#SARSCoV2
#SARSCoV2
Insights: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
November 13, 2025 at 5:03 PM
Insights: Bosteels, Stainier, and @reisesousalab.bsky.social highlight work by Tam et al. (rupress.org/jem/article/...) revealing that GPR34, a lysophosphatidylserine receptor, promotes apoptotic cell uptake and cross-presentation by type 1 #DendriticCells. rupress.org/jem/article/...
Chatterjee, Zeiser et al. report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activation and T cell infiltration. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 13, 2025 at 4:15 PM
Chatterjee, Zeiser et al. report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activation and T cell infiltration. rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
New findings from the Shiyang Li group highlight the role of unfolded protein response in sensing gut environment to regulate ILC2 function and suggest folate-mediated 1C metabolism as a potential target for #UlcerativeColitis therapy. rupress.org/jem/article/...
#MucosalImmunology #IBD
#MucosalImmunology #IBD
November 13, 2025 at 3:31 PM
New findings from the Shiyang Li group highlight the role of unfolded protein response in sensing gut environment to regulate ILC2 function and suggest folate-mediated 1C metabolism as a potential target for #UlcerativeColitis therapy. rupress.org/jem/article/...
#MucosalImmunology #IBD
#MucosalImmunology #IBD
#Radiotherapy induces YTHDF2 in #DendriticCells impairing cross-presentation and T cell function, say Dapeng Chen, Chuan He, Hua Laura Liang, Ralph Weichselbaum @ludwigcancer.bsky.social and colleagues: rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors
November 13, 2025 at 3:30 PM
#Radiotherapy induces YTHDF2 in #DendriticCells impairing cross-presentation and T cell function, say Dapeng Chen, Chuan He, Hua Laura Liang, Ralph Weichselbaum @ludwigcancer.bsky.social and colleagues: rupress.org/jem/article/...
#TumorImmunology #SolidTumors
#TumorImmunology #SolidTumors