Ignasi Casanellas
@igcasane.bsky.social
CIRM Postdoc Fellow at UC Irvine: Piezo1, cell migration, neural development, high-res microscopy. Cinema lover.
Reposted by Ignasi Casanellas
The bot doesn't know what Watson & Crick mean by "suggests", because the entire concept of formulating a hypothesis and doing any sort of thinking is not something a LLM can relate to.
November 3, 2025 at 2:40 PM
The bot doesn't know what Watson & Crick mean by "suggests", because the entire concept of formulating a hypothesis and doing any sort of thinking is not something a LLM can relate to.
Reposted by Ignasi Casanellas
Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...
October 24, 2025 at 11:32 PM
Cell-cell junction proteins like ZO-1 not only play a critical role in the mechanical interaction between cells, but also participate in the biochemical signalling to coordinate the cell sheet. Check out this review on collective cell migration here to learn more: doi.org/10.1016/j.cd...
Reposted by Ignasi Casanellas
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
October 22, 2025 at 2:06 PM
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
Reposted by Ignasi Casanellas
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by Ignasi Casanellas
A new review from the @mayorlab.bsky.social on the chemical and physical cues regulating neural crest cells migration is out. Check it out!
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Neural Crest Migration Orchestrated by Molecular and Mechanical Signals
The neural crest is a highly migratory multipotent cell population traveling large distances in the vertebrate embryo. Neural crest cells migrate collectively in subpopulations, ranging in size from s...
www.annualreviews.org
October 13, 2025 at 8:15 PM
A new review from the @mayorlab.bsky.social on the chemical and physical cues regulating neural crest cells migration is out. Check it out!
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by Ignasi Casanellas
Fish keratocytes isolated from a fish scale crawling around. Technique: DIC microscopy. #CellBiology.
Another #NikonSmallWorldReject
Another #NikonSmallWorldReject
October 11, 2025 at 8:14 PM
Fish keratocytes isolated from a fish scale crawling around. Technique: DIC microscopy. #CellBiology.
Another #NikonSmallWorldReject
Another #NikonSmallWorldReject
Reposted by Ignasi Casanellas
Happy #FluorescenceFriday! This is a maximum intensity projection of depth shaded actin (🌈) in a section from an E9.5 🐭 neural tube (NT). 🔬 by postdoc @christinaadaly.bsky.social 👩🔬 🧪 Image shows the floor plate and lumen of the developing NT.
#SciArt #DevBio #DevNeuro
#SciArt #DevBio #DevNeuro
October 10, 2025 at 3:19 PM
Happy #FluorescenceFriday! This is a maximum intensity projection of depth shaded actin (🌈) in a section from an E9.5 🐭 neural tube (NT). 🔬 by postdoc @christinaadaly.bsky.social 👩🔬 🧪 Image shows the floor plate and lumen of the developing NT.
#SciArt #DevBio #DevNeuro
#SciArt #DevBio #DevNeuro
Reposted by Ignasi Casanellas
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted by Ignasi Casanellas
Perhaps one way to evaluate the quality of a research article is to assess its teachability.
Is the article clear about its identifying assumptions?
Does it lay out the results clearly?
Does it engage with its limitations transparently?
Is the article clear about its identifying assumptions?
Does it lay out the results clearly?
Does it engage with its limitations transparently?
October 1, 2025 at 8:03 PM
Perhaps one way to evaluate the quality of a research article is to assess its teachability.
Is the article clear about its identifying assumptions?
Does it lay out the results clearly?
Does it engage with its limitations transparently?
Is the article clear about its identifying assumptions?
Does it lay out the results clearly?
Does it engage with its limitations transparently?
Reposted by Ignasi Casanellas
The integrin odyssey – a journey full of fundamental discoveries url: journals.biologists.com/jcs/article/...
Great to start the day while reading this #integrin odyssey.
Great to start the day while reading this #integrin odyssey.
The integrin odyssey – a journey full of fundamental discoveries
Summary: This Perspective highlights the key discoveries in integrin research that laid the foundation for a successful field.
journals.biologists.com
October 1, 2025 at 6:37 AM
The integrin odyssey – a journey full of fundamental discoveries url: journals.biologists.com/jcs/article/...
Great to start the day while reading this #integrin odyssey.
Great to start the day while reading this #integrin odyssey.
Reposted by Ignasi Casanellas
If anyone ever wants to brush up on a lot of cell migration concepts don't forget we have several wonderful scientists who have given talks previously in cell migration seminars. I find it so comforting to go look at old videos, maybe someone else who will do as well!!
youtube.com/@cellmigrati...
youtube.com/@cellmigrati...
Cell Migration Seminars
Cell Migration Seminars every Tuesday at 16:00 BST.
youtube.com
September 29, 2025 at 1:48 AM
If anyone ever wants to brush up on a lot of cell migration concepts don't forget we have several wonderful scientists who have given talks previously in cell migration seminars. I find it so comforting to go look at old videos, maybe someone else who will do as well!!
youtube.com/@cellmigrati...
youtube.com/@cellmigrati...
Reposted by Ignasi Casanellas
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
www.biorxiv.org
September 18, 2025 at 3:23 PM
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ignasi Casanellas
How can we use cell shapes and geometry to study mechanics of tissues?
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
September 13, 2025 at 7:15 AM
How can we use cell shapes and geometry to study mechanics of tissues?
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
Reposted by Ignasi Casanellas
We are excited to announce our new #partnership with the Mechanobiology Institute (MBI) in Singapore! 🇸🇬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
August 27, 2025 at 8:55 AM
We are excited to announce our new #partnership with the Mechanobiology Institute (MBI) in Singapore! 🇸🇬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
This collaboration will combine MBI’s expertise on molecular, cell, and tissue mechanobiology with our research on spatiotemporal organization of living matter to understand how organisms form 🔬
Reposted by Ignasi Casanellas
A fascinating paper! I think in hindsight, us scientists are all expecting this to happen when we knockout something. But to actually characterise its effects and see it happening in real time is still eye opening. Watch out for Transcriptional Adaptation!
If you find a difference in phenotype between knockout and inhibitor/knockdown, transcriptional adaptation may be the culprit. This remarkable phenomenon demonstrates the robustness & complexity of cells, but can hamper CRISPR-based investigations if you aren't aware of it!
doi.org/10.1242/jcs....
doi.org/10.1242/jcs....
Transcriptional adaptation after deletion of Cdc42 in primary T cells
Highlighted Article: CRISPR/Cas9-mediated deletion of Cdc42 in primary T cells triggers transcriptional adaptation, leading to enhanced T cell function. Chemical inhibition with CASIN is highly specif...
doi.org
August 21, 2025 at 10:34 PM
A fascinating paper! I think in hindsight, us scientists are all expecting this to happen when we knockout something. But to actually characterise its effects and see it happening in real time is still eye opening. Watch out for Transcriptional Adaptation!
Reposted by Ignasi Casanellas
Hello. I wrote a nice long essay about AI and this very strange moment where we're constantly told we're living in the dawn of a strange new future but the only thing that's actually clear is that everyone feels pretty unmoored and uncertain. I hope you'll read it
AI Is a Mass-Delusion Event
Three years in, one of AI’s enduring impacts is to make people feel like they’re losing it.
www.theatlantic.com
August 18, 2025 at 9:21 PM
Hello. I wrote a nice long essay about AI and this very strange moment where we're constantly told we're living in the dawn of a strange new future but the only thing that's actually clear is that everyone feels pretty unmoored and uncertain. I hope you'll read it
Reposted by Ignasi Casanellas
The number of children injured or killed by cars while walking or riding a bike has fallen steadily since the 1970s, but CDC researcher note that this decline is not because streets are safer, but because fewer kids are out and about in the first place.
Kids need freedom. Dangerous roads make it hard to grant it.
Bigger cars, distracted drivers and worried parents mean fewer kids are roaming freely.
www.washingtonpost.com
August 13, 2025 at 4:38 PM
The number of children injured or killed by cars while walking or riding a bike has fallen steadily since the 1970s, but CDC researcher note that this decline is not because streets are safer, but because fewer kids are out and about in the first place.
Reposted by Ignasi Casanellas
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
August 10, 2025 at 7:50 PM
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
Reposted by Ignasi Casanellas
Mechanotransduction in the nucleus
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
August 6, 2025 at 11:01 AM
Mechanotransduction in the nucleus
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
Reposted by Ignasi Casanellas
Out now! Our very first [email protected], an impressive feat by @tobyandrews.bsky.social where we show how a developing heart grows and scales up its morphological complexity to keep beating...an excellent summary below ⬇️
www.cell.com/developmenta...
www.cell.com/developmenta...
August 6, 2025 at 4:36 PM
Out now! Our very first [email protected], an impressive feat by @tobyandrews.bsky.social where we show how a developing heart grows and scales up its morphological complexity to keep beating...an excellent summary below ⬇️
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Ignasi Casanellas
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
July 27, 2025 at 5:26 PM
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
Reposted by Ignasi Casanellas
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
July 16, 2025 at 6:35 PM
Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!
Reposted by Ignasi Casanellas
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Reposted by Ignasi Casanellas
Collective cell migration is fascinating!
Some tissues behave like fluids (motile), others like solids (jammed).
Check out some papers exploring this topic in this thread.
Some tissues behave like fluids (motile), others like solids (jammed).
Check out some papers exploring this topic in this thread.
May 11, 2025 at 1:02 PM
Collective cell migration is fascinating!
Some tissues behave like fluids (motile), others like solids (jammed).
Check out some papers exploring this topic in this thread.
Some tissues behave like fluids (motile), others like solids (jammed).
Check out some papers exploring this topic in this thread.
Reposted by Ignasi Casanellas
🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸♀️. Try it now on 🤗 huggingface.co/spaces/mouse...
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n
May 3, 2025 at 7:12 PM
🚀🔬🦠 Releasing 🤖Cellpose-SAM🤖, a cellular segmentation algorithm with superhuman generalization 🦸♀️. Try it now on 🤗 huggingface.co/spaces/mouse...
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n
paper: www.biorxiv.org/content/10.1...
w/ @computingnature.bsky.social 1/n