@nate13ailey.bsky.social
Reposted
Several tech YouTubers I follow have gotten more publicly political over the years because you cannot advocate for the pragmatic without, on some level, getting political.
January 30, 2026 at 11:25 PM
Several tech YouTubers I follow have gotten more publicly political over the years because you cannot advocate for the pragmatic without, on some level, getting political.
Reposted
Reposted
Look closely at the surface of the sea cucumber…
There’s a strange little creature hiding there!
This scale worm changes its coloring to match its sea cucumber host.
You’d never notice it unless it moves. Such amazing camouflage! ✨️
There’s a strange little creature hiding there!
This scale worm changes its coloring to match its sea cucumber host.
You’d never notice it unless it moves. Such amazing camouflage! ✨️
January 24, 2026 at 12:26 PM
Look closely at the surface of the sea cucumber…
There’s a strange little creature hiding there!
This scale worm changes its coloring to match its sea cucumber host.
You’d never notice it unless it moves. Such amazing camouflage! ✨️
There’s a strange little creature hiding there!
This scale worm changes its coloring to match its sea cucumber host.
You’d never notice it unless it moves. Such amazing camouflage! ✨️
Reposted
It really is just all kinds of bad folks. I wonder when Democrats in Congress will notice.
No reforming this.
No reforming this.
Minnesota: "School officials say the [5-year-old] child was used as bait. They say [ICE] agents made little Liam knock on the door to ask to be let in in order to see if anyone else was home."
January 22, 2026 at 1:05 AM
It really is just all kinds of bad folks. I wonder when Democrats in Congress will notice.
No reforming this.
No reforming this.
Reposted
The Shingles vaccine has outperformed all expectations. Why?
erictopol.substack.com/p/spotlight-...
erictopol.substack.com/p/spotlight-...
January 22, 2026 at 3:11 PM
The Shingles vaccine has outperformed all expectations. Why?
erictopol.substack.com/p/spotlight-...
erictopol.substack.com/p/spotlight-...
Reposted
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
January 21, 2026 at 1:56 PM
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
Reposted
Crazy idea. What if we just didn’t sell the plurality of all of the world’s memory to the AI companies? Or what if we charged them a massive “negative externality” tax to acquire it in large quantities?
January 20, 2026 at 3:26 PM
Crazy idea. What if we just didn’t sell the plurality of all of the world’s memory to the AI companies? Or what if we charged them a massive “negative externality” tax to acquire it in large quantities?
Reposted
Meet Duobrachium sparksae: a newly described comb jelly that looks like a glowing hot-air balloon drifting just above the deep seafloor. Transparent, delicate, and unmistakably transfixing, it reminds us how much biodiversity is in the deep oceans.
www.fisheries.noaa.gov/feature-stor...
www.fisheries.noaa.gov/feature-stor...
January 16, 2026 at 3:54 PM
Meet Duobrachium sparksae: a newly described comb jelly that looks like a glowing hot-air balloon drifting just above the deep seafloor. Transparent, delicate, and unmistakably transfixing, it reminds us how much biodiversity is in the deep oceans.
www.fisheries.noaa.gov/feature-stor...
www.fisheries.noaa.gov/feature-stor...
Reposted
The healthiest thing for me to do right now is to fight ignorance and I'm taking the kid gloves off.
January 7, 2026 at 6:45 PM
The healthiest thing for me to do right now is to fight ignorance and I'm taking the kid gloves off.
Reposted
“WAGMI” — we're all gonna make it — was crypto's 2021 rallying cry. But those with wealth and power knew it was a lie, and that “all” just meant them. My latest traces the last five years from hype to technoligarchy — and why they're not all gonna make it either.
The year of technoligarchy
In 2025, Trump brought tech executives into power to dismantle regulators and write their own rules. But the instabilities they’re creating may be their downfall.
www.citationneeded.news
January 7, 2026 at 6:44 PM
“WAGMI” — we're all gonna make it — was crypto's 2021 rallying cry. But those with wealth and power knew it was a lie, and that “all” just meant them. My latest traces the last five years from hype to technoligarchy — and why they're not all gonna make it either.
Reposted
Now published in Nature Biotechnology:
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
January 6, 2026 at 9:38 AM
Now published in Nature Biotechnology:
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below
Reposted
Actually, it turns out that getting vaccines has some wonderful side effects.
Like lowering the risk of dementia, Alzheimer’s, heart disease and stroke
Like lowering the risk of dementia, Alzheimer’s, heart disease and stroke
January 4, 2026 at 2:35 PM
Actually, it turns out that getting vaccines has some wonderful side effects.
Like lowering the risk of dementia, Alzheimer’s, heart disease and stroke
Like lowering the risk of dementia, Alzheimer’s, heart disease and stroke
Reposted
At this moment, 17:15 UTC (12:15 Eastern US time) Earth is at perihelion: the closest point to the sun on its elliptical orbit, about 147.5 million kilometers (center to center, which is how astronomers measure things).
aa.usno.navy.mil/calculated/s...
aa.usno.navy.mil/calculated/s...
aa.usno.navy.mil
January 3, 2026 at 5:18 PM
At this moment, 17:15 UTC (12:15 Eastern US time) Earth is at perihelion: the closest point to the sun on its elliptical orbit, about 147.5 million kilometers (center to center, which is how astronomers measure things).
aa.usno.navy.mil/calculated/s...
aa.usno.navy.mil/calculated/s...
Reposted
Reposted
Something I think about a lot is the active process of divorcing yourself from evil companies: Microsoft, X, Google, countless others. I think there’s a real importance to articulating each of their use cases and dismantling them, making alternatives viable, otherwise the effort is stillborne.
January 2, 2026 at 5:50 PM
Something I think about a lot is the active process of divorcing yourself from evil companies: Microsoft, X, Google, countless others. I think there’s a real importance to articulating each of their use cases and dismantling them, making alternatives viable, otherwise the effort is stillborne.
Reposted
The Trump administration is shutting NASA's Goddard library down today and things will be archived in a warehouse or "thrown away."
Much of this material is literally irreplaceable.
www.nytimes.com/2025/12/31/c...
Much of this material is literally irreplaceable.
www.nytimes.com/2025/12/31/c...
NASA’s Largest Library Is Closing Amid Staff and Lab Cuts
www.nytimes.com
January 2, 2026 at 1:29 PM
The Trump administration is shutting NASA's Goddard library down today and things will be archived in a warehouse or "thrown away."
Much of this material is literally irreplaceable.
www.nytimes.com/2025/12/31/c...
Much of this material is literally irreplaceable.
www.nytimes.com/2025/12/31/c...
Reposted
Take a break from the horrors of the news and learn about the weirdest physics there is—entanglement! The team at @veritasium.bsky.social interviewed me for this video & I'm thrilled to see it up. They give a hearty endorsement to my first book, WHAT IS REAL?, which is just lovely. #quantum #physics
There Is Something Faster Than Light
YouTube video by Veritasium
youtu.be
December 19, 2025 at 4:52 PM
Take a break from the horrors of the news and learn about the weirdest physics there is—entanglement! The team at @veritasium.bsky.social interviewed me for this video & I'm thrilled to see it up. They give a hearty endorsement to my first book, WHAT IS REAL?, which is just lovely. #quantum #physics
Reposted
SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
'Skull of St. Thomas Aquinas being transported to Fossanova Abbey.'
Photograph by Daniel Ibanez
Photograph by Daniel Ibanez
December 10, 2025 at 5:10 PM
SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
Reposted
If you ever need to fuzzy search some DNA, sassy is your tool.
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
December 10, 2025 at 3:50 PM
If you ever need to fuzzy search some DNA, sassy is your tool.
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
Reposted
And if you have a .fastq.gz.mim already present, you get another up to 2x speedup (or more with >6 cores).
December 7, 2025 at 11:54 PM
And if you have a .fastq.gz.mim already present, you get another up to 2x speedup (or more with >6 cores).
Reposted
Today I was listening to a podcast about how bad sports gambling has gotten, a game that cannibalizes the game under it even for the players. Then I watched a video about RAM prices, Steve was upset, because the game of the stock market threatens the very concept of a home computer.
The interrogation of and fascination with gameplay systems will only get you so far by itself because The Machine Zone is the dominant cultural force right now and it poisons everything it touches a little. Anyway, you should play Saga Frontier 2.
December 6, 2025 at 4:06 AM
Today I was listening to a podcast about how bad sports gambling has gotten, a game that cannibalizes the game under it even for the players. Then I watched a video about RAM prices, Steve was upset, because the game of the stock market threatens the very concept of a home computer.
Reposted
1/9 Just out:
k-mer indexes are the backbone of fast search in genomic data, but many degrade under small k, subsampling, or high diversity.
With Ondřej Sladký and @pavelvesely.bsky.social we asked: can we build one that works efficiently for any k-mer set?
k-mer indexes are the backbone of fast search in genomic data, but many degrade under small k, subsampling, or high diversity.
With Ondřej Sladký and @pavelvesely.bsky.social we asked: can we build one that works efficiently for any k-mer set?
🧮 Just out in Bioinformatics Advances: “FroM Superstring to Indexing: A space-efficient index for unconstrained k-mer sets using the Masked Burrows-Wheeler Transform (MBWT)”
Full article available: https://doi.org/10.1093/bioadv/vbaf290
Authors include: @pavelvesely.bsky.social, @brinda.eu
Full article available: https://doi.org/10.1093/bioadv/vbaf290
Authors include: @pavelvesely.bsky.social, @brinda.eu
December 5, 2025 at 5:42 PM
1/9 Just out:
k-mer indexes are the backbone of fast search in genomic data, but many degrade under small k, subsampling, or high diversity.
With Ondřej Sladký and @pavelvesely.bsky.social we asked: can we build one that works efficiently for any k-mer set?
k-mer indexes are the backbone of fast search in genomic data, but many degrade under small k, subsampling, or high diversity.
With Ondřej Sladký and @pavelvesely.bsky.social we asked: can we build one that works efficiently for any k-mer set?
Reposted
Bedtools in rust has to be bedder
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
1/n
1/n
Intro to Bedder – The Quinlan Lab
quinlanlab.org
December 5, 2025 at 6:55 PM
Bedtools in rust has to be bedder