Sam Connell
@samuelconnell.3i.social
Scientist and Global Sales Director at 3i (@the.3i.social), foodie, family man. Tai Chi and meditation matter. Compassion Heals. Microscopes Rock. https://www.intelligent-imaging.com
Reposted by Sam Connell
Some news 🎉
After five incredible years in Tübingen, it’s time to say goodbye.
Starting February, the Mutualisms Lab will relocate to the John Innes Centre, right next door to @berasymbionts.bsky.social and her group at The Sainsbury Laboratory 🪲🦠
After five incredible years in Tübingen, it’s time to say goodbye.
Starting February, the Mutualisms Lab will relocate to the John Innes Centre, right next door to @berasymbionts.bsky.social and her group at The Sainsbury Laboratory 🪲🦠
November 24, 2025 at 6:42 PM
Some news 🎉
After five incredible years in Tübingen, it’s time to say goodbye.
Starting February, the Mutualisms Lab will relocate to the John Innes Centre, right next door to @berasymbionts.bsky.social and her group at The Sainsbury Laboratory 🪲🦠
After five incredible years in Tübingen, it’s time to say goodbye.
Starting February, the Mutualisms Lab will relocate to the John Innes Centre, right next door to @berasymbionts.bsky.social and her group at The Sainsbury Laboratory 🪲🦠
Reposted by Sam Connell
Rejon Taylor was one of 37 people on federal death row whose death sentence was commuted by then-President Biden. This year, he learned the Trump administration was sending him to a supermax prison once called a “clean version of hell.”
Death Row Prisoners Granted Clemency by Biden Brace for “Living Hell” Under Trump
Trump officials are retaliating by imposing the harshest conditions in the entire federal prison system, including near total isolation.
boltsmag.org
November 24, 2025 at 11:00 PM
Rejon Taylor was one of 37 people on federal death row whose death sentence was commuted by then-President Biden. This year, he learned the Trump administration was sending him to a supermax prison once called a “clean version of hell.”
Reposted by Sam Connell
For scale: I spent eleven days in the maximum security wing of a local county lockup before a judge heard my case and moved me to min. I had one hour out of the cell a day. The cell was small. There was a speaker in the ceiling. By the end I was talking to the speaker and spending hours each day
Rejon Taylor was one of 37 people on federal death row whose death sentence was commuted by then-President Biden. This year, he learned the Trump administration was sending him to a supermax prison once called a “clean version of hell.”
Death Row Prisoners Granted Clemency by Biden Brace for “Living Hell” Under Trump
Trump officials are retaliating by imposing the harshest conditions in the entire federal prison system, including near total isolation.
boltsmag.org
November 25, 2025 at 12:07 AM
For scale: I spent eleven days in the maximum security wing of a local county lockup before a judge heard my case and moved me to min. I had one hour out of the cell a day. The cell was small. There was a speaker in the ceiling. By the end I was talking to the speaker and spending hours each day
Reposted by Sam Connell
With the goal of reaching new ppl w/biodiversity action, we're expanding the Native Plant Project to bars. We're calling it Biodiversity Beers.
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
November 25, 2025 at 1:59 AM
With the goal of reaching new ppl w/biodiversity action, we're expanding the Native Plant Project to bars. We're calling it Biodiversity Beers.
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
In collab w/artists Marian Bailey, @hanfranstudio.bsky.social, & @the666cat.bsky.social, we're making pint glasses that encourage planting of native 🌱
Reposted by Sam Connell
Statement from @health.nationalacademies.org "...based on our body of work on this topic and the overwhelming scientific consensus, we support the statement that vaccines do not cause autism."
www.nationalacademies.org/news/stateme...
www.nationalacademies.org/news/stateme...
National Academies - Statement on CDC’s Updated Vaccine Guidance
National Academies respond to CDC’s updated vaccine guidance, offering scientific context and clarity on vaccine safety.
www.nationalacademies.org
November 25, 2025 at 1:29 AM
Statement from @health.nationalacademies.org "...based on our body of work on this topic and the overwhelming scientific consensus, we support the statement that vaccines do not cause autism."
www.nationalacademies.org/news/stateme...
www.nationalacademies.org/news/stateme...
Reposted by Sam Connell
Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods
TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.
www.nature.com
November 24, 2025 at 9:38 PM
Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...
Reposted by Sam Connell
New septin paper by our next door lab neighbors @ebrahim-lab.bsky.social, and on the cover of JCI Insight no less.
Septin 9 reinforces intestinal epithelial junctions, preventing leaky gut and inflammation.
Check it out!
Septin 9 reinforces intestinal epithelial junctions, preventing leaky gut and inflammation.
Check it out!
This issue’s Cover: @ebrahim-lab.bsky.social @dominikrobak.bsky.social& team report on the septin cytoskeleton at apical junctions of intestinal epithelial cells, whereby it maintains barrier integrity & protects from inflammation: insight.jci.org/articles/vie...
November 24, 2025 at 7:45 PM
New septin paper by our next door lab neighbors @ebrahim-lab.bsky.social, and on the cover of JCI Insight no less.
Septin 9 reinforces intestinal epithelial junctions, preventing leaky gut and inflammation.
Check it out!
Septin 9 reinforces intestinal epithelial junctions, preventing leaky gut and inflammation.
Check it out!
Reposted by Sam Connell
Costco sells 908g pecan halves for about $15. Every Autumn, I use unbroken halves for an elaborate confection. The thing is, some are always broken and only 70-80% are usable for it.
So if you buy Kirkland pecans for pies, candies, etc that require perfect, unbroken halves, plan accordingly.
So if you buy Kirkland pecans for pies, candies, etc that require perfect, unbroken halves, plan accordingly.
November 24, 2025 at 4:01 PM
Costco sells 908g pecan halves for about $15. Every Autumn, I use unbroken halves for an elaborate confection. The thing is, some are always broken and only 70-80% are usable for it.
So if you buy Kirkland pecans for pies, candies, etc that require perfect, unbroken halves, plan accordingly.
So if you buy Kirkland pecans for pies, candies, etc that require perfect, unbroken halves, plan accordingly.
Reposted by Sam Connell
ARC says they’ll announce DECRA and LIEF outcomes tomorrow (Tuesday 25th Nov).
In recent times these announcements have been around 11am Canberra time. With 2 schemes on the same day, I assume they’ll announce one of them later in the day (probably DECRA first).
In recent times these announcements have been around 11am Canberra time. With 2 schemes on the same day, I assume they’ll announce one of them later in the day (probably DECRA first).
November 23, 2025 at 11:40 PM
ARC says they’ll announce DECRA and LIEF outcomes tomorrow (Tuesday 25th Nov).
In recent times these announcements have been around 11am Canberra time. With 2 schemes on the same day, I assume they’ll announce one of them later in the day (probably DECRA first).
In recent times these announcements have been around 11am Canberra time. With 2 schemes on the same day, I assume they’ll announce one of them later in the day (probably DECRA first).
Reposted by Sam Connell
What has mindfulness ever done for us?! It's highly effective for chronic pain bit.ly/2lCDwcr
How to breathe yourself happier: This week doctors claimed meditation can beat pain and depression. I'm living proof... - Mindfulness: Finding Peace in a Frantic World
William Bankes-Jones had horrific para-gliding accident in Norfolk Was in terrible pain for weeks afterwards – until he tried meditation His suffering reduced by around 90 per cent after only 20 minutes...
bit.ly
November 24, 2025 at 7:12 PM
What has mindfulness ever done for us?! It's highly effective for chronic pain bit.ly/2lCDwcr
Reposted by Sam Connell
Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him
Interview with Journal of Cell Science Editor Subhojit Roy
ABSTRACT. Subhojit Roy is Professor of Pathology at the University of California San Diego (UCSD) in the USA. Subhojit completed his MD in Kolkata, India and then moved to Temple University in Philade...
journals.biologists.com
November 24, 2025 at 4:14 PM
Did you know that @jcellsci.bsky.social has a new editor for neuronal cell biology? It's that guy @roylab-ucsd.bsky.social, I've heard good things about him
Reposted by Sam Connell
Spatiotemporal dynamics of CYCLOIDEA expression during early floral development in monkeyflower www.cell.com/current-biol...
Spatiotemporal dynamics of CYCLOIDEA expression during early floral development in monkeyflower
Bilateral floral symmetry is a repeated evolutionary innovation governed by the CYCLOIDEA-dependent
program, yet how the dorsal-specific CYC expression is initiated and maintained remains
elusive. Min...
www.cell.com
November 23, 2025 at 10:50 PM
Spatiotemporal dynamics of CYCLOIDEA expression during early floral development in monkeyflower www.cell.com/current-biol...
Reposted by Sam Connell
Never cross a picket line.
Physical or virtual.
Don’t do it. Respect the workers rights and process.
Physical or virtual.
Don’t do it. Respect the workers rights and process.
Remember that striking Starbucks workers are asking you not to buy Starbucks right now
November 24, 2025 at 3:29 PM
Never cross a picket line.
Physical or virtual.
Don’t do it. Respect the workers rights and process.
Physical or virtual.
Don’t do it. Respect the workers rights and process.
Reposted by Sam Connell
Very happy to share that this paper is now online on @currentbiology.bsky.social !! 🥳🧪 Check out the final published verion here: www.cell.com/current-biol...
#mimuluspropaganda
#mimuluspropaganda
November 24, 2025 at 4:25 PM
Very happy to share that this paper is now online on @currentbiology.bsky.social !! 🥳🧪 Check out the final published verion here: www.cell.com/current-biol...
#mimuluspropaganda
#mimuluspropaganda
Reposted by Sam Connell
"Hawaiians drink the most coffee in the US, with 2.7 cups per day & 57,159 cups in a lifetime." Lots more fun coffee data here... cafely.com/blogs/resear...
Coffee Consumption by Country 2025: Lifetime Data & Statistics
Ever wondered what you'll spend on coffee your whole life? We crunched the numbers globally, looking at life expectancy and coffee habits.
cafely.com
November 24, 2025 at 7:05 AM
"Hawaiians drink the most coffee in the US, with 2.7 cups per day & 57,159 cups in a lifetime." Lots more fun coffee data here... cafely.com/blogs/resear...
Reposted by Sam Connell
Anyone have good recommendations for science books for very curious young boys (aged 8-12)?
November 24, 2025 at 7:58 AM
Anyone have good recommendations for science books for very curious young boys (aged 8-12)?
Reposted by Sam Connell
Twitter accounts are based in Russia. BlueSky accounts are based in homes with, frankly, too many books, plants, obsolete cables, and pieces of rustic pottery, that could do with a bit of a tidying up, to be honest.
November 23, 2025 at 8:29 PM
Twitter accounts are based in Russia. BlueSky accounts are based in homes with, frankly, too many books, plants, obsolete cables, and pieces of rustic pottery, that could do with a bit of a tidying up, to be honest.
A movie that takes place where you're from
November 23, 2025 at 6:20 AM
A movie that takes place where you're from
UCSD, my girlfriend's stepbrother's girlfriend worked at Pharmingen. Good folks introduced me to the head of R&D-cue scene a few months later, I'm standing with colleagues staring at a lightbox with GFP, licensed from Roger Tsien, staring back at me. Flow cytometry & microscopy opened all doors.🔬🥽🧬🧪
November 23, 2025 at 3:02 AM
UCSD, my girlfriend's stepbrother's girlfriend worked at Pharmingen. Good folks introduced me to the head of R&D-cue scene a few months later, I'm standing with colleagues staring at a lightbox with GFP, licensed from Roger Tsien, staring back at me. Flow cytometry & microscopy opened all doors.🔬🥽🧬🧪
Reposted by Sam Connell
Either:
1) Those in the Trump administration who are pursuing this suit do not know history, or…
2) Those in the Trump administration who are pursuing this suit know the history of govt. lists of Jews very well.
Either option is terrifying.
There is no reason for them to collect this information
1) Those in the Trump administration who are pursuing this suit do not know history, or…
2) Those in the Trump administration who are pursuing this suit know the history of govt. lists of Jews very well.
Either option is terrifying.
There is no reason for them to collect this information
New York Times coverage of lawsuit requesting names of Jewish employees at Penn.
[Gift Link]
www.nytimes.com/2025/11/21/u...
[Gift Link]
www.nytimes.com/2025/11/21/u...
Federal Suit Seeking Names of Some Jewish Employees at Penn Sparks Backlash
www.nytimes.com
November 22, 2025 at 10:14 PM
Either:
1) Those in the Trump administration who are pursuing this suit do not know history, or…
2) Those in the Trump administration who are pursuing this suit know the history of govt. lists of Jews very well.
Either option is terrifying.
There is no reason for them to collect this information
1) Those in the Trump administration who are pursuing this suit do not know history, or…
2) Those in the Trump administration who are pursuing this suit know the history of govt. lists of Jews very well.
Either option is terrifying.
There is no reason for them to collect this information
Reposted by Sam Connell
Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
www.nature.com/articles/s42...
www.nature.com/articles/s42...
November 22, 2025 at 7:59 PM
Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Sam Connell
Shocker... 🙃 www.embopress.org/doi/full/10....
Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro | EMBO reports
imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific
manner, both in cells and in vitro, highlighting the need for careful validation in
condensate studi...
www.embopress.org
November 22, 2025 at 3:55 PM
Shocker... 🙃 www.embopress.org/doi/full/10....
Reposted by Sam Connell
My favorite method would be FRET, but it's a challenging one. A somewhat easier method is Bimolecular fluorescence complementation (BiFC) analysis. Most common of the bunch is Split YFP. The S:N is VERY high and less caveats compared to FRET, but as a pair of methods together...very cool tools.
November 22, 2025 at 3:16 AM
My favorite method would be FRET, but it's a challenging one. A somewhat easier method is Bimolecular fluorescence complementation (BiFC) analysis. Most common of the bunch is Split YFP. The S:N is VERY high and less caveats compared to FRET, but as a pair of methods together...very cool tools.
Reposted by Sam Connell
Ok. I have a boring science question. And it’s very basic but not necessarily easy to answer:
What method would be your top choice for showing that two proteins physically interact?
What method would be your top choice for showing that two proteins physically interact?
November 21, 2025 at 9:04 PM
Ok. I have a boring science question. And it’s very basic but not necessarily easy to answer:
What method would be your top choice for showing that two proteins physically interact?
What method would be your top choice for showing that two proteins physically interact?
Reposted by Sam Connell
Thanks to @nature.com for featuring our work in this piece on genetically-encoded sensors.
The article does a great job highlighting their importance for both basic research and translational impact, such as in our lab's research on serotonin.
www.nature.com/articles/d41...
The article does a great job highlighting their importance for both basic research and translational impact, such as in our lab's research on serotonin.
www.nature.com/articles/d41...
How genetically encoded sensors have lit up neuroscience
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.
www.nature.com
November 21, 2025 at 5:56 PM
Thanks to @nature.com for featuring our work in this piece on genetically-encoded sensors.
The article does a great job highlighting their importance for both basic research and translational impact, such as in our lab's research on serotonin.
www.nature.com/articles/d41...
The article does a great job highlighting their importance for both basic research and translational impact, such as in our lab's research on serotonin.
www.nature.com/articles/d41...