December 2, 2025 at 11:25 PM
🧵New observational study:
Starting metformin within 6 days of COVID was linked to half the long COVID risk compared with patients given other meds (fluvoxamine, fluticasone, ivermectin, montelukast): 4.0% vs 8.5% (aRR 0.47). Small study, but aligns with #BlueSky #MedSky #NewsSky #IDSky #SciSky 1/2
Starting metformin within 6 days of COVID was linked to half the long COVID risk compared with patients given other meds (fluvoxamine, fluticasone, ivermectin, montelukast): 4.0% vs 8.5% (aRR 0.47). Small study, but aligns with #BlueSky #MedSky #NewsSky #IDSky #SciSky 1/2
Metformin at the time of Covid-19 infection and risk of Long Covid: A Target Trial Emulation Study
Background: Our objective was to evaluate metformin prescribed at the time of SARS-CoV-2 infection on the risk of developing Long Covid (LC) in electronic health record data. Methods: We conducted a n...
shorturl.at
November 30, 2025 at 7:46 PM
Our paper is out in @natcomms.nature.com 🧵
We estimated key epidemiological parameters for scabies, a disease affecting 400M people globally that's been rising across Europe. These are the first estimates of serial interval, R0 and Rt.
www.nature.com/articles/s41...
#AcademicSky #EpiSky #IDSky
We estimated key epidemiological parameters for scabies, a disease affecting 400M people globally that's been rising across Europe. These are the first estimates of serial interval, R0 and Rt.
www.nature.com/articles/s41...
#AcademicSky #EpiSky #IDSky
Estimation of the epidemiological characteristics of scabies - Nature Communications
Scabies is a common cause of skin disease in many low- and middle-income countries and incidence is increasing in Europe, but key epidemiological parameters are not well defined. Here, the authors use...
www.nature.com
November 28, 2025 at 3:57 AM
Our paper is out in @natcomms.nature.com 🧵
We estimated key epidemiological parameters for scabies, a disease affecting 400M people globally that's been rising across Europe. These are the first estimates of serial interval, R0 and Rt.
www.nature.com/articles/s41...
#AcademicSky #EpiSky #IDSky
We estimated key epidemiological parameters for scabies, a disease affecting 400M people globally that's been rising across Europe. These are the first estimates of serial interval, R0 and Rt.
www.nature.com/articles/s41...
#AcademicSky #EpiSky #IDSky
Very pleased to plug our latest preprint, lead author @microberamon.bsky.social - fantastic collaboration with labs of Dario Carugo (Oxford) and Martha Clokie (Leicester) https:// - and others #UTISKy #UTI #IDSky #MicroSky www.biorxiv.org/content/10.1101/2025.11.12.688052v1 more below👇🧵
Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli
Urinary tract infections (UTI) remain a major global health burden, with high recurrence despite antibiotic treatment. The escalating prevalence of antimicrobial resistance further compromises therape...
www.biorxiv.org
November 13, 2025 at 9:20 AM
Very pleased to plug our latest preprint, lead author @microberamon.bsky.social - fantastic collaboration with labs of Dario Carugo (Oxford) and Martha Clokie (Leicester) https:// - and others #UTISKy #UTI #IDSky #MicroSky www.biorxiv.org/content/10.1101/2025.11.12.688052v1 more below👇🧵
I will try to do a tweetorial about this paper when I have more energy but this is really important data. It looks (tentatively, preliminarily) that COVID-19 mRNA vaccines might significantly enhance the effectiveness of cancer immunotherapy (subject to many caveats).
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
Nature - mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
rdcu.be
October 25, 2025 at 5:53 PM
How do we have productive abx stewardship conversations?
Like many successful interventions, they take planning and thought, and it helps to use an evidence-based structure.
* Advocacy
* Inquiry
* Listen
* Teach
Alyssa Y Castillo, som.cuanschutz.edu/Profiles/Fac... #IDWeek #IDSky
🧵1/3
Like many successful interventions, they take planning and thought, and it helps to use an evidence-based structure.
* Advocacy
* Inquiry
* Listen
* Teach
Alyssa Y Castillo, som.cuanschutz.edu/Profiles/Fac... #IDWeek #IDSky
🧵1/3
October 20, 2025 at 12:58 PM
How do we have productive abx stewardship conversations?
Like many successful interventions, they take planning and thought, and it helps to use an evidence-based structure.
* Advocacy
* Inquiry
* Listen
* Teach
Alyssa Y Castillo, som.cuanschutz.edu/Profiles/Fac... #IDWeek #IDSky
🧵1/3
Like many successful interventions, they take planning and thought, and it helps to use an evidence-based structure.
* Advocacy
* Inquiry
* Listen
* Teach
Alyssa Y Castillo, som.cuanschutz.edu/Profiles/Fac... #IDWeek #IDSky
🧵1/3
/1 Short thread 🧵 on new LANCET lNFECTIOUS DISEASES paper examining whether COVID-19 increases future risk of other infections
Findings indicate that SARS-CoV-2 can leave behind more than fatigue/brain fog—it also seems to impair immune defenses
#IDSky #LongCOVID
www.thelancet.com/journals/lan...
Findings indicate that SARS-CoV-2 can leave behind more than fatigue/brain fog—it also seems to impair immune defenses
#IDSky #LongCOVID
www.thelancet.com/journals/lan...
April 3, 2025 at 10:12 AM
/1 Short thread 🧵 on new LANCET lNFECTIOUS DISEASES paper examining whether COVID-19 increases future risk of other infections
Findings indicate that SARS-CoV-2 can leave behind more than fatigue/brain fog—it also seems to impair immune defenses
#IDSky #LongCOVID
www.thelancet.com/journals/lan...
Findings indicate that SARS-CoV-2 can leave behind more than fatigue/brain fog—it also seems to impair immune defenses
#IDSky #LongCOVID
www.thelancet.com/journals/lan...
Viral persistence is a complex phenomenon observed in several viruses, particularly those from the herpes family. These viruses can enter a latent state, evading detection by the innate immune system through mechanisms that aren't fully understood.
December 4, 2024 at 7:42 AM
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
buff.ly
January 2, 2025 at 8:03 AM
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
So, this bloot about my paper blew up. Most common reaction: Duh! You need proof that masking in hospitals works?
The reality: Yes, many healthcare epidemiologists, including CDC advisors, have advocated for weaker guidance on masking and testing. Read on... 1/🧵 #IDSky #MedSky
The reality: Yes, many healthcare epidemiologists, including CDC advisors, have advocated for weaker guidance on masking and testing. Read on... 1/🧵 #IDSky #MedSky
When the mask mandate was lifted from Mass General Brigham in May '23, hospital transmission of resp virus went up. When the mandate was re-instituted in Jan '24, infection rates went down. www.news-medical.net/news/2024052...
Study confirms face masks' effectiveness in reducing disease transmission, calls for improved public understanding
Researchers reviewed the benefits, practicalities, and harms of masks and masking, finding that masks are effective in reducing respiratory disease transmission despite some adverse effects, and empha...
www.news-medical.net
November 29, 2024 at 9:14 PM
As the plot shows, there was an immediate increase in the ratio of hospital-onset to community-onset respiratory viral infections when masking/testing stopped: without adjustment, 7.6% → 15.5% (13.6-17.4%).
In an adjusted model, the rate ratio was 1.25 (1.02-1.53) 7/🧵 #IDSky
In an adjusted model, the rate ratio was 1.25 (1.02-1.53) 7/🧵 #IDSky
November 28, 2024 at 8:27 PM
As the plot shows, there was an immediate increase in the ratio of hospital-onset to community-onset respiratory viral infections when masking/testing stopped: without adjustment, 7.6% → 15.5% (13.6-17.4%).
In an adjusted model, the rate ratio was 1.25 (1.02-1.53) 7/🧵 #IDSky
In an adjusted model, the rate ratio was 1.25 (1.02-1.53) 7/🧵 #IDSky
There’s still a lot to do for stewies in transplant units!
In this table, we propose some future research priorities to optimize antibiotic use in SOT patients.
🔓 www.sciencedirect.com/science/arti...
#IDSky #AMSsky #TxID
🧵(5/6)
In this table, we propose some future research priorities to optimize antibiotic use in SOT patients.
🔓 www.sciencedirect.com/science/arti...
#IDSky #AMSsky #TxID
🧵(5/6)
July 13, 2025 at 7:37 AM
There’s still a lot to do for stewies in transplant units!
In this table, we propose some future research priorities to optimize antibiotic use in SOT patients.
🔓 www.sciencedirect.com/science/arti...
#IDSky #AMSsky #TxID
🧵(5/6)
In this table, we propose some future research priorities to optimize antibiotic use in SOT patients.
🔓 www.sciencedirect.com/science/arti...
#IDSky #AMSsky #TxID
🧵(5/6)
The absolute risk difference of relapse for oral BL is low (<5%) in most studies pointing this problem, and it didn’t seem to be confirmed in works specifically assessing high-dose oral BL (🧵1/4).
www.clinicalmicrobiologyandinfection.com/article/S119... #UTIsky #AMSsky #IDsky
www.clinicalmicrobiologyandinfection.com/article/S119... #UTIsky #AMSsky #IDsky
Highly versus less bioavailable oral antibiotics in the treatment of gram-negative bloodstream infections: a propensity-matched cohort analysis
In this study, we evaluated the clinical outcomes associated with the use of highly
bioavailable oral antibiotics (fluoroquinolones and trimethoprim-sulfamethoxazole)
compared with the less-bioavailab...
www.clinicalmicrobiologyandinfection.com
July 20, 2025 at 9:48 PM
The absolute risk difference of relapse for oral BL is low (<5%) in most studies pointing this problem, and it didn’t seem to be confirmed in works specifically assessing high-dose oral BL (🧵1/4).
www.clinicalmicrobiologyandinfection.com/article/S119... #UTIsky #AMSsky #IDsky
www.clinicalmicrobiologyandinfection.com/article/S119... #UTIsky #AMSsky #IDsky
Faculty Dr. William M. Stauffer co-led the 2025 International Refugee and Migration Health Conference in Halifax—bringing together 600+ global leaders to address health equity for displaced people. 🧵#IDSky
The Halifax Declaration: protecting health, dignity, and human rights in an era of forced displacement
www.sciencedirect.com
July 30, 2025 at 2:00 PM
Faculty Dr. William M. Stauffer co-led the 2025 International Refugee and Migration Health Conference in Halifax—bringing together 600+ global leaders to address health equity for displaced people. 🧵#IDSky
#Medsky🧪#IDsky #immunosky #publichealth #COVID19 Report
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
November 9, 2025 at 11:04 AM
#Medsky🧪#IDsky #immunosky #publichealth #COVID19 Report
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
🧵 All of this. Speak up. Being quiet isn't going to save you anyway. #idsky 🦠 public health
Weeks ago I highlighted the false balance of “if only scientists could communicate better”.
One OpEd writer kindly reached out to me and I want to share my main response to them because I find it remarkable that people still can’t see what we are now all seeing has been under way for years.
🧵👇
One OpEd writer kindly reached out to me and I want to share my main response to them because I find it remarkable that people still can’t see what we are now all seeing has been under way for years.
🧵👇
February 10, 2025 at 4:05 AM
🧵 All of this. Speak up. Being quiet isn't going to save you anyway. #idsky 🦠 public health
Here’s a "shorter" (😅) tweetorial…why do we use a combination of beta-lactam + vancomycin for cellulitis or MSSA bacteremia?
If vancomycin covers both strep and staph, why not use it alone? Let’s dive in! 🧵 #medsky #pharmsky #EMsky #MedEd #IDsky #AMSky #nursesky
If vancomycin covers both strep and staph, why not use it alone? Let’s dive in! 🧵 #medsky #pharmsky #EMsky #MedEd #IDsky #AMSky #nursesky
maybe we could kill two birds with one stone
ALT: maybe we could kill two birds with one stone
media.tenor.com
February 18, 2025 at 8:59 AM
MedSky🧪IDSky Zooming around a bacteria cell 🧵 by @timd_ca
x.com/timd_ca/stat...
x.com/timd_ca/stat...
October 17, 2023 at 10:57 AM
MedSky🧪IDSky Zooming around a bacteria cell 🧵 by @timd_ca
x.com/timd_ca/stat...
x.com/timd_ca/stat...
Wow this Oster op-ed is so awful and unhelpful for a number of reasons... 🧵
1. She's concerned about telling public health how to do health promotion that she...(checks notes) writes an op-ed for a lay audience. Quite on brand for her in avoiding public health. There's more...
🛟medsky idsky 😷
1/
1. She's concerned about telling public health how to do health promotion that she...(checks notes) writes an op-ed for a lay audience. Quite on brand for her in avoiding public health. There's more...
🛟medsky idsky 😷
1/
Opinion | How to Talk About Fluoride, Vaccines and Raw Milk
How to build trust and make America healthy again.
www.nytimes.com
November 14, 2024 at 12:58 AM
Wow this Oster op-ed is so awful and unhelpful for a number of reasons... 🧵
1. She's concerned about telling public health how to do health promotion that she...(checks notes) writes an op-ed for a lay audience. Quite on brand for her in avoiding public health. There's more...
🛟medsky idsky 😷
1/
1. She's concerned about telling public health how to do health promotion that she...(checks notes) writes an op-ed for a lay audience. Quite on brand for her in avoiding public health. There's more...
🛟medsky idsky 😷
1/
MedSky🧪 #IDSky Efficacy of Antiviral humoral immunity against #SARSCoV2 omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive & XBB-infected individuals
www.thelancet.com/journals/lan...
In details 🧵by @SystemsVirology
x.com/systemsvirol...
www.thelancet.com/journals/lan...
In details 🧵by @SystemsVirology
x.com/systemsvirol...
Antiviral humoral immunity against SARS-CoV-2 omicron subvariants induced by XBB.1.5 monovalent vacc...
To control infection with SARS-CoV-2 omicron XBB subvariants, the XBB.1.5 monovalent
mRNA vaccine has been available since September, 2023. However, we have found that
natural infection with XBB subva...
www.thelancet.com
January 9, 2024 at 6:18 AM
MedSky🧪 #IDSky Efficacy of Antiviral humoral immunity against #SARSCoV2 omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive & XBB-infected individuals
www.thelancet.com/journals/lan...
In details 🧵by @SystemsVirology
x.com/systemsvirol...
www.thelancet.com/journals/lan...
In details 🧵by @SystemsVirology
x.com/systemsvirol...
🧵2/2
Dengue in the EU/EEA: www.ecdc.europa.eu/en/dengue/su...
West Nile virus infections in humans in EU/EEA:
www.ecdc.europa.eu/en/west-nile...
More info: ecdc.europa.eu
#EpiSky #IdSky #VectorBorne #MosquitoBorne #EVD #Dengue #WestNileVirus #Chikungunya #CCHF
Dengue in the EU/EEA: www.ecdc.europa.eu/en/dengue/su...
West Nile virus infections in humans in EU/EEA:
www.ecdc.europa.eu/en/west-nile...
More info: ecdc.europa.eu
#EpiSky #IdSky #VectorBorne #MosquitoBorne #EVD #Dengue #WestNileVirus #Chikungunya #CCHF
Seasonal surveillance of dengue in the EU/EEA
This report gives an overview of the countries and areas where dengue cases – and their corresponding case numbers - have been reported to the European surveillance portal for infectious diseases (Epi...
www.ecdc.europa.eu
August 8, 2025 at 1:05 PM
🧵2/2
Dengue in the EU/EEA: www.ecdc.europa.eu/en/dengue/su...
West Nile virus infections in humans in EU/EEA:
www.ecdc.europa.eu/en/west-nile...
More info: ecdc.europa.eu
#EpiSky #IdSky #VectorBorne #MosquitoBorne #EVD #Dengue #WestNileVirus #Chikungunya #CCHF
Dengue in the EU/EEA: www.ecdc.europa.eu/en/dengue/su...
West Nile virus infections in humans in EU/EEA:
www.ecdc.europa.eu/en/west-nile...
More info: ecdc.europa.eu
#EpiSky #IdSky #VectorBorne #MosquitoBorne #EVD #Dengue #WestNileVirus #Chikungunya #CCHF
We have evidence from several observational studies that show how, if adequately selected, uncomplicated infections may be safely treated with shorter courses, even in severely immunocompromised hosts like SOT or neutropenic patients.
(🧵2/3) #AMSky #IDsky #TxID #IDOnc
bsky.app/profile/jose...
(🧵2/3) #AMSky #IDsky #TxID #IDOnc
bsky.app/profile/jose...
#ShorterIsBetter in immunocompromised hosts?
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
April 29, 2025 at 10:16 PM
We have evidence from several observational studies that show how, if adequately selected, uncomplicated infections may be safely treated with shorter courses, even in severely immunocompromised hosts like SOT or neutropenic patients.
(🧵2/3) #AMSky #IDsky #TxID #IDOnc
bsky.app/profile/jose...
(🧵2/3) #AMSky #IDsky #TxID #IDOnc
bsky.app/profile/jose...