Prasad Jallepalli, MD, PhD
@prasad.bsky.social
Prof & Lab Head in NYC. 100% research: cell division, genome integrity, cancer.
Curious to a fault. Also πολύτροπος. Talking here for me alone. I listen to the finest worksong. Like/repost = bookmark/news, not agreement/endorsement.
Curious to a fault. Also πολύτροπος. Talking here for me alone. I listen to the finest worksong. Like/repost = bookmark/news, not agreement/endorsement.
Reposted by Prasad Jallepalli, MD, PhD
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
Hearing news that Carl Dieffenbach, the Director of the Division of AIDS at #NIH (NIAID), has been removed from his position because he was "not aligned with HHS/OMB."
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
Russell Vought continues to remove great scientists as part of the Project 2025 mission to politicize and destroy NIH.
🧪 1/
November 24, 2025 at 5:49 AM
Unfortunately, I can confirm that this is true.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
I have known Carl for 2 decades and he is smart, dedicated, and quite apolitical, focused on science and getting stuff done on important problems.
Huge unnecessary loss of leadership and expertise.
no offense to friends quoted, but this is a trip on several levels
November 24, 2025 at 6:08 AM
no offense to friends quoted, but this is a trip on several levels
the least lagomorph was here with us all the time
November 24, 2025 at 5:13 AM
the least lagomorph was here with us all the time
Reposted by Prasad Jallepalli, MD, PhD
My thoughts on ABC news- Scientists, not political appointees, should be who advises the public on clinical guidance. RFK needs to meet with CDC career leaders and learn about the agency's responses to outbreaks and overall programs vs directing CDC website changes based on ideology not science
Video Former CDC chief on agency webpage saying autism, vaccines link ignored
Dr. Debra Houry, who resigned from her position as chief medical officer of the CDC in 2025, called the change on the CDC’s website "disturbing."
abcnews.go.com
November 22, 2025 at 8:10 PM
My thoughts on ABC news- Scientists, not political appointees, should be who advises the public on clinical guidance. RFK needs to meet with CDC career leaders and learn about the agency's responses to outbreaks and overall programs vs directing CDC website changes based on ideology not science
Reposted by Prasad Jallepalli, MD, PhD
“Do not trust the CDC website and quite certainly do not trust anything that RFK says around your own health” Former CDC official @drdemetre.bsky.social says plainly that information coming out of the CDC cannot be trusted under Robert F. Kennedy’s leadership.
November 23, 2025 at 3:06 PM
“Do not trust the CDC website and quite certainly do not trust anything that RFK says around your own health” Former CDC official @drdemetre.bsky.social says plainly that information coming out of the CDC cannot be trusted under Robert F. Kennedy’s leadership.
Reposted by Prasad Jallepalli, MD, PhD
I have been saying I wanted to write about this, so I am glad that I was able to just spend two solid days working on this story, basically without interruption. I haven’t had much of that since January, but it’s important, and I hope folks who appreciate it subscribe if they don’t already!
NEW: Multiple judges call out DOJ's methods of defending its invasive trans care subpoenas.
A trio of public rulings, including one on Friday, all side with providers. Two rulings also raised sharp questions about DOJ's moves in recent months.
Tonight, at Law Dork:
A trio of public rulings, including one on Friday, all side with providers. Two rulings also raised sharp questions about DOJ's moves in recent months.
Tonight, at Law Dork:
Multiple judges call out DOJ's methods of defending its invasive trans care subpoenas
A trio of public rulings, including one on Friday, all side with providers. Two rulings also raised sharp questions about DOJ's moves in recent months.
www.lawdork.com
November 24, 2025 at 4:37 AM
I have been saying I wanted to write about this, so I am glad that I was able to just spend two solid days working on this story, basically without interruption. I haven’t had much of that since January, but it’s important, and I hope folks who appreciate it subscribe if they don’t already!
Reposted by Prasad Jallepalli, MD, PhD
This is concerning.
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
November 24, 2025 at 12:29 AM
This is concerning.
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
NIH is changing their policy so that staff have to prepare justification for every application that is funded BUT NO DOCUMENTATION FOR APPLICATIONS THAT ARE SKIPPED (BASED ON PERCENTILES).
1/2
at root, the question is whether we (as a society) prefer to accommodate the people and the land we share, or else prefer to fight a violent and pointless Second Civil War to settle the question
I think we win on both, but sometimes fools run in regardless
I think we win on both, but sometimes fools run in regardless
“A tamale vendor was detained outside a Home Depot.
“Soon after, federal agents arrested a flower seller in Archer Heights.
“Then they came for a cotton candy vendor in Little Village.”
apnews.com/article/chic...
“Soon after, federal agents arrested a flower seller in Archer Heights.
“Then they came for a cotton candy vendor in Little Village.”
apnews.com/article/chic...
Chicagoans buy out street vendors amid a federal immigration crackdown
Across Chicago’s Latino neighborhoods, fear of a federal immigration crackdown has emptied the streets.
apnews.com
November 24, 2025 at 12:56 AM
at root, the question is whether we (as a society) prefer to accommodate the people and the land we share, or else prefer to fight a violent and pointless Second Civil War to settle the question
I think we win on both, but sometimes fools run in regardless
I think we win on both, but sometimes fools run in regardless
JFC — in a just world this would be an impeachable offense all alone
Putting a US person with no credible allegation of criminal misconduct through this Kafkaesque horror is wrong on principle
If it’s allowed for KAG, it’s allowed for us all
Putting a US person with no credible allegation of criminal misconduct through this Kafkaesque horror is wrong on principle
If it’s allowed for KAG, it’s allowed for us all
Kilmar Abrego Garcia's lawyers inform a federal judge about the Washington Post's bombshell: The government's claim that Costa Rica will no longer accept Abrego has been exposed as a lie.
More evidence—"if any were needed"—of vindictive prosecution.
Doc storage.courtlistener.com/recap/gov.us...
More evidence—"if any were needed"—of vindictive prosecution.
Doc storage.courtlistener.com/recap/gov.us...
November 24, 2025 at 12:32 AM
JFC — in a just world this would be an impeachable offense all alone
Putting a US person with no credible allegation of criminal misconduct through this Kafkaesque horror is wrong on principle
If it’s allowed for KAG, it’s allowed for us all
Putting a US person with no credible allegation of criminal misconduct through this Kafkaesque horror is wrong on principle
If it’s allowed for KAG, it’s allowed for us all
Reposted by Prasad Jallepalli, MD, PhD
Twitter accounts are based in Russia. BlueSky accounts are based in homes with, frankly, too many books, plants, obsolete cables, and pieces of rustic pottery, that could do with a bit of a tidying up, to be honest.
November 23, 2025 at 8:29 PM
Twitter accounts are based in Russia. BlueSky accounts are based in homes with, frankly, too many books, plants, obsolete cables, and pieces of rustic pottery, that could do with a bit of a tidying up, to be honest.
this is the crux — by definition, an illegal order has no validity, no effect, and no safe harbor to spare one’s own duties to the Constitution
I’ll take Lafayette over Louis XIV every single time
I’ll take Lafayette over Louis XIV every single time
November 24, 2025 at 12:25 AM
this is the crux — by definition, an illegal order has no validity, no effect, and no safe harbor to spare one’s own duties to the Constitution
I’ll take Lafayette over Louis XIV every single time
I’ll take Lafayette over Louis XIV every single time
Reposted by Prasad Jallepalli, MD, PhD
There is a post circulating on Bluesky encouraging the moving of a frozen turkey straight into a pot of hot oil. We are combating this misinformation the best way we know how - through the power of dance music.
November 23, 2025 at 1:31 PM
There is a post circulating on Bluesky encouraging the moving of a frozen turkey straight into a pot of hot oil. We are combating this misinformation the best way we know how - through the power of dance music.
I just had a long conversation with dear friends about this
we’ve strayed so far from Washington’s apocryphal “I cannot tell a lie”
There are virtues in truth-telling and truth-demanding that are incredibly powerful, as the example of science shows
That’s one reason people like me are a threat
we’ve strayed so far from Washington’s apocryphal “I cannot tell a lie”
There are virtues in truth-telling and truth-demanding that are incredibly powerful, as the example of science shows
That’s one reason people like me are a threat
Used to be, one trait associated with integrity was the ability to acknowledge a mistake, apologize, and attempt to correct it.
TAPPER: You were the deciding vote that allowed RFK Jr to ascend to the role of Health Secretary. Did you give him too much credit?
CASSIDY: The fact is the scientific community agrees that vaccines are safe. That's all I can say.
CASSIDY: The fact is the scientific community agrees that vaccines are safe. That's all I can say.
November 23, 2025 at 10:24 PM
I just had a long conversation with dear friends about this
we’ve strayed so far from Washington’s apocryphal “I cannot tell a lie”
There are virtues in truth-telling and truth-demanding that are incredibly powerful, as the example of science shows
That’s one reason people like me are a threat
we’ve strayed so far from Washington’s apocryphal “I cannot tell a lie”
There are virtues in truth-telling and truth-demanding that are incredibly powerful, as the example of science shows
That’s one reason people like me are a threat
Reposted by Prasad Jallepalli, MD, PhD
I might throw up.
What a place.
What a place.
November 23, 2025 at 10:14 PM
I might throw up.
What a place.
What a place.
this is obscene
November 23, 2025 at 10:12 PM
this is obscene
one of the fun things I like to do in debates is to accept premises like this one and then explore the contrapositive, which as we all know are logically equivalent to the original statement
play stupid games, win stupid prizes
play stupid games, win stupid prizes
November 23, 2025 at 9:50 PM
one of the fun things I like to do in debates is to accept premises like this one and then explore the contrapositive, which as we all know are logically equivalent to the original statement
play stupid games, win stupid prizes
play stupid games, win stupid prizes
How can one pretend to be this dumb?
November 23, 2025 at 9:44 PM
How can one pretend to be this dumb?
Reposted by Prasad Jallepalli, MD, PhD
Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineered chromatin readers track damaged chromatin dynamics in live cells and animals - Nature Communications
DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling r...
www.nature.com
November 22, 2025 at 12:13 PM
Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Prasad Jallepalli, MD, PhD
West Point is committing "a crime of serious proportion" then.
November 23, 2025 at 4:56 PM
West Point is committing "a crime of serious proportion" then.
Reposted by Prasad Jallepalli, MD, PhD
FWIW, a court reporter's account, submitted *by the govt* on 11/19 in the Comey case--before it switched positions on 11/20—shows that the full grand jury could not possibly have approved the operational 2-count indictment.
The jury was "released" when deliberations ended.
The jury was "released" when deliberations ended.
November 23, 2025 at 4:48 PM
FWIW, a court reporter's account, submitted *by the govt* on 11/19 in the Comey case--before it switched positions on 11/20—shows that the full grand jury could not possibly have approved the operational 2-count indictment.
The jury was "released" when deliberations ended.
The jury was "released" when deliberations ended.
Reposted by Prasad Jallepalli, MD, PhD
This is a story about how America’s world-leading cancer and dementia research system was destroyed by frauds and naifs who broke the law.
There must be consequences.
There must be consequences.
Some incredible details in this piece
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
*one DOGE faction was planning the future of the US government at a venture capital firm
*illegally communicating on Signal to avoid transparency laws was deeply embedded into organizational culture to be taken for granted
November 22, 2025 at 10:12 PM
This is a story about how America’s world-leading cancer and dementia research system was destroyed by frauds and naifs who broke the law.
There must be consequences.
There must be consequences.
Reposted by Prasad Jallepalli, MD, PhD
TAPPER: RFK Jr, according to his own family, is causing real damage. You don't seem willing to criticize him by name
CASSIDY: Clearly you want me to be on the record saying something negative. It makes news if Republicans fight each other
T: I don't even know that he's a Republican
C: Or whatever
CASSIDY: Clearly you want me to be on the record saying something negative. It makes news if Republicans fight each other
T: I don't even know that he's a Republican
C: Or whatever
November 23, 2025 at 2:41 PM
TAPPER: RFK Jr, according to his own family, is causing real damage. You don't seem willing to criticize him by name
CASSIDY: Clearly you want me to be on the record saying something negative. It makes news if Republicans fight each other
T: I don't even know that he's a Republican
C: Or whatever
CASSIDY: Clearly you want me to be on the record saying something negative. It makes news if Republicans fight each other
T: I don't even know that he's a Republican
C: Or whatever
Reposted by Prasad Jallepalli, MD, PhD
Welker: Do you think that Trump is a fascist?
Mamdani: That’s something that I’ve said in the past. I say it today.
Welker: You’ve called him a despot. Do you still believe Trump is a threat to the democracy?
Mamdani: Everything that I’ve said in the past, I continue to believe.
Mamdani: That’s something that I’ve said in the past. I say it today.
Welker: You’ve called him a despot. Do you still believe Trump is a threat to the democracy?
Mamdani: Everything that I’ve said in the past, I continue to believe.
November 23, 2025 at 3:06 PM
Welker: Do you think that Trump is a fascist?
Mamdani: That’s something that I’ve said in the past. I say it today.
Welker: You’ve called him a despot. Do you still believe Trump is a threat to the democracy?
Mamdani: Everything that I’ve said in the past, I continue to believe.
Mamdani: That’s something that I’ve said in the past. I say it today.
Welker: You’ve called him a despot. Do you still believe Trump is a threat to the democracy?
Mamdani: Everything that I’ve said in the past, I continue to believe.
Reposted by Prasad Jallepalli, MD, PhD
Just an absolutely gutting essay by Tatiana Schlossberg, a writer, mother of two young children, and cousin of RFK Jr who is dying of leukemia.
www.newyorker.com/culture/the-...
www.newyorker.com/culture/the-...
November 22, 2025 at 4:09 PM
Just an absolutely gutting essay by Tatiana Schlossberg, a writer, mother of two young children, and cousin of RFK Jr who is dying of leukemia.
www.newyorker.com/culture/the-...
www.newyorker.com/culture/the-...