Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
October 28, 2025 at 6:50 PM
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Amazing work, congratulations! This is a brilliant step forward in establishing condensates as functional post-transcriptional mechanisms outside germ cells! 👏🏼👏🏼
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 29, 2025 at 1:39 PM
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7/ Our findings establish a fundamental, conserved role for P-bodies in cell fate specification and reveal novel strategies to manipulate RNA condensates for directing cell identity in regenerative medicine.
October 28, 2025 at 4:02 PM
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The results suggest using the new method researchers will be able to produce light-induced Bose-Einstein condensates of high-energy magnons at room temperature. This would pave the way to researching AI quantum effects without the need for extensive cooling. www.sciencedaily.com/releases/202...
Scientists just changed the nature of matter with a flash of light
Researchers in Konstanz discovered a way to manipulate materials with light by exciting magnon pairs, reshaping their magnetic “fingerprint.” This allows non-thermal control of magnetic states and dat...
www.sciencedaily.com
October 26, 2025 at 12:17 AM
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Conserved intrinsically disordered region of DNAJB6 dictates its surveillance of FG-Nup condensates
I've been lucky enough to work on this paper of Tessa and Maiara in Veenhoff and Kampinga's lab.
www.biorxiv.org/content/10.1...
I've been lucky enough to work on this paper of Tessa and Maiara in Veenhoff and Kampinga's lab.
www.biorxiv.org/content/10.1...
Conserved intrinsically disordered region of DNAJB6 dictates its surveillance of FG-Nup condensates
Molecular chaperones can prevent protein aggregation and assist proteins in reaching their structurally functional state. The molecular chaperone DNAJB6, a J-domain protein that partners with Hsp70s a...
www.biorxiv.org
October 21, 2025 at 5:54 AM
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Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
Paralogs with distinct phase behaviors broaden the in vivo stress response range of condensates
Paralogs are widespread, but their physiological roles are often masked by redundancy. H-NS, a nucleoid-associated protein in Gram-negative bacteria, typically coexists with paralogs such as StpA, who...
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October 20, 2025 at 7:55 PM
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Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@cp-cellbiomat.bsky.social, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"!
🔓 : www.cell.com/cell-biomate...
🔓 : www.cell.com/cell-biomate...
October 20, 2025 at 10:46 PM
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Shower thought: there will likely not be any beings that excrete Einstein-Bose condensates as waste, since waste is generally high entropy for open thermodynamic systems maintaining themselves and BEC is quite low entropy. Same for laser light.
October 21, 2025 at 7:08 AM
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My latest column for @chemistryworld.com looks at a wonderful recent paper showing how condensates in cells can act as integrators of contextual information.
www.chemistryworld.com/opinion/the-...
www.chemistryworld.com/opinion/the-...
The molecular mechanisms behind cell cognition
Condensate formation is central to how budding yeast cells decide their response to environmental and internal conditions
www.chemistryworld.com
October 15, 2025 at 1:08 PM
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Whi3 is an interesting protein. Aficionados of this stuff will correctly guess that it's a disordered protein. It seems to help protect against heat/cold shock by forming condensates, as in this example in fungi.
pubmed.ncbi.nlm.nih.gov/38076832/
pubmed.ncbi.nlm.nih.gov/38076832/
Biomolecular condensates in fungi are tuned to function at specific temperatures - PubMed
Temperature can impact every reaction and molecular interaction essential to a cell. For organisms that cannot regulate their own temperature, a major challenge is how to adapt to temperatures that fl...
pubmed.ncbi.nlm.nih.gov
October 15, 2025 at 1:13 PM
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#NMRchat Water-detected NMR allows dynamic observations of repeat-expansion RNA condensates https://www.nature.com/articles/s41557-025-01968-9
October 15, 2025 at 12:30 PM
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@science.org ATP-dependent remodeling of #chromatin #condensates reveals distinct #mesoscale outcomes | Science www.science.org/doi/10.1126/...
October 13, 2025 at 1:50 AM
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Thrilled to see the growing interest in adhesion condensates — more discoveries on the horizon!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Optogenetic construction of de novo integrin-adhesion complexes reveals role for biocondensation in adhesion nucleation
Integrin-adhesion complexes (IACs) form spontaneously in cells on extracellular matrix substrates, allowing them to sense matrix composition and transduce force. However, IACs often do not form unifor...
www.biorxiv.org
October 12, 2025 at 6:55 PM
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Looking forward to visit @friedlab.bsky.social @jhu.edu on Tuesday Oct 14th to talk about
Prediction and Design of Intrinsically Disordered Proteins and Condensates 🍝💦
chemistry.jhu.edu/event/the-ep...
Prediction and Design of Intrinsically Disordered Proteins and Condensates 🍝💦
chemistry.jhu.edu/event/the-ep...
October 12, 2025 at 2:51 PM
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Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 12, 2025 at 1:22 PM
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Maybe they're on track of turning collective graphene quantum dots into fermionic condensates for eternal energy harvesting?
www.nature.com/articles/nco...
www.sciencedirect.com/science/arti...
www.nature.com/articles/nco...
www.sciencedirect.com/science/arti...
Coal as an abundant source of graphene quantum dots - Nature Communications
Coal is widely used for energy generation, but has not been considered for possible functional materials. Here, the authors report the one-step formation of graphene quantum dots from coal at yields of up to 20%, which is advantageous when compared with their syntheses from sp2-type carbon structures.
www.nature.com
October 12, 2025 at 11:59 PM
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Peter Rüegg wrote a great summary of our recent paper about how yeast cells use biomolecular condensates to make decisions. Thank you, Peter!
All cells – from mammalian cells to microbes – can follow different biological paths. Whether they grow and divide, specialise, age or die depends on the pathway they take. New findings by researchers at ETH Zurich could help influence a cell’s decisions to target diseases such as cancer.
Protein condensates determine a cell’s fate
Do cells contain a mechanism that decides on their fates? Researchers at ETH Zurich have demonstrated in a new study that large clusters of molecules determine a cell’s future.
ethz.ch
October 11, 2025 at 7:32 AM
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Attention colleagues! Interested in an interdisciplinary #PhD? 🧬 Apply now for one of 12 PhD positions exploring biomolecular #condensates! This program involves several PoL PIs, bridging the gap between physics and biology.
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
Apply here: dresdencondensates.org/join-us/
🗓Deadline: 24. October
October 9, 2025 at 2:32 PM
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Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?
In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!
www.biorxiv.org/content/10.1...
In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!
www.biorxiv.org/content/10.1...
Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability
Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...
www.biorxiv.org
October 7, 2025 at 11:32 PM
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We conducted a #ChemNobel prediction poll in the group on the #NobelPrize in Chemistry Eve!
(PS: we might be a little biased 😉) #chemsky #compchem #compchemsky
(PS: we might be a little biased 😉) #chemsky #compchem #compchemsky
October 8, 2025 at 3:14 AM
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Preprint: Aberrant Host mRNA Partitioning in Ebola Virus Condensates Driven by RNA Folding Perpetuates Species-Dependent IFN Response @lji.org
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
October 7, 2025 at 5:08 PM
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A Dynamical Density Functional Theory Framework for Non-Equilibrium Phase Dynamics in Biomolecular Condensates https://www.biorxiv.org/content/10.1101/2025.10.02.680159v1
October 5, 2025 at 4:48 AM
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Check out our latest, where we investigate the molecular origin of differences between Lys and Arg and their roles in biomolecular #condensates
@dipcehu.bsky.social
www.biorxiv.org/content/10.1...
@dipcehu.bsky.social
www.biorxiv.org/content/10.1...
October 3, 2025 at 5:21 AM
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Bitumen pucks make more sense than another pipeline. Safe to transport by rail and by ship. Instead of adding goop (condensates) to goop (bitumen) so it's liquid enough to go through pipelines, goop is extracted from the goop so it can be transported as a solid.
I think U of Calgary was involved.
I think U of Calgary was involved.
October 2, 2025 at 3:19 PM
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Out now in #ACSMacroLett: we demonstrate how molecular charge asymmetry can control the size of condensates! Work done in collaboration with @zwickergroup.bsky.social!!
Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!
pubs.acs.org/doi/10.1021/...
Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!
pubs.acs.org/doi/10.1021/...
Theory of Condensate Size Control by Molecular Charge Asymmetry
Biomolecular condensates are complex droplets comprising diverse molecules that interact by various mechanisms. Condensation is often driven by short-range attraction, but net charges can also mediate...
pubs.acs.org
September 30, 2025 at 12:48 AM
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