Chhabi Govind, PhD
@govindlab.bsky.social
Professor, Oakland University, MICHIGAN.
Visiting Faculty@ LSI, UMich (Klionsky lab).
| Chromatin |Transcription |Autophagy | Yeast | Genomics |🧪
Visiting Faculty@ LSI, UMich (Klionsky lab).
| Chromatin |Transcription |Autophagy | Yeast | Genomics |🧪
Reposted by Chhabi Govind, PhD
Online Now: Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress Online now:
Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress
Under stress, cells adapt their gene expression programs through changes in transcription and translation. It is unclear how cells determine which mRNAs are translated or repressed. Zedan et al. show that the timing of mRNA production alone determines the selectivity of translation, thereby coupling the processes of transcription and translation.
dlvr.it
November 27, 2025 at 8:15 PM
Online Now: Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress Online now:
Reposted by Chhabi Govind, PhD
eIF5A coordinates the transcription and translation of its target genes https://www.biorxiv.org/content/10.1101/2025.11.25.690413v1
November 26, 2025 at 3:17 PM
eIF5A coordinates the transcription and translation of its target genes https://www.biorxiv.org/content/10.1101/2025.11.25.690413v1
Reposted by Chhabi Govind, PhD
Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications
Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...
www.nature.com
November 26, 2025 at 2:28 PM
Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Chhabi Govind, PhD
In a potentially dramatic change to how it chooses what science to fund, NIH is ending a long-running practice at many of its institutes of establishing, and making public, a threshold peer-review score needed for a grant application’s approval. https://scim.ag/48ck2zu
NIH shake-up to grant decision-making draws concerns of political meddling
Policy drops “paylines” based on peer-review scores and requires geography and other factors to guide approvals
scim.ag
November 25, 2025 at 3:18 PM
In a potentially dramatic change to how it chooses what science to fund, NIH is ending a long-running practice at many of its institutes of establishing, and making public, a threshold peer-review score needed for a grant application’s approval. https://scim.ag/48ck2zu
Reposted by Chhabi Govind, PhD
Reposted by Chhabi Govind, PhD
This seems like it could be a cool paper in the quote post trying to get at mechanism of super important surveillance kinase 1/
November 24, 2025 at 2:24 AM
This seems like it could be a cool paper in the quote post trying to get at mechanism of super important surveillance kinase 1/
Reposted by Chhabi Govind, PhD
New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
www.science.org
November 23, 2025 at 7:22 PM
New paper out: An archaeal genetic code with all TAG codons as pyrrolysine: www.science.org/doi/10.1126/...
Reposted by Chhabi Govind, PhD
☕Li et al. uncover a connection between #metabolic cues and #mitochondria protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquitylation and promoting mitochondrial respiration.
bit.ly/48t7ZPw
bit.ly/48t7ZPw
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology
Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...
bit.ly
November 23, 2025 at 7:00 AM
☕Li et al. uncover a connection between #metabolic cues and #mitochondria protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquitylation and promoting mitochondrial respiration.
bit.ly/48t7ZPw
bit.ly/48t7ZPw
Reposted by Chhabi Govind, PhD
This week's (on time) selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
bims-proteo 2025-11-23 papers
biomed.news
November 23, 2025 at 9:30 AM
This week's (on time) selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
Highlight - @drsimoncook.bsky.social RAF inhibitors activate the integrated stress response by direct activation of GCN2 www.nature.com/articles/s41...
Reposted by Chhabi Govind, PhD
I wrote this in 2018 for a resource that doesn’t seem to exist anymore about how to respond to sexual harassment in STEM. I’m so disappointed, but not surprised, that I need to post it again
psychiatry.ucsd.edu/_files/diver...
psychiatry.ucsd.edu/_files/diver...
psychiatry.ucsd.edu
November 22, 2025 at 5:31 PM
I wrote this in 2018 for a resource that doesn’t seem to exist anymore about how to respond to sexual harassment in STEM. I’m so disappointed, but not surprised, that I need to post it again
psychiatry.ucsd.edu/_files/diver...
psychiatry.ucsd.edu/_files/diver...
Reposted by Chhabi Govind, PhD
Swiss researchers identify amino acid #supplementation to promote collagen & #longevity!
www.nature.com/articles/s41...
— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans
#science 🧪
www.nature.com/articles/s41...
— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans
#science 🧪
A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo - npj Aging
npj Aging - A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo
www.nature.com
November 21, 2025 at 11:47 PM
Swiss researchers identify amino acid #supplementation to promote collagen & #longevity!
www.nature.com/articles/s41...
— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans
#science 🧪
www.nature.com/articles/s41...
— ratio of 3 glycine: 1 proline: 1 hydroxyproline
— motility-healthspan of C. elegans
— grip strength in mice
— skin features & biological age after 6 mo in humans
#science 🧪
Reposted by Chhabi Govind, PhD
The premise of Ozempic came from a lizard.
World-changing discoveries are serendipitous; are built on DECADES of basic research. Private companies provide short-term returns & do not provide long term support from molecule to cure.
Transcription occurs before translation.
🧪 archive.today/2qNTr
World-changing discoveries are serendipitous; are built on DECADES of basic research. Private companies provide short-term returns & do not provide long term support from molecule to cure.
Transcription occurs before translation.
🧪 archive.today/2qNTr
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
www.nature.com
November 21, 2025 at 8:35 PM
The premise of Ozempic came from a lizard.
World-changing discoveries are serendipitous; are built on DECADES of basic research. Private companies provide short-term returns & do not provide long term support from molecule to cure.
Transcription occurs before translation.
🧪 archive.today/2qNTr
World-changing discoveries are serendipitous; are built on DECADES of basic research. Private companies provide short-term returns & do not provide long term support from molecule to cure.
Transcription occurs before translation.
🧪 archive.today/2qNTr
Reposted by Chhabi Govind, PhD
In August, NIH institute and center directors received this document entitled "Achieving NIH Mission: Leveraging Funding Policies".
1/6
1/6
November 20, 2025 at 3:55 PM
In August, NIH institute and center directors received this document entitled "Achieving NIH Mission: Leveraging Funding Policies".
1/6
1/6
Reposted by Chhabi Govind, PhD
Aha.
NIH LRP application due date extended to Dec 4th. grants.nih.gov/grants/guide...
NOT-OD-26-010: Notice of Change in Application Due Date for NIH Extramural Loan Repayment Program
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Change in Application Due Date for NIH Extramural Loan Repayment Program NOT-OD-26-010. OD
grants.nih.gov
November 19, 2025 at 11:07 PM
Aha.
Reposted by Chhabi Govind, PhD
Assistant Professor position posted for my Department, Biological Sciences at UNC Charlotte! Current research foci: Immunology, Microbiology, Virology; Biomolecular Function; Proteostasis; Genome Integrity; Epigenome Regulation; Cancer; Environmental Risks. jobs.charlotte.edu/postings/65141
Assistant Professor
Applicants should possess a Ph.D. in the biological sciences or related fields.Candidates are expected to document expertise in their specialty by a record of postdoctoral training, peer reviewed publ...
jobs.charlotte.edu
November 19, 2025 at 2:16 PM
Assistant Professor position posted for my Department, Biological Sciences at UNC Charlotte! Current research foci: Immunology, Microbiology, Virology; Biomolecular Function; Proteostasis; Genome Integrity; Epigenome Regulation; Cancer; Environmental Risks. jobs.charlotte.edu/postings/65141
Reposted by Chhabi Govind, PhD
Do you have new stoichiometric research to share? If so, consider submitting an abstract to our special session SS027. Abstract deadline is Nov 24 (yes, under a week!). Can't wait to see people in Montreal, to spill the tea on all things ratios. @helenaklip.bsky.social #ASLOSIL26
November 19, 2025 at 8:41 PM
Do you have new stoichiometric research to share? If so, consider submitting an abstract to our special session SS027. Abstract deadline is Nov 24 (yes, under a week!). Can't wait to see people in Montreal, to spill the tea on all things ratios. @helenaklip.bsky.social #ASLOSIL26
Reposted by Chhabi Govind, PhD
A new £2.5 million Government-funded laboratory is set to open at the University of Essex to train workplace-ready scientists for the NHS and the life-sciences sector www.essex.ac.uk/news/2025/11...
Essex to train workplace-ready NHS scientists in new lab | University of Essex
www.essex.ac.uk
November 19, 2025 at 4:47 PM
A new £2.5 million Government-funded laboratory is set to open at the University of Essex to train workplace-ready scientists for the NHS and the life-sciences sector www.essex.ac.uk/news/2025/11...
Reposted by Chhabi Govind, PhD
Autolamellasomes: An Autophagy-Dependent Parallel Pathway for Bulk ER Degradation and Lysosome Biogenesis https://www.biorxiv.org/content/10.1101/2025.11.16.688694v1
November 17, 2025 at 12:30 AM
Autolamellasomes: An Autophagy-Dependent Parallel Pathway for Bulk ER Degradation and Lysosome Biogenesis https://www.biorxiv.org/content/10.1101/2025.11.16.688694v1
Reposted by Chhabi Govind, PhD
I'm getting old. 👴
Sometimes I have to reread old papers that I've already read but have little or no memory of.
Like this one, for example
www.cell.com/molecular-ce...
Sometimes I have to reread old papers that I've already read but have little or no memory of.
Like this one, for example
www.cell.com/molecular-ce...
Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals
Transcription of eukaryotic genes requires an efficient termination to avoid pervasive
transcript synthesis. Here, Shah and Maqbool et al. show that tyrosine residues of
RNA polymerase II CTD are esse...
www.cell.com
November 14, 2025 at 8:57 AM
I'm getting old. 👴
Sometimes I have to reread old papers that I've already read but have little or no memory of.
Like this one, for example
www.cell.com/molecular-ce...
Sometimes I have to reread old papers that I've already read but have little or no memory of.
Like this one, for example
www.cell.com/molecular-ce...
Reposted by Chhabi Govind, PhD
Researchers from the @narayanlab.bsky.social have unlocked a novel mechanism for transforming molecules. Their findings, described in a new @nature.com study, open new ways to develop important molecules with fewer wasteful byproducts.
nature.com/articles/s41...
nature.com/articles/s41...
Synthesis of enantioenriched atropisomers by biocatalytic deracemization - Nature
A new method for deracemization of atropisomers is described which leverages a P450 enzyme-mediated process involving bond rotation for enantioenrichment.
nature.com
November 12, 2025 at 8:39 PM
Researchers from the @narayanlab.bsky.social have unlocked a novel mechanism for transforming molecules. Their findings, described in a new @nature.com study, open new ways to develop important molecules with fewer wasteful byproducts.
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Chhabi Govind, PhD
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
A role for human senataxin in contending with pausing and backtracking during transcript elongation
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…
www.sciencedirect.com
November 12, 2025 at 5:36 PM
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
Reposted by Chhabi Govind, PhD
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Reposted by Chhabi Govind, PhD
Biological Chemistry's position is still taking applications. UM is a great place to be a PI, I'd love to see a new membrane biology or lipids expert join our community.
This is open for new and established investigators.
This is open for new and established investigators.
Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...
November 11, 2025 at 3:33 PM
Biological Chemistry's position is still taking applications. UM is a great place to be a PI, I'd love to see a new membrane biology or lipids expert join our community.
This is open for new and established investigators.
This is open for new and established investigators.
Reposted by Chhabi Govind, PhD
DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress
DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress
Shawky et al. show that DDX3X selectively promotes or represses mRNA translation in a stress-dependent manner. This bidirectional regulation involves position-specific binding to the mRNA 5′ UTR and early coding region, reflecting distinct mechanisms, including initiation control during 48S scanning and translational repression associated with ac4C post-transcriptional modification.
dlvr.it
November 9, 2025 at 3:31 PM