Jeff Mold
@jeffmold.bsky.social
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
Pinned
Jeff Mold
@jeffmold.bsky.social
· Nov 15
My policy on this app is to follow as many scientists as possible. I want a robust, highly varied network of people to discuss all biological research. Especially students
Reposted by Jeff Mold
reading this interesting preprint on time-resolved scRNA-seq. while technically impressive, i would argue simpler methods for multiplexed scRNA-seq outperform ChronoSeq.
Minute-scale single-cell transcriptomics enables dynamic modeling of cellular behavior
Dynamic cellular processes such as signaling, fate decisions, and intercellular communication unfold on minute timescales, a regime inaccessible to conventional transcriptomic methods. This temporal g...
www.biorxiv.org
November 28, 2025 at 7:45 PM
reading this interesting preprint on time-resolved scRNA-seq. while technically impressive, i would argue simpler methods for multiplexed scRNA-seq outperform ChronoSeq.
Best. Title. Ever. www.science.org/doi/10.1126/...
Monkeys have rhythm
Synchronizing movements to music is a hallmark of human culture, but its evolutionary and neurobiological origins remain unknown. This ability requires (i) extracting a steady rhythmic pulse, or beat,...
www.science.org
November 27, 2025 at 9:52 PM
Best. Title. Ever. www.science.org/doi/10.1126/...
Has anyone ever done a calculation on how much time is spent reviewing papers and grants by senior academics? From the volume of publications and the length of modern papers the top 10-20 biomedical journals must generate 1000s of hours of work per month I’d say a top tier paper takes me 8-10 hours
November 27, 2025 at 11:10 AM
Has anyone ever done a calculation on how much time is spent reviewing papers and grants by senior academics? From the volume of publications and the length of modern papers the top 10-20 biomedical journals must generate 1000s of hours of work per month I’d say a top tier paper takes me 8-10 hours
Reposted by Jeff Mold
If you dont have full text access, here is a link provided to authors by Cell Press that should open for the next 49 days:
authors.elsevier.com/c/1mARi_278y...
authors.elsevier.com/c/1mARi_278y...
November 27, 2025 at 8:23 AM
If you dont have full text access, here is a link provided to authors by Cell Press that should open for the next 49 days:
authors.elsevier.com/c/1mARi_278y...
authors.elsevier.com/c/1mARi_278y...
Reposted by Jeff Mold
AID's role in class switch recombination & somatic hypermutation was published in @cellpress.bsky.social 25 years ago, a tour de force combo of mouse gene discovery & mechanistic work (Honjo lab) and human genetics (Durandy, Fischer et al).
What a privilege to write this with Sidonia & Masamichi
What a privilege to write this with Sidonia & Masamichi
Activation-induced cytidine deaminase: The missing piece of many puzzles
Twenty-five years ago, two Cell papers reported the key missing functional piece in
three molecular puzzles. The genetic swapping of immunoglobulin constant regions,
the mutational fine-tuning of anti...
www.cell.com
November 26, 2025 at 5:58 PM
AID's role in class switch recombination & somatic hypermutation was published in @cellpress.bsky.social 25 years ago, a tour de force combo of mouse gene discovery & mechanistic work (Honjo lab) and human genetics (Durandy, Fischer et al).
What a privilege to write this with Sidonia & Masamichi
What a privilege to write this with Sidonia & Masamichi
“For a transitory enchanted moment man must have held his breath in the presence of this UMAP, compelled into an aesthetic contemplation he neither understood nor desired, face to face for the last time in history with something commensurate to his capacity for wonder.”
November 26, 2025 at 2:11 PM
“For a transitory enchanted moment man must have held his breath in the presence of this UMAP, compelled into an aesthetic contemplation he neither understood nor desired, face to face for the last time in history with something commensurate to his capacity for wonder.”
Reposted by Jeff Mold
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jeff Mold
'As we observe in our paper ‘[w]hile rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work.’'
blogs.lse.ac.uk/impactofsoci...
blogs.lse.ac.uk/impactofsoci...
Money, Time, Trust, Control – How commercial publishers drain science - Impact of Social Sciences
Have the interests of commercial publishers now become antithetical to the pursuit of knowledge?
blogs.lse.ac.uk
November 19, 2025 at 5:04 PM
'As we observe in our paper ‘[w]hile rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work.’'
blogs.lse.ac.uk/impactofsoci...
blogs.lse.ac.uk/impactofsoci...
Anyone have good recommendations for science books for very curious young boys (aged 8-12)?
November 24, 2025 at 7:58 AM
Anyone have good recommendations for science books for very curious young boys (aged 8-12)?
Reposted by Jeff Mold
"If the data is accurate...it would call into question the business model of OpenAI and nearly every other general-purpose LLM vendor" www.ft.com/content/fce7...
How high are OpenAI’s compute costs? Possibly a lot higher than we thought
Inference inferred, revenue reconstructed, cash burn quantified
www.ft.com
November 22, 2025 at 2:13 PM
"If the data is accurate...it would call into question the business model of OpenAI and nearly every other general-purpose LLM vendor" www.ft.com/content/fce7...
Holy crap the USA is really a full blown idiocracy now - to quote their leader SAD!!! www.nature.com/articles/d41...
Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance
The Make America Healthy Again summit, attended by health secretary Robert F. Kennedy Jr and vice-president JD Vance, gave a sense of what’s driving US health policy.
www.nature.com
November 22, 2025 at 12:01 PM
Holy crap the USA is really a full blown idiocracy now - to quote their leader SAD!!! www.nature.com/articles/d41...
Reposted by Jeff Mold
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
November 21, 2025 at 8:15 PM
Cinque, Verheyden, Adnane et al. @leuccilrcb.bsky.social reveal the contribution of #lncRNAs to the generation of cancer-specific #ribosomes and identify an RNA-based strategy to overcome resistance to immune checkpoint blockade. rupress.org/jem/article/...
#Melanoma
#Melanoma
Reposted by Jeff Mold
New midweek podcast! Check your feeds 👇
Hats off to @onthemedia.bsky.social for calling out the spam machines behind politics. Bravo! I for one, have created a series of filters and fake emails just to defeat this crapola pain in the butt money shilling. Damn, I hope Dems take the hint.
www.wnycstudios.org/podcasts/otm...
www.wnycstudios.org/podcasts/otm...
The Democratic Party's Spam Machine | On the Media | WNYC Studios
If you’ve ever donated to a Democratic candidate, you’ve probably been rewarded with a never-ending stream of pleas for more money.
www.wnycstudios.org
November 20, 2025 at 7:40 PM
New midweek podcast! Check your feeds 👇
Interesting: www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 7:36 PM
Interesting: www.science.org/doi/10.1126/...
Reposted by Jeff Mold
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples - Nature
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 19, 2025 at 9:00 PM
Our new paper is out in Nature - online today!
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Huge congrats to shared first authors Sofía Ibáñez-Molero & Johanna Veldman, the whole team & all collaborators.
📄 Open-access paper: www.nature.com/articles/s41...
Love Kevin Mitchell’s views on big data - open.spotify.com/episode/01w8...
Autism, Microbiomes, & Mice Burying Marbles with Kevin Mitchell
open.spotify.com
November 19, 2025 at 10:14 AM
Love Kevin Mitchell’s views on big data - open.spotify.com/episode/01w8...
Reposted by Jeff Mold
"academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it... The dominant four collectively generated... $12 billion in profits between 2019 and 2024."
November 18, 2025 at 6:48 AM
"academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it... The dominant four collectively generated... $12 billion in profits between 2019 and 2024."
Reposted by Jeff Mold
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Reposted by Jeff Mold
Post 1
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
November 18, 2025 at 7:22 AM
Post 1
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)