Etienne Becht
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ebecht.bsky.social
Etienne Becht
@ebecht.bsky.social
510 followers 660 following 7 posts

Computational immunologist. Interested in immunooncology, cytometry, single cell data, spatial data, T and B cell specificities...

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Biology 56%
Medicine 40%
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Reposted by Jonathan A. Eisen, Brian A. Nosek, Gavin L. Foster , and 22 more

theo.io
Theo Sanderson @theo.io · 2d
I made a map of 3.4 million Bluesky users - see if you can find yourself!

bluesky-map.theo.io

I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail
Bluesky Map
Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.
bluesky-map.theo.io

Reposted by Étienne Becht

shainlab.bsky.social
Hunter Shain @shainlab.bsky.social · 14d
I am just reading this paper, and it is absolutely wild. Tumor cells acquire mutations in mitochondria, and then transfer them to T-cells, and the mutant mitochondria drives dysfunction in the T-cells?! www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com

Reposted by Étienne Becht

naultjc.bsky.social
naultjc.bsky.social @naultjc.bsky.social · Nov 27
1) We recently published a multicentric study in
cghjournal.org/article/S154...
We analyzed using machine learning an international cohort of 1,399 pts treated for HCC with atezo/bev across 12 centers to uncover clinically meaningful subgroups. @etrepo.bsky.social
The “A-B-C” classification reveals outcome trajectories in patients with hepatocellular carcinoma under atezolizumab/bevacizumab
We aimed to identify subgroups of patients with unresectable hepatocellular carcinoma (HCC) using a non‐a priori, data‐driven machine learning approach to uncover subgroups with distinct profiles acro...
cghjournal.org

Reposted by Étienne Becht

labliston.bsky.social
Adrian Liston @labliston.bsky.social · Nov 20
An education in tolerance: the 2025 Nobel Prize in Physiology or Medicine

journals.biologists.com/dmm/article/...

Reposted by Étienne Becht

davidusharauli.bsky.social
David Usharauli @davidusharauli.bsky.social · Nov 19
As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.

#immunology
#science
#tumor
#immunotherapy

buff.ly/pETJPEH
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com

ebecht.bsky.social
Etienne Becht @ebecht.bsky.social · Oct 30
Thanks, will try it ! We use cells for unstained/autofluorescence and viability, for the other markers we use beads

ebecht.bsky.social
Etienne Becht @ebecht.bsky.social · Oct 30
Thanks a lot for the informative thread! Looks very exciting

Are single stained cellular controls necessary or only better ? We are using rare human samples so it's difficult to cells for single color controls, can we still hope to see improvements with AutoSpectral unmixing ?

Reposted by Étienne Becht

labliston.bsky.social
Adrian Liston @labliston.bsky.social · Oct 28
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

Reposted by Étienne Becht

iannaconelab.bsky.social
Iannacone Lab @iannaconelab.bsky.social · Sep 26
🧵 (1/2) Interested in tertiary lymphoid structures (TLSs)? Check out our latest review, where we chart how TLSs form across organs and contexts — from lung to liver, CNS, skin, gut & more — and their dual roles in protection vs. pathology.
Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers
Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be....
onlinelibrary.wiley.com

Reposted by Étienne Becht

nature.com
Nature @nature.com · Sep 5
Nature research paper: One mother for two species via obligate cross-species cloning in ants

go.nature.com/45PYV6d
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same mother having distinct genomes and morphologies.
go.nature.com

Reposted by Étienne Becht

ritastrack.bsky.social
Rita Strack @ritastrack.bsky.social · Apr 10
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

ebecht.bsky.social
Etienne Becht @ebecht.bsky.social · Mar 11
🧪💻 We're hiring ! Post-doctoral position open for a data scientist

👉 Come work with us on high-throughput single cell protein expression data : drive.google.com/file/d/1w8Zv...

Reposted by Kevin F. McCarthy, Robbie Gilligan, Ankur Pandya , and 3 more

dkthomp.bsky.social
Derek Thompson @dkthomp.bsky.social · Feb 27
Unbelievable news.

Pancreatic is one of the deadliest cancers.

New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.

www.nature.com/articles/s41...

ebecht.bsky.social
Etienne Becht @ebecht.bsky.social · Feb 23
6. found just enough strength to relay dread while being funny

That is no tiny victory.

I hope you find support until you are strong enough to support those who need it !

Reposted by Étienne Becht

niclag.bsky.social
Nicole La Gruta @niclag.bsky.social · Feb 21
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org

ebecht.bsky.social
Etienne Becht @ebecht.bsky.social · Feb 20
Flow cytometry batch effect correction without requiring normalization controls 🤩
onlinelibrary.wiley.com/doi/full/10....
CytoNorm 2.0: A flexible normalization framework for cytometry data without requiring dedicated controls
Cytometry is a single cell, high-dimensional, high-throughput technique that is being applied across a range of disciplines. However, many elements alongside the data acquisition process might give r...
onlinelibrary.wiley.com

Reposted by Étienne Becht

carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 18
Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes.

www.biorxiv.org/content/10.1...
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters
The cell surface is a dynamic interface that controls cell-cell communication and signal transduction relevant to organ development, homeostasis and repair, immune reactivity, and pathologies driven b...
www.biorxiv.org

Reposted by Thomas R. Cox, Étienne Becht

Reposted by Étienne Becht

hipcproject.bsky.social
HIPC @hipcproject.bsky.social · Feb 17
Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...
tagtango: an application to compare single-cell annotations
AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c
academic.oup.com

Reposted by Étienne Becht

follicular.bsky.social
Alexander Dent @follicular.bsky.social · Feb 13
So THAT'S what Granzyme K does-- cleave complement and promote inflammation in the airway. Fascinating!
#ImmunoSky #AsthmaSky
#InflammationSky
www.nature.com/articles/s41...
GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases - Nature
Comparing T cells in nasal polyps from repeated surgeries shows that effector memory-like persistent clones colonize the mucosal tissue during disease recurrence and promote inflammation by producing ...
www.nature.com

Reposted by Étienne Becht

cancerparisnord.bsky.social
Institut du Cancer AP-HP. Nord @cancerparisnord.bsky.social · Jan 23
La FHU* MOSAIC² relabellisée pour 5 ans !

Félicitations à la Pr Valérie Paradis et ses équipes qui portent ce FHU, illustrant l’engagement de l'Institut du Cancer en faveur de la recherche !

Plus d'informations sur le projet prochainement.

@hopitalbeaujon.bsky.social @ap-hp.bsky.social

Reposted by Étienne Becht

acir-org.bsky.social
ACIR @acir-org.bsky.social · Jan 16
Luo et al. developed ATLAS-seq (Aptamer-based T-Lymphocyte Activity Screening and Sequencing), a microfluidic-based high-throughput platform for isolating and profiling antigen-reactive T cells. bit.ly/4fThnwo

Reposted by Étienne Becht

labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Jan 15
Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org‪
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....

ebecht.bsky.social
Etienne Becht @ebecht.bsky.social · Jan 7
Permanent position (research and teaching) for a bioinformatician immunologist available in a great lab and institute, in a beautiful campus in the center of Paris

www.linkedin.com/posts/isabel...
Isabelle Cremer on LinkedIn: Poste MCU immunologie-bioinformatique
Un poste de maître de conférences en immunologie-bioinformatique est ouvert au concours à Sorbonne Université, au sein de la Faculté des Sciences et…
www.linkedin.com

Reposted by Étienne Becht

jsantoyo.bsky.social
Javier Santoyo @jsantoyo.bsky.social · Dec 19
Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references. #GenomeAssembly #HaplotypeResolved #Pangenomes #Genomics #GenomeBiology 🧬 🖥️
genomebiology.biomedcentral.com/articles/10....
Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references - Genome Biology
Background Long-read technologies from Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) have transformed genomics research by providing diverse data types like HiFi, Duplex, and ult...
genomebiology.biomedcentral.com

Reposted by Andreas J. Bäumler, Étienne Becht

mfgrp.bsky.social
Michael Fischbach @mfgrp.bsky.social · Dec 11
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Reposted by Rémy Nicolle

ebecht.bsky.social
Etienne Becht @ebecht.bsky.social · Dec 10
🌟 Calling all computational biology enthusiasts! 🌟 The awesome @remynicolle.bsky.social & friends created this Discord community to connect, collaborate, and share insights in this rapidly evolving field.

👉 Click here to join : discord.gg/2PzSE4dC

#Bioinformatics #ComputationalBiology

Reposted by Étienne Becht

Reposted by Étienne Becht

tmontsay.bsky.social
Tomàs Montserrat Ayuso @tmontsay.bsky.social · Dec 3

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com

Reposted by Étienne Becht