Mitchell Bijnen
@mitchellgow.bsky.social
Immunologist at the University of Zurich (Greter lab). Working on brain macrophages in Alzheimer's disease and stromal cell-myeloid cell interactions.
Reposted by Mitchell Bijnen
GM-CSF instructs vertebral emergency myelopoiesis in neuropathic pain https://www.biorxiv.org/content/10.1101/2025.11.23.690022v1
November 26, 2025 at 5:16 PM
GM-CSF instructs vertebral emergency myelopoiesis in neuropathic pain https://www.biorxiv.org/content/10.1101/2025.11.23.690022v1
Reposted by Mitchell Bijnen
Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage controlling type 1 and 2 immune balance @natimmunol.nature.com @champalimaudf.bsky.social @neuroimmune-rok.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 8:36 PM
Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage controlling type 1 and 2 immune balance @natimmunol.nature.com @champalimaudf.bsky.social @neuroimmune-rok.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mitchell Bijnen
Today at #preprinthub2, Maria and Öykü from Vienna will present Maud Mayoux's preprint “CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastases” from the labs of Dr. Sonia Tugues and Dr. Bettina Sobottka 💯✅
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastases
Colorectal cancer frequently progresses to liver metastases (CRLM), a stage with limited treatment options and poor prognosis. Neoadjuvant chemotherapy is used to control tumor growth and enable resec...
www.biorxiv.org
November 25, 2025 at 1:26 PM
Today at #preprinthub2, Maria and Öykü from Vienna will present Maud Mayoux's preprint “CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastases” from the labs of Dr. Sonia Tugues and Dr. Bettina Sobottka 💯✅
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mitchell Bijnen
Do tissue resident #macrophages survive through intestinal #inflammation? Are they terminally differentiated or can they adapt? @lizihegarty.bsky.social asked these Qs during her @wellcometrust.bsky.social PhD and her findings are now published @mucosalimmunol.bsky.social
@edinuni-irr.bsky.social
@edinuni-irr.bsky.social
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair
Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…
www.sciencedirect.com
November 24, 2025 at 10:51 AM
Do tissue resident #macrophages survive through intestinal #inflammation? Are they terminally differentiated or can they adapt? @lizihegarty.bsky.social asked these Qs during her @wellcometrust.bsky.social PhD and her findings are now published @mucosalimmunol.bsky.social
@edinuni-irr.bsky.social
@edinuni-irr.bsky.social
Reposted by Mitchell Bijnen
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience
Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...
www.nature.com
November 24, 2025 at 2:35 PM
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mitchell Bijnen
Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials
novonordisk.com/content/nnco...
novonordisk.com/content/nnco...
News Details
novonordisk.com
November 24, 2025 at 2:55 PM
Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials
novonordisk.com/content/nnco...
novonordisk.com/content/nnco...
Reposted by Mitchell Bijnen
Nice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 24, 2025 at 4:20 PM
Nice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
“Resolving the mysteries of brain clearance and immune surveillance”
Check it out 👇🏻
authors.elsevier.com/sd/article/S...
Reposted by Mitchell Bijnen
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease - Nature Neuroscience
Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...
www.nature.com
November 24, 2025 at 2:33 PM
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Mitchell Bijnen
🚨 Last CAJAL course of 2025 in Bordeaux!
Full list of speakers and their talks for “Neuroimmunology in Physiology and Disease” is now available.
@paolicellilab.bsky.social @agnesnadjar.bsky.social @pluchinolab.bsky.social
#Neuroimmunology #Neuroscience
Full list of speakers and their talks for “Neuroimmunology in Physiology and Disease” is now available.
@paolicellilab.bsky.social @agnesnadjar.bsky.social @pluchinolab.bsky.social
#Neuroimmunology #Neuroscience
November 20, 2025 at 2:07 PM
🚨 Last CAJAL course of 2025 in Bordeaux!
Full list of speakers and their talks for “Neuroimmunology in Physiology and Disease” is now available.
@paolicellilab.bsky.social @agnesnadjar.bsky.social @pluchinolab.bsky.social
#Neuroimmunology #Neuroscience
Full list of speakers and their talks for “Neuroimmunology in Physiology and Disease” is now available.
@paolicellilab.bsky.social @agnesnadjar.bsky.social @pluchinolab.bsky.social
#Neuroimmunology #Neuroscience
Reposted by Mitchell Bijnen
Great Review on the #evolution of #microglia
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Microglia across evolution: from conserved origins to functional divergence - Cellular & Molecular Immunology
Cellular & Molecular Immunology - Microglia across evolution: from conserved origins to functional divergence
www.nature.com
November 22, 2025 at 7:20 AM
Great Review on the #evolution of #microglia
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Microglia across evolution: from conserved origins to functional divergence | Cellular
www.nature.com/articles/s41...
Reposted by Mitchell Bijnen
🧠 Check out our new study!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 20, 2025 at 2:35 PM
🧠 Check out our new study!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.
🙏🙏🙏 A big thank you to everyone involved!
Reposted by Mitchell Bijnen
Delighted to share this! We identify gut #macrophages as key players in preventing dissemination of intestinal microbes in liver cirrhosis. Best collab with my partner in crime @lenasmets.bsky.social, featuring some stunning live imaging with @colindascheele.bsky.social
👇
gut.bmj.com/content/earl...
👇
gut.bmj.com/content/earl...
Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis
Background Bacterial translocation in cirrhosis can trigger infection and hepatic decompensation, leading to systemic inflammation, organ failure and increased mortality. These infections often origin...
gut.bmj.com
November 19, 2025 at 9:42 PM
Delighted to share this! We identify gut #macrophages as key players in preventing dissemination of intestinal microbes in liver cirrhosis. Best collab with my partner in crime @lenasmets.bsky.social, featuring some stunning live imaging with @colindascheele.bsky.social
👇
gut.bmj.com/content/earl...
👇
gut.bmj.com/content/earl...
Reposted by Mitchell Bijnen
Insulin cream offers needle-free option for diabetes @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
November 19, 2025 at 7:17 PM
Insulin cream offers needle-free option for diabetes @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
Reposted by Mitchell Bijnen
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal
imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital
parameters within physiological ranges. This study characterizes how mouse monocyte-derived
macrophages...
www.embopress.org
November 19, 2025 at 2:11 PM
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Reposted by Mitchell Bijnen
A new #ScienceImmunology study finds that mice and humans have pancreatic islet-resident macrophages with elevated antioxidant profiles, which could shield β cells from oxidative stress. https://scim.ag/49cqs3M
An islet-resident macrophage antioxidant program preserves β cell physiology
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.
scim.ag
November 18, 2025 at 4:00 PM
A new #ScienceImmunology study finds that mice and humans have pancreatic islet-resident macrophages with elevated antioxidant profiles, which could shield β cells from oxidative stress. https://scim.ag/49cqs3M
Reposted by Mitchell Bijnen
Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com!
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis - Nature Neuroscience
Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...
www.nature.com
November 17, 2025 at 10:30 AM
Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com!
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Check it out at:
www.nature.com/articles/s41...
with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Reposted by Mitchell Bijnen
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
Dynamic modulation of the blood–brain barrier in the healthy brain - Nature Reviews Neuroscience
The blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ...
www.nature.com
November 16, 2025 at 3:48 PM
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
Reposted by Mitchell Bijnen
APOE4 genotype promotes a brain Pericyte-to-Myofibroblast transition
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
November 16, 2025 at 12:20 PM
APOE4 genotype promotes a brain Pericyte-to-Myofibroblast transition
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Evidence from APOE4🐭, miBrain & 👤🧠
What's 🧠Myofibroblast?
👉Distinct from Perivascular fibroblast
👉Source of fibronectin, soiling amyloid aggr.
👉Can scatter in 🧠parenchyma
👉TGFβ-driven
bioRxiv 2025
www.biorxiv.org/content/10.1...
Reposted by Mitchell Bijnen
Very excited to share that our paper on pancreatic islet-resident macrophages is out ! Grateful to contribute to our understanding of these fascinating cells - special thanks to all of our collaborators ! #worlddiabetesday www.science.org/doi/10.1126/...
An islet-resident macrophage antioxidant program preserves β cell physiology
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.
www.science.org
November 14, 2025 at 10:03 PM
Very excited to share that our paper on pancreatic islet-resident macrophages is out ! Grateful to contribute to our understanding of these fascinating cells - special thanks to all of our collaborators ! #worlddiabetesday www.science.org/doi/10.1126/...
Reposted by Mitchell Bijnen
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @inserm.fr
www.science.org/doi/10.1126/... @inserm.fr
November 15, 2025 at 3:26 AM
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis @sciimmunology.bsky.social
www.science.org/doi/10.1126/... @inserm.fr
www.science.org/doi/10.1126/... @inserm.fr
Reposted by Mitchell Bijnen
At the #ADDRM, @sabinedaemen.bsky.social, postdoc in my group, presented her work on sex differences in a mouse model of #MASH, an area where most data still rely on male mice. She found sex-specific differences in hepatic steatosis, fibrosis progression, and glucose intolerance.👏🐭🔬
November 14, 2025 at 6:11 PM
At the #ADDRM, @sabinedaemen.bsky.social, postdoc in my group, presented her work on sex differences in a mouse model of #MASH, an area where most data still rely on male mice. She found sex-specific differences in hepatic steatosis, fibrosis progression, and glucose intolerance.👏🐭🔬
Reposted by Mitchell Bijnen
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
November 14, 2025 at 3:06 AM
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
www.cell.com/molecular-th...
www.cell.com/molecular-th... @moltherapy.bsky.social @fchrisbennett.bsky.social @blurtonjoneslab.bsky.social
@ucirvine.bsky.social @upenn.edu
Reposted by Mitchell Bijnen
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
November 14, 2025 at 3:39 AM
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
Reposted by Mitchell Bijnen
Are you working on research that challenges the classical function of the immune system? Submit an abstract to @CellSymposia #CSImmuneHomeostasis26 and be considered for a poster or short talk at the meeting in Shanghai, China, May 11–13, 2026 http://dlvr.it/TPFG1h
November 13, 2025 at 12:48 PM
Are you working on research that challenges the classical function of the immune system? Submit an abstract to @CellSymposia #CSImmuneHomeostasis26 and be considered for a poster or short talk at the meeting in Shanghai, China, May 11–13, 2026 http://dlvr.it/TPFG1h
Reposted by Mitchell Bijnen
Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
November 12, 2025 at 11:21 PM
Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social