Pietro Pichierri
@pietropichierri.bsky.social
Among other things, a scientist trying to understand how cells avoid things going wrong during DNA replication.
http://www.genomestabilitygroup.com/
http://www.genomestabilitygroup.com/
Reposted by Pietro Pichierri
Join us next Tuesday, December 2 at 5pm (Rome) / 11am (NYC) for an exciting GIIN webinar featuring @peterlylab.bsky.social and @alebrambati.bsky.social!
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
November 27, 2025 at 12:16 AM
Join us next Tuesday, December 2 at 5pm (Rome) / 11am (NYC) for an exciting GIIN webinar featuring @peterlylab.bsky.social and @alebrambati.bsky.social!
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...
Reposted by Pietro Pichierri
💥 Working with iPSCs?
We’ve got you covered , culture, neuronal & muscle differentiation, organ-on-chip, training, and ready-to-use progenitors.
Happy to support your projects!
📩 [email protected]
IPSC-neuron platform (POM-biocampus, Montpellier)
We’ve got you covered , culture, neuronal & muscle differentiation, organ-on-chip, training, and ready-to-use progenitors.
Happy to support your projects!
📩 [email protected]
IPSC-neuron platform (POM-biocampus, Montpellier)
November 16, 2025 at 9:47 AM
💥 Working with iPSCs?
We’ve got you covered , culture, neuronal & muscle differentiation, organ-on-chip, training, and ready-to-use progenitors.
Happy to support your projects!
📩 [email protected]
IPSC-neuron platform (POM-biocampus, Montpellier)
We’ve got you covered , culture, neuronal & muscle differentiation, organ-on-chip, training, and ready-to-use progenitors.
Happy to support your projects!
📩 [email protected]
IPSC-neuron platform (POM-biocampus, Montpellier)
Reposted by Pietro Pichierri
Placebo effect is more psychologically complex than previously thought.
The mind-bending power of placebo
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com/articles/s41...
The mind-bending power of placebo - Nature Medicine
Studies with open-label placebos — sugar pills given without deception — suggest that the placebo effect is more psychologically complex than previously thought.
www.nature.com
November 14, 2025 at 5:44 PM
Placebo effect is more psychologically complex than previously thought.
www.corriere.it
November 11, 2025 at 7:02 PM
Reposted by Pietro Pichierri
Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.
November 6, 2025 at 5:46 PM
Work published today in @natbiotech.nature.com from Arc’s Luke Gilbert and Patrick Hsu labs presents a new way to insert large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell's repair machinery.
Reposted by Pietro Pichierri
Basta con questo bla bla inconcludente e disinformato sull’IRPEF. Le tasse le paga chi ha redditi medi e alti. Se abbassi le aliquote il beneficio va a chi paga le tasse, non va ai poveri che non le pagano. Per sostenere i redditi bassi ci sono altre misure.
November 7, 2025 at 6:58 PM
Basta con questo bla bla inconcludente e disinformato sull’IRPEF. Le tasse le paga chi ha redditi medi e alti. Se abbassi le aliquote il beneficio va a chi paga le tasse, non va ai poveri che non le pagano. Per sostenere i redditi bassi ci sono altre misure.
Reposted by Pietro Pichierri
Excited to share: NAR Cancer Editor's Choice review article from Kyungjae Myung and colleagues provides a snapshot of the blossoming field of DNA damage response- and repair-targeted therapeutics. Focus is on small molecules currently in clnical trials. academic.oup.com/narcancer/ar...
November 7, 2025 at 6:57 PM
Excited to share: NAR Cancer Editor's Choice review article from Kyungjae Myung and colleagues provides a snapshot of the blossoming field of DNA damage response- and repair-targeted therapeutics. Focus is on small molecules currently in clnical trials. academic.oup.com/narcancer/ar...
Reposted by Pietro Pichierri
DirectRM: integrated detection of landscape and crosstalk between multiple RNA modifications using direct RNA sequencing. #DirectRNAseq #RNAmodifications @nanoporetech.com #Sequencing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 2, 2025 at 6:05 PM
DirectRM: integrated detection of landscape and crosstalk between multiple RNA modifications using direct RNA sequencing. #DirectRNAseq #RNAmodifications @nanoporetech.com #Sequencing @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pietro Pichierri
"...researchers who invest time in their students tend to lead more-productive, more-collaborative groups and attract stronger future students than those who do not." "Time spent with the next generation of scientists is an investment."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
www.nature.com
October 24, 2025 at 10:46 PM
"...researchers who invest time in their students tend to lead more-productive, more-collaborative groups and attract stronger future students than those who do not." "Time spent with the next generation of scientists is an investment."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Read it guys; it is very nice. Kudos to the @stapleslab.bsky.social lab
New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A nuclease-driven mechanism of post-replicative ssDNA gap suppression.
The persistence of post-replicative ssDNA gaps following PRIMPOL-mediated replication repriming is linked to chemosensitivity, and in all models reported to date the nuclease MRE11 has been implicated...
www.biorxiv.org
October 25, 2025 at 4:01 PM
Read it guys; it is very nice. Kudos to the @stapleslab.bsky.social lab
Reposted by Pietro Pichierri
My quote of the day
It is not the young people that degenerate; they are not spoiled till those of mature age are already sunk into corruption.
Charles Louis de Secondat, baron de La Brède et de Montesquieu (Montesquieu)
It is not the young people that degenerate; they are not spoiled till those of mature age are already sunk into corruption.
Charles Louis de Secondat, baron de La Brède et de Montesquieu (Montesquieu)
October 25, 2025 at 11:10 AM
My quote of the day
It is not the young people that degenerate; they are not spoiled till those of mature age are already sunk into corruption.
Charles Louis de Secondat, baron de La Brède et de Montesquieu (Montesquieu)
It is not the young people that degenerate; they are not spoiled till those of mature age are already sunk into corruption.
Charles Louis de Secondat, baron de La Brède et de Montesquieu (Montesquieu)
Reposted by Pietro Pichierri
Il cosiddetto turbocancro non esiste, è un’invenzione di ciarlatani senza scrupoli. Se un tumore viene diagnosticato 2 mesi fa in fase avanzata non significa che 3 mesi fa non ci fosse.
La diagnosi precoce è molto importante, fate gli screening.
La diagnosi precoce è molto importante, fate gli screening.
October 25, 2025 at 3:48 PM
Il cosiddetto turbocancro non esiste, è un’invenzione di ciarlatani senza scrupoli. Se un tumore viene diagnosticato 2 mesi fa in fase avanzata non significa che 3 mesi fa non ci fosse.
La diagnosi precoce è molto importante, fate gli screening.
La diagnosi precoce è molto importante, fate gli screening.
Reposted by Pietro Pichierri
Great point. It it possible to attribute grants in myncbi if your co-author “forgot”, or you were young and foolish and didn’t realize it matters.
Btw I think you can link papers with funding through eRA commons and myNCBI if not done directly in the paper.
October 24, 2025 at 6:17 PM
Great point. It it possible to attribute grants in myncbi if your co-author “forgot”, or you were young and foolish and didn’t realize it matters.
Reposted by Pietro Pichierri
Draghi: «Tutti i nostri principi sotto attacco, quanto deve aggravarsi una crisi perché i leader uniscano le forze e agiscano?»
https://www.corriere.it/economia/finanza/25_ottobre_24/draghi-discorso-asturias-24635e06-0b27-4a2c-8873-c0dcf5bf8xlk.shtml
https://www.corriere.it/economia/finanza/25_ottobre_24/draghi-discorso-asturias-24635e06-0b27-4a2c-8873-c0dcf5bf8xlk.shtml
October 24, 2025 at 6:40 PM
Draghi: «Tutti i nostri principi sotto attacco, quanto deve aggravarsi una crisi perché i leader uniscano le forze e agiscano?»
https://www.corriere.it/economia/finanza/25_ottobre_24/draghi-discorso-asturias-24635e06-0b27-4a2c-8873-c0dcf5bf8xlk.shtml
https://www.corriere.it/economia/finanza/25_ottobre_24/draghi-discorso-asturias-24635e06-0b27-4a2c-8873-c0dcf5bf8xlk.shtml
Reposted by Pietro Pichierri
I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.
October 24, 2025 at 5:44 PM
I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.
Reposted by Pietro Pichierri
The data is from April but holy moly
October 11, 2025 at 5:11 PM
The data is from April but holy moly
Reposted by Pietro Pichierri
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
Reposted by Pietro Pichierri
It should be noted that Google has noticed the backlash enough that they quietly published a code that would removed AI results for their searches.
An enterprising person built a default site to search without AI, and the results are goddamn refreshing as hell.
udm14.org
An enterprising person built a default site to search without AI, and the results are goddamn refreshing as hell.
udm14.org
&udm=14 | the search engine Konami code
A quick way to get an AI-free search without any extra work.
udm14.org
October 5, 2025 at 9:36 AM
It should be noted that Google has noticed the backlash enough that they quietly published a code that would removed AI results for their searches.
An enterprising person built a default site to search without AI, and the results are goddamn refreshing as hell.
udm14.org
An enterprising person built a default site to search without AI, and the results are goddamn refreshing as hell.
udm14.org
Reposted by Pietro Pichierri
RAD51 and Cancer. A must read by Bernard Lopez in Oncogene.
In a review article published in the Journal #Oncogene, Bernard Lopez proposes that #RAD51 -mediated homologous recombination is a Pro-tumour driver pathway, contradicting the generally accepted dogma
institutcochin.fr/en/news/plot...
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social
institutcochin.fr/en/news/plot...
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social
Plot twist: homologous recombination promotes cancer development
The prevailing view considers homologous recombination to be a tumour-suppressing mechanism. However, a re-analysis of data and concepts published in the journal Oncogene concludes that, in fact, homo...
institutcochin.fr
October 4, 2025 at 12:28 PM
RAD51 and Cancer. A must read by Bernard Lopez in Oncogene.
Reposted by Pietro Pichierri
Excited to have contributed to this new @cp-molcell.bsky.social paper on how PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed.
A big congrats to Jonas for driving this work forward, great to see the results out!
👉 10.1016/j.molcel.2025.09.006
A big congrats to Jonas for driving this work forward, great to see the results out!
👉 10.1016/j.molcel.2025.09.006
October 3, 2025 at 6:21 PM
Excited to have contributed to this new @cp-molcell.bsky.social paper on how PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed.
A big congrats to Jonas for driving this work forward, great to see the results out!
👉 10.1016/j.molcel.2025.09.006
A big congrats to Jonas for driving this work forward, great to see the results out!
👉 10.1016/j.molcel.2025.09.006
Reposted by Pietro Pichierri
Reposted by Pietro Pichierri
Republicans would rather shut down the government than help millions of Americans afford health care. This article tells some of their stories, and is a good reminder of what’s at stake.
These people have found their health care at the center of a shutdown showdown
Small business owners, self-employed people and early retirees are among the 24 million Americans who could lose the tax credit
www.usatoday.com
September 28, 2025 at 4:02 PM
Republicans would rather shut down the government than help millions of Americans afford health care. This article tells some of their stories, and is a good reminder of what’s at stake.
Reposted by Pietro Pichierri
ICYMI: Can we drive anti-tumor immunity in advanced prostate and ovarian cancers?
Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/dtduyFp
Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/dtduyFp
September 28, 2025 at 12:04 PM
ICYMI: Can we drive anti-tumor immunity in advanced prostate and ovarian cancers?
Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/dtduyFp
Arul M. Chinnaiyan & team find pharmacologic degradation of CDK12/13 delays tumor growth and improves ICB response in several cancer models: buff.ly/dtduyFp
Reposted by Pietro Pichierri
Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.
Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds
September 28, 2025 at 9:43 AM
Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.