TRAstonDrs
@castltrastondrs.bsky.social
"Not all those who wander are lost" JR Tolkien
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
🧬🔬📚🔎🦠🧫 📌
Melbourne 🇦🇺 Oxford 🇬🇧& 🏴 #MedSky🧪
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
🧬🔬📚🔎🦠🧫 📌
Melbourne 🇦🇺 Oxford 🇬🇧& 🏴 #MedSky🧪
Pinned
Our greatest strength lies in the gentleness and tenderness of our heart.
Rumi
Rumi
#Medsky🧪 #oncosky Activation-induced cytidine deaminase (AID)- a member of the cytidine deaminase family, encoded by the AICDA gene & is evolutionarily conserved within the AID/APOBEC family. It is a DNA/RNA editing enzyme that catalyzes the deamination of cytidine to uridine in single-stranded DNA,
If you dont have full text access, here is a link provided to authors by Cell Press that should open for the next 49 days:
authors.elsevier.com/c/1mARi_278y...
authors.elsevier.com/c/1mARi_278y...
November 27, 2025 at 1:24 PM
#Medsky🧪 #oncosky Activation-induced cytidine deaminase (AID)- a member of the cytidine deaminase family, encoded by the AICDA gene & is evolutionarily conserved within the AID/APOBEC family. It is a DNA/RNA editing enzyme that catalyzes the deamination of cytidine to uridine in single-stranded DNA,
Reposted by TRAstonDrs
AID's role in class switch recombination & somatic hypermutation was published in @cellpress.bsky.social 25 years ago, a tour de force combo of mouse gene discovery & mechanistic work (Honjo lab) and human genetics (Durandy, Fischer et al).
What a privilege to write this with Sidonia & Masamichi
What a privilege to write this with Sidonia & Masamichi
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in
three molecular puzzles. The genetic swapping of immunoglobulin constant regions,
the mutational fine-tuning of anti...
www.cell.com
November 26, 2025 at 5:58 PM
AID's role in class switch recombination & somatic hypermutation was published in @cellpress.bsky.social 25 years ago, a tour de force combo of mouse gene discovery & mechanistic work (Honjo lab) and human genetics (Durandy, Fischer et al).
What a privilege to write this with Sidonia & Masamichi
What a privilege to write this with Sidonia & Masamichi
Reposted by TRAstonDrs
The stuff you find when you actually read the RCTs in a systematic review...
This paper is one of the foundational studies on vitamin D to prevent respiratory infections in kids. Cited 1,400 times as per Google Scholar.
This paper is one of the foundational studies on vitamin D to prevent respiratory infections in kids. Cited 1,400 times as per Google Scholar.
November 26, 2025 at 9:15 PM
The stuff you find when you actually read the RCTs in a systematic review...
This paper is one of the foundational studies on vitamin D to prevent respiratory infections in kids. Cited 1,400 times as per Google Scholar.
This paper is one of the foundational studies on vitamin D to prevent respiratory infections in kids. Cited 1,400 times as per Google Scholar.
When you see this, post an image from your gallery to describe your mental health.
November 27, 2025 at 7:25 AM
When you see this, post an image from your gallery to describe your mental health.
#Medsky🧪 #IDsky #immunosky #publichealth #LongCOVID pathophysiology is a complex & not fully established process. One prevailing theory is that the formation of fibrin amyloid microclots ( #fibrinaloids), due to #Covid infection, can induce persistent inflammation & capillary blockage .
November 27, 2025 at 5:15 AM
#Medsky🧪 #IDsky #immunosky #publichealth #LongCOVID pathophysiology is a complex & not fully established process. One prevailing theory is that the formation of fibrin amyloid microclots ( #fibrinaloids), due to #Covid infection, can induce persistent inflammation & capillary blockage .
Reposted by TRAstonDrs
Another US BA.3.2 wastewater detection.
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
November 26, 2025 at 11:01 PM
Another US BA.3.2 wastewater detection.
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
This time from Bristol County, RI on Nov 11. It was about a third of the seqs.
I wonder if it was someone who flew back from Australia through SF?
@ryanhisner.bsky.social @snpoehlm.bsky.social @rajlabn.bsky.social
#Medsky🧪 #IDsky #Covid19Vaccine worked #immunosky #publichealth The study @systemsvirology.bsky.social shows immune boosting by the LP.8.1-based vaccine is effective in achieving cross neutralization against a broad range of JN.1 sublineages in a JN.1-naïve population
November 27, 2025 at 4:43 AM
#Medsky🧪 #IDsky #Covid19Vaccine worked #immunosky #publichealth The study @systemsvirology.bsky.social shows immune boosting by the LP.8.1-based vaccine is effective in achieving cross neutralization against a broad range of JN.1 sublineages in a JN.1-naïve population
#Medsky🧪 #IDsky #immunosky #publichealth
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
November 26, 2025 at 7:37 PM
#Medsky🧪 #IDsky #immunosky #publichealth
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
@thjournal.bsky.social
Outpatient LMWH ( low-molecular weight heparin) given pre-admission for high-risk #Covid patients was associated with improved outcome following diagnosis:
Reposted by TRAstonDrs
Thanksgiving reminder… ⚖️
November 26, 2025 at 4:12 PM
Thanksgiving reminder… ⚖️
#Medsky🧪 #IDsky #pedsky #episky #publichealth Multisystem Inflammatory Syndrome in Children (MIS-C) a rare, severe & potentially life threatening condition that occurs in children & adolescents following post covid with manifesting 2–6 wks post infection , often asymptomatic or mild disease
November 26, 2025 at 5:43 PM
#Medsky🧪 #IDsky #pedsky #episky #publichealth Multisystem Inflammatory Syndrome in Children (MIS-C) a rare, severe & potentially life threatening condition that occurs in children & adolescents following post covid with manifesting 2–6 wks post infection , often asymptomatic or mild disease
#Medsky🧪 #IDsky #microsky #pharmsky #immunosky #publichealth
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
November 26, 2025 at 3:56 PM
#Medsky🧪 #IDsky #microsky #pharmsky #immunosky #publichealth
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
@natrevdrugdiscov.nature.com
Novartis’s #ganaplacide plus #lumefantrine ( #GanLum) is as effective as standard-of-care artemether plus lumefantrine (Coartem) for acute, uncomplicated malaria due to P. falciparum
I don't like those who know, I like those who love…
#ChristianBobin
#ChristianBobin
November 26, 2025 at 11:50 AM
I don't like those who know, I like those who love…
#ChristianBobin
#ChristianBobin
Reposted by TRAstonDrs
Mornings on the beach be like...
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
November 20, 2025 at 3:41 AM
Mornings on the beach be like...
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
Sunrise and enjoying the view, but not the wind.
#photography #nature #landscapephotography
#Mesky🧪 #IDsky #endosky #immunosky #publichealth This review highlights the need to consider #obesity in general & adipose tissue in particular as an active disease modifier of viral infection with implications for future pandemics.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
#Medsky🧪 #IDsky #endosky #cardiosky #publichealth In this large, prospective, population-based study of 15,516 participants from the MDCS cohort, the study observed that familial burden of diabetes was independently associated with increased relative risk of a hospital diagnosis of #COVID
November 26, 2025 at 8:36 AM
#Mesky🧪 #IDsky #endosky #immunosky #publichealth This review highlights the need to consider #obesity in general & adipose tissue in particular as an active disease modifier of viral infection with implications for future pandemics.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
i sense the fleetness of the earthly mirage more sure than anything
A hiraeth - There's a long ago lost distant home
on the passageway's other side
A hiraeth - There's a long ago lost distant home
on the passageway's other side
November 26, 2025 at 8:18 AM
i sense the fleetness of the earthly mirage more sure than anything
A hiraeth - There's a long ago lost distant home
on the passageway's other side
A hiraeth - There's a long ago lost distant home
on the passageway's other side
#Medsky🧪#IDsky #immunosky #publichealth in This review of 25 studies on the relationship between pre-COVID & post-COVID vaccination on #longCOVID.
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
November 26, 2025 at 6:08 AM
#Medsky🧪#IDsky #immunosky #publichealth in This review of 25 studies on the relationship between pre-COVID & post-COVID vaccination on #longCOVID.
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
🔑 findings :
- 2 dose preCOVID vaccination was associated with a 24% reduced odds of #longCOVID
Reposted by TRAstonDrs
📣 Heavy Menstrual Bleeding in Women Treated with DOACs: Results of the HEMBLED Registry ⬇️
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
November 21, 2025 at 7:31 PM
📣 Heavy Menstrual Bleeding in Women Treated with DOACs: Results of the HEMBLED Registry ⬇️
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
📌 Lindhoff-Last report differences among DOACs and their influence on the intensity of sponteneous menstrual bleeding
🆓 on TH: www.thieme-connect.de/products/ejo...
#Thrombosis #DOAC #VTE #HemeSky
Reposted by TRAstonDrs
Patient came in with sore throat. While waiting for rapid Strep test result we glanced back at the Covid-19 RAT result: positive. Reminder that masking in health care makes sense, if you don’t want everyone in your waiting room to go home sick, your staff to get sick, and physicians to get sick.
November 25, 2025 at 4:35 PM
Patient came in with sore throat. While waiting for rapid Strep test result we glanced back at the Covid-19 RAT result: positive. Reminder that masking in health care makes sense, if you don’t want everyone in your waiting room to go home sick, your staff to get sick, and physicians to get sick.
#Medsky🧪 #virosk #idsky #immunosky #publichealth Structural and functional characterizations of infectivity & immune evasion of #SARSCoV2 Omicron revival
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron
(Cell 185, 860–871.e1–e4; March 3, 2022)
www.cell.com
November 25, 2025 at 1:50 PM
#Medsky🧪 #virosk #idsky #immunosky #publichealth Structural and functional characterizations of infectivity & immune evasion of #SARSCoV2 Omicron revival
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
#Medsky🧪 #IDsky #Drugrepurpose #pharmsky #publichealth Current Evidences for #Sirolimus in #LongCOVID
Clinical Trials & Research Activity
Clinical Trials & Research Activity
Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution
danilobuonsenso.substack.com/p/low-dose-r...
danilobuonsenso.substack.com/p/low-dose-r...
Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution
Over the past months, I have written several posts exploring the potential role of low-dose rapamycin in Long COVID and ME/CFS (Part 1, Part 2, Part 3).
danilobuonsenso.substack.com
November 25, 2025 at 11:56 AM
#Medsky🧪 #IDsky #Drugrepurpose #pharmsky #publichealth Current Evidences for #Sirolimus in #LongCOVID
Clinical Trials & Research Activity
Clinical Trials & Research Activity
Reposted by TRAstonDrs
🫁🧬 Preclinical signal: can lung clots protect? Moderate thrombosis in sepsis ARDS limited endothelial injury via ALOX15-driven lipids.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
New Clues to Protecting Lungs in Sepsis Lung Injury
Mouse and human data suggest endothelial ALOX15 and its lipids may help turn some lung clots into protection in sepsis lung injury, highlighting future therapeutic opportunities.
www.emjreviews.com
November 25, 2025 at 11:43 AM
🫁🧬 Preclinical signal: can lung clots protect? Moderate thrombosis in sepsis ARDS limited endothelial injury via ALOX15-driven lipids.
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
www.emjreviews.com/en-us/amj/re...
#AMJRespiratory #Sepsis #ARDS
Reposted by TRAstonDrs
My work on SARS-CoV-2 variants informed a recent piece in The Lancet: "Epidemiological and virological update on the emerging SARS-CoV-2 variant BA.3.2".
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
Epidemiological and virological update on the emerging SARS-CoV-2 variant BA.3.2
The constant emergence of novel SARS-CoV-2 variants has driven the COVID-19 pandemic
and sustains the current endemic. Saltation variants, such as BA.2.86,1 encode highly
mutated spike (S) proteins th...
www.thelancet.com
November 25, 2025 at 1:30 AM
My work on SARS-CoV-2 variants informed a recent piece in The Lancet: "Epidemiological and virological update on the emerging SARS-CoV-2 variant BA.3.2".
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
The authors were kind enough to mention me and the Variant Hunters Ryan Hisner and Federico Gueli.
www.thelancet.com/journals/lan...
🧵
The texture of life…
November 25, 2025 at 10:27 AM
The texture of life…
We all need something to start the day …
November 25, 2025 at 8:32 AM
We all need something to start the day …
Growing old is deeply sweet & tragic
November 25, 2025 at 8:23 AM
Growing old is deeply sweet & tragic