Nature Biotechnology
@natbiotech.nature.com
Publishing the best of biotech science and business. Find us on Twitter, Facebook & Instagram. Part of @natureportfolio.nature.com.
The suitability of different AAV capsids for gene therapy is assessed in human livers go.nature.com/3PWpD4o
rdcu.be/eUK3m
rdcu.be/eUK3m
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion - Nature Biotechnology
The suitability of different AAV capsids for gene therapy is assessed in human livers.
go.nature.com
December 16, 2025 at 2:48 AM
The suitability of different AAV capsids for gene therapy is assessed in human livers go.nature.com/3PWpD4o
rdcu.be/eUK3m
rdcu.be/eUK3m
In vivo CAR-Ts captivate big pharma www.nature.com/articles/s41...
In vivo CAR-Ts captivate big pharma - Nature Biotechnology
In-body manufacturing promises a faster, cheaper and simpler alternative to CAR-T cell therapy — if the field can deliver clinical readouts that prove long-term safety and efficacy.
www.nature.com
December 15, 2025 at 5:46 PM
In vivo CAR-Ts captivate big pharma www.nature.com/articles/s41...
Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - @arccoesb.bsky.social go.nature.com/48Fqxwi
Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - Nature Biotechnology
The Synthetic Yeast Genome Project (Sc2.0) set out to redesign and chemically synthesize an entire eukaryotic genome. This Comment summarizes the design- and construction-related defects revealed duri...
go.nature.com
December 15, 2025 at 4:41 PM
Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - @arccoesb.bsky.social go.nature.com/48Fqxwi
Reposted by Nature Biotechnology
Predicting better lipids: In a cover-winning @natbiotech.nature.com paper, the Anderson & Langer Labs screened 1.6M lipids in silico to speed up successful designs for mRNA delivery to lungs. www.nature.com/articles/s41...
December 12, 2025 at 5:15 PM
Predicting better lipids: In a cover-winning @natbiotech.nature.com paper, the Anderson & Langer Labs screened 1.6M lipids in silico to speed up successful designs for mRNA delivery to lungs. www.nature.com/articles/s41...
Reposted by Nature Biotechnology
Our @natbiotech.nature.com editorial team picks our favorite research articles from 2025. We’ve also posted a Chinese version here 👉 mp.weixin.qq.com/s/fY10zwuljH...
December 9, 2025 at 7:36 AM
Our @natbiotech.nature.com editorial team picks our favorite research articles from 2025. We’ve also posted a Chinese version here 👉 mp.weixin.qq.com/s/fY10zwuljH...
Five questions with Pranam Chatterjee @pranam.bsky.social go.nature.com/4pzXi3P
Five questions with Pranam Chatterjee - Nature Biotechnology
This pioneer in programmable biology creates new methods for the computer science and bioengineering communities and translates those advances to try to solve some of the most fundamental problems fac...
go.nature.com
December 12, 2025 at 7:16 PM
Five questions with Pranam Chatterjee @pranam.bsky.social go.nature.com/4pzXi3P
Our editors pick their favorite research articles from 2025 go.nature.com/4oCK84L
December 12, 2025 at 5:21 PM
Our editors pick their favorite research articles from 2025 go.nature.com/4oCK84L
The December issue is live nature.com/nbt/volumes/...
Hybrid quantum computing for drug design. Ghazi Vakili et al. present a hybrid quantum–classical generative model to design molecules to inhibit KRAS activity. Two candidates are synthesized and further characterized go.nature.com/3EitbLm
Hybrid quantum computing for drug design. Ghazi Vakili et al. present a hybrid quantum–classical generative model to design molecules to inhibit KRAS activity. Two candidates are synthesized and further characterized go.nature.com/3EitbLm
December 12, 2025 at 3:09 PM
The December issue is live nature.com/nbt/volumes/...
Hybrid quantum computing for drug design. Ghazi Vakili et al. present a hybrid quantum–classical generative model to design molecules to inhibit KRAS activity. Two candidates are synthesized and further characterized go.nature.com/3EitbLm
Hybrid quantum computing for drug design. Ghazi Vakili et al. present a hybrid quantum–classical generative model to design molecules to inhibit KRAS activity. Two candidates are synthesized and further characterized go.nature.com/3EitbLm
The outlook for patients with certain forms of fibrosis has finally started to brighten, after a string of clinical trial setbacks over the past decade. In October @US_FDA approved @Boehringer's oral drug Jascayd (nerandomilast) for idiopathic pulmonary fibrosis www.nature.com/articles/s41...
FDA approves new mechanism to treat idiopathic pulmonary fibrosis, expanding limited arsenal - Nature Biotechnology
The first-in-class small molecule Jascayd targets a fibrotic signaling cascade, offering new hope in a stagnant therapeutic field, as several other programs near maturity.
www.nature.com
December 11, 2025 at 5:16 PM
The outlook for patients with certain forms of fibrosis has finally started to brighten, after a string of clinical trial setbacks over the past decade. In October @US_FDA approved @Boehringer's oral drug Jascayd (nerandomilast) for idiopathic pulmonary fibrosis www.nature.com/articles/s41...
Obituary: David Baltimore (1938–2025) go.nature.com/4959dRm
David Baltimore (1938–2025) - Nature Biotechnology
Nature Biotechnology - David Baltimore (1938–2025)
go.nature.com
December 10, 2025 at 5:01 PM
Obituary: David Baltimore (1938–2025) go.nature.com/4959dRm
A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...
Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues
We developed a bioprinting strategy that turns living cells into cell-only bioinks,
enabling light-based 3D bioprinting of tissues at native, ultrahigh cell densities
(up to ∼109 cells mL−1) to rapidl...
www.cell.com
December 9, 2025 at 2:46 PM
A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...
Top ten news stories in 2025 www.nature.com/articles/s41...
Top ten news stories in 2025 - Nature Biotechnology
This year’s most popular stories are a testament to biotech ingenuity and a cause for celebration: the gene editing triumph that cured ‘baby KJ’ of a rare genetic disorder in record time; the bispecif...
www.nature.com
December 9, 2025 at 2:36 PM
Top ten news stories in 2025 www.nature.com/articles/s41...
RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate #NBTNV go.nature.com/4iyZmGv
rdcu.be/eTR4A
rdcu.be/eTR4A
Modulating RNA condensates to control cell fate - Nature Biotechnology
RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate.
go.nature.com
December 9, 2025 at 2:12 PM
RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate #NBTNV go.nature.com/4iyZmGv
rdcu.be/eTR4A
rdcu.be/eTR4A
2025: research in review go.nature.com/4oCK84L
December 8, 2025 at 7:47 PM
2025: research in review go.nature.com/4oCK84L
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - Nature Biotechnology
Virus-like particles are engineered to edit human hematopoietic cells in vivo.
go.nature.com
December 8, 2025 at 6:53 PM
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
Reposted by Nature Biotechnology
By creating a network of early-career principal investigators, Gianvito Scaringi and his colleagues have enacted change and battled bureaucracy. You can read more about how a group of novice lab leaders are supporting each other: spklr.io/63329B5TIW
#AcademicSky
#AcademicSky
‘Anyone hired a student before?’ How a group of novice lab leaders are supporting each other
By creating a network of early-career principal investigators, my colleagues and I have enacted change and battled bureaucracy.
spklr.io
December 7, 2025 at 1:45 PM
By creating a network of early-career principal investigators, Gianvito Scaringi and his colleagues have enacted change and battled bureaucracy. You can read more about how a group of novice lab leaders are supporting each other: spklr.io/63329B5TIW
#AcademicSky
#AcademicSky
Reposted by Nature Biotechnology
Thanks @natbiotech.nature.com for the shoutout and supporting our work at attempting QC in this emerging field of #spatial #transcriptomics @lgmartelotto.bsky.social @christophermason.bsky.social
Spatial Touchstone brings quality control to spatial transcriptomics #NBTintheNews via @stjuderesearch.bsky.social www.stjude.org/media-resour...
Spatial Touchstone brings quality control to spatial transcriptomics
Explore Spatial Touchstone’s open-source tools and data for standardized spatial transcriptomics, enabling reliable, cross-institutional gene expression analysis.
www.stjude.org
December 5, 2025 at 10:55 PM
Thanks @natbiotech.nature.com for the shoutout and supporting our work at attempting QC in this emerging field of #spatial #transcriptomics @lgmartelotto.bsky.social @christophermason.bsky.social
Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model #NBTNV go.nature.com/4hWkUwE
rdcu.be/eSP1Q
rdcu.be/eSP1Q
Ultrasound mops up damage from hemorrhagic stroke - Nature Biotechnology
Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model.
go.nature.com
December 6, 2025 at 3:26 PM
Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model #NBTNV go.nature.com/4hWkUwE
rdcu.be/eSP1Q
rdcu.be/eSP1Q
Obituary: Pedro Cuatrecasas (1936–2025) go.nature.com/4pHtmCC
Pedro Cuatrecasas (1936–2025) - Nature Biotechnology
Nature Biotechnology - Pedro Cuatrecasas (1936–2025)
go.nature.com
December 4, 2025 at 5:07 PM
Obituary: Pedro Cuatrecasas (1936–2025) go.nature.com/4pHtmCC
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds #NBTNV go.nature.com/47fxSSv
rdcu.be/eSIvL
rdcu.be/eSIvL
Deep learning speeds the search for new antibiotic scaffolds - Nature Biotechnology
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds.
go.nature.com
December 4, 2025 at 4:50 PM
A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds #NBTNV go.nature.com/47fxSSv
rdcu.be/eSIvL
rdcu.be/eSIvL
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals go.nature.com/4hZnzW5
rdcu.be/eRy6o
rdcu.be/eRy6o
Recovery of biological signals lost in single-cell batch integration with CellANOVA - Nature Biotechnology
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals.
go.nature.com
December 4, 2025 at 4:49 PM
A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals go.nature.com/4hZnzW5
rdcu.be/eRy6o
rdcu.be/eRy6o
Biotech news from around the world: Uganda, UK, Brazil, India nature.com/articles/s41...
rdcu.be/eSP9B
rdcu.be/eSP9B
Biotech news from around the world - Nature Biotechnology
Nature Biotechnology - Biotech news from around the world
nature.com
December 3, 2025 at 11:52 PM
Biotech news from around the world: Uganda, UK, Brazil, India nature.com/articles/s41...
rdcu.be/eSP9B
rdcu.be/eSP9B
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - @jasmineplummer.bsky.social @lgmartelotto.bsky.social go.nature.com/4rBC1Z0
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - Nature Biotechnology
A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.
go.nature.com
December 3, 2025 at 7:58 PM
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - @jasmineplummer.bsky.social @lgmartelotto.bsky.social go.nature.com/4rBC1Z0
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology
Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.
go.nature.com
December 3, 2025 at 7:43 PM
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy
Recent patents relating to mRNA vaccine compositions and methods of use go.nature.com/48dVmb4
rdcu.be/eSP7I
rdcu.be/eSP7I
mRNA vaccines - Nature Biotechnology
Recent patents relating to mRNA vaccine compositions and methods of use.
go.nature.com
December 3, 2025 at 4:49 PM
Recent patents relating to mRNA vaccine compositions and methods of use go.nature.com/48dVmb4
rdcu.be/eSP7I
rdcu.be/eSP7I