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TRAstonDrs

@castltrastondrs.bsky.social

9.4K followers 1.8K following 13K posts

"Not all those who wander are lost" JR Tolkien #Clinicalresearcher #DrugDevelopment #Clinicaltrials & Registration 🧬🔬📚🔎🦠🧫 📌 Melbourne 🇦🇺 Oxford 🇬🇧& 🏴󠁧󠁢󠁳󠁣󠁴󠁿 #MedSky🧪

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TRAstonDrs @castltrastondrs.bsky.social · Dec 6

Our greatest strength lies in the gentleness and tenderness of our heart.
Rumi

Glenshee 🏴󠁧󠁢󠁳󠁣󠁴󠁿 my former home Nov 2016

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Reposted by TRAstonDrs

Trish Greenhalgh @trishgreenhalgh.bsky.social · 2h

From the picture it looks like this is IN MICE, but a cautious WOW from me.

Chise @sailorrooscout.bsky.social · 2h

GOOD NEWS! Researchers have developed a cancer vaccine that has shown STUNNING results, PREVENTING up to 88% of MULTIPLE aggressive cancers by harnessing dual-pathway nanoparticles that train the immune system to recognize and destroy tumor cells. In some cases, it COMPLETELY prevented metastasis.

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TRAstonDrs @castltrastondrs.bsky.social · 19m

marking a major progress in the development of next-generation cancer vaccines.
It will be a long process from 🐁 to human trial .

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TRAstonDrs @castltrastondrs.bsky.social · 20m

While a promising breakthrough in preclinical studies, significant hurdles remain in translating the technology from 🐁 models to human clinical trials. However, the approach demonstrates the potential of nanotechnology to deliver more potent & coordinated immune activation,

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TRAstonDrs @castltrastondrs.bsky.social · 21m

You are absolutely right to be cautious about it . This technology is currently being developed by a startup company, NanoVax Therapeutics, based on research from the University of Massachusetts Amherst.

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TRAstonDrs @castltrastondrs.bsky.social · 36m

A humble drop of water fallen from flower to flower,
A cloud, a bird, occupy me for a whole day.
Contemplation fills my heart with love.

TRAstonDrs @castltrastondrs.bsky.social · 37m

Vous le savez, la pierre où court un scarabée,
Une humble goutte d’eau de fleur en fleur tombée,
Un nuage, un oiseau, m’occupent tout un jour.
La contemplation m’emplit le coeur d’amour.
#VictorHugo, Aux Arbres
You know it, the stone where a beetle runs,

Another evening run,
Sunday gives you another excuse to escape the maddening crowd.

The autumn sunset cleansed the soul and softened the heart.

Nature paints your world with colours, autumn berries.

It doesn’t matter what. The mute swans are still playing on the lake.

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Reposted by TRAstonDrs

Stefan Marciniak @profmarciniak.bsky.social · 6h

Many things at play here, but hard to ignore the fact that the UK left an enormous trading bloc and raised barriers to commerce with its nearest neighbours for petty nationalist reasons based on disinformation.

Want economic growth and improved regional investment?

Rejoin the EU.

Tom Calver @tomcalver.bsky.social · 6h

🇵🇱 My @thetimes column: Poland’s economic miracle

12 out of 17 Polish regions are now richer than West Wales. It has faster internet, cheaper electricity and more high speed rail than Britain

When it comes to regional development it’s the UK, not Poland, that needs to catch up

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Reposted by TRAstonDrs

Craig McGowan @craigmcg.bsky.social · 14h

Follow the Light.

I love photographing nature. Further, there are endless photographic possibilities when immersing yourself in forests. Both forest types - the well kept and paved, as well as the 100% natural and relatively untouched forest land.

#photography #nature #landscapephotography

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TRAstonDrs @castltrastondrs.bsky.social · 5h

Recaps
@sagepub.com

journals.sagepub.com/doi/full/10....

@tandfresearch.bsky.social
www.tandfonline.com/doi/pdf/10.2...

www.frontiersin.org/journals/imm...

pmc.ncbi.nlm.nih.gov/articles/PMC...

www.frontiersin.org/journals/imm...

Frontiers | Pathophysiological, immunological, and inflammatory features of long COVID

The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing s...

www.frontiersin.org

TRAstonDrs @castltrastondrs.bsky.social · 5h

An imbalance between proteases & antiproteases is implicated as a central mechanism driving systemic inflammation, tissue damage & hypercoagulability in LC . Though initially linked to severe #COVID . The proteolytic dysregulation can persist & contribute to long term complications

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TRAstonDrs @castltrastondrs.bsky.social · 5h

In this study the authors highlight therapeutic strategies aimed at restoring the balance such as targeted inhibitors & therapies that enhance natural antiprotease mechanisms.The review also explores the potential relevance of this mechanism in the management of post-acute sequelae, #longCOVID

Overview of the protease/antiprotease imbalance in COVID-19 pathogenesis. SARS-CoV-2 entry via ACE2 and heparan sulphate initiates a cascade of inflammatory and proteolytic responses. Activation of multiple protease systems, including the complement cascade, the kallikrein–kinin system (KKS), the renin–angiotensin system (RAS), and the coagulation cascade, leads to cytokine release, endothelial injury, and immunothrombosis. Dysregulation of natural antiprotease mechanisms (eg, antithrombin, α1-antitrypsin, thrombomodulin) contributes to impaired fibrinolysis and promotes a hypercoagulable state. The resulting systemic manifestations include acute respiratory distress syndrome (ARDS), venous thromboembolism (VTE), arterial thrombosis, and multiorgan dysfunction. The diagram also highlights potential therapeutic targets aimed at restoring proteolytic balance.

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TRAstonDrs @castltrastondrs.bsky.social · 5h

& hypercoagulable state.
This increases the risk of both venous & arterial thrombosis, incl venous thromboembolism (VTE) & coronary heart disease.
- The proteolytic dysregulation is an underlying mechanism for the multisystem organ dysfunction seen in severe #COVID , including acute ARDS

TRAstonDrs @castltrastondrs.bsky.social · 5h

🔑 Key findings
-Viral entry & replication are facilitated by proteases, specifically TMPRSS2, furin, neutrophil elastase .
- The imbalance contributes to a cycle of systemic inflammation from cytokine storm which can have severe systemic repercussions.
- Endothelial dysfunction

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TRAstonDrs @castltrastondrs.bsky.social · 5h

#Medsky🧪 #IDsky #Immunosky # public health A comprehensive overview of how a dysregulated balance between #proteases (enzymes that break down proteins) & their inhibitors (antiproteases) can drive the systemic complications observed in #COVID .
pmc.ncbi.nlm.nih.gov/articles/PMC...

COVID-19: A Disease Driven by Protease/Antiprotease Imbalance? A Specific Review Five Years into the Pandemic

COVID-19, caused by SARS-CoV-2, has profoundly impacted global health since late 2019. Beyond respiratory complications, the disease involves systemic manifestations driven by immune dysregulation, in...

pmc.ncbi.nlm.nih.gov

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Reposted by TRAstonDrs

Mr. Dr. Prof. Patrick @mr-dr-prof-patrick.bsky.social · 11h

I got my first pregnant patient who refused Tylenol tonight. “I’ve heard that it’s bad for my baby” was her explanation. Love that Trump is now involved in my practice of medicine. #medsky #emsky

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Reposted by TRAstonDrs

Mike Honey @mikehoney.bsky.social · 1d

Here's the latest variant picture with a global scope, to late September.

XFG.* "Stratus" was higher at 73%.

NB.1.8.1 "Nimbus" fell to 18%.

#COVID19 #SARSCoV2 #Global #NB_1_8_1 #Nimbus #XFG #Stratus
🧵

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Reposted by TRAstonDrs

Dr Eric Levi @drericlevi.bsky.social · 8h

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TRAstonDrs @castltrastondrs.bsky.social · 7h

Sometimes the smallest things take up the most room in your heart.
A. A. Milne

TRAstonDrs @castltrastondrs.bsky.social · 7h

It always seems impossible until it’s done.
#NelsonMandela

The sun rises on this square inch of the chaotic world, another morning. Something happened that we couldn’t prevent, but we can control the event & move on. Another deal is being broken and made. With peace, we can move on.
Life full of care

As the autumn sunrise cleared the foggy day, let peace and happiness be bestowed upon all.

There’s always hope and care arising at the horizon of each new day.

Every day will be different. Some days will be bad, but not today.

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TRAstonDrs @castltrastondrs.bsky.social · 10h

@polybiorf.bsky.social

polybio.org/new-microflu...

New microfluidic blood test accurately identifies microclots in Long COVID children - PolyBio Research Foundation

Researchers develop device to quantify the microclot biomarker linked to persistent spike protein, paving the way for faster and more precise...

polybio.org

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TRAstonDrs @castltrastondrs.bsky.social · 10h

Recap
www.jcvaonline.com/article/S105...

onlinelibrary.wiley.com/doi/full/10....

@dbkell.bsky.social
www.mdpi.com/1420-3049/30...

pmc.ncbi.nlm.nih.gov/articles/PMC...

www.sciencedirect.com/science/arti...

Published Thesis
studenttheses.uu.nl/bitstream/ha...

Long COVID Mechanisms, Microvascular Effects, and Evaluation Based on Incidence

Since the initial reports of Long COVID symptoms, numerous pathophysiological mechanisms have been proposed to explain them; nevertheless, no consensus has been reached. Some of these mechanisms are d...

pmc.ncbi.nlm.nih.gov

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TRAstonDrs @castltrastondrs.bsky.social · 11h

Further studies will evaluate the utility of the assay as a screening test for LC in larger populations and for assessing treatment responses…

www.s4me.info/threads/quan....

assets-eu.researchsquare.com/files/rs-748...

Preprint - Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients using a microfluidic assay, 2025, Irimia, Swank, VanElzakker, Yonker+

Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients using a microfluidic assay Long COVID (LC) impacts one in five children after an acute SARS-CoV-2 infection. Typical ...

www.s4me.info

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TRAstonDrs @castltrastondrs.bsky.social · 11h

a microfluidic assay for quantifying fibrinolytic clots in the plasma of #LongCOVIDkid . This study found significantly higher #microclot levels in children with LC vs to healthy controls, overcoming the limitations of previous qualitative assessment methods.

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TRAstonDrs @castltrastondrs.bsky.social · 11h

#Medsky🧪 #IDsky #pedsky #immunosky #publichealth As we move from the beginning of the #Covid19pandemic to the present, we’ve learned that #COVID can have devastating effects on a host’s immunity, particularly in children. A recent study led by Irimia et al. demonstrated

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TRAstonDrs @castltrastondrs.bsky.social · 20h

Your prison is your mind;
and your mind is your habit. Break the pattern,
and live in the moment.
#Rumi

Autumn sunset, a peaceful moment on this side of the world.

A walk in town & the pavement littered with acorns.

A typical autumn day in this oldest university town

The autumn sun set, painting the leaves deep with colour.