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Anh Hoang Le, PhD 🏳️‍🌈

@anhhle2702.bsky.social

2.1K followers 1K following 200 posts

Sir Henry Wellcome fellow studying macrophage migration and mechanobiology @UCL. BSc Biochemistry @Bristol. PhD Cancer Biology @CRUK Scotland Institute. 🏴󠁧󠁢󠁳󠁣󠁴󠁿 Cell lover by day, takeaway lover by night. https://hoanganhle2602.wixsite.com/cellsandtheirwonders

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · Nov 9

My first post will be of course my proudest thing I've ever achieved. My cover image for @jcellbiol.bsky.social. It remains something I'm forever grateful and proud of.

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 14h

When they are in a tumbling phase, they form many blebs

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 15h

thank you. My favorite cell.

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 16h

Such a delicate process!

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 16h

I love it so much. Seeing these classical structures that people have seen and described and documented always gives me so much joy. Like what do you mean I'm seeing the same thing you saw decades ago and those things are still true!

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 17h

The best process!

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 20h

Thanks. This is just Airyscan.

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 21h

I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

International Society of Developmental Biology @isdb.bsky.social · 1d

A new review from the @mayorlab.bsky.social on the chemical and physical cues regulating neural crest cells migration is out. Check it out!
www.annualreviews.org/content/jour...

Neural Crest Migration Orchestrated by Molecular and Mechanical Signals

The neural crest is a highly migratory multipotent cell population traveling large distances in the vertebrate embryo. Neural crest cells migrate collectively in subpopulations, ranging in size from s...

www.annualreviews.org

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 1d

Interviews conducted by AI are creeping me out. What do you mean I just look into the camera and talk to a machine asking me about my skills? Plus, your voice and your face are being recorded by AI. How do I know that my personal biometric data will be safe? I do not like this.

Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · 3d

In honor of the passing of Sir John Gurdon, we will revisit the concept of chimerism across scales in this review from the lab of @drmichaellevin.bsky.social. Grafting and nucleus transplanting have been the cornerstone of modern #devbio. We have come so far!
www.sciencedirect.com/science/arti...

Schematic of the study of multiscale chimerism.

Chimeras at different scales: subcellular, molecular, cellular, tissue, organ, and population.

What determines the anatomical setpoint of regenerative homeostasis?

Planarian flatworms regenerate after amputation using a resident population of stem cells. This process reliably stops when the correct species-specific head shape is restored. The following thought experiment illustrates the profound knowledge gap in our understanding of the rules of morphogenesis despite ample information about genes required for neoblast differentiation.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Journal of Cell Science @jcellsci.bsky.social · 5d

Edward Jenkins, Clare Latta and Hoang Anh Le @anhhle2702.bsky.social reflect on the major themes and discussion points from The Company of Biologists @biologists.bsky.social Workshop on ‘Immune Cell Interactions in Development, Homeostasis and Immunity’.
journals.biologists.com/jcs/article/...

Screenshot of pdf on 'Immune cell interactions in development and homeostasis and immunity' by Edward Jenkins, Clare Latta and Hoang Anh Le.

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 6d

So I found InterPro. Not directly tell you the interaction interface but you can search in the literature to get this info. Also UniProt has the domain tab too so kind of what I need.

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 6d

Does anyone know a database where let say I have 2 proteins: Integrin and FAK, I can find out what motif/sequence of amino acids mediate their interaction? Thank you.
#questions #academia

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 11d

I said it before and I'll say it again: The whole Microsoft package Outlook, Teams, etc are literally the worst software package ever created. They give us emoji to respond, but emails would be packed into chains that are so difficult to find or even to delete. Clunky and unintuitive.

The Ass is the father of the legs @internethippo.bsky.social · 11d

"We're going to create superintelligence" How about making outlook search work first. How about that

Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · 11d

We often talk about what signals does the organiser release. But have you ever stopped and asked what does it mean to be the organiser? What cells make up the organiser? Where do they go? What do they do?
Well this review by Claudio Stern may give you the answers:
doi.org/10.1016/j.cd...

Cell movements around the organizer/node after stage HH4.

Fate maps of the ectodermal (dorsal) layer of the organizer/node, based on Selleck and Stern (1991) (Selleck and Stern, 1991).

Cell movements of populations contributing to the organizer.

Stages of early chick development referred to in the text. The diagrams show some of the features used to classify the stages in relation to primitive streak formation.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Journal of Cell Biology @jcb.org · 11d

@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...

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Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 12d

And we got a tree as well! A Wild cherry (Prunus avium) 🌸 So cool! Thank you to @biologists.bsky.social and @seemagrewal.bsky.social for the opportunity.
forest.biologists.com/landscape/?i...

Anh Hoang Le, PhD 🏳️‍🌈 @anhhle2702.bsky.social · 12d

An essay that I wrote with 2 of my newly-met colleagues sharing our experiences attending the Immune Cell Interaction workshop in February. I'm not an immunologist by any traditional means so being given an opportunity to branch out is very much appreciated.
journals.biologists.com/jcs/article/...

Immune cell interactions in development, homeostasis and immunity

ABSTRACT. Immune cells play a fundamental role in coordinating physiological processes, from early stage development through to trained host immunity. Hence, an enhanced insight into the dynamic inter...

journals.biologists.com

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · 18d

In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · Sep 12

Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms.
doi.org/10.1016/j.cd...

Fig. 1. EMT dynamics in developmental models.

Fig. 2. A hypothetical model of EMT dynamics.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · Sep 12

Our September issue cover is now online.
You can check out the issue here:
www.sciencedirect.com/journal/cell...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

tabdanov.bsky.social @tabdanov.bsky.social · Sep 9

Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · Sep 5

For decades, living embryos were the favourite tool to study development. However, their complexity hindered precise dissection of many processes. This comprehensive review provides a comparison between embryos and the power of gastruloids, opening up a new wave of dev bio.
doi.org/10.1016/j.cd...

Fig. 1. Schematic overview of mouse gastrulation

Fig. 4. Different aspects of computational modelling of gastrulation.

Fig. 3. Protein localisation, cell sorting behaviours and signalling pathway activation in gastruloids. Depicted are schematic representations based on integration of existing, fragmented data. Note that there is considerable variation in gastruloid development and existing data quality and resolution, and these cartoons represent our interpretation of average domains of immunofluorescence staining.

Fig. 2. Schematic overview of signalling induced GRNs during gastrulation.

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

International Society of Developmental Biology @isdb.bsky.social · Aug 29

A cryosection from an embryo stained for the neural crest (🟠) using HCR, and DAPI (⚪).
Can you guess what embryo this is?
#FluorescenceFriday
Image credit: Ines Fernandez Mosquera, PhD student at @ucl.ac.uk

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Reposted by Anh Hoang Le, PhD 🏳️‍🌈

Cells & Development @cellsdev.bsky.social · Aug 29

Many phenotypes from cells on plastic dishes just don't seem to translate to cells in vivo, particularly isolated primary cells. @raimonsunyer.bsky.social et al discussed how cells mechanically adapt, and the different ways we can mitigate this in this very helpful review:
doi.org/10.1016/j.cd...

The molecular clutch model offers insights into how cells adapt to rigid substrates such as tissue culture polystyrene (TCPS).

Culturing cells on stiff substrates alters their mechanical phenotype. Stiff substrates, such as tissue culture polystyrene (TCPS), trigger adhesion reinforcement.

Cell selection and mechanoadaptation when isolating primary cells. This figure illustrates how primary cells isolated from a tissue explant are affected by the stiffness of the culture surface.

Strategies to mitigate stiff mechanoadaptation in cell culture.

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