Jeff Mold
@jeffmold.bsky.social
1.5K followers 2.2K following 910 posts
American/Swedish Biomedical Scientist studying immunology and cancer. My favorite cell atlases say “here be dragons” on the UMAPs. @karolinska institute https://scholar.google.com/citations?hl=en&user=_owb98cAAAAJ&view_op=list_works&sortby=pubdate
Posts Media Videos Starter Packs
Pinned
jeffmold.bsky.social
My policy on this app is to follow as many scientists as possible. I want a robust, highly varied network of people to discuss all biological research. Especially students
jeffmold.bsky.social
And wouldn’t you expect clones with p53 mutations to acquire more mutations over time?
jeffmold.bsky.social
Yes it does! I was just curious if the accumulated data pointed towards cells with extreme levels of mutations or a more random process leading to selection of a few fit clones. So you never see highly mutated clones (for example with apobec signatures )
jeffmold.bsky.social
@imartincorena.bsky.social Perhaps this is a silly question - but do you think that you more often observe that there are several (10s-100s) clones which have many distinct mutations or do you find that the mutations are evenly distributed among a larger number of clones with each having only a few?
Reposted by Jeff Mold
biorxiv-cancer.bsky.social
Genetic elements promote retention of extrachromosomal DNA in cancer cells https://www.biorxiv.org/content/10.1101/2025.10.10.681495v1
Reposted by Jeff Mold
robp.bsky.social
Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬
robp.bsky.social
And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!
Reposted by Jeff Mold
stephenturner.us
Lost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...
jeffmold.bsky.social
It’s one thing to be wrong but a totally different thing to push crazy theories in the real scientific literature without doing even a modest amount of negative hypothesis testing. This is the real world outcome of the impact chasing game we have created in science…
jeffmold.bsky.social
For me it’s this paper that started the ridiculous “covid is like hiv” insanity. And then a pile on by uninformed people on social media misunderstanding how T cells relocate during acute inflammatory responses… I’ll make a point of clearly teaching this to my students this fall
jeffmold.bsky.social
One more in a growing number of irresponsible publications which use “big data” to try and look for any signs of an effect and then market it like hell for cites/impact
jeffmold.bsky.social
It’s insane how one crappy nature immunology paper and efforts to spin a narrative to increase impact can have so much damage… or at least I credit it to that “il7r- naive” T cells are depleted hogwash
jeffmold.bsky.social
I think it’s given by the Norwegians… but I highly doubt Trump knows that or the area codes of either country
jeffmold.bsky.social
Love your work. It’s inspiring!
Reposted by Jeff Mold
raflynn5.bsky.social
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
jeffmold.bsky.social
Ah of course shevach!
jeffmold.bsky.social
I always associated Wildin with the scurfy story too
jeffmold.bsky.social
I guess the focus was on foxp3 or else one could’ve included Maria Grazia Roncarolo and it’s a shame rudensky was left off since he was right there on foxp3 huh
jeffmold.bsky.social
I’m just a big fan of his early work and perseverance to study something everyone else had given up on is all :)