Nature Biotechnology
@natbiotech.nature.com
Publishing the best of biotech science and business. Find us on Twitter, Facebook & Instagram. Part of @natureportfolio.nature.com.
A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...
Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues
We developed a bioprinting strategy that turns living cells into cell-only bioinks,
enabling light-based 3D bioprinting of tissues at native, ultrahigh cell densities
(up to ∼109 cells mL−1) to rapidl...
www.cell.com
December 9, 2025 at 2:46 PM
A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...
Top ten news stories in 2025 www.nature.com/articles/s41...
Top ten news stories in 2025 - Nature Biotechnology
This year’s most popular stories are a testament to biotech ingenuity and a cause for celebration: the gene editing triumph that cured ‘baby KJ’ of a rare genetic disorder in record time; the bispecif...
www.nature.com
December 9, 2025 at 2:36 PM
Top ten news stories in 2025 www.nature.com/articles/s41...
RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate #NBTNV go.nature.com/4iyZmGv
rdcu.be/eTR4A
rdcu.be/eTR4A
Modulating RNA condensates to control cell fate - Nature Biotechnology
RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate.
go.nature.com
December 9, 2025 at 2:12 PM
RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate #NBTNV go.nature.com/4iyZmGv
rdcu.be/eTR4A
rdcu.be/eTR4A
2025: research in review go.nature.com/4oCK84L
December 8, 2025 at 7:47 PM
2025: research in review go.nature.com/4oCK84L
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - Nature Biotechnology
Virus-like particles are engineered to edit human hematopoietic cells in vivo.
go.nature.com
December 8, 2025 at 6:53 PM
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
Reposted by Nature Biotechnology
By creating a network of early-career principal investigators, Gianvito Scaringi and his colleagues have enacted change and battled bureaucracy. You can read more about how a group of novice lab leaders are supporting each other: spklr.io/63329B5TIW
#AcademicSky
#AcademicSky
‘Anyone hired a student before?’ How a group of novice lab leaders are supporting each other
By creating a network of early-career principal investigators, my colleagues and I have enacted change and battled bureaucracy.
spklr.io
December 7, 2025 at 1:45 PM
By creating a network of early-career principal investigators, Gianvito Scaringi and his colleagues have enacted change and battled bureaucracy. You can read more about how a group of novice lab leaders are supporting each other: spklr.io/63329B5TIW
#AcademicSky
#AcademicSky
Reposted by Nature Biotechnology
Thanks @natbiotech.nature.com for the shoutout and supporting our work at attempting QC in this emerging field of #spatial #transcriptomics @lgmartelotto.bsky.social @christophermason.bsky.social
Spatial Touchstone brings quality control to spatial transcriptomics #NBTintheNews via @stjuderesearch.bsky.social www.stjude.org/media-resour...
Spatial Touchstone brings quality control to spatial transcriptomics
Explore Spatial Touchstone’s open-source tools and data for standardized spatial transcriptomics, enabling reliable, cross-institutional gene expression analysis.
www.stjude.org
December 5, 2025 at 10:55 PM
Thanks @natbiotech.nature.com for the shoutout and supporting our work at attempting QC in this emerging field of #spatial #transcriptomics @lgmartelotto.bsky.social @christophermason.bsky.social
Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model #NBTNV go.nature.com/4hWkUwE
rdcu.be/eSP1Q
rdcu.be/eSP1Q
Ultrasound mops up damage from hemorrhagic stroke - Nature Biotechnology
Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model.
go.nature.com
December 6, 2025 at 3:26 PM
Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model #NBTNV go.nature.com/4hWkUwE
rdcu.be/eSP1Q
rdcu.be/eSP1Q
Obituary: Pedro Cuatrecasas (1936–2025) go.nature.com/4pHtmCC
Pedro Cuatrecasas (1936–2025) - Nature Biotechnology
Nature Biotechnology - Pedro Cuatrecasas (1936–2025)
go.nature.com
December 4, 2025 at 5:07 PM
Obituary: Pedro Cuatrecasas (1936–2025) go.nature.com/4pHtmCC
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds #NBTNV go.nature.com/47fxSSv
rdcu.be/eSIvL
rdcu.be/eSIvL
Deep learning speeds the search for new antibiotic scaffolds - Nature Biotechnology
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds.
go.nature.com
December 4, 2025 at 4:50 PM
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds #NBTNV go.nature.com/47fxSSv
rdcu.be/eSIvL
rdcu.be/eSIvL
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals go.nature.com/4hZnzW5
rdcu.be/eRy6o
rdcu.be/eRy6o
Recovery of biological signals lost in single-cell batch integration with CellANOVA - Nature Biotechnology
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals.
go.nature.com
December 4, 2025 at 4:49 PM
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals go.nature.com/4hZnzW5
rdcu.be/eRy6o
rdcu.be/eRy6o
Biotech news from around the world: Uganda, UK, Brazil, India nature.com/articles/s41...
rdcu.be/eSP9B
rdcu.be/eSP9B
Biotech news from around the world - Nature Biotechnology
Nature Biotechnology - Biotech news from around the world
nature.com
December 3, 2025 at 11:52 PM
Biotech news from around the world: Uganda, UK, Brazil, India nature.com/articles/s41...
rdcu.be/eSP9B
rdcu.be/eSP9B
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - @jasmineplummer.bsky.social @lgmartelotto.bsky.social go.nature.com/4rBC1Z0
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - Nature Biotechnology
A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.
go.nature.com
December 3, 2025 at 7:58 PM
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - @jasmineplummer.bsky.social @lgmartelotto.bsky.social go.nature.com/4rBC1Z0
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology
Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.
go.nature.com
December 3, 2025 at 7:43 PM
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy
Recent patents relating to mRNA vaccine compositions and methods of use go.nature.com/48dVmb4
rdcu.be/eSP7I
rdcu.be/eSP7I
mRNA vaccines - Nature Biotechnology
Recent patents relating to mRNA vaccine compositions and methods of use.
go.nature.com
December 3, 2025 at 4:49 PM
Recent patents relating to mRNA vaccine compositions and methods of use go.nature.com/48dVmb4
rdcu.be/eSP7I
rdcu.be/eSP7I
Beyond the unprecedented efficacy of GLP-1s in obesity and type 2 diabetes, evidence that they improve comorbidities has been accumulating at an impressive pace in recent years go.nature.com/49aN7gR
December 3, 2025 at 2:11 PM
Beyond the unprecedented efficacy of GLP-1s in obesity and type 2 diabetes, evidence that they improve comorbidities has been accumulating at an impressive pace in recent years go.nature.com/49aN7gR
An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development #NBTNV go.nature.com/48PpE4O
rdcu.be/eSPZd
rdcu.be/eSPZd
Long-term imaging of cell divisions in human preimplantation embryos - Nature Biotechnology
An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development.
go.nature.com
December 3, 2025 at 2:10 PM
An optimized approach for live imaging of human embryos enables visualization of mitotic errors during blastocyst development #NBTNV go.nature.com/48PpE4O
rdcu.be/eSPZd
rdcu.be/eSPZd
Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls go.nature.com/4giANvD
rdcu.be/eRy4P
rdcu.be/eRy4P
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology
Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.
go.nature.com
December 3, 2025 at 5:47 AM
Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls go.nature.com/4giANvD
rdcu.be/eRy4P
rdcu.be/eRy4P
Spurred by the extraordinary success of the GLP-1 agonist class in diabetes and obesity, drug-makers are doubling down on the hunt for better solutions for atherosclerotic cardiovascular disease, hypertension and related conditions go.nature.com/4r9HhTw
rdcu.be/eSQbO
rdcu.be/eSQbO
Heart matters: new treatments, tools and access channels - Nature Biotechnology
Biopharma’s reawakened interest in cardiovascular diseases spans new targets and modalities, with more convenient formulations to boost access and adherence.
go.nature.com
December 3, 2025 at 5:47 AM
Spurred by the extraordinary success of the GLP-1 agonist class in diabetes and obesity, drug-makers are doubling down on the hunt for better solutions for atherosclerotic cardiovascular disease, hypertension and related conditions go.nature.com/4r9HhTw
rdcu.be/eSQbO
rdcu.be/eSQbO
The New York University Biomedical Entrepreneurship Educational Program’s career development awards boost early-stage scientists’ business knowledge and acumen to ease their transition from academia to industry go.nature.com/4ob0vVV
rdcu.be/eSP4C
rdcu.be/eSP4C
Career development awards support early-stage researchers in life sciences entrepreneurship - Nature Biotechnology
The New York University Biomedical Entrepreneurship Educational Program’s career development awards boost early-stage scientists’ business knowledge and acumen to ease their transition from academia t...
go.nature.com
December 2, 2025 at 9:44 PM
The New York University Biomedical Entrepreneurship Educational Program’s career development awards boost early-stage scientists’ business knowledge and acumen to ease their transition from academia to industry go.nature.com/4ob0vVV
rdcu.be/eSP4C
rdcu.be/eSP4C
Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors go.nature.com/4f7daor
rdcu.be/eRy1T
rdcu.be/eRy1T
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells - Nature Biotechnology
Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.
go.nature.com
December 2, 2025 at 7:58 PM
Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors go.nature.com/4f7daor
rdcu.be/eRy1T
rdcu.be/eRy1T
Recent moves of note in and around the biotech and pharma industries go.nature.com/4ifiI3g
rdcu.be/eRy9R
rdcu.be/eRy9R
People - Nature Biotechnology
Recent moves of note in and around the biotech and pharma industries.
go.nature.com
December 1, 2025 at 3:30 PM
Recent moves of note in and around the biotech and pharma industries go.nature.com/4ifiI3g
rdcu.be/eRy9R
rdcu.be/eRy9R
Cell type inference in cell-free nucleic acid liquid biopsy - @sevahn.bsky.social @genentech.bsky.social go.nature.com/4paJOLH
Cell type inference in cell-free nucleic acid liquid biopsy - Nature Biotechnology
Recent computational and experimental advances enable noninvasive inference of cell type in cell-free nucleic acid liquid biopsies, expanding their use across diverse settings.
go.nature.com
December 1, 2025 at 1:35 PM
Cell type inference in cell-free nucleic acid liquid biopsy - @sevahn.bsky.social @genentech.bsky.social go.nature.com/4paJOLH
Reposted by Nature Biotechnology
#NatMicroPicks
Peptibody mRNA therapy for AMR infections! 💉🧬
mRNA-delivered peptibody AMPs eradicate MDR pneumonia and outperform FDA-approved antibiotics while reducing inflammation
#SynBio #MicroSky 🦠 @natbiotech.nature.com
www.nature.com/articles/s41...
Peptibody mRNA therapy for AMR infections! 💉🧬
mRNA-delivered peptibody AMPs eradicate MDR pneumonia and outperform FDA-approved antibiotics while reducing inflammation
#SynBio #MicroSky 🦠 @natbiotech.nature.com
www.nature.com/articles/s41...
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - Nature Biotechnology
Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.
www.nature.com
November 28, 2025 at 1:31 PM
#NatMicroPicks
Peptibody mRNA therapy for AMR infections! 💉🧬
mRNA-delivered peptibody AMPs eradicate MDR pneumonia and outperform FDA-approved antibiotics while reducing inflammation
#SynBio #MicroSky 🦠 @natbiotech.nature.com
www.nature.com/articles/s41...
Peptibody mRNA therapy for AMR infections! 💉🧬
mRNA-delivered peptibody AMPs eradicate MDR pneumonia and outperform FDA-approved antibiotics while reducing inflammation
#SynBio #MicroSky 🦠 @natbiotech.nature.com
www.nature.com/articles/s41...
Reposted by Nature Biotechnology
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
November 27, 2025 at 4:40 AM
Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)