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Debby Silver

@debbysilver.bsky.social

1.5K followers 440 following 69 posts

Scientist, prof at Duke, mom, food, travel, ocean lover. Fascinated by how the brain develops and is modified in disease and evolution. RNA biology intersects neural development. Views my own not employer. https://sites.duke.edu/silverlab/

sites.duke.edu

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Debby Silver @debbysilver.bsky.social · 6h

Thanks so much Kathy!

Debby Silver @debbysilver.bsky.social · 8h

Thanks! Enjoying working together and looking forward to more collaboration!

Debby Silver @debbysilver.bsky.social · 1d

Thanks so much! We are excited about it and hope it is broadly useful.

Debby Silver @debbysilver.bsky.social · 1d

Thanks Matt!

Debby Silver @debbysilver.bsky.social · 2d

Grateful for funding from NINDS which made this possible!!! And for our outstanding team and collaborators including Phoebe Lee, Lucas Serdar, Stephany Perez-Sanchez, Virginia Fernandez, and @borrell-lab.bsky.social.

Debby Silver @debbysilver.bsky.social · 2d

Finally, we develop a new CRISPR-based method for spatial and temporal manipulation of mRNAs. We hope our tool will propel new discoveries across cells of the nervous system.

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Debby Silver @debbysilver.bsky.social · 2d

Our study highlights conserved and unique principles of mRNA localization across the nervous system, and associated with neurodevelopment disease. This generates new hypotheses about functions of radial glia. From this we discover Dynein components control radial glia morphology and interneurons.

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Debby Silver @debbysilver.bsky.social · 2d

Radial glia have complex morphologies that are critical for their function. Yet, how they are subcellularly controlled to dictate cortical development remains largely elusive. We discover over 800 transcripts sub-cellularly enriched in radial glia basal compartments.

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Debby Silver @debbysilver.bsky.social · 2d

I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...

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Debby Silver @debbysilver.bsky.social · 29d

Thanks @blibep.bsky.social for hosting me in Marseille and sharing your exciting science on cerebellar evolution!!
Thanks as well to @alexbaffet.bsky.social and @sbaulac.bsky.social for hosting me in Paris!! What a treat to visit with and discuss fantastic science with all! #internationalscience!

Baptiste Libé-Philippot @blibep.bsky.social · 29d

We were glad to receive @debbysilver.bsky.social 🇺🇸 for a @ibdm.bsky.social keynote lecture "The choreography of brain development: From RNA biology to evolution"!
Thank you for coming in Marseille! Very nice chats on neurodevelopment, human evolution, gene regulation! Food and sea also in the menu!

Reposted by Debby Silver

MPI for Biological Intelligence @mpiforbi.bsky.social · Sep 11

From RNA to evolution: Come join our next keynote lecture on the choreography of brain development by @debbysilver.bsky.social, Professor at Duke University!

📍September 15 at 11am in NQ105 in Martinsried
Art by @somedonkey.bsky.social

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Reposted by Debby Silver

Carolyn Johnson @carolynyjohnson.bsky.social · Aug 18

"What I would simply say is cancer can't wait." --Richard Schlueter, a 56-year-old metastatic cancer patient whose therapy was delayed due to terminations at NIH.

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Debby Silver @debbysilver.bsky.social · Aug 13

Thanks Mariah!

Debby Silver @debbysilver.bsky.social · Aug 11

Thanks Matt!!

Debby Silver @debbysilver.bsky.social · Aug 11

Thanks Madeline!!