Objective Epilepsy patients face significantly elevated cardiovascular risks, with cardiac arrhythmias occurring 2–3 times more frequently than in the general population. Current knowledge of brain–.....

This study reveals how distal DNA ‘switches’ control gene activity in human astrocytes. Using CRISPRi screens and single-cell RNA-seq, we map enhancer–gene links, highlight Alzheimer’s disease-related...

The prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.

This randomized clinical trial compares the efficacy and adverse effects of valacyclovir vs placebo in patients with early symptomatic Alzheimer disease and seropositivity to herpes simplex viruses.

Gonzalez-Gallego et al. developed a fully iPS-cell-based human three-dimensional blood–brain barrier (BBB) model and used it to study roles of the stroke risk gene FOXF2 in BBB dysregulation, demonstr...

The authors found that the Alzheimer’s disease-associated protein tau, widely considered pathogenic when hyperphosphorylated, has a natural function as part of the innate immune system in the brain an...

Nature Reviews Neurology, Published online: 10 December 2025; doi:10.1038/s41582-025-01178-4Loss of TDP43 from the nucleus in amyotrophic lateral sclerosis and frontemporal dementia leads to changes in polyadenylation that alter mRNA processing, according to new research.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01175-7A drug that targets lysosomal damage could boost the effects of gene therapy for Duchenne muscular dystrophy, according to new research.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01174-8A new study indicates that physical activity reduces cognitive decline, possibly through attenuation of tau accumulation in the brain.

Nature Reviews Neurology, Published online: 10 December 2025; doi:10.1038/s41582-025-01178-4Loss of TDP43 from the nucleus in amyotrophic lateral sclerosis and frontemporal dementia leads to changes in polyadenylation that alter mRNA processing, according to new research.

Nature Reviews Neurology, Published online: 05 December 2025; doi:10.1038/s41582-025-01171-xEmerging evidence suggests that a better understanding of the heterogeneity in symptoms and survival among people with glioma requires a network-based approach. This Review describes three major types of network scaffolds relevant in glioma — symptom networks, the connectome and tumour biology networks — and explores the interactions between each scaffold.

Nature Reviews Neurology, Published online: 10 December 2025; doi:10.1038/s41582-025-01178-4Loss of TDP43 from the nucleus in amyotrophic lateral sclerosis and frontemporal dementia leads to changes in polyadenylation that alter mRNA processing, according to new research.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01175-7A drug that targets lysosomal damage could boost the effects of gene therapy for Duchenne muscular dystrophy, according to new research.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01174-8A new study indicates that physical activity reduces cognitive decline, possibly through attenuation of tau accumulation in the brain.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01176-6Recent research indicates that the brain-first and body-first subtypes of Parkinson disease can be distinguished by patterns of cutaneous α-synuclein deposition.

Nature Reviews Neurology, Published online: 03 December 2025; doi:10.1038/s41582-025-01163-xCognitive impairment is one of a range of non-motor symptoms that people with Parkinson disease (PD) can experience in addition to the hallmark motor symptoms of the disease. In this Review, Oikonomou et al. outline the epidemiology and natural history of cognitive decline in PD and related disorders, and discuss the key underlying pathophysiological factors and mechanisms.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01176-6Recent research indicates that the brain-first and body-first subtypes of Parkinson disease can be distinguished by patterns of cutaneous α-synuclein deposition.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01174-8A new study indicates that physical activity reduces cognitive decline, possibly through attenuation of tau accumulation in the brain.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01175-7A drug that targets lysosomal damage could boost the effects of gene therapy for Duchenne muscular dystrophy, according to new research.

Nature Reviews Neurology, Published online: 05 December 2025; doi:10.1038/s41582-025-01171-xEmerging evidence suggests that a better understanding of the heterogeneity in symptoms and survival among people with glioma requires a network-based approach. This Review describes three major types of network scaffolds relevant in glioma — symptom networks, the connectome and tumour biology networks — and explores the interactions between each scaffold.

Nature Reviews Neurology, Published online: 05 December 2025; doi:10.1038/s41582-025-01171-xEmerging evidence suggests that a better understanding of the heterogeneity in symptoms and survival among people with glioma requires a network-based approach. This Review describes three major types of network scaffolds relevant in glioma — symptom networks, the connectome and tumour biology networks — and explores the interactions between each scaffold.

Nature Reviews Neurology, Published online: 03 December 2025; doi:10.1038/s41582-025-01163-xCognitive impairment is one of a range of non-motor symptoms that people with Parkinson disease (PD) can experience in addition to the hallmark motor symptoms of the disease. In this Review, Oikonomou et al. outline the epidemiology and natural history of cognitive decline in PD and related disorders, and discuss the key underlying pathophysiological factors and mechanisms.

Nature Reviews Neurology, Published online: 28 November 2025; doi:10.1038/s41582-025-01162-yGrowing evidence indicates important roles for microglial phagocytosis in Alzheimer disease. This Review summarizes the latest insights into the mechanisms by which microglial phagocytosis can affect Alzheimer disease pathology and how this process might be harnessed for therapeutic interventions.

Akçimen et al. report the first systematic screening for intronic FGF14 GAA repeat expansions and their association with Parkinson's disease, using long-re

Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...