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rsankowski.bsky.social
Roman Sankowski
@rsankowski.bsky.social
430 followers 1.1K following 180 posts
Neuropathologist | #clinicianScientist | #singleCell | Neuro-immunologist | Neuro-oncologist @ University Clinic of Freiburg Dad | Foodie | hobby barista | views my own
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rsankowski.bsky.social
Roman Sankowski @rsankowski.bsky.social · May 20
#microglia and other tissue #macrophages are highly plastic. This makes them look differently depending on their respective context. Granular methods like #single-cell sequencing are merely snapshots that may simplify the complexity found in the tissue. In our perspective in @natneuro.nature.com
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Reposted by Roman Sankowski
helloeacr.bsky.social
EACR - European Association for Cancer Research @helloeacr.bsky.social · 21h
New podcast episode 🚨 we hear from Andreas Trumpp & Vera Thiel about trace-n-Seq, a new technology that enables the molecular characterisation at single cell resolution of neurons, innervating any organ or tumour in preclinical models.

Listen or read: magazine.eacr.org/unlocking-ca...
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Reposted by Roman Sankowski
dieworkwear.bsky.social
derek guy @dieworkwear.bsky.social · 22h
You gently run your hand through the rack. You can feel it—pure cotton, rich wool, Irish linen. The plump buttonholes are handsewn; the buttons attached with a firm shank. You flip the price tag over. It's affordable

You buy the jacket and go home, which is only 15 mins away. Your apt is $600/month
Headline reads: Altman says ChatGPT will soon allow erotic for adult users.
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rsankowski.bsky.social
Roman Sankowski @rsankowski.bsky.social · 6d
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions | Science Translational Medicine

www.science.org/doi/10.1126/...
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.
www.science.org
Reposted by Roman Sankowski
natmethods.nature.com
Nature Methods @natmethods.nature.com · 7d
Nimbus predicts the likelihood of marker positivity from multiplexed image data in single cells.

www.nature.com/articles/s41...
Automated classification of cellular expression in multiplexed imaging data with Nimbus - Nature Methods
Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.
www.nature.com
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Reposted by Roman Sankowski
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 8d
Preprint: The Autoantibodyome Neuroimmune Signature of Neurodegeneration
papers.ssrn.com/sol3/papers....
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Reposted by Roman Sankowski
thelancet.com
The Lancet @thelancet.com · 9d
On this week’s cover of The Lancet, a new letter: “Gaza’s healthocide: medical societies must not stay silent”.

Read the letter and more in our latest issue: tinyurl.com/5n85x448
Cover of The Lancet's Oct 4, 2025 issue. Cover quote reads: "Most medical and surgical societies worldwide have remained silent or issued vague statements about Gaza's healthocide [...] Staying silent while pretending to be neutral is, in effect, a form of complicity."
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Reposted by Roman Sankowski
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · 12d
Review @sciimmunology.bsky.social @platten-lab.bsky.social
@dkfz.bsky.social
The immunology of brain tumors
www.science.org/doi/10.1126/...
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rsankowski.bsky.social
Roman Sankowski @rsankowski.bsky.social · 11d
Great update on #immunity of #brain #tumors by the Platten lab

The immunology of brain tumors | Science Immunology

www.science.org/doi/10.1126/...
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
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Reposted by Roman Sankowski
scinews.bsky.social
Science News @scinews.bsky.social · 17d
Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production

www.sciencedirect.com/science/arti...
Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production
The ketogenic diet (KD) is a potential therapeutic strategy for glioma; however, the underlying mechanisms remain unclear. Herein, we first identify t…
www.sciencedirect.com
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rsankowski.bsky.social
Roman Sankowski @rsankowski.bsky.social · 19d
@d-kirschenbaum.bsky.social Presenting his data on immune cell dynamics in glioblastoma at the #DGNN annual meeting
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Reposted by Roman Sankowski
jamescomey.bsky.social
James Comey @jamescomey.bsky.social · 20d
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Reposted by Roman Sankowski
crick.ac.uk
The Francis Crick Institute @crick.ac.uk · 26d
Applications are now open for our single-cell genomics course.

This course covers the complete end-to-end workflow of single-cell sequencing, from experimental design to data analysis.

📅 18 – 21 November
Learn more and apply 👇
www.crick.ac.uk/whats-on/sin...
Single-cell genomics: from bench to bioinformatics
www.crick.ac.uk
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Reposted by Roman Sankowski
nixonlab.bsky.social
Nixon Lab @nixonlab.bsky.social · Sep 15
Nixon Lab is hoping to recruit a postdoctoral fellow interested in alcohol-microglia and/or alcohol-neural stem cell interactions in recovery from alcohol-induced brain and behavioral damage/dysfunction. Open fellowships on our NIAAA-funded T32! Please spread the word!
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Reposted by Roman Sankowski
jeroenpasterkamp.bsky.social
Jeroen Pasterkamp @jeroenpasterkamp.bsky.social · Sep 13
In our new study in BRAIN, we use a brain organoid model in which microglia innately develop to further dissect the mechanisms that cause changes in microglia in C9ORF72-ALS and show that PU.1 can help to reverse these pathogenic phenotypes. #GoALS
academic.oup.com/brain/advanc...
PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids
Accumulating evidence implicates non-neuronal cells in ALS pathogenesis. Using patient-derived cerebral organoids, Ljubikj et al. reveal reduced microglial
academic.oup.com
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Reposted by Roman Sankowski
nature.com
Nature @nature.com · Sep 8
Nature research paper: PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

go.nature.com/46cuA0E
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia - Nature
A PICALM allele associated with increased risk of late-onset Alzheimer’s disease has a microglial-specific role in lipid droplet accumulation.
go.nature.com
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Reposted by Roman Sankowski
douglaspdyer.bsky.social
Doug Dyer @douglaspdyer.bsky.social · Sep 12
We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...
Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road
Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:
www.jobs.manchester.ac.uk
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rsankowski.bsky.social
Roman Sankowski @rsankowski.bsky.social · 29d
Great Work! Congrats to Katrin and Team!!
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Reposted by Roman Sankowski
katrinkierdorf.bsky.social
Katrin Kierdorf @katrinkierdorf.bsky.social · Sep 10
Our newest study is out🥳! Big shout out to Alex and Philippe for their amazing work here 🫶🏻 and thx to all collaborators who helped us during this journey! And let me tell you… this is just one tiny puzzle piece of understanding microglia/macrophage tissue homing 😎 www.cell.com/developmenta...
Early microglia progenitors colonize the embryonic CNS via integrin-mediated migration from the pial surface
Petry et al. demonstrate a defined migration route of microglia progenitors from the surrounding mesenchyme into the embryonic CNS. This process relies on integrin activation and interactions with the...
www.cell.com
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Reposted by Roman Sankowski
plosbiology.org
PLOS Biology @plosbiology.org · Sep 15
What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @plosbiology.org 🧪 plos.io/46cBaE4
Top left: Immunofluorescence images of anti-GFP (green) and anti-ATRX (red) counterstained with DAPI (blue) illustrating absence of ATRX in Sun1GFP+ microglia nuclei in 2-month-old ATRX miKO mice. Scale bar, 50 µm. Bottom left: Representative images of microglia tracings; Sholl analysis reveals excessive branching in ATRX miKO compared to control microglia. Right: Immunofluorescence staining of CD68 (green) and Ai14+ (red) cortical and hippocampal CA1 microglia. Scale bar, 50 µm.
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rsankowski.bsky.social
Roman Sankowski @rsankowski.bsky.social · Sep 14
#retroviral activation leads to microglia dysfunction and #cofnitive deficits in a non-cell autonomous way

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior | PLOS Biology

journals.plos.org/plosbiology/...
Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior
Chromatin-mediated processes are critical for neurodevelopment, but their role in microglia is less understood. This study shows that loss of the ATRX chromatin remodeler in microglia disrupts chromat...
journals.plos.org
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Reposted by Roman Sankowski
senguptalab.bsky.social
Piali Sengupta @senguptalab.bsky.social · Sep 13
Whoa - neuronal ciliary proteome! Tons to dig into here - different from kidney cilia proteome (perhaps unsurprising) and enriched for many postsynaptic proteins, strengthening previous suggestions of cilia as postsynaptic signaling structures.
@nachury.bsky.social
www.biorxiv.org/content/10.1...
In situ Proteomics Unveils Specialized Domains for Extrasynaptic Signaling on Neuronal Cilia
Neuronal cilia have emerged as crucial signaling hubs, yet their molecular composition and integration with synaptic communication remain poorly understood. Using a newly developed Arl13b-TurboID mous...
www.biorxiv.org
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Reposted by Roman Sankowski
glialclub.bsky.social
French Glial Cell Club @glialclub.bsky.social · Aug 18
📢 Join us for the 2nd Microglia & Neuroinflammation Workshop in Bordeaux, Nov 3–7, 2025!
Pre-registration deadline extended to Sept 3—don’t miss out!
#Neuroscience #Microglia #Workshop2025
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Reposted by Roman Sankowski
erc.europa.eu
European Research Council (ERC) @erc.europa.eu · Sep 9
Today Lucía takes you by the hand and walks you through the entire ERC #evaluation process — from panel selection to interview.

Learn who reviews your #proposal, how decisions are made, & how to best increase your chance of success. 👇

#research #funding #grant #AcademicSky
How do we evaluate your ERC proposal?
In this video, Lucía Rubio Fernández walks you through the entire ERC evaluation process — from panel selection to interviews. Learn who reviews your proposal, how decisions are made, and how to best…
buff.ly
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rsankowski.bsky.social
Roman Sankowski @rsankowski.bsky.social · Sep 6
Multimodal analysis of pediatric pilocytic astrocytomas reveals tumor location-associated cellular and transcriptional heterogeneity | Neuro-Oncology | Oxford Academic #brain #tumor

academic.oup.com/neuro-oncolo...
Validate User
academic.oup.com
Reposted by Roman Sankowski
scinews.bsky.social
Science News @scinews.bsky.social · Sep 6
Improve the stewardship of federal research funds. #Science

"It is up to the research community to provide constructive solutions that improve accountability for federal money..."

www.science.org/doi/10.1126/...
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