Anh Hoang Le, PhD 🏳️🌈
@anhhle2702.bsky.social
Sir Henry Wellcome fellow studying macrophage migration and mechanobiology @UCL. BSc Biochemistry @Bristol. PhD Cancer Biology @CRUK Scotland Institute. 🏴
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
Pinned
My first post will be of course my proudest thing I've ever achieved. My cover image for @jcellbiol.bsky.social. It remains something I'm forever grateful and proud of.
Reposted by Anh Hoang Le, PhD 🏳️🌈
Looks like a really useful tool!
#SpatialTranscriptomics
STcompare
github.com/JEFworks-Lab...
Test your gene of interest if it is differentially spatially patterned (r, p, s)🤠
Spatial correlation
Spatial fold change
Control for spatial autocorrelation
@jef.works bioRxiv 2025
www.biorxiv.org/content/10.1...
STcompare
github.com/JEFworks-Lab...
Test your gene of interest if it is differentially spatially patterned (r, p, s)🤠
Spatial correlation
Spatial fold change
Control for spatial autocorrelation
@jef.works bioRxiv 2025
www.biorxiv.org/content/10.1...
December 12, 2025 at 2:13 PM
Looks like a really useful tool!
Reposted by Anh Hoang Le, PhD 🏳️🌈
One of our favourite activities each year too.
Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Don’t miss your chance to have your say in celebrating the beauty of science. Voting closes on December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...
#ScienceArt
#ScienceArt
December 12, 2025 at 2:18 PM
One of our favourite activities each year too.
Reposted by Anh Hoang Le, PhD 🏳️🌈
Vertebrates can use entirely different mechanisms to generate its anterior and posterior dorsal tissue. In this thorough review from the lab of Lance Davidson, different morphogenetic events are compared between the front and the back in a developing embryo. Check it out:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
December 12, 2025 at 2:00 PM
Vertebrates can use entirely different mechanisms to generate its anterior and posterior dorsal tissue. In this thorough review from the lab of Lance Davidson, different morphogenetic events are compared between the front and the back in a developing embryo. Check it out:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Reposted by Anh Hoang Le, PhD 🏳️🌈
If you or your trainees are just getting started with image analysis of cells & are #CellProfiler -curious, here is a fairly thorough walk-through demo I did recently. Loading files, extracting metadata (fun with Regex!), identifying objects, measuring, filtering, QC, exporting:
youtu.be/fO5nJdhj_7I
youtu.be/fO5nJdhj_7I
Introduction to CellProfiler - by a biologist, for biologists!
YouTube video by CellMorphoJSero
youtu.be
December 4, 2025 at 12:37 PM
If you or your trainees are just getting started with image analysis of cells & are #CellProfiler -curious, here is a fairly thorough walk-through demo I did recently. Loading files, extracting metadata (fun with Regex!), identifying objects, measuring, filtering, QC, exporting:
youtu.be/fO5nJdhj_7I
youtu.be/fO5nJdhj_7I
Reposted by Anh Hoang Le, PhD 🏳️🌈
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins.
buff.ly/hFHjKy9
buff.ly/hFHjKy9
December 8, 2025 at 11:28 PM
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins.
buff.ly/hFHjKy9
buff.ly/hFHjKy9
Reposted by Anh Hoang Le, PhD 🏳️🌈
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
December 8, 2025 at 9:48 AM
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
Reposted by Anh Hoang Le, PhD 🏳️🌈
You can also find the Github code here:
github.com/WhoIsJack/Dy...
github.com/WhoIsJack/Dy...
GitHub - WhoIsJack/DySTrack: A simple automated feedback microscopy tool for live tracking of moving samples.
A simple automated feedback microscopy tool for live tracking of moving samples. - WhoIsJack/DySTrack
github.com
December 8, 2025 at 9:31 PM
You can also find the Github code here:
github.com/WhoIsJack/Dy...
github.com/WhoIsJack/Dy...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Do your samples move out of view? Tired of manually adjusting the stage? Introducing DySTrack developed by @zimengwu33.bsky.social and Jonas Hartmann from UCL, a tool that can be integrated into modern microscopes to automate the tracking of moving samples. #MicroscopyMonday doi.org/10.64898/202...
December 8, 2025 at 9:31 PM
Do your samples move out of view? Tired of manually adjusting the stage? Introducing DySTrack developed by @zimengwu33.bsky.social and Jonas Hartmann from UCL, a tool that can be integrated into modern microscopes to automate the tracking of moving samples. #MicroscopyMonday doi.org/10.64898/202...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Aneesa Shaikh, Maddy Parsons and colleagues investigate ligand- and integrin-independent mechano-sensitive EGFR activation in lung cancer cells.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
December 8, 2025 at 9:45 AM
Aneesa Shaikh, Maddy Parsons and colleagues investigate ligand- and integrin-independent mechano-sensitive EGFR activation in lung cancer cells.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Principles in mechanical engineering can be applied to study biomaterials, such as the notochord. In this theoretical study, Curcio et al investigated how the different ways of notochord stacking affects its structural rigidity. A staircase stacking seems to be better!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
December 6, 2025 at 2:51 PM
Principles in mechanical engineering can be applied to study biomaterials, such as the notochord. In this theoretical study, Curcio et al investigated how the different ways of notochord stacking affects its structural rigidity. A staircase stacking seems to be better!
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Reposted by Anh Hoang Le, PhD 🏳️🌈
We invite you to submit your latest research to our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: @franbottanelli.bsky.social & Giulia Zanetti, with our Editor @guijacquemet.bsky.social. journals.biologists.com/jcs/pages/im...
November 28, 2025 at 2:04 PM
We invite you to submit your latest research to our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: @franbottanelli.bsky.social & Giulia Zanetti, with our Editor @guijacquemet.bsky.social. journals.biologists.com/jcs/pages/im...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Stunning @anhhle2702.bsky.social 😍
For this week #FluorescenceFriday, we'll be treated with one of our favourite animal models 🐸 . Here is a Xenopus laevis embryo imaged with a Lightsheet microscope showing macrophage migration.
Purple🟣 = ectoderm nuclei, Red🔴 = macrophages.
📹: Hoang Anh Le, postdoc in the Mayor lab, UCL.
Purple🟣 = ectoderm nuclei, Red🔴 = macrophages.
📹: Hoang Anh Le, postdoc in the Mayor lab, UCL.
November 28, 2025 at 6:39 PM
Stunning @anhhle2702.bsky.social 😍
Reposted by Anh Hoang Le, PhD 🏳️🌈
For this week #FluorescenceFriday, we'll be treated with one of our favourite animal models 🐸 . Here is a Xenopus laevis embryo imaged with a Lightsheet microscope showing macrophage migration.
Purple🟣 = ectoderm nuclei, Red🔴 = macrophages.
📹: Hoang Anh Le, postdoc in the Mayor lab, UCL.
Purple🟣 = ectoderm nuclei, Red🔴 = macrophages.
📹: Hoang Anh Le, postdoc in the Mayor lab, UCL.
November 28, 2025 at 6:32 PM
For this week #FluorescenceFriday, we'll be treated with one of our favourite animal models 🐸 . Here is a Xenopus laevis embryo imaged with a Lightsheet microscope showing macrophage migration.
Purple🟣 = ectoderm nuclei, Red🔴 = macrophages.
📹: Hoang Anh Le, postdoc in the Mayor lab, UCL.
Purple🟣 = ectoderm nuclei, Red🔴 = macrophages.
📹: Hoang Anh Le, postdoc in the Mayor lab, UCL.
Reposted by Anh Hoang Le, PhD 🏳️🌈
Tissue-resident macrophages are doing more than just protecting from infection. In this interesting paper, René Fernando Abarca-Buis et al shows that they can promote reepithelialization and blastema formation and regulate the maturation of chondrocytes. Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
November 28, 2025 at 5:57 PM
Tissue-resident macrophages are doing more than just protecting from infection. In this interesting paper, René Fernando Abarca-Buis et al shows that they can promote reepithelialization and blastema formation and regulate the maturation of chondrocytes. Check it out here:
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Think about craniofacial biology in sunny California😎! Don't forget to submit an abstract for the 2026 GRC Craniofacial. Many talk slots available from abstract selections. Deadline for talk abstracts 14 Dec, coming soon.... ☠️🐭🐟🐸🧬 #craniofacial #genetics #neuralcrest www.grc.org/craniofacial...
2026 Craniofacial Morphogenesis and Tissue Regeneration Conference GRC
The 2026 Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration will be held in Ventura, California. Apply today to reserve your spot.
www.grc.org
November 28, 2025 at 5:39 PM
Think about craniofacial biology in sunny California😎! Don't forget to submit an abstract for the 2026 GRC Craniofacial. Many talk slots available from abstract selections. Deadline for talk abstracts 14 Dec, coming soon.... ☠️🐭🐟🐸🧬 #craniofacial #genetics #neuralcrest www.grc.org/craniofacial...
Reposted by Anh Hoang Le, PhD 🏳️🌈
We love zebrafish too! <3 #FluorescenceFriday #devbio
Happy #FluorescenceFriday. This beautiful video shows slice by slice section of a zebrafish embryo's head. The embryo is almost completely transparent, proving that zebrafish is an amazing model system for microscopy.
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)
November 21, 2025 at 5:36 PM
We love zebrafish too! <3 #FluorescenceFriday #devbio
Reposted by Anh Hoang Le, PhD 🏳️🌈
It is not often that Sialoglycoproteins and sialyltransferases are mentioned during early development. This interesting review from the lab of Katia Cailliau brings the interesting biology of sialic acid into the context of #devbio, particularly during blastula formation.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
November 21, 2025 at 5:46 PM
It is not often that Sialoglycoproteins and sialyltransferases are mentioned during early development. This interesting review from the lab of Katia Cailliau brings the interesting biology of sialic acid into the context of #devbio, particularly during blastula formation.
doi.org/10.1016/j.cd...
doi.org/10.1016/j.cd...
Reposted by Anh Hoang Le, PhD 🏳️🌈
Happy #FluorescenceFriday. This beautiful video shows slice by slice section of a zebrafish embryo's head. The embryo is almost completely transparent, proving that zebrafish is an amazing model system for microscopy.
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)
November 21, 2025 at 5:34 PM
Happy #FluorescenceFriday. This beautiful video shows slice by slice section of a zebrafish embryo's head. The embryo is almost completely transparent, proving that zebrafish is an amazing model system for microscopy.
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)
Brightfield, red = actin, blue = DAPI
📹: Postdoc Matyas BL (@Mongera lab, UCL)
Today I did my annual lecture on Critical Thinking to first year Biochemistry students. We had about 15 mins standing outside the lecture theater waiting for the previous one to finish. I asked a group of students if they were here for the Critical thinking lecture. And one of them immediately...
November 17, 2025 at 8:40 PM
Today I did my annual lecture on Critical Thinking to first year Biochemistry students. We had about 15 mins standing outside the lecture theater waiting for the previous one to finish. I asked a group of students if they were here for the Critical thinking lecture. And one of them immediately...
Reposted by Anh Hoang Le, PhD 🏳️🌈
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
November 14, 2025 at 8:38 PM
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
Reposted by Anh Hoang Le, PhD 🏳️🌈
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 14, 2025 at 2:14 PM
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Anh Hoang Le, PhD 🏳️🌈
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
November 14, 2025 at 9:33 AM
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
Reposted by Anh Hoang Le, PhD 🏳️🌈
Call for papers: Chilean Developmental Biology: at Home and Around the World - Cells & Development.
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
November 14, 2025 at 5:31 PM
Call for papers: Chilean Developmental Biology: at Home and Around the World - Cells & Development.
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
If you're a Chile-based scientist and Chilean researcher working abroad, please consider submit to us for this special issue.
‼️Submission deadline: 30 June 2026
www.sciencedirect.com/special-issu...
Reposted by Anh Hoang Le, PhD 🏳️🌈
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
November 14, 2025 at 5:45 PM
This week's #FluorescenceFriday, we'll be treated with one of the classical models of #devbio, the neural crest cells. Here is a beautiful video of neural crest cells with GFP-tagged focal adhesion kinase (🔵) and LifeAct-RFP (🟣) migrating on a Fibronectin matrix.
📹: Adam Shellard
📹: Adam Shellard
Reposted by Anh Hoang Le, PhD 🏳️🌈
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
How weakness in cell structure affects the host-microbiome relationship
Mice lacking a gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk
November 13, 2025 at 7:56 PM
Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...