Thiago Carvalho
@cyrilpedia.bsky.social
I've worked on all of science, from T cells to B cells.
https://fellowsherpa.com
https://fellowsherpa.com
Reposted by Thiago Carvalho
Of course:
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
Want to sway an election? Here’s how much fake online accounts cost
Systematic price monitoring sheds light on economics of online manipulation
www.science.org
December 15, 2025 at 1:29 AM
Of course:
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
Reposted by Thiago Carvalho
'So we have something of a paradox. Species interactions have unquestionably shaped the history of life on Earth, even—perhaps especially—interactions that have not been shown to meet the strict-sense definition of coevolution.'
academic.oup.com/evolut/artic...
academic.oup.com/evolut/artic...
Don't ask “when is it coevolution?”—ask “how?”
Abstract. Coevolution has come to be widely understood as specific, simultaneous, reciprocal adaptation by pairs of interacting species. This strict-sense
academic.oup.com
December 15, 2025 at 2:12 AM
'So we have something of a paradox. Species interactions have unquestionably shaped the history of life on Earth, even—perhaps especially—interactions that have not been shown to meet the strict-sense definition of coevolution.'
academic.oup.com/evolut/artic...
academic.oup.com/evolut/artic...
Reposted by Thiago Carvalho
'At 70, the former M.I.T. lab director and co-creator of the widely selling Roomba robot vacuum lives in that world. But now, Mr. Brooks, who has spent his career making intelligent machines a part of everyday life, finds himself playing the skeptic.'
www.nytimes.com/2025/12/14/b...
www.nytimes.com/2025/12/14/b...
He’s the Godfather of Modern Robotics. He Says the Field Has Lost Its Way.
www.nytimes.com
December 15, 2025 at 4:19 AM
'At 70, the former M.I.T. lab director and co-creator of the widely selling Roomba robot vacuum lives in that world. But now, Mr. Brooks, who has spent his career making intelligent machines a part of everyday life, finds himself playing the skeptic.'
www.nytimes.com/2025/12/14/b...
www.nytimes.com/2025/12/14/b...
Reposted by Thiago Carvalho
'The Ebola crisis demonstrated that public engagement is most effective when communities feel a sense of ownership over health interventions (...) when local leaders and cultural contexts are integrated into the response, engagement improves, and disease control measures are more successful.'
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Public trust and cooperation in infectious disease control rest on three pillars: engagement, vaccine communication, and data presentation. Together, these foundations support resilient and inclusive....
onlinelibrary.wiley.com
December 15, 2025 at 5:45 AM
'The Ebola crisis demonstrated that public engagement is most effective when communities feel a sense of ownership over health interventions (...) when local leaders and cultural contexts are integrated into the response, engagement improves, and disease control measures are more successful.'
Reposted by Thiago Carvalho
Online now: Opposing functions of distinct regulatory T cell subsets in colorectal cancer
Opposing functions of distinct regulatory T cell subsets in colorectal cancer
Huang et al. study the heterogeneity of regulatory T (Treg) cells in a genetic model of colorectal cancer (CRC) and find that interleukin (IL)-10− Treg cells promote tumor progression, whereas IL-10+ Treg cells restrain tumor growth by suppressing IL-17 production from CD4+ T cells. This functional dichotomy between Treg subsets is seen in human CRC and may be relevant in other barrier tissue cancers.
dlvr.it
December 15, 2025 at 8:55 PM
Online now: Opposing functions of distinct regulatory T cell subsets in colorectal cancer
Reposted by Thiago Carvalho
É isso
Juizes declararam inconstitucionais normas da lei da nacionalidade que o Marques Mendes não enviaria para o tribunal constitucional, por não ter quaisquer dúvidas? É isto? Li bem?
Juízes declararam inconstitucional normas da lei da nacionalidade e das alterações ao Código Penal que abriam a porta à perda da nacionalidade.
December 15, 2025 at 9:59 PM
É isso
Reposted by Thiago Carvalho
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
One of the pleasures of writing this piece with Sidonia and Masamichi was getting to see the original lab notebooks of the AID project (images from them are in the @cellpress.bsky.social article).
In a @cp-cell.bsky.social Benchmarks article, Masamichi Muramatsu, Sidonia Fagarasan et al tell the story of the discovery of AID in the Honjo lab, solving the decades long mystery of the molecular effector of Ig class switch recombination and somatic hypermutation.
#Immunology
#Immunology
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in
three molecular puzzles. The genetic swapping of immunoglobulin constant regions,
the mutational fine-tuning of anti...
www.cell.com
December 15, 2025 at 6:16 AM
One of the pleasures of writing this piece with Sidonia and Masamichi was getting to see the original lab notebooks of the AID project (images from them are in the @cellpress.bsky.social article).
Reposted by Thiago Carvalho
Prof Tasuku Honjo is now the Director of CCII, our new center in Kyoto University, dedicated to deciphering anti-tumor immunity and discovering the next generation of cancer immunotherapies.
www.ccii.med.kyoto-u.ac.jp/en/
www.ccii.med.kyoto-u.ac.jp/en/
December 15, 2025 at 6:14 AM
Prof Tasuku Honjo is now the Director of CCII, our new center in Kyoto University, dedicated to deciphering anti-tumor immunity and discovering the next generation of cancer immunotherapies.
www.ccii.med.kyoto-u.ac.jp/en/
www.ccii.med.kyoto-u.ac.jp/en/
Reposted by Thiago Carvalho
In the same issue, Revy, Fischer and Durandy showed that the same gene, AID, was responsible for a mysterious form of hyper-IgM syndrome that was not linked to mutations in the CD40 pathway, demonstrating that AID also controlled CSR and SHM in humans.
www.cell.com/fulltext/S00...
www.cell.com/fulltext/S00...
Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal
center B cells in mice, is a member of the cytidine deaminase family. We herein report
mutations in the human c...
www.cell.com
December 15, 2025 at 6:12 AM
In the same issue, Revy, Fischer and Durandy showed that the same gene, AID, was responsible for a mysterious form of hyper-IgM syndrome that was not linked to mutations in the CD40 pathway, demonstrating that AID also controlled CSR and SHM in humans.
www.cell.com/fulltext/S00...
www.cell.com/fulltext/S00...
Reposted by Thiago Carvalho
Muramatsu had previously reported the discovery of the AID gene in a screen. In the 2000 Cell paper, he and his collaborators in the Honjo lab, including Fagarasan demonstrated its function in mice.
www.cell.com/AJHG/fulltex...
www.cell.com/AJHG/fulltex...
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching
from IgM to IgA without cytokine stimulation. AID deficiency caused a complete defect
in class switching and showed...
www.cell.com
December 15, 2025 at 6:10 AM
Muramatsu had previously reported the discovery of the AID gene in a screen. In the 2000 Cell paper, he and his collaborators in the Honjo lab, including Fagarasan demonstrated its function in mice.
www.cell.com/AJHG/fulltex...
www.cell.com/AJHG/fulltex...
Reposted by Thiago Carvalho
In a @cp-cell.bsky.social Benchmarks article, Masamichi Muramatsu, Sidonia Fagarasan et al tell the story of the discovery of AID in the Honjo lab, solving the decades long mystery of the molecular effector of Ig class switch recombination and somatic hypermutation.
#Immunology
#Immunology
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in
three molecular puzzles. The genetic swapping of immunoglobulin constant regions,
the mutational fine-tuning of anti...
www.cell.com
December 15, 2025 at 6:07 AM
In a @cp-cell.bsky.social Benchmarks article, Masamichi Muramatsu, Sidonia Fagarasan et al tell the story of the discovery of AID in the Honjo lab, solving the decades long mystery of the molecular effector of Ig class switch recombination and somatic hypermutation.
#Immunology
#Immunology
This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain:
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
PD-L2 Regulates Natural Antibody and IL-10 Secretion by B-1 cells
B-1 cells are innate-like lymphocytes that play a critical role in homeostasis by secreting natural antibodies, typically IgM, and immunosuppressive molecules such as IL-10. However, the regulation of...
www.biorxiv.org
December 15, 2025 at 6:03 AM
This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain:
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
"Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains"
#Immunology
'The Ebola crisis demonstrated that public engagement is most effective when communities feel a sense of ownership over health interventions (...) when local leaders and cultural contexts are integrated into the response, engagement improves, and disease control measures are more successful.'
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Public trust and cooperation in infectious disease control rest on three pillars: engagement, vaccine communication, and data presentation. Together, these foundations support resilient and inclusive....
onlinelibrary.wiley.com
December 15, 2025 at 5:45 AM
'The Ebola crisis demonstrated that public engagement is most effective when communities feel a sense of ownership over health interventions (...) when local leaders and cultural contexts are integrated into the response, engagement improves, and disease control measures are more successful.'
Reposted by Thiago Carvalho
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Retroviral insertions contributed to the divergence of human and chimpanzee brains
Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...
www.biorxiv.org
December 14, 2025 at 8:16 PM
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
'At 70, the former M.I.T. lab director and co-creator of the widely selling Roomba robot vacuum lives in that world. But now, Mr. Brooks, who has spent his career making intelligent machines a part of everyday life, finds himself playing the skeptic.'
www.nytimes.com/2025/12/14/b...
www.nytimes.com/2025/12/14/b...
He’s the Godfather of Modern Robotics. He Says the Field Has Lost Its Way.
www.nytimes.com
December 15, 2025 at 4:19 AM
'At 70, the former M.I.T. lab director and co-creator of the widely selling Roomba robot vacuum lives in that world. But now, Mr. Brooks, who has spent his career making intelligent machines a part of everyday life, finds himself playing the skeptic.'
www.nytimes.com/2025/12/14/b...
www.nytimes.com/2025/12/14/b...
Reposted by Thiago Carvalho
Are frameworks independent from CDRs in antibodies? Exploring CDR-framework correlation networks of antibodies https://www.biorxiv.org/content/10.64898/2025.12.11.693675v1
December 15, 2025 at 2:15 AM
Are frameworks independent from CDRs in antibodies? Exploring CDR-framework correlation networks of antibodies https://www.biorxiv.org/content/10.64898/2025.12.11.693675v1
Reposted by Thiago Carvalho
Ribosomal Epistatic Interactions Drive the Emergence of High-Level Streptomycin Resistance in Escherichia coli https://www.biorxiv.org/content/10.64898/2025.12.13.694165v1
December 15, 2025 at 2:16 AM
Ribosomal Epistatic Interactions Drive the Emergence of High-Level Streptomycin Resistance in Escherichia coli https://www.biorxiv.org/content/10.64898/2025.12.13.694165v1
Reposted by Thiago Carvalho
“We almost had a midair collision up here,” the JetBlue pilot said, according to a recording of his conversation with air traffic control. “They passed directly in our flight path. … They don’t have their transponder turned on, it’s outrageous.” www.cnn.com/2025/12/14/p...
JetBlue plane near Venezuela avoids ‘midair collision’ with US Air Force aircraft | CNN Politics
A JetBlue flight from the small Caribbean nation of Curaçao halted its ascent to avoid colliding with a US Air Force refueling tanker on Friday, and the pilot blamed the military plane for crossing hi...
www.cnn.com
December 15, 2025 at 2:10 AM
“We almost had a midair collision up here,” the JetBlue pilot said, according to a recording of his conversation with air traffic control. “They passed directly in our flight path. … They don’t have their transponder turned on, it’s outrageous.” www.cnn.com/2025/12/14/p...
'So we have something of a paradox. Species interactions have unquestionably shaped the history of life on Earth, even—perhaps especially—interactions that have not been shown to meet the strict-sense definition of coevolution.'
academic.oup.com/evolut/artic...
academic.oup.com/evolut/artic...
Don't ask “when is it coevolution?”—ask “how?”
Abstract. Coevolution has come to be widely understood as specific, simultaneous, reciprocal adaptation by pairs of interacting species. This strict-sense
academic.oup.com
December 15, 2025 at 2:12 AM
'So we have something of a paradox. Species interactions have unquestionably shaped the history of life on Earth, even—perhaps especially—interactions that have not been shown to meet the strict-sense definition of coevolution.'
academic.oup.com/evolut/artic...
academic.oup.com/evolut/artic...
Reposted by Thiago Carvalho
absolutely losing it at my 14yo's biology homework
December 15, 2025 at 2:02 AM
absolutely losing it at my 14yo's biology homework
Reposted by Thiago Carvalho
"There are people who are genuinely good souls."
December 15, 2025 at 12:48 AM
"There are people who are genuinely good souls."
Reposted by Thiago Carvalho
This is fucking grim. Somebody invented a white guy, an "IT professional" named Edward Crabtree, who stopped the Bondi shooting and spread it all over the internet, which was picked up by AI agents and slop aggregation sites.
The real hero is a fruit stand owner named Ahmed el Ahmed.
The real hero is a fruit stand owner named Ahmed el Ahmed.
December 14, 2025 at 8:02 PM
This is fucking grim. Somebody invented a white guy, an "IT professional" named Edward Crabtree, who stopped the Bondi shooting and spread it all over the internet, which was picked up by AI agents and slop aggregation sites.
The real hero is a fruit stand owner named Ahmed el Ahmed.
The real hero is a fruit stand owner named Ahmed el Ahmed.
Of course:
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
Want to sway an election? Here’s how much fake online accounts cost
Systematic price monitoring sheds light on economics of online manipulation
www.science.org
December 15, 2025 at 1:29 AM
Of course:
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
"Inventories of accounts also varied by platform, with accounts on X being by far the most widely available for purchase."
www.science.org/content/arti...
Reposted by Thiago Carvalho
Not all pain is created equal: stepping on a nail feels different from a stomachache. We know there are many nociceptor types, but a key question remains: how is mechanical pain encoded across the body by those sensory neurons? Our new work helps answer this. 1/8
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Hierarchical organization of mechano-nociceptive pathways revealed by activity labeling
Noxious mechanical stimuli give rise to distinct percepts, from sharp cutaneous pain to diffuse visceral discomfort, yet the nociceptor ensembles that underlie these differences remain poorly defined....
www.biorxiv.org
December 14, 2025 at 6:25 PM
Not all pain is created equal: stepping on a nail feels different from a stomachache. We know there are many nociceptor types, but a key question remains: how is mechanical pain encoded across the body by those sensory neurons? Our new work helps answer this. 1/8
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...